- |||||||||| Undercover Ulcers: The Misleading Presentation of Duodenal Bulb Perforation as Pancreatitis (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_2075;
Her home medications included aspirin, lisinopril, meloxicam, and donepezil...Intravenous fluids, morphine, bowel rest, and pantoprazole were started considering it as a case of AP...Figure: Figure A: Chest Xray demonstrating air under diaphragm (yellow arrow). Figure B: CT scan of abdomen with contrast showing large amount of free intraperitoneal air and moderately large amount of ascites adjacent to the liver (red star).
- |||||||||| morphine sulphate / Generic mfg., enoxaparin sodium / Generic mfg., apixaban / Generic mfg.
Unveiling the Mystery of Veins: A Unique Combination of Portal and Inferior Mesenteric Venous Thrombosis (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_1781; Case Description/ A 75-year-old male with a history of hyperlipidemia and type 2 diabetes mellitus presented to the emergency department (ED) with severe, sudden, sharp periumbilical pain that was relieved with intravenous morphine...He was started on intramuscular Lovenox 70 mg injection twice daily...The patient's pain and labs improved over the next couple of days, and was discharged on apixaban 10 mg twice daily for 7 days followed by 5 mg twice daily...Figure: Figure 1: (A, B, C) Contrast Enhanced Computed Tomography (CT) scan of abdomen and pelvis showing filling defect within the inferior mesenteric vein consistent with non-occlusive thrombus. (D) filling defect within the right portal vein consistent with non-occlusive thrombus.
- |||||||||| Abdominal Pain in Gastroparesis: Comparing PAGI-SYM and SF-8 Survey Scores Among Opiate and Non-Opiate Analgesic Management (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_1128;
(D) filling defect within the right portal vein consistent with non-occlusive thrombus. Patients reported managing AP with 31.3% using nothing, 25% ice, hot showers or heating pads, 20.8% acetaminophen, 14.6% hyoscyamine, 11% opiate analgesics, 11% marijuana, 8.3% NSAIDs, 3.7% benzodiazepines, 2.1% calcium carbonate, 2.1% dicyclomine, 2.1% domperidone, and 2.1% gabapentin...Patients taking opiates for AP had more morphine milliequivalent use than for non-AP (77.5
- |||||||||| morphine sulphate / Generic mfg.
A Rare Case of Cannabis Induced Pancreatitis (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_622; Patient received intravenous fluids and intravenous morphine for pain and diet slowly advanced...More literature and research should be directed towards understanding relation between cannabis exposure leading to AP and its implications. Figure: CT abdomen and pelvis showed peripancreatic inflammatory changes consistent with pancreatitis.
- |||||||||| morphine sulphate / Generic mfg.
Pain Medication Use in Chronic Pancreatitis Patients Undergoing ERCP (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_541; The number of patients using opioids increased from 1 year before index ERCP (51.55%) to 1 year after (62.89%). The number of patients using adjuvant pain medications also increased in the year after index ERCP (17.53% to 51.55%).
- |||||||||| morphine sulphate / Generic mfg.
Investigation of Geospatial Disparities in Chronic Pancreatitis Outcomes (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_521; Among 324 CP patients followed over 8 years, we noted trends of higher dependence on governmental insurance or no insurance among patients in higher SVI quartiles (III/IV vs. I/II) but no differences in demographics, comorbidities, or etiology of CP. In patients residing in more vulnerable SVI quartiles, we noted significantly higher frequency of hospitalizations for CP flares and lower daily MME (p< 0.05).
- |||||||||| morphine sulphate / Generic mfg.
Preclinical, Journal: Benzofuran Iboga-analogs Modulate Nociception and Inflammation in an Acute Mouse Pain Model. (Pubmed Central) - Aug 19, 2024 Derivatives of the naturally occurring iboga alkaloids have previously shown promising behavior in anti-addiction of morphine by virtue of their interaction with opioid receptors...Behavioral patterns after oral administration of the best analog were also analyzed. Taken together, these results show that the iboga family of alkaloid has huge potential in pain management.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Ketogenic diet mitigates opioid-induced hyperalgesia by restoring short-chain fatty acids-producing bacteria in the gut. (Pubmed Central) - Aug 19, 2024 In this study, we show that the ketogenic diet recovers the abnormal pain behavior caused by chronic morphine treatment in male mice, and we further show that the therapeutic effect of the ketogenic diet is mediated through gut microbiome...Our findings suggest that gut microbiome could be targeted to treat OIH, and the ketogenic diet can be used as a complementary approach for pain relief in patients with chronic opioid treatment. We only used male mice in this study, and thus, our findings cannot be generalized to both sexes.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Pericapsular Nerve Group Block Did Not Reduce Post-Operative Pain or Opioid Use After Total Hip Arthroplasty. (Pubmed Central) - Aug 17, 2024 Our results show that use of the PENG block did not result in lower postoperative pain scores or opioid consumption after THA using the posterior surgical approach. The study group had a shorter length of stay and time to mobilization than the control group, though this was likely due to standard hospital procedure shifting to same-day discharge for THA between 2019 and 2021 due to COVID-19.
- |||||||||| morphine sulphate / Generic mfg.
Journal, Surgery: A "just in time" educational intervention for opioid overprescribing in dialysis access surgery. (Pubmed Central) - Aug 17, 2024 In conclusion, our results show that GABAB receptors have a regulatory role in the rewarding effects of morphine that could be of interest for a potential future therapeutic application in opioid use disorders. This low-cost and timely learning intervention may be a useful adjunct to reduce post-operative opioid prescriptions.
- |||||||||| fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
Journal, Surgery: Bilateral ultrasound-guided erector spinae plane block for postoperative pain relief in major traumatic spine surgery: A randomized controlled trial. (Pubmed Central) - Aug 16, 2024 VAS scores at rest and movement at 0, 3, 6, 9, 12, 18, and 24 hours were significantly lower (P value = 0.05) in the ESPB group compared with the control group at all time points. Bilateral ultrasound-guided Erector spinae plane block, when administered in traumatic spine patients undergoing spine fixation surgery, provides better analgesia with statistically decreased VAS scores and less postoperative opioid requirement.
- |||||||||| Exparel (bupivacaine liposome injectable suspension) / Pacira
Journal, Video, Surgery: Early adoption of robotic lung resection in an established video assisted thoracic surgery practice. (Pubmed Central) - Aug 16, 2024 Bilateral ultrasound-guided Erector spinae plane block, when administered in traumatic spine patients undergoing spine fixation surgery, provides better analgesia with statistically decreased VAS scores and less postoperative opioid requirement. Patients who underwent segmentectomy or lobectomy from May 2016-December 2018 were propensity-matched 2: 1 (VATS: robotic) and compared using weighted logistic regression with age, gender, Charlson Comorbidity Index, surgery type, stage, Exparel, and epidural as covariates...Interestingly, robotic resections had higher 72-hour pain scores (median 3 (IQR 3.25) vs. 2 (IQR 3.50); p
- |||||||||| Olinvyk (oliceridine) / Trevena
Journal: Activation of ? receptors by SR-17018 through a distinctive mechanism. (Pubmed Central) - Aug 15, 2024 Patients who underwent segmentectomy or lobectomy from May 2016-December 2018 were propensity-matched 2: 1 (VATS: robotic) and compared using weighted logistic regression with age, gender, Charlson Comorbidity Index, surgery type, stage, Exparel, and epidural as covariates...Interestingly, robotic resections had higher 72-hour pain scores (median 3 (IQR 3.25) vs. 2 (IQR 3.50); p Limiting receptor availability by prior exposure to ?-FNA (100
- |||||||||| morphine sulphate / Generic mfg.
Journal: Management of Refractory Cancer Pain with Intrathecal Drug Delivery and Spinal Cord Stimulation. (Pubmed Central) - Aug 15, 2024 Primary outcomes were pain numeric rating scale (NRS) and daily morphine equivalents (MEQs)...ITP and SCS may both provide efficacy for cancer pain, but the opioid-sparing effects of SCS may be limited. ITP and SCS may potentially be complementary in their ability to provide relief from cancer-related pain.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Predictors of opioid use for rib fractures in a regional Australian hospital. (Pubmed Central) - Aug 14, 2024 The model is effective at identifying predictors of opioid use in this regional centre, which are similar to those described in evidence from MTCs. However, the low R2 with wide prediction intervals limits its utility on an individual level.
- |||||||||| morphine sulphate / Generic mfg., midazolam hydrochloride / Generic mfg.
Journal, Real-world evidence, Real-world: The Feasibility, Safety and Outcome of Very High-Power Short Duration Radiofrequency Ablation in Pulmonary Vein Isolation: A Real-World Observation Study. (Pubmed Central) - Aug 14, 2024 In this study, vHPSD demonstrated a comparable safety profile to the other treatment arms. Procedural duration and energy application time was substantially reduced along with sedation requirement notwithstanding the limitations of observational study design, these preliminary findings are promising with respect to periprocedural outcomes and safety of vHPSD however longitudinal outcomes will be essential to assessing the overall efficacy of this novel technology.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Challenges of perioperative pain control in opioid use disorder patients following intramedullary nail fixation. (Pubmed Central) - Aug 14, 2024 Patients with opioid use disorder (n?=?42) required greater morphine equivalents and reported higher pain than controls (n?=?42) at all time points but did not differ in change of morphine equivalents over the perioperative period. This highlights the challenge of perioperative pain control in this population and need for improved specific pain management protocols.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Opioid use after surgical treatment in the Danish population-Protocol for a register-based cohort study. (Pubmed Central) - Aug 12, 2024 The study will use extensive national register-based data, ensuring consistent data collection and enhancing the generalizability of the findings to similar healthcare systems. The study may identify high-risk populations for long-term opioids and provide information to support opioid prescribing guidelines and public health policies.
- |||||||||| hydromorphone hydrochloride / Generic mfg.
Clinical, Retrospective data, Review, Journal: Efficacy and safety of hydromorphone for cancer pain: a systematic review and meta-analysis. (Pubmed Central) - Aug 10, 2024 These findings are consistent with prior comprehensive analyses, suggesting that hydromorphone is a feasible choice for alleviating cancer-associated pain. Additional investigations are warranted to determine its efficacy in distinct patient cohorts and for different modes of administration.
- |||||||||| morphine sulphate / Generic mfg., aspirin / Generic mfg.
Journal: Phytochemical analysis and investigation of analgesic, anti-inflammatory, and antispasmodic activities of hydroethanolic extracts of Alternanthera dentata, Ocimum carnosum, and Plectranthus barbatus, three species with vernacular names derived from analgesic drugs. (Pubmed Central) - Aug 10, 2024 The neuroprotective potentials of these selected lactic acid bacteria against CCI induced neuropathic pain may be attributed to their anti-oxidant, anti-inflammatory properties and reduced calcium deposition in sciatic nerve. Pharmacological tests supported some popular uses, suggesting peripheral antinociceptive and anti-inflammatory effects, while the phytochemical analysis showed the presence of several flavonoids in the three hydroethanolic extracts and steroids in PB, with some barbatusterol derivatives described for the first time in the species.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Postoperative outcomes and trends in computer-navigated and robotic-assisted total hip arthroplasty. (Pubmed Central) - Aug 8, 2024 Opioid consumption was reported in morphine milligram equivalents (MME) for postoperative days (POD) 0 and 1...CN-THA was associated with reduced rates of PJI and dislocation, but increased rates of blood transfusion while RA-THA was associated with decreased rates of dislocation, but increased rates of blood transfusion, prosthesis complications, and periprosthetic fracture compared to CON-THA. Technology-assisted THA was associated with lower postoperative opioid consumption.
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