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7 Diseases |  |
379 Trials |
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379 Trials |  |
12426 News |  |
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- | fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
Journal: Preoperative Pericapsular Nerve Group Block Results in Less Pain, Decreased Narcotic Use, and Quicker Discharge Time Than No Block in Patients Who Were Surgically Treated for Femoroacetabular Impingement Syndrome. (Pubmed Central) - Nov 1, 2022
For patients undergoing hip arthroscopy for FAIS, the addition of a preoperative PENG block showed a significant decrease in initial PACU pain, PACU narcotic consumption, intraoperative fentanyl usage, and quicker time to discharge without complications when compared to a no block, post-free control group. III, retrospective cohort study.
- | fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
Journal: Perioperative Outcomes of Immersive Virtual Reality as Adjunct Anesthesia in Primary Total Hip and Knee Arthroplasty. (Pubmed Central) - Nov 1, 2022
Acute perioperative outcomes, including 24-hour oral morphine equivalent (OME), first ambulation distance, length of stay, and 30-day complications, were also analyzed...When compared to non-IVR primary THAs and TKAs, those performed with IVR utilized significantly less intraoperative sedation (48 mg vs 708 mg of propofol; P .3) postoperative outcomes were noted in both cohorts' 24-hour OME use, distance at first ambulation, length of stay, and 30-day complications. The use of spinal anesthesia with the IVR adjunct to perform primary THAs and TKAs appears to be well-tolerated and associated with less intraoperative sedative medication usage than spinal anesthesia alone.
- | morphine sulphate / Generic mfg.
Journal: Development of an Effective Monoclonal Antibody against Heroin and Its Metabolites Reveals Therapies Have Mistargeted 6-Monoacetylmorphine and Morphine over Heroin. (Pubmed Central) - Nov 1, 2022
Examination of these antibodies through in vitro and in vivo tests revealed monoclonal antibody 11D12 as the optimal therapeutic and provided crucial insights into the key chemical species to target for blunting heroin's psychoactive and lethal effects. These findings offer clarification into the problematic attempts of therapeutics targeting heroin's metabolites and provide a path forward for future heroin immunopharmacotherapy development.
- | morphine sulphate / Generic mfg.
Preclinical, Journal: High-fat diet attenuates morphine withdrawal effects on sensory-evoked locus coeruleus norepinephrine neural activity in male obese rats. (Pubmed Central) - Nov 1, 2022
In a separate group of age-matched SD rats, a similar weight loss (5-7%) in response to the morphine did not alter sensory-evoked rate but decreased signal-to-noise ratio (Control: 22 cells/8 rats; Weight-matched: 23 cells/8 rats). Taken together, our findings suggest that obesity and diet alter the sensory-evoked LC-NE neural responses, which could have implication for emotional stress and opioid-withdrawal behaviors.
- | morphine sulphate / Generic mfg.
Journal: In-Hospital Outcomes of Intercostal Nerve Cryoablation and Surgical Stabilization of Rib Fractures. (Pubmed Central) - Nov 1, 2022
Taken together, our findings suggest that obesity and diet alter the sensory-evoked LC-NE neural responses, which could have implication for emotional stress and opioid-withdrawal behaviors. Combining INCA with SSRF may further improve in-hospital outcomes for patients with traumatic rib fractures.
- | Kengreal (cangrelor) / Chiesi
Journal: Clinical pharmacology of antiplatelet drugs. (Pubmed Central) - Nov 1, 2022
Key clinical drug-drug interactions of antiplatelet agents involve acetylsalicylic acid - ibuprofen, clopidogrel - omeprazole, and morphine - oral P2Y inhibitors, all of which lead to an attenuated antiplatelet effect...High on-treatment platelet reactivity presents a key problem in the acute management of ST-elevation myocardial infarction (STEMI). A treatment strategy involving early initiation of an intravenous antiplatelet agent may be able to bridge the gap of insufficient platelet inhibition in high ischemic risk patients with STEMI.
- | fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
Retrospective data, Journal: The effect of intraoperative intrathecal opioid administration on the length of stay and postoperative pain control for patients undergoing lumbar interbody fusion. (Pubmed Central) - Nov 1, 2022
In conclusion, our study provides results in a large sample of patients undergoing transforaminal lumbar fusions. The results demonstrated that ITO administration is effective in reducing POD1 pain scores and POD1-2 opioid requirement while not increasing the risk of any opioid-related side effects.
- | orphenadrine hydrochloride / Generic mfg.
Journal: Analgesic and opioid-sparing effects of a fixed combination of diclofenac and orphenadrine in the early postoperative period in cardiac surgery patients (Pubmed Central) - Nov 1, 2022
The results demonstrated that ITO administration is effective in reducing POD1 pain scores and POD1-2 opioid requirement while not increasing the risk of any opioid-related side effects. There were demonstrated high analgesic efficacy, safety and significant opioid-sparing effect of a fixed combination of orphenadrine and diclofenac in the early postoperative period of cardiac surgery patients.
- | morphine sulphate / Generic mfg.
Retrospective data, Journal, Head-to-Head: Prepectoral Breast Reconstruction Reduces Opioid Consumption and Pain After Mastectomy: A Head-to-Head Comparison With Submuscular Reconstruction. (Pubmed Central) - Nov 1, 2022
Prepectoral breast reconstruction was associated with less postoperative opioid consumption and lower postoperative pain scores as compared with subpectoral reconstruction, when controlling for other surgical and anesthesia factors. Future randomized controlled trials are warranted to study how postoperative pain and chronic pain are influenced by the location of prosthesis placement in implant-based postmastectomy breast reconstruction.
- | morphine sulphate / Generic mfg.
Preclinical, Journal: Development of anxiety-like behaviors during adolescence: Persistent effects of adolescent morphine exposure in male rats. (Pubmed Central) - Nov 1, 2022
Thus, long-term exposure to morphine during adolescence has the profound potential of altering the anxiety-like behavior profile in the period from adolescence to adulthood. The maturation of the nervous system can be affected by drug abuse during the developmental window of adolescence and these effects may lead to behaviorally stable alterations.
- | morphine sulphate / Generic mfg.
Reimbursement, Retrospective data, Journal, Real-world evidence: Real-world opioid use among patients with migraine enrolled in US commercial insurance and risk factors associated with migraine progression. (Pubmed Central) - Nov 1, 2022
Despite guidelines and the availability of more migraine-specific treatments, opioids are still commonly prescribed to patients with migraines in real-world practice, especially for those with CM. In this study population, a higher risk of new-onset CM was associated with receiving higher opioid doses.
- | morphine sulphate / Generic mfg.
Journal: Comparison of postoperative analgesic effects of posterior quadratus lumborum block and intrathecal morphine in laparoscopic donor hepatectomy: in reply. (Pubmed Central) - Nov 1, 2022
In this study population, a higher risk of new-onset CM was associated with receiving higher opioid doses. No abstract available
- | Relistor (methylnaltrexone bromide) / Ono Pharma, Bausch Health
Journal: Naloxone Versus Methylnaltrexone for Opioid-Induced Constipation in Critically Ill Patients. (Pubmed Central) - Nov 1, 2022
Both NLX and MNTX appear to be effective for the management of OIC without causing reversal of analgesia. Future controlled, prospective trials comparing these agents are warranted.
- | morphine sulphate / Generic mfg.
New trial: Comparative Study on the Effect of Quadratus Lumborum Block Versus Intrathecal Morphine on the Incidence of Chronic Pain Post Caesarean Section in a University Hospital of Middle-income Country (clinicaltrials.gov) - Nov 1, 2022
P=N/A, N=100, Not yet recruiting, Sponsor: Menoufia University
- morphine sulphate / Generic mfg.
Preliminary Evidence of Reduced Ventral Pallido-Striatal Synaptic Density in Opioid Use Disorder: A Pilot 11C-UCB-J Pet Study (Grand Saguaro) - Oct 31, 2022 - Abstract #ACNP2022ACNP_1234;
To our knowledge, this represents the first in vivo clinical imaging demonstrating synaptic density differences in OUD as compared to HC participants. Though these preliminary findings align with literature preclinical work, there are several limitations such as small samples, no females, and potential confounding effects for nicotine.
- morphine sulphate / Generic mfg.
Molecularly-Defined Cell Types Within the Septal Complex and Their Putative Role in Opioid Dependence and Withdrawal (Grand Saguaro) - Oct 31, 2022 - Abstract #ACNP2022ACNP_1165;
In situ mapping of cell types identified in scRNAseq showed that there are gradient-like overlaps among each population. Further analysis suggested that cells co-expressing Nts and Met, a novel genetic marker, are the most predictive of LS activation during withdrawal.
- morphine sulphate / Generic mfg.
Scarcity Early in Life Alters Both the Basolateral Amygdala Transcriptome and Addiction-Related Behaviors (Grand Saguaro) - Oct 31, 2022 - Abstract #ACNP2022ACNP_1157;
Furthermore, LBN does not affect cue-driven incubation of morphine craving. LBN also induces sex-specific patterns of gene transcription within the BLA.
- morphine sulphate / Generic mfg.
Depletion of the Gut Microbiome Influences Morphine Reward and Medial Prefrontal Cortex Gene Expression in an Age-Dependent Manner in Males and Females (Grand Saguaro) - Oct 31, 2022 - Abstract #ACNP2022ACNP_968;
This series of studies demonstrated that adolescents are more sensitive to brief microbiome disruption than adults- observed effects were seen in both behavior and gene expression in the mPFC. Further work will demonstrate whether microbiome manipulations during the adolescent period can have long lasting effects on brain and behavior into adulthood.
- morphine sulphate / Generic mfg.
Human Cancer Biopsies Elucidate Cancer Pain Targets (Grand Sonoran G) - Oct 31, 2022 - Abstract #ACNP2022ACNP_959;
A syngeneic mouse oral cancer orthotopic transplant model was used to evaluate analgesic morphine on the tumor immune response as well as immune cell-mediated endogenous opioid expression...Conclusions Together these data suggest that exogenous opioids given for pain management may directly impair tumor immunosurveillance and weaken immune checkpoint immunotherapy (ICI) therapeutic efficacy. Alternatively, ICI may be employed to stimulate the immune response for endogenous opioid-mediated cancer pain treatment.
- Permax (pergolide) / Eli Lilly
Targeting Immune Signaling in Genetic Models of Risk for Alcohol and Substance Abuse (Grand Sonoran G) - Oct 31, 2022 - Abstract #ACNP2022ACNP_958;
(b) Terreic acid, pergolide, and apremilast significantly reduced nicotine (p’s<0.01) and morphine (p’s<0.01) intake in male and female HDID-1 and -2 mice. Conclusions Together, this work tells us that increasing anti-inflammatory signaling reduces excessive substance use in unique animal models that exhibit construct validity, face validity, and predictive validity for AUD and SUD.
- morphine sulphate / Generic mfg., diazepam / Generic mfg.
Orally Administered Heteroaromatic Salvinorin a Analogue (AK-1402) Elicits Antinociceptive and Anxiolytic-Like Effects in Mice () - Oct 31, 2022 - Abstract #ACNP2022ACNP_876;
Acute oral administration of AK-1402 (1, 3, or 10 mg/kg), morphine (MOR 5 mg/kg), diazepam (DZP 1 mg/kg), or vehicle 10 ml/kg in male and female Swiss mice [5-week-old with weight = 25 ± 3 g; n = 8 (4 mice per sex) randomly distributed into the treatment groups to the acetic acid-induced abdominal writhing, formalin-induced hind paw licking, the thermal reaction in the hotplate as well as aversive response in the elevated plus-maze (EPM), and light-dark box (LDB). The antinociceptive and anxiolytic-like effects of AK-1402 are promising and demand additional pharmacological characterizations.
- morphine sulphate / Generic mfg.
Single Cell Transcriptional Profiling Highlights Ventral Tegmental Area Heterogeneity and Unique Experience-Dependent Modulation (Grand Canyon 3-5) - Oct 31, 2022 - Abstract #ACNP2022ACNP_849;
Conclusions Taken together, these results highlight the heterogeneity of the VTA and provide a resource for further exploration of VTA gene expression. Additionally, these studies reveal novel VTA cell-specific molecular adaptations to morphine exposure with or without chronic pain.
- morphine sulphate / Generic mfg.
Behavioral and Brainstem Transcriptome Analysis of FVB/N Substrains in a Mouse Model for Neonatal Opioid Withdrawal Syndrome (NOWS) (Grand Saguaro) - Oct 31, 2022 - Abstract #ACNP2022ACNP_757;
MOR pups emitted more USVs than controls and a greater proportion of complex 3 syllables that were alleviated by a subsequent MOR maintenance dose. Based on the connection between USVs and emotional states in pups, our data suggest that complex 3 syllables could indicate negative emotional states associated with opioid withdrawal.
- morphine sulphate / Generic mfg.
Preliminary Evidence for an Elevated Neuroinflammatory Signal in Opioid Use Disorder: Findings from a PET TSPO Imaging Study (Grand Saguaro) - Oct 31, 2022 - Abstract #ACNP2022ACNP_715;
Longer inpatient stay prior to scanning was correlated with lower, i.e., more ‘normal’, TSPO levels in the PFC, suggestive of neuroimmune recovery with treatment. Further, lower TSPO levels in the PFC were ‘trend-level’ correlated with less subjective opioid craving.
- morphine sulphate / Generic mfg.
Determining Parabrachial Nucleus Physiology and Function During Naloxone-Precipitated Opioid Withdrawal (Grand Saguaro) - Oct 31, 2022 - Abstract #ACNP2022ACNP_654;
Based on the Fos and fiber photometry results in morphine dependent mice, PBN CGRP neurons are regulated by naloxone-precipitated opioid withdrawal. Future studies will determine the causal role these neurons may play in mediating opioid withdrawal symptoms.
- morphine sulphate / Generic mfg.
Safety, Immunogenicity, and Preliminary Efficacy of OXY-sKLH, a Vaccine That Targets Oxycodone, and Exploratory Biomarkers of Opioid Use Disorder and Vaccine Efficacy in Humans (Grand Sonoran F) - Oct 31, 2022 - Abstract #ACNP2022ACNP_626;
The frequency of B cells specific for heroin/morphine (M) were more prevalent than the OXY-specific B cell population...These biomarkers also may be predictive of vaccine efficacy, which would be consistent with our data collected in rodents. Thus far, the vaccine has proven to be safe and some participants are exhibiting long-lasting antibody levels.
- morphine sulphate / Generic mfg.
Effects of Endogenous Orexin and Dynorphin Corelease on Ventral Tegmental Dopamine Neuronal Activity (Grand Saguaro) - Oct 31, 2022 - Abstract #ACNP2022ACNP_610;
Our findings provide evidence that LHox/dyn co-release tune the output of the VTA by simultaneously inhibiting and activating different VTA projection neurons. Morphine tolerance may lead to a shift in the balance of excitatory and inhibitory effects of LH ox/dyn co-release.
- Permax (pergolide) / Eli Lilly
Targeting Neuroimmune Signaling in Substance Use Disorders (Grand Sonoran G) - Oct 31, 2022 - Abstract #ACNP2022ACNP_526;
Dr. Mason presents data for the first clinical study of apremilast for the treatment of AUD.
- ITI-333 - Intra / Cellular Therapies
Mechanism of Action of ITI-333, a Novel Modulator of Mu Opioid, Serotonin, and Dopamine and for the Treatment of Opioid Use Disorder (Grand Sonoran F) - Oct 31, 2022 - Abstract #ACNP2022ACNP_476;
Results Cell-based assays demonstrate ITI-333 is a biased MOP receptor partial agonist, acting as an antagonist to block effects of high doses of morphine in pain and motor activity models; acting alone as an analgesic in acute and inflammatory pain models...ITI-333 (0.3, 1, and 3mg/kg, SC) dose-dependently suppresses signs of opioid withdrawal precipitated by naloxone injection in oxycodone-dependent mice (i.e., oxycodone dosed for 8 days; increasing daily doses of 9-33 mg/kg, n=10/group)...ITI-333 was safe and well-tolerated in a first-in-human safety study and continues in clinical development as a treatment for OUD. Conclusions Data support a role for ITI-333 in mitigating opioid withdrawal symptoms with no significant indications of abuse liability.
- Olinvyk (oliceridine) / Trevena, Jiangsu NHWA Pharma
Oliceridine Demonstrates a Reduced Effect on Neurocognitive Function in Humans, Compared to Morphine: A Phase 1 Randomized, Placebo-Controlled, Dose-Ranging Partial Block Cross-Over Study (Grand Saguaro) - Oct 31, 2022 - Abstract #ACNP2022ACNP_461;
Conclusions Data support a role for ITI-333 in mitigating opioid withdrawal symptoms with no significant indications of abuse liability. IV oliceridine has a reduced impact on several clinically relevant measures of cognitive performance, compared to IV morphine, including certain measures of sedation, motor performance, and eye-hand coordination.
- naloxone injection / Generic mfg., morphine sulphate / Generic mfg.
Physiological Changes in Noradrenergic Neurons in a Mouse Model of Opioid Use Disorder (Grand Saguaro) - Oct 31, 2022 - Abstract #ACNP2022ACNP_378;
Our data here suggest that the MN model results in profound plasticity on glutamatergic synapses promotion the insertion of CP-AMPA receptors, and regulates the intrinsic excitability of these neurons. Future studies will explore these phenomena in male mice, and examine how long lasting and/or transient these changes are.
- morphine sulphate / Generic mfg.
Exploring a Role for GalR1-MOR Heteromers in Modulating the Cellular Effects of Opioids in the VTA (Grand Saguaro) - Oct 31, 2022 - Abstract #ACNP2022ACNP_339;
By contrast, most non-GABAergic cells within these brain regions do not co-express these receptors. Our electrophysiological results indicate that galanin opposes the GABA-mediated effects of opioids on VTA DA neurons under certain conditions.
- morphine sulphate / Generic mfg.
A Novel µ-Opioid Receptor Transgenic Cre Rat: Cellular and Behavioral Characterization (Grand Saguaro) - Oct 31, 2022 - Abstract #ACNP2022ACNP_124;
We test basal response to pain, morphine analgesia and tolerance... The novel Oprm1-Cre transgenic rat can be used to study the role of brain Oprm1-expressing cells in opioid addiction- and pain-related behaviors, as well as other opioid-mediated learned and innate behaviors.
- morphine sulphate / Generic mfg., duloxetine / Generic mfg.
Characterization and Optimization of Rat Models of Osteoarthritis Pain to Profile Novel Assets in Support of the NIH HEAL Initiative Preclinical Screening Platform for Pain (PSPP) (Grand Saguaro) - Oct 31, 2022 - Abstract #ACNP2022ACNP_83;
Evaluation of novel assets following single and repeated administration in the MIA model using multiple pain endpoints may be a viable strategy to accelerate the development of non-opioid, non-addictive therapeutics for the treatment of osteoarthritis pain. The utility of evaluating novel assets at Week 1 vs Week 6 will continue to be examined.
- morphine sulphate / Generic mfg.
Early Scarcity Alters the Basolateral Amygdala Transcriptome and Addiction-Related Behaviors (Grand Sonoran F) - Oct 31, 2022 - Abstract #ACNP2022ACNP_44;
Conclusions LBN reduces morphine and cocaine drug taking in male rats but does not affect cue-driven incubation of morphine craving. LBN also induces sex-specific patterns of gene transcription within the BLA.
- morphine sulphate / Generic mfg.
A Translational Rodent Model of Gestational Opioid exposure: Effects of Morphine Compared to Buprenorphine on the Maternal Brain, Maternal Behavior, and Offspring Outcome (Grand Saguaro) - Oct 31, 2022 - Abstract #ACNP2022ACNP_25;
Our results suggest that BUP exposure during pregnancy negatively influences pup survival rates, which may be due to BUP’s unique pharmacological action on the maternal brain interfering with maternal caregiving behaviors. More research is critical to elucidate how BUP mechanistically interacts with the neural network during the transition to motherhood to help alleviate possible negative consequences for mothers and their offspring.
- ||| morphine sulphate / Generic mfg., furosemide / Generic mfg.
Think POND instead of LMNOP for pulmonary oedema! P - Pressure and Position O - Oxygen N - Nitrates D - Diuretics L - Lasix M -Morphine 🚫 N - Nitrates O - Oxygen P - Pressure and Position https://t.co/4Cmita6XZU (Twitter) - Oct 31, 2022
- ||| morphine sulphate / Generic mfg., tramadol hydrochloride / Generic mfg.
Vous savez avec tous les pb de santé que j’ai eu depuis 2015 tramadol doublé de zaldiar pdt des mois,puis cortisone,zona declaré donc morphine, ainsi de suite quand on est à son compte avec 70 salariés onnpeutpas s’arrêter même pour une fracture du pied sur pied dès le lendemain (Twitter) - Oct 30, 2022
- | morphine sulphate / Generic mfg.
Journal: Analgesic efficacy and safety of nalbuphine versus morphine for perioperative tumor ablation: a randomized, controlled, multicenter trial. (Pubmed Central) - Oct 30, 2022
P4
More research is critical to elucidate how BUP mechanistically interacts with the neural network during the transition to motherhood to help alleviate possible negative consequences for mothers and their offspring. This study, to the best of our knowledge, is the first randomized controlled trial of nalbuphine patient-controlled analgesia in ablation surgery.
- | morphine sulphate / Generic mfg.
Journal: Postoperative ileus risk after posterior thoracolumbar fusion performed with total intravenous anesthesia versus inhaled anesthesia. (Pubmed Central) - Oct 30, 2022
In a large cohort of PSF patients, TIVA was associated with a higher rate of PI compared with inhaled anesthetic. This effect is likely due to higher intraoperative opiate use in these patients.
- | morphine sulphate / Generic mfg.
Retrospective data, Journal: A retrospective investigation of the relationship between neuroblastoma response to anti-GD2 monoclonal antibodies and exposure to opioids for pain management. (Pubmed Central) - Oct 30, 2022
This effect is likely due to higher intraoperative opiate use in these patients. Our study found no statistically significant correlation between opioid consumption and natural killer (NK) cell-mediated killing of NB cells as measured by effects on tumor volume/tumor load.
- | morphine sulphate / Generic mfg.
Journal: Locus coeruleus input-modulated reactivation of dentate gyrus opioid-withdrawal engrams promotes extinction. (Pubmed Central) - Oct 29, 2022
Here, naloxone-precipitated conditioned place aversion (CPA) in morphine-dependent mice was mainly used as a pathological memory model...We also found that activating this circuit caused an increase in the ensemble size of DG engram cells activated during the extinction, which was confirmed by a cFos targeted strategy to label cells combined with immunohistochemical and in vivo calcium imaging techniques. Collectively, our data uncover that the recall experience is important for updating the memory during the reconsolidation window; they also suggest a promising neural circuit or target based on the recall-extinction procedure for weakening pathological aversion memory, such as opioid withdrawal memory and fear memory.
- | morphine sulphate / Generic mfg.
Journal: Ultrasound-guided bilateral erector spinae plane nerve blocks: a novel application for the management of acute postoperative pain in awake spine surgery. Illustrative case. (Pubmed Central) - Oct 29, 2022
Collectively, our data uncover that the recall experience is important for updating the memory during the reconsolidation window; they also suggest a promising neural circuit or target based on the recall-extinction procedure for weakening pathological aversion memory, such as opioid withdrawal memory and fear memory. The placement of bilateral erector spine plane nerve block catheters at the T12 level with an ambulatory infusion pump may help to improve acute postoperative pain management for patients undergoing lumbar spinal fusion.
- | ropivacaine / Generic mfg.
Journal: Comparison of transversus abdominis plane blocks with liposomal bupivacaine versus ropivacaine in open total abdominal hysterectomy. (Pubmed Central) - Oct 29, 2022
Opioid requirements at 24 hours (P < 0.04) and 48 hours (P < 0.01), as well as total morphine equivalent requirements (P < 0.05), were significantly lower in the liposomal bupivacaine group compared to the ropivacaine group. Patients undergoing open TAH who received liposomal bupivacaine TAP blocks required fewer postoperative opioids to achieve similar pain scores when compared to patients who received ropivacaine TAP blocks.
- || morphine sulphate / Generic mfg.
Clinical, Journal: Efficacy of Adductor Canal Blocks in Total Knee Arthroplasty. (Pubmed Central) - Oct 29, 2022
Patients who had an ACB had a similar ROM on discharge and did not have an increased rate of readmission or return to theater. This study demonstrates that ACB are efficacious when used as part of a multimodal analgesia regime for TKA.
- || fentanyl citrate / Generic mfg.
Retrospective data, Review, Journal: Effects of fentanyl administration in mechanically ventilated patients in the intensive care unit: a systematic review and meta-analysis. (Pubmed Central) - Oct 29, 2022
However, the GRADE evaluation provides little certainty to support the results of this systematic review. Therefore, further large RCTs are required to confirm our conclusions.
- | hydroxyzine hydrochloride / Generic mfg., morphine sulphate / Generic mfg.
Reimbursement, Journal, Medicare: High opioid doses, naloxone, and central nervous system active medications received by Medicare-enrolled adults. (Pubmed Central) - Oct 29, 2022
Naloxone may be underprescribed among eligible adults. Targeted medication services may ensure optimal prescribing among Medicare patients with chronic opioid therapies.
- | morphine sulphate / Generic mfg.
Retrospective data, Journal: A Retrospective Comparison of Three Patient-Controlled Analgesic Strategies: Intravenous Opioid Analgesia Plus Abdominal Wall Nerve Blocks versus Epidural Analgesia versus Intravenous Opioid Analgesia Alone in Open Liver Surgery. (Pubmed Central) - Oct 29, 2022
For postoperative pain management, it is expected that the TEA group required the least amount of opioid; however, IV-PCA + NBs and TEA demonstrated comparable postoperative outcomes, namely, the time to remove nasogastric tube/urinary catheter, to start the diet, and the length of hospital stay. IV-PCA with NBs could thus be a reliable analgesic modality for patients undergoing open liver resections.
- | Nucynta (tapentadol) / Collegium Pharma, Grunenthal
Journal, Real-world evidence: Sex Differences in Oxycodone/Naloxone vs. Tapentadol in Chronic Non-Cancer Pain: An Observational Real-World Study. (Pubmed Central) - Oct 29, 2022
Sex-differences were found related to poorer female drug tolerability and higher hospital resources, even worst in OXN female users. Other differences related to older female ages and benzodiazepine prescription, need to be further analysed from a gender perspective.
- | morphine sulphate / Generic mfg.
Journal, IO biomarker: Receptor Transporter Protein 4 (RTP4) in the Hypothalamus Is Involved in the Development of Antinociceptive Tolerance to Morphine. (Pubmed Central) - Oct 28, 2022
Next, we examined the mechanism of regulation of RTP4 and found that, in neuronal cells, Rtp4 induction is via Gi and MAPK activation, while, in microglial cells, the induction is via Toll-like receptor 4. Together, these studies highlight the role of MOR activity in regulating RTP4, which, in turn, plays an important role in modulating morphine effects in vivo.