morphine sulphate / Generic mfg. 
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  • ||||||||||  Intra-transport Medication Use by a Regional Neonatal Transport Service (H0259: Section on Transport Medicine) -  Nov 10, 2022 - Abstract #AAPNCE2022AAP_NCE_2123;    
    Many neonatal transports require the provision of fluids and medications, with hydration and nutritional fluids, antibiotics, prostaglandin, and pain medications being the most common. Transport teams need to be equipped and trained to provide a wide variety of medications and fluids.
  • ||||||||||  morphine sulphate / Generic mfg.
    Reducing Post-operative Opioids Prescribed on a Pediatric Surgery Service: An Educational Countermeasure Quality Initiative (Anaheim Marriott, Marquis Ballroom Center, Board # 064) -  Nov 10, 2022 - Abstract #AAPNCE2022AAP_NCE_1811;    
    There was a statistically significant decrease in median OME/kg prescribed at discharge that was sustained after the intervention period [pre: 2.25 (IQR 1.25, 3.75), during: 1.875 (1.00, 3.75), post: 1.875 (.94, 2.81) with p=0.009]. The percentage of patients who were prescribed opioids remained unchanged [15.0% (pre), vs 16.0% (during), and 13.3% (post), p=0.42].
  • ||||||||||  ketorolac / Generic mfg., morphine sulphate / Generic mfg., paracetamol / Generic mfg.
    Quadratus Lumborum Blocks Reduce Post-operative Opioid Utilization After Laparoscopic Appendectomy: A Single Institution Review (H0222: Section on Surgery) -  Nov 10, 2022 - Abstract #AAPNCE2022AAP_NCE_1791;    
    Our results also underscore the fact that consistent administration of acetaminophen and ibuprofen is a critical component of opioid stewardship. The observed reduction in morphine equivalents in the PACU which did not persist in the 24-hour post-operative period is not surprising since QL blocks are most effective for 6 to 8 hours.
  • ||||||||||  morphine sulphate / Generic mfg.
    Dural Tears in Pediatric Posterior Spinal Fusions (H0102: Section on Orthopaedics) -  Nov 10, 2022 - Abstract #AAPNCE2022AAP_NCE_1680;    
    Incidental dural tears occurred in 3% of posterior spinal fusions in this series, and intra-operative repair was clinically successful in 96% (85/89) of patients. Post-operative bed rest did not affect post-operative headaches.
  • ||||||||||  morphine sulphate / Generic mfg.
    Dose-delivery Time Interval of Morphine in Labour and Its Impact on the Likelihood of Adverse Neonatal Outcomes (Anaheim Convention Center, Hall A, Board # 126) -  Nov 10, 2022 - Abstract #AAPNCE2022AAP_NCE_1644;    
    This could suggest that standardized post-operative protocols, such as our hospital’s scoliosis pathway, help ensure more equitable care. A dose-delivery interval between 155 and 314 minutes may lead to a higher incidence of requirement for resuscitation at birth, in addition to specific types of resuscitation including tactile stimulation, continuous positive airway pressure and intermittent positive pressure ventilation.
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
    Demographics and Disposition of Infants Exposed to Opioids in Utero (Anaheim Convention Center, Hall A, Board # 122) -  Nov 10, 2022 - Abstract #AAPNCE2022AAP_NCE_1640;    
    Forty-four percent of infants in this study required treatment with MS after delivery. About 1/3 of the infants admitted to the NICU for clinical concerns who did not have signs of withdrawal on admission did not require MS administration despite the lack of continuous maternal support.
  • ||||||||||  morphine sulphate / Generic mfg.
    Trial primary completion date:  Gene Polymorphisms and Morphine Analgesic Consumption (clinicaltrials.gov) -  Nov 10, 2022   
    P=N/A,  N=300, Recruiting, 
    Overall, the results of our meta-analysis do not support the routine use of continuous ACB for postoperative analgesia after TKA. Trial primary completion date: Mar 2022 --> Dec 2022
  • ||||||||||  morphine sulphate / Generic mfg.
    Trial completion date, Trial primary completion date:  Neuraxial Preservative Free Morphine for Normal Spontaneous Vaginal Delivery (clinicaltrials.gov) -  Nov 10, 2022   
    P4,  N=140, Enrolling by invitation, 
    Trial primary completion date: Mar 2022 --> Dec 2022 Trial completion date: Mar 2023 --> Oct 2023 | Trial primary completion date: Dec 2022 --> Oct 2023
  • ||||||||||  Review, Journal:  Opioid toxicity: histamine, hypersensitivity, and MRGPRX2. (Pubmed Central) -  Nov 9, 2022   
    Whether there is a correlation between histamine release by individual OADs, MRGPRX2 activation, and presence or absence of adverse cutaneous effects is not known. To investigate the question, ongoing research with recently pursued methodologies and strategies employing basophil and mast cell tests resulting from MRGPRX2 insights should help to elucidate whether or not an opioid's histamine-releasing potency, and its property of provoking an adverse reaction, are each a reflection of its activation of MRGPRX2.
  • ||||||||||  Journal:  Assessment of compatibility of rhIGF-1/rhIGFBP-3 with neonatal intravenous medications. (Pubmed Central) -  Nov 9, 2022   
    To investigate the question, ongoing research with recently pursued methodologies and strategies employing basophil and mast cell tests resulting from MRGPRX2 insights should help to elucidate whether or not an opioid's histamine-releasing potency, and its property of provoking an adverse reaction, are each a reflection of its activation of MRGPRX2. Co-administration of rhIGF-1/rhIGFBP-3 drug product with various medications was assessed by in vitro studies using case-by-case risk analyses to determine the suitability of the products for co-administration.
  • ||||||||||  morphine sulphate / Generic mfg.
    Review, Journal:  Single shot regional anesthesia for laparoscopic cholecystectomies: a systematic review and network meta - analysis. (Pubmed Central) -  Nov 9, 2022   
    We searched PubMed, The Cochrane Central Register of Controlled Trials (CENTRAL), Scopus and Web of Science (Science and Social Science Citation Index) using the following PICOS criteria: adult patients undergoing LC (P), Any RA single shot technique with injection of local anesthetics (I),placebo or no intervention (C), postoperative opioid consumption expressed as morphine milligram equivalents(MME) rest pain at postoperative 12 h and 24 h, postoperative nausea and vomiting (PONV), length of stay (O); randomized controlled trials (S)...Patients benefit the most from bilateral paravertebral block, ESP block, QL block and TAP block. Heterogeneity limits the strength of our results.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Efficacy of opioid spinal analgesia for postoperative pain management after pancreatoduodenectomy. (Pubmed Central) -  Nov 9, 2022   
    An own developed novel tablet-based system like our system may be a promising potential tool useful in various future intensive care applications. There was no significant difference in postoperative pain scores, opioid use, or LOS between patients managed with TEA or opioid spinal after pancreatoduodenectomy.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Negative allosteric modulation of CB cannabinoid receptor signaling suppresses opioid-mediated reward. (Pubmed Central) -  Nov 9, 2022   
    In the nucleus accumbens shell, a key component of the mesocorticolimbic reward pathway, morphine increased electrically-evoked dopamine efflux and this effect was blocked by a dose of GAT358 that lacked intrinsic effects on evoked dopamine efflux...Finally, GAT358 also reduced oral oxycodone (but not water) consumption in a two-bottle choice paradigm. Our results support the therapeutic potential of CB-NAMs as novel drug candidates aimed at preventing opioid reward and treating opioid abuse while avoiding unwanted side-effects.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Fascia iliaca Block with General Anaesthesia vs. Subarachnoid Morphine Block in Total Hip Arthroplasty (Pubmed Central) -  Nov 9, 2022   
    CONCLUSIONS If subarachnoid anaesthesia cannot be used in hip arthroplasty, general anaesthesia with fascia iliaca block provides comparable analgesia and quality of postoperative course. Key words: total hip arthroplasty, general anaesthesia, fascia iliaca block, subarachnoid anaesthesia, postoperative analgesia, postoperative course.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Molecular identification of bulbospinal ON neurons by GPER which drives pain and morphine tolerance. (Pubmed Central) -  Nov 9, 2022   
    In contrast, genetic ablation or pharmacological blockade of GPER attenuated pain, enhanced morphine analgesia and delayed the development of morphine tolerance in diverse preclinical pain models. Our data strongly support GPER as a marker for GABAergic ON cells and also illuminate the mechanisms underlying hormonal regulation of pain and analgesia, highlighting GPER as a promising target for the treatment of pain and opioid tolerance.
  • ||||||||||  Lodonal (naltrexone low dose oral) / Immune Therap, Statera BioPharma
    Preclinical, Journal:  Antinociceptive Effect of Ultra-Low Dose Naltrexone in A Pre-Clinical Model of Postoperative Orofacial Pain. (Pubmed Central) -  Nov 8, 2022   
    Stimulation of macrophages with LPS resulted in increase of nitric oxide, IL-1β and CXCL-2 levels which were reduced by NTX. Altogether, these results provide evidence for an antinociceptive effect of ULDN in postoperative orofacial pain and suggest that blockade of TLR4 and downstream signaling pathway contribute to its effect.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Laparoscopic transversus abdominis plane block reduces postoperative opioid requirements after laparoscopic cholecystectomy. (Pubmed Central) -  Nov 8, 2022   
    Altogether, these results provide evidence for an antinociceptive effect of ULDN in postoperative orofacial pain and suggest that blockade of TLR4 and downstream signaling pathway contribute to its effect. Performing a laparoscopic transversus abdominis plane block during elective laparoscopic cholecystectomy is a safe and effective strategy to reduce postoperative opioid requirements for the treatment of acute postoperative pain.
  • ||||||||||  morphine sulphate / Generic mfg.
    Review:  Efficacy and safety of stereotactic body radiotherapy for painful bone metastases: Evidence from randomized controlled trials. (Pubmed Central) -  Nov 8, 2022   
    The secondary outcomes included the rate of pain responders at one month and six months, oral morphine equivalent dose (OMED) use, and any adverse events...This study shows that for painful bone metastases, patients with SBRT experienced better pain relief 3 months after radiation than patients with cRT, and SBRT did not increase the incidence of adverse events. https://inplasy.com/inplasy-2022-6-0099/, identifier INPLASY202260099.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Opioid Use in Vaso-Occlusive Crisis During Intravenous Opioid Drug Shortage. (Pubmed Central) -  Nov 8, 2022   
    The implementation of IV opioid restrictions resulted in a decrease in IV opioid use in treatment of VOC in patients with SCD without causing increases in length of stay or readmissions. Oral opioids should be considered an option for VOC management in patients with SCD.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal, Adverse events:  A novel nomogram for predicting respiratory adverse events during transport after interventional cardiac catheterization in children. (Pubmed Central) -  Nov 8, 2022   
    Multivariate analysis identified age (vs. ≤3 years, adjusted odds ratio (aOR) = 0.507, 95% confidence interval (CI), 0.268-0.958, P = 0.036), preoperative upper respiratory tract infections (URI, aOR = 2.335, 95% CI, 1.223-4.460, P = 0.01), type of surgery (vs. VSD, for ASD, aOR =  2.856, 95% CI, 1.272-6.411, P = 0.011; for PDA, aOR = 5.518, 95% CI, 2.425-12.553, P < 0.001), morphine equivalent (vs. ≤0.153 mg/kg, aOR = 2.904, 95% CI, 1.371-6.150, P = 0.005), atropine usage (aOR = 0.463, 95% CI, 0.244-0.879, P = 0.019), and RAEs during extubation to transport (aOR = 5.004, 95% CI, 2.633-9.511, P < 0.001) as independent predictors of RAEs during transport...The proposed nomogram can reliably identify pediatric patients at high risk of RAEs during transport and guide clinicians to make proper transport plans. Our findings have important and meaningful implications for RAEs risk prediction, clinical intervention and healthcare quality control.
  • ||||||||||  morphine sulphate / Generic mfg.
    Opioid use in a Caerulein-Induced Chronic Pancreatitis Mouse Model is Associated with Gut Dysbiosis () -  Nov 7, 2022 - Abstract #APAPancreatic2022APA_Pancreatic_432;    
    Our data also suggest that injection of an AMPARs antagonist into the LHb may alter the AMPA-induced morphine response in a dose-dependent manner. Together, these analyses reveal that opioid use can induce pronounced alteration in the gut microbiome composition, diversity, and function in caerulein-induced CP mouse model.