- |||||||||| morphine sulphate / Generic mfg., papaverine / Generic mfg.
Journal: Alkaloid binding to opium poppy major latex proteins triggers structural modification and functional aggregation. (Pubmed Central) - Nov 16, 2022
Using a combination of sucrose density-gradient fractionation-coupled proteomics, differential scanning fluorimetry, isothermal titration calorimetry, and X-ray crystallography, we show that the major latex proteins are a family of alkaloid-binding proteins that display altered conformation in the presence of certain ligands. Addition of MLP/PR10 proteins to yeast strains engineered with morphine biosynthetic genes from the plant significantly enhanced the conversion of salutaridine to morphinan alkaloids.
- |||||||||| morphine sulphate / Generic mfg., clonidine / Generic mfg., ropivacaine / Generic mfg.
Journal: Postinterventional Patient Comfort After Uterine Artery Embolization and Superior Hypogastric Nerve Block. (Pubmed Central) - Nov 16, 2022
Addition of MLP/PR10 proteins to yeast strains engineered with morphine biosynthetic genes from the plant significantly enhanced the conversion of salutaridine to morphinan alkaloids. Superior hypogastric nerve block using a mixture of ropivacaine and clonidine provides good pain relief for 9 h after uterine artery embolization requiring only very low amounts of additional opioids.
- |||||||||| Review, Journal: Pharmacological interventions for pain and sedation management in newborn infants undergoing therapeutic hypothermia. (Pubmed Central) - Nov 16, 2022
We included randomized controlled trials (RCT), quasi-RCTs and cluster-randomized trials comparing drugs used for the management of pain or sedation, or both, during therapeutic hypothermia: any opioids (e.g. morphine, fentanyl), alpha-2 agonists (e.g. clonidine, dexmedetomidine), N-Methyl-D-aspartate (NMDA) receptor antagonist (e.g. ketamine), other analgesics (e.g. paracetamol), and sedatives (e.g. benzodiazepines such as midazolam) versus another drug, placebo, no intervention, or non-pharmacological interventions. Primary outcomes were analgesia and sedation, and all-cause mortality to discharge...Amongst the four excluded studies, topiramate and atropine were used in two and one trial, respectively; one study used dexmedetomidine and was initially reported in 2019 to be a randomized trial...We identified one ongoing study comparing dexmedetomidine to morphine. We found no studies that met our inclusion criteria and hence there is no evidence to recommend or refute the use of pharmacological interventions for pain and sedation management in newborn infants undergoing therapeutic hypothermia.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Electrochemical Determination of Morphine in Urine Samples by Tailoring FeWO/CPE Sensor. (Pubmed Central) - Nov 16, 2022
The FeW@CPE sensor resulted in good selectivity and excellent repeatability with relative standard deviation (RSD) and was applied in real-world samples of human urine. Application for direct MORPH detection, without tedious sample pretreatment procedures, suggests that developed electrochemical sensor has appeared to be a suitable competitor for efficient, precise, and accurate monitoring of the MORPH in biological fluids.
- |||||||||| dalargin (leu-enkephalin) / Burnasyan Federal Medical & Biophysical Center
Journal: Molecular insights into the mechanism of sugar-modified enkephalin binding to opioid receptors. (Pubmed Central) - Nov 16, 2022
In conclusion, the conjugation of an enkephalin molecule with the glucuronic acid has a direct and strong impact on the receptor-ligand interactions. The enhancement of ligand binding is much stronger in the delta receptor than in the mu receptor; thus, enkephalin conjugated with glucuronic acid shows greater selectivity toward the delta opioid receptor than the original peptide.
- |||||||||| morphine sulphate / Generic mfg., naltrexone / Generic mfg.
Journal: Functional consequences of short-term exposure to opioids versus cannabinoids in nonhuman primates. (Pubmed Central) - Nov 16, 2022
Additionally, morphine, but not CP 55,940, enhanced the monkeys' hypersensitivity to the algogen capsaicin. Collectively, these results demonstrate that in nonhuman primates, both opioids and cannabinoids exert comparable antinociception; however, physical dependence on opioids, but not cannabinoids, at their antinociceptive doses, occurs following short-term exposures.
- |||||||||| Review, Journal: Evaluation and Treatment of Pain in Fetuses, Neonates and Children. (Pubmed Central) - Nov 16, 2022
Patient-controlled analgesia is an adequate alternative for adolescent and older children in specific situations, such as after surgery. In patients with severe or persistent pain, it is very important to consult with specific pain services.
- |||||||||| aspirin / Generic mfg.
Journal: Do We Really Need Aspirin Loading for STEMI? (Pubmed Central) - Nov 16, 2022
We therefore suggest studying the effects of aspirin loading before reperfusion on the infarct size limiting effects of statins, ticagrelor, morphine, and/ or postconditioning in large animal models using long reperfusion periods (at least 24 h). If indeed aspirin attenuates the protective effects, clinical trials should be conducted comparing aspirin loading to alternative antiplatelet regimens without aspirin loading in patients with STEMI undergoing primary percutaneous coronary intervention.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Coincident Regulation of PLCβ Signaling by Gq-Coupled and μOpioid Receptors Opposes Opioid- Mediated Antinociception. (Pubmed Central) - Nov 16, 2022
Deletion of phospholipase Cβ3 (PLCβ3) or selective inhibition of Gβγ regulation of PLCβ3 enhances the potency of the antinociceptive effects of morphine suggesting a novel strategy for achieving opioid-sparing effects...We show that PLC dependent DAG generation is cooperatively regulated by MOR-Gβγ and Gq-coupled receptor signaling through PLCβ3, and that blockade of either Gq-signaling or Gβγ signaling enhances the potency of opioids in ex vivo brain slices and in vivo. These results reveal potential novel strategies for improving opioid analgesic potency and safety.
- |||||||||| ketamine / Generic mfg.
Retrospective data, Journal: Efficacy and safety in ketamine-guided prehospital analgesia for abdominal pain. (Pubmed Central) - Nov 16, 2022
With ketamine, analgesia comparable to fentanyl can be achieved. Ketamine appears to be a safe and effective option for the treatment of patients with abdominal pain in emergency medicine.Trial registration number DRKS00027343, date of registration: 09.12.2021, retrospectively registered.
- |||||||||| dexamethasone / Generic mfg., morphine sulphate / Generic mfg., celecoxib oral / Generic mfg.
Journal: On the Bioactivity of Echinacea purpurea Extracts to Modulate the Production of Inflammatory Mediators. (Pubmed Central) - Nov 16, 2022
Moreover, E. purpurea extracts demonstrated generally a more robust anti-inflammatory activity than clinically used anti-inflammatory drugs (dexamethasone, diclofenac, salicylic acid, and celecoxib). Therefore, E. purpurea extracts may be used to develop new effective therapeutic formulations for disorders in which the immune system is either overactive or impaired.
- |||||||||| fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
Journal: Molecular recognition of morphine and fentanyl by the human μ-opioid receptor. (Pubmed Central) - Nov 15, 2022
Ligands designed to reduce TM6/7 interactions display preferential G protein signaling. Our results provide crucial insights into fentanyl recognition and signaling of μOR, which may facilitate rational design of next-generation analgesics.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Optimizing discharge opioid prescribing in trauma patients: A quasi-experimental study. (Pubmed Central) - Nov 15, 2022
These results suggest that, in our experimental model, reconsolidation is mediated through updating of the emotional valence of contextual memory associated with the administration of morphine. A departmental guideline aimed at optimizing opioid prescription patterns successfully lowers the amount of morphine milligram equivalents prescribed to trauma patients and improves compliance with Centers for Disease Control and Prevention recommendations.
- |||||||||| morphine sulphate / Generic mfg.
Preclinical, Journal, MRI: Magnetic resonance imaging as a non-invasive tool to assess gastric emptying in mice. (Pubmed Central) - Nov 15, 2022
A departmental guideline aimed at optimizing opioid prescription patterns successfully lowers the amount of morphine milligram equivalents prescribed to trauma patients and improves compliance with Centers for Disease Control and Prevention recommendations. Our data indicate that MRI is a reliable and reproducible tool to assess gastric emptying in mice and represents a useful technique to study gastroparesis in disease models or for evaluation of pharmacological compounds.
- |||||||||| morphine sulphate / Generic mfg.
Clinical, Journal: Association of Postoperative Opioid Prescription Size and Patient Satisfaction. (Pubmed Central) - Nov 15, 2022
In a large cohort of patients undergoing common surgical procedures, there was no association between opioid prescription size at discharge after surgery and patient satisfaction. This implies that surgeons can provide significantly smaller opioid prescriptions after surgery without negatively affecting patient satisfaction.
- |||||||||| morphine sulphate / Generic mfg., ropivacaine / Generic mfg.
Retrospective data, Journal: Erector Spinae Plane Catheter Analgesia in Minimally Invasive Mitral Valve Surgery: A Retrospective Case-Control Study for Inclusion in an Enhanced Recovery Program. (Pubmed Central) - Nov 15, 2022
Erector spinae catheters (ESCs) were placed preoperatively, using a loading dose of 30 mL .5% ropivacaine, followed by an infusion of .2% ropivacaine at 10 mL/h throughout the study period...Secondary outcomes included intraoperative morphine equivalents, extubation within 24 hours, reintubation, ICU length of stay and hospital length of stay and 30-day mortality...A reduced hospital length of stay as well as an acceptable safety profile was also observed in the ESC group. An adequately powered, prospective trial is warranted to accurately assess the potential role for ESP catheters for patients undergoing minimally invasive mitral valve surgery.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Natural history of pediatric morphine leukoencephalopathy on CT and MRI. (Pubmed Central) - Nov 15, 2022
Moreover, we have provided brain computed tomography and magnetic resonance imaging and highlighted findings in the acute and chronic stages of the disease trajectory. This case report highlights the importance for radiologists, especially those involved in emergency care, to have a high index of suspicion for toxic leukoencephalopathy, a potentially devastating but treatable condition.
- |||||||||| hydromorphone hydrochloride / Generic mfg.
Journal: Hydromorphone for dyspnoea in terminally ill patients with cancer: case series. (Pubmed Central) - Nov 15, 2022
Further electronic order-set changes or other methodologies should be explored to affect inpatient opioid use. Using hydromorphone for dyspnoea in patients with cancer seems to be appropriate if morphine use is contraindicated.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Long-term use of Wearable Health Technology by Chronic Pain Patients. (Pubmed Central) - Nov 15, 2022
Data trends suggest that WHT use may positively impact depression and prescribed medication. Additional research is warranted to investigate the potential of WHT to improve the negative consequences of chronic pain.
- |||||||||| morphine sulphate / Generic mfg.
Preclinical, Journal: Selank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats. (Pubmed Central) - Nov 15, 2022
Single intraperitoneal injection of Selank in an anxiolytic dose of 0.3 mg/kg reduced the total index of morphine withdrawal syndrome by 39.6%, significantly (р<0.0001) attenuated convulsive reactions, ptosis, and posture disorders, and 9-fold increased the tactile sensitivity threshold in morphine-dependent rats in comparison with the group of active control; at the same time, Selank was slightly inferior to diazepam in a dose of 2 mg/kg by pharmacological activity (the decrease in total index of morphine withdrawal syndrome by 49.3% and 13-fold increase in sensitivity threshold). Thus, Selank, like diazepam, weakens the aversive signs of morphine withdrawal in rats with opiate dependence.
- |||||||||| remifentanil / Generic mfg., morphine sulphate / Generic mfg.
Regional erector spinae block for medical thoracoscopy (Westminster, 4th floor) - Nov 15, 2022 - Abstract #BTSWM2022BTS_WM_410;
Pain scores during procedure, in recovery and at home were recorded by retrospective interview and review of recovery charts, and a functional pain questionnaire was administered via telephone.Results The average greatest depth of sedation required using propofol target controlled infusion was 1.92 (standard error of mean [SEM] 0.27), with remifentanil 2.52 (SEM 0.46)...Patients used an average of 3.33 mg oral morphine (SEM 2.35) in hospital, and 3 mg (SEM 2) on post-op day 1...The project showed pain outcomes and patient acceptability were good for the use of regional anaesthesia for MT. A formal randomised controlled trial is now planned.
- |||||||||| lidocaine topical / Generic mfg.
Clinical, Journal: Analgesic effect of ketorolac added to lidocaine in surgery of traumatic arm injuries: A double-blind, randomized clinical trial. (Pubmed Central) - Nov 15, 2022
In terms of the occurrence of complications related to the use of ketorolac, no complications were observed in any of the groups receiving this drug. In general, by conducting this study, it can be said that the administration of Ketorolac reduces the intensity of postoperative pain in the recovery room and transfer to the inpatient ward, and reduces the amount of morphine received by patients, but the time of the first request for pain relief by the patient It does not significantly delay and does not affect the overall satisfaction of patients with the quality of analgesia during and after the operation and their satisfaction with the anesthesia method they received.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Changes in Opioid Prescription Rates at Discharge After Targeted Provider Education in the Emergency Department. (Pubmed Central) - Nov 15, 2022
In general, by conducting this study, it can be said that the administration of Ketorolac reduces the intensity of postoperative pain in the recovery room and transfer to the inpatient ward, and reduces the amount of morphine received by patients, but the time of the first request for pain relief by the patient It does not significantly delay and does not affect the overall satisfaction of patients with the quality of analgesia during and after the operation and their satisfaction with the anesthesia method they received. After targeting providers through education, a reduction in opioid prescribing was identified through all endpoints.
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