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7 Diseases |  |
379 Trials |
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379 Trials |  |
12426 News |  |
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- morphine sulphate / Generic mfg.
Biomarker, Observational data, Journal: The Pharmacogenetics of Cannabis in the Treatment of Chronic Pain. (Pubmed Central) - Oct 28, 2022
The study we are presenting is the first observational study conducted on a large number of patients involving several polymorphic candidate genes. The data obtained suggest that genetic makeup can be a predictive factor in the response to cannabis therapy and that more extensive and planned studies are needed for the opening of new scenarios for the personalization of cannabis therapy.
- || Clinical, Journal: Nociception Level Index-Directed Erector Spinae Plane Block in Open Heart Surgery: A Randomized Controlled Clinical Trial. (Pubmed Central) - Oct 28, 2022
NOL index-directed ESPB reduced intraoperative fentanyl by 73.3% and 48 h morphine by 63.5%. It also hastened the extubation and liberation from vasopressor support and improved postoperative analgesia.
- || morphine sulphate / Generic mfg.
Clinical, Reimbursement, Journal: Sex, Race, Insurance, and Pain: Do Patient Sociodemographics Influence Postoperative Opioid Prescriptions Among Hand Surgeons? (Pubmed Central) - Oct 28, 2022
The average morphine milligram equivalent (MME) prescribed following each surgery was calculated and then classified by age, race, sex, type of insurance, and history of substance use or chronic pain...Numerous sociodemographic factors influenced postoperative opioid prescription among hand surgeons at our institution. These findings highlight the importance of establishing more uniform, evidence-based guidelines for postoperative pain management, which may help minimize subjectivity and prevent the overtreatment or undertreatment of pain in certain patient populations.
- | morphine sulphate / Generic mfg.
Journal: Total knee arthroplasty is associated with greater immediate post-surgical pain and opioid use than total hip arthroplasty. (Pubmed Central) - Oct 28, 2022
These findings highlight the importance of establishing more uniform, evidence-based guidelines for postoperative pain management, which may help minimize subjectivity and prevent the overtreatment or undertreatment of pain in certain patient populations. THA patients reported lower pain scores and were found to require less opioid medication in the immediate post-surgical period than TKA patients.
- | morphine sulphate / Generic mfg.
Journal: Enhancing Recovery in Congenital Cardiac Surgery. (Pubmed Central) - Oct 28, 2022
THA patients reported lower pain scores and were found to require less opioid medication in the immediate post-surgical period than TKA patients. An enhanced recovery program reduced the use of opioids, led to more extubation in the operating room, and reduced mechanical ventilation duration in patients undergoing congenital cardiac surgery.
- || dexamethasone / Generic mfg.
Retrospective data, Review, Journal: Dexamethasone does not provide additional clinical analgesia effect to local wound infiltration: A comprehensive systematic review and meta-analysis. (Pubmed Central) - Oct 28, 2022
In summary, the current evidence does not support routine clinical use of dexamethasone in LWI. However, further studies should explore the clinical value of preemptive analgesia and safety of a combination of dexamethasone with ropivacaine for LWI.
- | morphine sulphate / Generic mfg.
Journal: Effect of Pre-Incisional Liposomal Bupivacaine Sternal Blockade on Post-Sternotomy Opioid Use. (Pubmed Central) - Oct 28, 2022
However, further studies should explore the clinical value of preemptive analgesia and safety of a combination of dexamethasone with ropivacaine for LWI. Preincisional sternal blockade with liposomal bupivacaine did not reduce the amount of opioid medication administered to patients in the first 72 hours after sternotomy.
- | morphine sulphate / Generic mfg., diazepam / Generic mfg., ibuprofen / Generic mfg.
Journal: Universal Trends between Acid Dissociation Constants in Protic and Aprotic Solvents. (Pubmed Central) - Oct 28, 2022
We find, that neutral acids such as alcohols are strongly affected by the solvent properties. This is contrasted by cationic acids like ammonium ions whose pKa is often almost completely independent from the choice of solvent.
- | Journal: Accumulation and risk prioritization of psychoactive substances in the critically endangered Yangtze finless porpoise. (Pubmed Central) - Oct 28, 2022
Location-specific risk prioritization of psychoactive substances found that the top 3 substances are LSD, lorazepam (LORZ) and ALPZ in PYL, and COD, LSD and LORZ in TZO. The results disclose the accumulation of psychoactive substances in Yangtze finless porpoise and suggest that the potential adverse effects should be concerned.
- | morphine sulphate / Generic mfg.
Journal: Morphine disrupts macrophage functions even during HIV infection. (Pubmed Central) - Oct 28, 2022
Using downstream pathway analyses, we found that MOR dysregulates ER quality control and extracellular matrix invasion. Our data indicate that MOR enhances inflammatory functions and impacts additional cellular processes in HIV-infected MDMs to potentially increases neuropathogenesis in PWH using opioids.
- | morphine sulphate / Generic mfg.
Retrospective data, Journal: Bilateral bi-level erector spinae plane blocks in scoliosis surgery: a retrospective comparative study. (Pubmed Central) - Oct 28, 2022
Our data indicate that MOR enhances inflammatory functions and impacts additional cellular processes in HIV-infected MDMs to potentially increases neuropathogenesis in PWH using opioids. Given the need for improved recovery of the patients, ESPB seems to be an essential analgesic technique that may reduce both opioid consumption and the severity of the pain, thus increasing the satisfaction of the patients and decreasing the length of hospital stay.
- | morphine sulphate / Generic mfg.
Journal: PROSPECTIVE SINGLE CENTER PARADIGM SHIFT OF SURGICAL STABILIZATION OF RIB FRACTURES WITH DECREASED LENGTH OF STAY AND OPERATIVE TIME WITH AN INTRATHORACIC APPROACH. (Pubmed Central) - Oct 28, 2022
In this single center study, patients who underwent ITP had a decreased LOS and operative time in comparison to ETP in patients with similar injury severity. Future prospective multicenter research is needed to confirm these findings and may lead to further adoption of this minimally invasive technique.
- | rapastinel (GLYX-13) / AbbVie
Journal: Rapastinel accelerates loss of withdrawal signs after repeated morphine and blunts relapse to conditioned place preference. (Pubmed Central) - Oct 28, 2022
Rapastinel did not affect extinction of CPP, but rapastinel-treated animals spent significantly less time in the previously morphine-paired side than saline-treated animals during the relapse trial. These findings of accelerated loss of withdrawal signs and blunted relapse to CPP suggest that rapastinel could provide an adjunctive therapy for opioid dependence during initiation of pharmacotherapy for opioid dependence.
- | morphine sulphate / Generic mfg.
Journal: Comparison of subcutaneous analgesic system and epidural analgesia for postoperative pain control in open pediatric oncology operations: A randomized controlled trial. (Pubmed Central) - Oct 27, 2022
Parental satisfaction is excellent with both modalities. SAS could be considered as an alternative to epidural, especially in settings when epidural placement is not available or contraindicated.
- | morphine sulphate / Generic mfg.
Journal: Inhibition of the expression of rgs-3 alleviates propofol-induced decline in learning and memory in Caenorhabditis elegans. (Pubmed Central) - Oct 27, 2022
SAS could be considered as an alternative to epidural, especially in settings when epidural placement is not available or contraindicated. Inhibition of the expression of rgs-3 alleviated propofol-induced learning and memory deficits in Caenorhabditis elegans.
- || morphine sulphate / Generic mfg., ropivacaine / Generic mfg.
Clinical, Journal: Intraoperative Interpectoral and Subserratus Nerve Blocks in Breast Augmentation Surgery. (Pubmed Central) - Oct 27, 2022
Twenty patients were randomized into saline (n = 10) or ropivacaine adrenaline solution (n = 10)...All patients were closely followed up, and morphine equivalents were accurately recorded...There were no side effects attributable to the nerve blocks. Intraoperative targeted nerve blocks significantly reduce postoperative opiate requirements in breast augmentation surgery resulting in faster recovery and higher patient satisfaction.
- | morphine sulphate / Generic mfg.
Journal: Liposomal bupivacaine does not decrease postoperative opioid use or length of hospital stay in patients undergoing anterior cervical discectomy and fusion. (Pubmed Central) - Oct 27, 2022
For every vertebral level involved, 242 additional morphine milligram equivalents (MME) were consumed on POD0, 266 additional MME were utilized on POD1, and 130 additional MME were consumed in total per LOS...Patients whose procedures involved a greater number of cervical vertebrae were associated with greater opioid consumption on POD0, POD1, and total per LOS. ACDF patients, especially those who had a high number of vertebrae involved, may require alternative analgesia to LB.
- || morphine sulphate / Generic mfg.
Clinical, Journal: Is Opioid-Limiting Legislation Effective for Hand Surgery Patients? (Pubmed Central) - Oct 27, 2022
Patients undergoing "major surgery" saw a significant decrease in the number of pills issued in the first postoperative prescription (41.1 vs 21.0) and a corresponding decrease in morphine milligram equivalents (MMEs) (318.6 vs 159.2 MMEs) after implementation...Risk factors for prolonged opioid use included male sex and preoperative opioid use. In Rhode Island, opioid-limiting legislation resulted in a significant decrease in the number of pills and MMEs of the initial prescription and a 30% decrease in total MMEs in the 30-day postoperative period after "major hand surgery." Additional research is needed to explore the association between legislation and clinical outcomes.
- | morphine sulphate / Generic mfg.
Journal: Informal Caregivers' Administration of Concentrated Liquid Morphine to Hospice Patients Receiving Home Care: Does Regimen Matter? (Pubmed Central) - Oct 27, 2022
Morphine was frequently prescribed in the last week of life, but administration rates by caregivers were low, especially with less structured regimens. Caregivers may need more guidance regarding morphine's use at home, especially with more flexible regimens.
- | morphine sulphate / Generic mfg.
Journal: Postoperative pain management after concomitant sacrectomy for locally recurrent rectal cancer. (Pubmed Central) - Oct 27, 2022
Opioid use after concomitant sacrectomy for LRRC was higher in the high sacrectomy group. Prolonged postoperative pain or increasing pain was associated with local recurrence.
- | morphine sulphate / Generic mfg.
Journal: Comparison of ultrasound-quided quadratus lumborum block and erector spinae plane block in terms of their effects on postoperative pain in open nephrectomy. (Pubmed Central) - Oct 27, 2022
In conclusion, ultrasound-guided QLB 2 and ESP block were found to achieve similar results on at-rest and at movement pain scores and morphine consumption of the patients undergoing open nephrectomy. Both blocks may be preferred, depending on the clinician's experience.
- | morphine sulphate / Generic mfg.
Trial initiation date, Surgery: Comparative Study Between ESPB Versus IV Morphine as Postoperative Analgesia After Spine Surgeries . (clinicaltrials.gov) - Oct 27, 2022
P=N/A, N=60, Not yet recruiting, Sponsor: Sohag University
Both blocks may be preferred, depending on the clinician's experience. Initiation date: May 2022 --> Nov 2022
- ||| morphine sulphate / Generic mfg., ketamine / Generic mfg.
New P1 trial: Analgesic Effect of Ketamine Vs Ketamine Magnesium Infusion and Their Effect on Postoperative Morphine Consumption (clinicaltrials.gov) - Oct 27, 2022
P1, N=100, Completed, Sponsor: Egymedicalpedia
- ||| Xtandi (enzalutamide capsule) / Pfizer, Astellas, Savaysa (edoxaban) / Daiichi Sankyo
Enrollment open: MIND THE GAP: Determining the Clinical Relevance of the Interaction Between Enzalutamide and the Opioid Morphine and the DOAC Edoxaban (clinicaltrials.gov) - Oct 27, 2022
P=N/A, N=26, Recruiting, Sponsor: Radboud University Medical Center
Initiation date: May 2022 --> Nov 2022 Not yet recruiting --> Recruiting
- ||| fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
1/…Couldn’t agree with you more I do a spinal for most spine ops as analgesic technique with fentanyl or morphine To avoid going in the stenosed space , I get a surgeon to show me the level corresponding to crest ( interesting to see big variations ) (Twitter) - Oct 27, 2022
- | morphine sulphate / Generic mfg., ropivacaine / Generic mfg.
Trial completion: Comparison of Two Analgesic Strategies After Scheduled Caesarean (clinicaltrials.gov) - Oct 26, 2022
P4, N=104, Completed, Sponsor: GCS Ramsay Santé pour l'Enseignement et la Recherche
Not yet recruiting --> Recruiting Recruiting --> Completed
- | morphine sulphate / Generic mfg.
Journal: Morphine use in acute cardiogenic pulmonary oedema: Is MIMO trial enough to change practice? (Pubmed Central) - Oct 26, 2022
Recruiting --> Completed No abstract available
- || Clinical, Journal: The efficacy and safety of an adapted opioid-free anesthesia regimen versus conventional general anesthesia in gynecological surgery for low-resource settings: a randomized pilot study. (Pubmed Central) - Oct 26, 2022
P=N/A
No abstract available This OFA regimen without dexmedetomidine for a low-resource setting has a promising success rate with few perioperative complications including mild intraoperative hemodynamic changes, decrease postoperative complications, pain, and opioid consumption in patients undergoing elective gynecology surgery.
- || morphine sulphate / Generic mfg.
Review, Journal: Palliative care in a tertiary neonatal intensive care unit: a 10-year review. (Pubmed Central) - Oct 26, 2022
Clinical documentation of care plans was often incomplete, potentially leading to inconsistent delivery of care, increased risk of symptom breakthrough and/or inadequate psychosocial supports for family. Formal individualised palliative care plans are under development to standardise documentation and improve therapeutic and psychosocial interventions available to the infant and their family.
- || morphine sulphate / Generic mfg., hydromorphone hydrochloride / Generic mfg.
Clinical, Review, Journal: Threats to Narcotic Safety-A Narrative Review of Narcotic Incidents, Discrepancies and Near-Misses Within a Large Canadian Health System. (Pubmed Central) - Oct 26, 2022
Nurses have an important role in narcotic safety as an intermediary between narcotic administration and incident reporting. Further research is needed to understand the enablers, barriers and opportunities for nurses and other healthcare professionals to improve narcotic stewardship.
- | morphine sulphate / Generic mfg.
Journal: Opioid requirements in primary versus revision reverse shoulder arthroplasty. (Pubmed Central) - Oct 26, 2022
The perceived notion that revision shoulder arthroplasty is more painful may cause providers to be more inclined to increase narcotic use, or use more invasive pain control techniques. Based on these data, we found that revision shoulder arthroplasty did not require an increased opioid requirement, longer length of stay or increase VAS, suggesting that these patients can often be managed similarly to primary rTSA.
- | morphine sulphate / Generic mfg.
Journal: Integration of Life Care Specialists Into Orthopaedic Trauma Care to Improve Postoperative Outcomes: A Pilot Study. (Pubmed Central) - Oct 26, 2022
Based on these data, we found that revision shoulder arthroplasty did not require an increased opioid requirement, longer length of stay or increase VAS, suggesting that these patients can often be managed similarly to primary rTSA. The findings indicate feasibility to integrate LCS into orthopaedic trauma care, evident by participant engagement and satisfaction, and that LCS serve as valuable resources to assist with pain management and opioid education.
- || ondansetron / Generic mfg.
Clinical, Journal: A randomized controlled trial comparing incidences of postoperative nausea and vomiting after laparoscopic cholecystectomy for preoperative intravenous fluid loading, ondansetron, and control groups in a regional hospital setting in a developing country. (Pubmed Central) - Oct 26, 2022
Neither the preoperative intravenous fluid loading nor the ondansetron affected PONV in patients aged 50 and older undergoing LC, compared with control. Ondansetron was beneficial for PON prophylaxis in patients under the age of 50, whereas preoperative intravenous fluid loading was considered a risk factor for PON in this population.
- | fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
Retrospective data, Journal: Opioid prescribing practices in trauma patients at discharge: An exploratory retrospective chart analysis. (Pubmed Central) - Oct 26, 2022
A Morphine Milligram Equivalents per day (MME/day) was computed for each patient who was prescribed opioids and compared with standard practice guidelines...Only 7.5% were prescribed extended-release opioids and none were strong like fentanyl...These results are encouraging with respect to the feasibility of implementing opioid prescription guidelines effectively. However, routine monitoring is necessary to ensure that adherence is maintained.
- | tramadol hydrochloride / Generic mfg., dexmedetomidine / Generic mfg.
Journal: Comparative Study Between Early versus Late Intraperitoneal Administration of Either Bupivacaine/Tramadol or Bupivacaine/Dexmedetomidine for Perioperative Analgesia in Abdominal Laparoscopic Cancer Surgeries: A Prospective Randomized Study. (Pubmed Central) - Oct 26, 2022
P2/3
Early instillation reduced the intraoperative opioid consumption and late instillation resulted in reduced postoperative opioid consumption. https://clinicaltrials.gov/ct2/show/NCT04813016.
- | AM4113 / MAKScientific, Acomplia (rimonabant) / Sanofi
Preclinical, Journal: Effects of the cannabinoid CB-receptor neutral antagonist AM4113 and antagonist/inverse agonist rimonabant on fentanyl discrimination in male rats. (Pubmed Central) - Oct 26, 2022
These results extend our recent work showing that AM4113 can effectively block the behavioral effects of heroin without producing rimonabant-like adverse effects. Taken together, these data suggests that CB neutral antagonists effectively block the behavioral effects of structurally distinct morphinan (heroin) and phenylpiperidine-based (fentanyl) opioids and may provide a novel therapeutic option for the treatment of OUD.
- || morphine sulphate / Generic mfg.
Clinical data, Retrospective data, Review, Journal: Clinical outcomes of opioid administration in acute and chronic heart failure: A meta-analysis. (Pubmed Central) - Oct 26, 2022
Opioids are not recommended for acute HF management; however, they showed an advantage in exercise testing by improving ventilatory efficiency, chemosensitivity, and exercise test duration in stable patients with chronic HF NYHA Class II/III. Nonetheless, larger randomized controlled trials and individual patient-level data meta-analyses are warranted.
- | morphine sulphate / Generic mfg., tramadol hydrochloride / Generic mfg.
Journal: Investigation of the analgesic efficacy of ultrasound-guided thoracolumbar interfacial plane block in vertebral surgery: A prospective randomized clinical study. (Pubmed Central) - Oct 26, 2022
P=N/A
Therefore, it is an important regional analgesia technique. CLINICALTRIALSGOV GRANT NO: NCT04548076.
- | morphine sulphate / Generic mfg., tramadol hydrochloride / Generic mfg., quetiapine / Generic mfg.
Journal: Deaths caused by medication in persons not using illicit narcotic drugs - an autopsy study from Western Denmark. (Pubmed Central) - Oct 26, 2022
In conclusion, opioids and psychotropic medications dominated by morphine, tramadol and quetiapine most frequently caused medication-related deaths in PNUIDs. Monitoring this type of death may yield important knowledge to direct prophylactic initiatives regarding medication use and prescription.
- Chirocaine (levobupivacaine) / Purdue, AbbVie
Observational data, Journal, HEOR: Effects of an Intrathecal Drug Delivery System Connected to a Subcutaneous Port on Pain, Mood and Quality of Life in End Stage Cancer Patients: An Observational Study. (Pubmed Central) - Oct 26, 2022
Intrathecal combination therapy delivered by an IDDS-SP could ensure adequate control of cancer related symptoms, such as pain, depression, anxiety and sleep disturbances. These effects, with low rate of AEs and reduced BTcP episodes, could explain the improvement in QoL and the overall high levels of patients' satisfaction.
- | morphine sulphate / Generic mfg.
Journal: Paravertebral block versus erector spinae plane block for analgesia in modified radical mastectomy: a randomized, prospective, double-blind study. (Pubmed Central) - Oct 26, 2022
Thoracal paravertebral block reduced morphine consumption compared to ESPB after MRM, albeit a small difference. A through coverage of TPVB may be preferred with experienced operators in MRM due to lower pain scores.
- | morphine sulphate / Generic mfg.
Journal: Structural and functional analyses of a GPCR-inhibited ion channel TRPM3. (Pubmed Central) - Oct 26, 2022
This GPCR-TRPM3 signaling pathway contributes to the analgesic effect of morphine...Gβγ-TRPM3 interfaces vary depending on PIP occupancy; however, in all cases, Gβγ appears loosely attached to TRPM3. The IC50 in electrophysiology experiments raises the possibility that additional unknown factors may stabilize the TRPM3-Gβγ complex.
- | morphine sulphate / Generic mfg.
Journal, HEOR: The Cost Effectiveness of Unicompartmental versus Total Knee Arthroplasty. (Pubmed Central) - Oct 26, 2022
The IC50 in electrophysiology experiments raises the possibility that additional unknown factors may stabilize the TRPM3-Gβγ complex. This study demonstrated that the use of robotic arm-assisted UKA rather than TKA in suitably indicated patients may realize significant cost savings.
- | morphine sulphate / Generic mfg., aspirin / Generic mfg.
Enrollment open: PLAAFM: Platelet Reactivity With Fentanyl, Morphine, or no Narcotic (clinicaltrials.gov) - Oct 26, 2022
P1, N=100, Recruiting, Sponsor: Spectrum Health - Lakeland
This study demonstrated that the use of robotic arm-assisted UKA rather than TKA in suitably indicated patients may realize significant cost savings. Not yet recruiting --> Recruiting
- | morphine sulphate / Generic mfg.
Retrospective data, Journal: Intercostal Nerve Cryoanalgesia Versus Thoracic Epidural Analgesia in Lung Transplantation: A Retrospective Single-Center Study. (Pubmed Central) - Oct 25, 2022
In lung transplantation, Cryo was found to be safe with analgesic effectiveness similar to TEA. Cryo may be advantageous in this complex patient population, as it can be used in all clinical scenarios and eliminates risks and delays associated with TEA.
- | morphine sulphate / Generic mfg.
Observational data, Journal: Ultrasound assessment of residual gastric volume in older adults undergoing staged-bilateral total knee arthroplasty after consuming carbohydrate-containing fluids: A prospective observational study. (Pubmed Central) - Oct 25, 2022
Residual GV after drinking carbohydrate-containing fluid differed according to the stage of TKA, showing a larger residual GV in the second TKA than in the first one. In older adults scheduled to undergo bilateral staged TKA, caution is required in preoperative fasting practice, especially in second-stage surgery.
- | morphine sulphate / Generic mfg.
Retrospective data, Journal: Effect of CD4-positive T lymphocyte expression rate on pain control and prognosis in stage Ⅳ non-small cell lung cancer patients with cancerous pain (Pubmed Central) - Oct 25, 2022
The OS time and PFS time in the CD4 high expression group [M (Q, Q)] were 12.5 (8.1, 13.8) months and 8.5(3.1, 9.4) months, respectively, which were higher than those in the CD4 low expression group [8.6 (4.1, 12.9) months and 6.5 (2.1, 7.9) months, respectively] (all P<0.01). Cox multivariate analysis showed that high expression of CD4 was a protective factor affecting OS (HR=0.876, 95%CI: 1.224-6.641, P=0.004) and PFS (HR=0.675, 95%CI: 1.742-5.930, P=0.031) The stage Ⅳ NSCLC patients with cancerous pain and high expression of CD4-positive T lymphocytes have shorter pain control time, less morphine dosage, and longer OS and PFS time.
- || morphine sulphate / Generic mfg.
Retrospective data, Review: Analgesic efficacy and risk of low-to-medium dose intrathecal morphine in patients undergoing cardiac surgery: An updated meta-analysis. (Pubmed Central) - Oct 25, 2022
There was no subgroup difference in IMC except a lower pain score with 0.3-0.5 mg than <0.3 mg at postoperative 24 h. Respiratory depression events were not noted in the ITM group. Our results validated the analgesic efficacy of low-to-medium dose ITM for patients receiving cardiac surgery without increasing the risk of respiratory depression.
- | morphine sulphate / Generic mfg.
Journal: Hippocampal and amygdalar increased BDNF expression in the extinction of opioid-induced place preference. (Pubmed Central) - Oct 25, 2022
Finally, extinction-trained animals showed no difference in rears regardless of extinction outcome, suggesting that anxiety elicited by drug withdrawal did not significantly impact extinction of morphine CPP. Our results suggest that BDNF expression in brain regions of the mesolimbic reward system could play a key role in extinction of opioid-induced maladaptive behaviors and represents a potential therapeutic target for future combined pharmacological and extinction-based therapies.
- | morphine sulphate / Generic mfg.
Retrospective data, Journal: Sufentanil Combined with Nalbuphine via Patient-Controlled Intravenous Analgesia After Cesarean Section: A Retrospective Evaluation. (Pubmed Central) - Oct 25, 2022
Secondary outcomes were NRS scores at rest (NRS-R) at 24 and 48 h after CS, NRS-M at 48 h after CS, cumulative PCIA bolus times, and opioid consumption during the first 24 and 48 h postoperatively, which was measured in morphine-equivalent doses...However, the rates of dizziness and postoperative hypotension were slightly higher in the SN group, and those of nausea/vomiting were comparable. Compared with sufentanil alone, sufentanil combined with nalbuphine for PCIA provided superior analgesia in parturient women after CS.