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7 Diseases |  |
379 Trials |
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379 Trials |  |
12426 News |  |
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- | morphine sulphate / Generic mfg.
Journal: Postoperative opioid administration and post-traumatic stress symptoms in preschool children after cardiac surgery. (Pubmed Central) - Nov 6, 2022
Nurses caring for preschool children who undergo cardiac surgery should anticipate the potential development of PTSS in their patients. Studies using larger sample sizes and longitudinal design are needed to replicate the significant relationship between morphine administration and PTSS in preschoolers with single-ventricle physiology.
- ||| morphine sulphate / Generic mfg.
Clinical: Thanks. PCM? Is that patient controlled morphine?? (Twitter) - Nov 5, 2022
- | YM-254890 / Astellas
Journal: Exploring pharmacological inhibition of G as an analgesic strategy. (Pubmed Central) - Nov 5, 2022
Studies using larger sample sizes and longitudinal design are needed to replicate the significant relationship between morphine administration and PTSS in preschoolers with single-ventricle physiology. These findings indicate that pharmacological inhibition of G could be explored as an analgesic strategy.
- | Nucynta (tapentadol) / Collegium Pharma, Grunenthal
Journal: Trends in strong opioid prescription for cancer patients in Japan from 2010 to 2019: an analysis with large medical claims data. (Pubmed Central) - Nov 5, 2022
The prevalence of opioid prescriptions for terminally ill cancer patients has increased from 2010 to 2019 in Japan. The opioid-specific trends were similar to the global trend but differed by palliative care specialty.
- || morphine sulphate / Generic mfg.
PK/PD data, Journal: Pharmacokinetics of Morphine Sulfate Orodispersible Tablets and Bioequivalence with Immediate-Release Oral Morphine Sulfate Formulations in Healthy Adult Subjects Under Fasting Conditions: Single-Dose Comparative Bioavailability Studies. (Pubmed Central) - Nov 5, 2022
The ODTs were safe, well tolerated, and showed similar pharmacokinetics to those of the reference formulations. The development of a range of doses of morphine sulfate ODTs may provide a new alternative for the oral administration of immediate-release morphine for pain management in pediatric, geriatric and adult populations with swallowing problems.
- | morphine sulphate / Generic mfg.
Journal: Impact of Affective Disorders on Inpatient Opioid Consumption and Hospital Outcomes Following Open Posterior Spinal Fusion for Adult Spine Deformity. (Pubmed Central) - Nov 5, 2022
The development of a range of doses of morphine sulfate ODTs may provide a new alternative for the oral administration of immediate-release morphine for pain management in pediatric, geriatric and adult populations with swallowing problems. ADs may be associated with increased inpatient opioid consumption and healthcare resource utilization.
- COVID-19 Outcomes at a Comprehensive Sickle Cell Center: A Two-Year Report (ENMCC - Hall D) - Nov 4, 2022 - Abstract #ASH2022ASH_5505;
Chronic pain was defined in the patients experiencing daily pain episodes for more than 4 days a week for the last 3 months and calculation of daily morphine equivalents was reported based on the clinic follow-ups and the narcotic database utilization...The treatment utilized for the patients was most commonly Remdesivir in 33, dexamethasone in 26, red cell products in 21 and monoclonal antibody in 13 patients...To circumvent that, the SC center resorted to virtual visits utilization to deliver the needed healthcare visits to the patients. This measure has aided in protecting patients against COVID-19 during the multiple COVID-19 peaks occurring in the last 2 years and has accordingly reduced the mortality and morbidity of the patient population.
- morphine sulphate / Generic mfg.
Chronic Opioid Use Is Highly Prevalent and Associated with Inferior Survival in Myeloma Patients in Remission after Autologous Transplant (ENMCC - Hall D) - Nov 4, 2022 - Abstract #ASH2022ASH_3185;
Daily opioid doses were converted to morphine milligram milliequivalents (MME) using standard conversion factors (MME = 20 mg/day has been correlated with risk for overdose events)...These data highlight the need to improve understanding and management of pain in MM. Non-opioid analgesic use correlated with lower risk of COU and may be appropriate in managing pain effectively and safely.
- morphine sulphate / Generic mfg., hydroxyurea / Generic mfg.
Prediction of High Acute Care Utilization in Children with Sickle Cell Disease (ENMCC - Hall D) - Nov 4, 2022 - Abstract #ASH2022ASH_3130;
Demographic and clinical factors associated with high acute care utilization include Medicaid insurance status, asthma and mood disorders as well as number of opioid prescriptions in the year prior to meeting our criterion for high acute care utilization. Future studies should be conducted to prospectively identify predictors of high acute care utilization and the development of chronic pain in SCD.
- morphine sulphate / Generic mfg.
Age-related Impact of the CDC's 2016 Guideline for Prescribing Opioids for Chronic Pain on Opioid Prescribing Levels and Health Outcomes among the Patients with Sickle Cell Disease (ENMCC - Hall D) - Nov 4, 2022 - Abstract #ASH2022ASH_3122;
The CDC guideline release was associated with a decrease in opioid prescribing levels across all age groups even though the guideline was intended only for the adult population. Overall, pain-related health outcomes were negatively impacted by the guideline: older age groups with increased ED visits and younger age groups with increased hospitalizations, while there were no decreases in the rate of OUD.
- morphine sulphate / Generic mfg.
||Buprenorphine, It Works So Differently:|| Adults with Sickle Cell Disease Describe Their Experiences Transitioning to Buprenorphine for Treatment of Chronic Pain (ENMCC - Hall D) - Nov 4, 2022 - Abstract #ASH2022ASH_1890;
Limitations include the limited number of participants and the potential for self-selection bias. Patients should be invited to discuss their burden of symptoms, level of intrusiveness of their current regimen, and interest in or skepticism of buprenorphine.
- morphine sulphate / Generic mfg., hydroxyurea / Generic mfg.
Impact of Arginine Therapy on Clinical Outcomes, Mitochondrial Function and Oxidative Stress in Children with Sickle Cell Disease Hospitalized with Vasoocclusive Pain Episodes: A Randomized Controlled Trial (ENMCC - 391-392) - Nov 4, 2022 - Abstract #ASH2022ASH_1292;
P2
This is the first report to suggest a HU-related impact on mito activity in SCD. Prior reports show that Complex V inhibition leads to increased mito oxidant production in platelets from SCD patients.
- || morphine sulphate / Generic mfg.
Clinical, P2 data, Clinical Trial,Phase II, Journal: Methylene blue for intractable pain from oral mucositis related to cancer treatment: a randomized phase 2 clinical trial. (Pubmed Central) - Nov 4, 2022
P2
Prior reports show that Complex V inhibition leads to increased mito oxidant production in platelets from SCD patients. MB oral rinse showed significant pain reduction and improved oral functioning with minimal adverse effects.
- | fentanyl citrate / Generic mfg., vancomycin / Generic mfg., morphine sulphate / Generic mfg.
Retrospective data, Journal: Risk of serotonin syndrome in acutely ill patients receiving linezolid and opioids concomitantly: a retrospective cohort study. (Pubmed Central) - Nov 4, 2022
Combining linezolid with serotonergic agents may increase serotonin syndrome (SS) risk.Linezolid is recommended in patients with suspected or confirmed resistant Gram-positive bacterial infections, especially if vancomycin cannot be used...Morphine and fentanyl were the most prescribed opioids (37.7% and 34%, respectively)...In this study, the incidence of SS was low in acutely ill patients who received concomitant linezolid and opioids. However, larger prospective studies are required to confirm this finding.
- | morphine sulphate / Generic mfg.
Journal: Reduced Narcotic Utilization in Total Joint Arthroplasty Patients in an Urban Tertiary Care Center. (Pubmed Central) - Nov 4, 2022
The mean discharge opioid prescription was 264 morphine milligram equivalents (MMEs)...Body mass index, intraoperative opioid requirement, American Society of Anesthesiologists Classification score, race, total knee vs total hip arthroplasty, or surgical approach for total hip arthroplasty did not affect discharge opioid prescriptions. Reduction of opioid prescriptions at discharge in total joint arthroplasty patients may be possible with the use of preoperative and postoperative protocols, optimizing patient risk factors for opioid use and utilizing a patient-specific opioid taper regimen.
- | morphine sulphate / Generic mfg.
Journal: The Effects of Perioperative Peripheral Nerve Blocks on Peri- and Postoperative Opioid Use and Pain Management. (Pubmed Central) - Nov 4, 2022
Despite relatively robust efficacy data, utilization of peripheral nerve blocks is not ubiquitous; the potential reasons for which are also discussed. Lastly, clinical recommendations based on the available data are provided.
- | methadone / Generic mfg.
Journal: Novel use of methadone intraoperatively in pediatric burn patients. (Pubmed Central) - Nov 4, 2022
No adverse events were noted upon chart review. The data suggests methadone use is beneficial in pediatric burn patients, but further prospective studies are warranted on a larger population.
- | morphine sulphate / Generic mfg.
Journal: Changes in Opioid Dispensing by Medical Specialties after Release of the 2016 CDC Guideline for Prescribing Opioids for Chronic Pain. (Pubmed Central) - Nov 4, 2022
However, specialties outside the scope of the CDC Guideline (e.g., surgery) also exhibited accelerated decreases in prescribing. These declines illustrate that specialties beyond primary care could have interest in evaluating opioid prescribing practices, supporting the importance of specialty-specific guidance that balances the individualized risks and benefits of opioids and the role of non-opioid treatments.
- | Nucynta (tapentadol) / Collegium Pharma, Grunenthal
Journal: A Comparison of Institutional Opioid Equianalgesia Tools: A National Study. (Pubmed Central) - Nov 4, 2022
Opioid equianalgesia tools from across the United States demonstrated significant variation in their inclusion of guidance on adjustment for incomplete cross-tolerance, oral-to-IV, and oral-to-oral opioid equianalgesic ratios, and which opioids and formulations were listed. Tramadol and hydromorphone had the most variation in their equianalgesic guidance among the opioids.
- || morphine sulphate / Generic mfg.
Review, Journal: IPACK (Interspace between the Popliteal Artery and the Capsule of the Posterior Knee) Block Combined with SACB (Single Adductor Canal Block) Versus SACB for Analgesia after Total Knee Arthroplasty. (Pubmed Central) - Nov 4, 2022
With the iPACK added to SACB, pain scores, morphine consumption, functional ability were improved. Additional high-quality studies are required to further address this topic.
- | morphine sulphate / Generic mfg.
Journal: Palliative home care for older patients with respiratory disease in Japan: Practices and opinions of physicians. (Pubmed Central) - Nov 4, 2022
This study found a discrepancy between the proportion of physicians who considered palliative care as effective and those who prescribed it. Geriatr Gerontol Int 2022; 22: 943-949.
- || morphine sulphate / Generic mfg.
Retrospective data, Review, Journal: Systemic glucocorticoids as an adjunct to treatment of postoperative pain after total hip and knee arthroplasty: A systematic review with meta-analysis and trial sequential analysis. (Pubmed Central) - Nov 4, 2022
Pain levels were reduced but were below the predefined MID. The quality of evidence was generally low.
- | morphine sulphate / Generic mfg.
Trial initiation date, Surgery: Intrathecal Morphine for Analgesia in Video-assisted Thoracic Surgery (clinicaltrials.gov) - Nov 4, 2022
P4, N=90, Not yet recruiting, Sponsor: University of Chicago
The quality of evidence was generally low. Initiation date: Sep 2022 --> Jan 2023
- | morphine sulphate / Generic mfg.
Journal: A Multimodal Pain Management Strategy for Burn Patients. (Pubmed Central) - Nov 3, 2022
Nonpharmacologic adjuncts are more likely to be used consistently when protocolized. There is also evidence to support that certain aspects of self-efficacy may be enhanced during acute phase of burn care.
- || nefopam / Generic mfg.
Clinical, Journal: Single-dose intravenous nefopam on postoperative catheter-related bladder discomfort in patients undergoing transurethral resection of prostate: a randomized, double-blind placebo-controlled trial. (Pubmed Central) - Nov 3, 2022
There is also evidence to support that certain aspects of self-efficacy may be enhanced during acute phase of burn care. Single-dose nefopam significantly reduced the incidence and severity of CRBD in patients undergoing TURP with urinary catheter traction at 6 h after the procedure and before the end of catheter traction without increasing the adverse effects.
- | morphine sulphate / Generic mfg.
Journal: Variations in Postpartum Opioid Prescribing Practices among Obstetrician-Gynecologists. (Pubmed Central) - Nov 3, 2022
Opioid amounts were converted to oral morphine milligram equivalents (MME) for comparison, and total MME was calculated for each prescription...After cesarean sections, the specific post-operative day did not seem to impact the prescribing trends as there were no differences in MMEs, doses per day, or dosage between prescriptions that were written on the day of discharge and before the day of discharge. Patients whose deliveries occurred after the publication of ACOG Committee Opinion 742 received discharge prescriptions with fewer MMEs, fewer doses per day, and the same dosage than those whose deliveries occurred before the publication, reflecting the overall national trend of decreasing prescription opioids over these years.
- || morphine sulphate / Generic mfg.
Review, Journal: Animal evidence considered in determination of cannabis smoke and Δ -tetrahydrocannabinol (Δ -THC) as causing reproductive toxicity (developmental endpoint); part II. Neurodevelopmental effects. (Pubmed Central) - Nov 3, 2022
Increased rate of acquisition of morphine self-administration and/or enhanced sensitivity towards the rewarding effects of morphine or heroin were observed in adult rats prenatally exposed to Δ -THC...Mechanistic studies provided evidence for the biological plausibility of effects observed. Observations from animal studies of changes in motor behavior, cognitive performance, emotionality and susceptibility to drug sensitivity later in life were among the findings from animal and human studies considered by California's Developmental and Reproductive Toxicant Identification Committee, in concluding that cannabis smoke and Δ -THC are developmental toxicants.
- | morphine sulphate / Generic mfg., hydromorphone hydrochloride / Generic mfg.
Journal: A regional approach to reduce postoperative opioid prescribing in Ontario, Canada. (Pubmed Central) - Nov 3, 2022
Our approach resulted in a significant reduction in the number of postoperative opioids prescribed across a number of surgical specialties. Our findings indicate that evidence-based strategies derived from a regional collaborative network can be leveraged to promote and sustain quality improvement activities.
- ||| Review, Journal, Adverse events: Review of benefits and adverse effects of the most commonly used local anesthetic adjuvants in peripheral nerve blocks. (Pubmed Central) - Nov 3, 2022
Most of them are safe and possess little adverse effects, while none of them is acknowledged by the food and drug administration. Therefore, this review is aimed to delineate benefits and adverse effects for clinical anesthesia.
- | morphine sulphate / Generic mfg., methadone / Generic mfg.
Journal: Assessing Neonatal Opioid Withdrawal Syndrome Severity as a Function of Maternal Buprenorphine Dose and Umbilical Cord Tissue Concentrations. (Pubmed Central) - Nov 3, 2022
A 0.36 ng/g buprenorphine + norbuprenorphine UCT (CI = 0.002-0.72, P = 0.049) equated in a 1-point increase in modified peak Finnegan score. Buprenorphine and norbuprenorphine UCT concentrations can allow for quantification of in utero fetal exposure and demonstrate an association with a longer duration of exposure with the severity and treatment of NOWS in exposed infants.
- | morphine sulphate / Generic mfg.
Preclinical, Journal: Masseter muscle contraction and cervical muscle sensitization by nerve growth factor cause mechanical hyperalgesia in masticatory muscle with activation of the trigemino-lateral parabrachial nucleus system in female rats. (Pubmed Central) - Nov 3, 2022
We found mechanical hyperalgesia of the MM and activation of the pain pathway from the brainstem to parabrachial nucleus. The model reflects the characteristics of patients with craniofacial myalgia and might be helpful to clarify the pathogenic mechanisms underlying these disorders.
- || morphine sulphate / Generic mfg.
Retrospective data, Review, Journal: Analgesic efficacy of quadratus lumborum block in patients undergoing nephrectomy: A systematic review and meta-analysis. (Pubmed Central) - Nov 3, 2022
The QLB would be beneficial as part of multimodal analgesia. Future research may need to determine which approach of QLB is superior for postoperative analgesia after nephrectomy.
- | morphine sulphate / Generic mfg.
Trial completion date, Trial initiation date, Trial primary completion date: Regional Nerve Blocks to Improve Analgesia and Recovery in Older Adults Undergoing Spinal Fusion (clinicaltrials.gov) - Nov 3, 2022
P1, N=50, Not yet recruiting, Sponsor: University of Iowa
Future research may need to determine which approach of QLB is superior for postoperative analgesia after nephrectomy. Trial completion date: Sep 2024 --> Sep 2025 | Initiation date: Sep 2022 --> Sep 2023 | Trial primary completion date: Feb 2024 --> Feb 2025
- | morphine sulphate / Generic mfg., methamphetamine / Generic mfg.
Journal: Direct injection ultra-performance liquid chromatography-tandem mass spectrometry for the high-throughput determination of 11 illicit drugs and metabolites in wastewater. (Pubmed Central) - Nov 3, 2022
Application of the method to real wastewater samples collected from wastewater treatment plants revealed morphine in all samples, together with other illicit drugs (methamphetamine, codeine, ketamine, and nor-ketamine) in some samples. Small-volume direct injection showed great potential as an efficient method for the high-throughput determination of illicit drugs in wastewater.
- | morphine sulphate / Generic mfg.
Preclinical, Journal: Two kinds of transcription factors mediate chronic morphine-induced decrease in miR-105 in medial prefrontal cortex of rats. (Pubmed Central) - Nov 2, 2022
However, how chronic morphine treatment decreases miR-105 in the mPFC still remains unknown. The present study shows that chronic morphine induces addiction-related change in miR-105 in the mPFC via two kinds of transcription factors: the first transcription factor is CREB activated by mu receptors-ERK-p90RSK signaling pathway and the second transcription factor is glucocorticoid receptor (GR), which as a negative transcription factor, mediates chronic morphine-induced decrease in miR-105 in the mPFC of rats.
- | morphine sulphate / Generic mfg.
Journal: Benzo[b]thiophene-2-carboxamides as novel opioid receptor agonists with potent analgesic effect and reduced constipation. (Pubmed Central) - Nov 2, 2022
Compound 25 elicited potent antinociception in thermal-stimulated pain (ED value of 127.1 ± 34.65 μg/kg) and inflammatory-induced allodynia models with less gastrointestinal transit inhibition and antinociceptive tolerance than morphine. Overall, this study revealed a novel analgesic with reduced risks of side effects.
- | morphine sulphate / Generic mfg.
Retrospective data, Journal: Comparison between simultaneous bilateral total hip arthroplasty with and without drainage: A retrospective cohort study. (Pubmed Central) - Nov 2, 2022
But the morphine equivalent (I: 132.7 ± 314.1 mg, II: 732.2 ± 591.5 mg; P < .001) was significantly larger in the without drainage group...Therefore, SBTHA without drainage will be a good option to reduce the burden on the patient by reducing postoperative bleeding if it can control pain well after surgery. III, Retrospective case-control study.
- || morphine sulphate / Generic mfg.
Retrospective data, Review, Journal: In search of the optimal pain management strategy for children undergoing cleft lip and palate repair: A systematic review and meta-analysis. (Pubmed Central) - Nov 2, 2022
All studied interventions demonstrated safety in this pediatric cohort. The results of this review should be interpreted in the context of certain limitations, including the number and nature of comparison studies, and significant reporting heterogeneity.
- || nefopam / Generic mfg.
Clinical, Journal: Postoperative analgesia of intraoperative nefopam in patients undergoing anterior cervical spine surgery: A prospective randomized controlled trial. (Pubmed Central) - Nov 2, 2022
The results of this review should be interpreted in the context of certain limitations, including the number and nature of comparison studies, and significant reporting heterogeneity. A single, intraoperative infusion of 20 mg of nefopam did not significantly reduce postoperative (24 hours) morphine consumption in patients undergoing anterior cervical spine surgery.
- | morphine sulphate / Generic mfg.
Journal: Acupuncture Inhibits Morphine Induced-Immune Suppress via Antioxidant System. (Pubmed Central) - Nov 2, 2022
The morphine induced-immune suppression evidenced by spleen and left S-LN weights, splenic NK cell activities, histopathological findings, and the immunoreactive cell number were normalized by acupuncture. These results indicate that acupuncture inhibits morphine-induced immune suppression, maybe via antioxidative action.
- || morphine sulphate / Generic mfg., dexamethasone injection / Generic mfg.
Clinical, Journal: Pediatric Postoperative Pain Control With Quadratus Lumborum Block and Dexamethasone in Two Routes With Bupivacaine: A Prospective Randomized Controlled Clinical Trial. (Pubmed Central) - Nov 2, 2022
Dexamethasone may be more effective when added to bupivacaine than when given systemically in analgesic effects without any impact on the other secondary pain-related outcomes. Dexamethasone as an adjuvant to bupivacaine has a marked hand on prolongation of the postoperative duration of analgesia, less request for rescue analgesia, and fewer side effects as compared to bupivacaine if used as a sole agent in QLB.
- | dexmedetomidine / Generic mfg.
Journal: The Effect of Ultrasound-guided Bilateral Erector Spinae Plane Block With and Without Dexmedetomidine on Intraoperative and Postoperative Pain in Laparoscopic Cholecystectomies: A Randomized, Controlled, Double-blind, Prospective Trial. (Pubmed Central) - Nov 2, 2022
P=N/A
Dexamethasone as an adjuvant to bupivacaine has a marked hand on prolongation of the postoperative duration of analgesia, less request for rescue analgesia, and fewer side effects as compared to bupivacaine if used as a sole agent in QLB. Erector spinae plane block performed either with ropivacaine or with a combination of ropivacaine and dexmedetomidine is a novel and safe method, which was found to be more effective compared to standard analgesia protocols in patients undergoing laparoscopic cholecystectomy and thus, it can improve the quality of perioperative analgesia.
- | morphine sulphate / Generic mfg., gabapentin / Generic mfg.
Retrospective data, Journal: Effect of Repeated High-voltage Long-duration Pulsed Radiofrequency on Herpetic Neuralgia. (Pubmed Central) - Nov 2, 2022
Erector spinae plane block performed either with ropivacaine or with a combination of ropivacaine and dexmedetomidine is a novel and safe method, which was found to be more effective compared to standard analgesia protocols in patients undergoing laparoscopic cholecystectomy and thus, it can improve the quality of perioperative analgesia. Repeated high-voltage long-duration PRF therapy was an effective treatment for acute herpetic neuralgia and may prevent the occurrence of PHN.
- | morphine sulphate / Generic mfg.
Retrospective data, Journal: Spinal versus general anaesthesia in contemporary primary total knee arthroplasties. (Pubmed Central) - Nov 2, 2022
Additionally, spinal anaesthesia was associated with reduced risk of any revision and any reoperation after accounting for numerous patient and operative factors. When possible and safe, spinal anaesthesia should be considered in primary TKAs.Cite this article: Bone Joint J 2022;104-B(11):1209-1214.
- | Chirocaine (levobupivacaine) / Purdue, AbbVie
Journal: A randomized double-blind controlled study comparing erector spinae plane block and thoracic paravertebral block for postoperative analgesia after breast surgery. (Pubmed Central) - Nov 2, 2022
When possible and safe, spinal anaesthesia should be considered in primary TKAs.Cite this article: Bone Joint J 2022;104-B(11):1209-1214. Compared to ESPB, PVB provided lower postoperative opioid requirements, lower pain scores, and wider sensory blockade after mastectomy.
- | morphine sulphate / Generic mfg.
Journal: Perioperative Lidocaine Infusion Reduces Opioid Use in Enhanced Recovery After Surgery Patients Undergoing Laparoscopic Colectomy. (Pubmed Central) - Nov 2, 2022
This study demonstrates a significant reduction in post-op opioid use in ERAS patients who receive a lidocaine infusion after laparoscopic colectomy. Further studies should focus on measures to limit the treatment side effects in order to maximize the opioid-sparing benefits of this intervention.
- | methadone / Generic mfg.
Enrollment closed: Clinical Effectiveness and Safety of Intraoperative Methadone in Patients Undergoing Laparoscopic Hysterectomy (clinicaltrials.gov) - Nov 2, 2022
P=N/A, N=126, Active, not recruiting, Sponsor: University of Aarhus
Further studies should focus on measures to limit the treatment side effects in order to maximize the opioid-sparing benefits of this intervention. Recruiting --> Active, not recruiting
- | morphine sulphate / Generic mfg.
Journal: A regional and projection-specific role of RGSz1 in the ventrolateral periaqueductal grey in the modulation of morphine reward. (Pubmed Central) - Nov 1, 2022
We show that RGSz1 controls the rewarding efficacy of opioids by actions in vlPAG projections to the ventral tegmental area, a key component of the midbrain dopamine pathway. These studies highlight novel mechanisms by which pain-modulating structures control the rewarding efficacy of opioids.
- | morphine sulphate / Generic mfg.
Journal: Systems biology analyses reveal enhanced chronic morphine distortion of gut-brain interrelationships in simian human immunodeficiency virus infected rhesus macaques. (Pubmed Central) - Nov 1, 2022
Finally, morphine also altered the regulation of CNS inflammation by reducing the levels of IL1 Receptor antagonist (IL1Ra). These findings are suggestive that morphine promotes CNS inflammation by altering receptor modulation, increasing myeloid brain activation, distorting gut-brain crosstalk, and causing selective enhancement of SHIV persistence in sites of neurogenesis.
- | morphine sulphate / Generic mfg.
Trial completion date, Trial primary completion date: PAciFy Cough: Morphine Sulfate/Placebo for the Treatment of PulmonAry Fibrosis Cough (clinicaltrials.gov) - Nov 1, 2022
P3, N=44, Recruiting, Sponsor: Royal Brompton & Harefield NHS Foundation Trust
These findings are suggestive that morphine promotes CNS inflammation by altering receptor modulation, increasing myeloid brain activation, distorting gut-brain crosstalk, and causing selective enhancement of SHIV persistence in sites of neurogenesis. Trial completion date: Aug 2022 --> Mar 2023 | Trial primary completion date: Aug 2022 --> Mar 2023