morphine sulphate / Generic mfg. 
Welcome,         Profile    Billing    Logout  
 7 Diseases   379 Trials   379 Trials   12426 News 


«12...6162636465666768697071...216217»
  • ||||||||||  Instanyl (fentanyl) / Takeda
    Journal:  IF IM in a crisis: Intranasal fentanyl versus intravenous morphine in adult vaso-occlusive crisis. (Pubmed Central) -  Dec 9, 2022   
    In conclusion, our study showed that INF was non-inferior when compared to IV morphine in reducing pain scores after drug administration. Therefore, INF is an effective alternative to IV morphine for pain management in adults presenting to the ED for VOC particularly in those with limited IV access.
  • ||||||||||  dexamethasone injection / Generic mfg.
    Clinical, Journal:  Intravenous Dexamethasone Reduces Pain in Middle Ear Surgery. (Pubmed Central) -  Dec 8, 2022   
    Paracetamol demand was lower in group 2 at all points of assessment during the first 24 hours postoperatively. Intravenous dexamethasone is effective in decreasing pain and analgesic requirement, during the first 24 hours postoperatively, in patients undergoing middle ear surgery.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Pain management for the Nuss procedure: comparison between erector spinae plane block, thoracic epidural, and control. (Pubmed Central) -  Dec 8, 2022   
    The primary outcome measure was opioid consumption measured in morphine milligram equivalents...This study supports use of ESP block as a superior choice when choosing among the three postoperative pain management options that were evaluated. ESP resulted in reduced opioid consumption postoperatively and shorter LOS than TE or PCA for patients undergoing the Nuss procedure for surgical repair of pectus excavatum.
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  Burrowing as an index of inflammatory pain in male vs. female rats. (Pubmed Central) -  Dec 7, 2022   
    When administered 30 min before testing, once daily for 5 days post-CFA, the nonsteroidal anti-inflammatory drug ketoprofen (0.01-3.2 mg/kg) and the opioid morphine (0.1-3.2 mg/kg) significantly increased CFA-suppressed burrowing, whereas the purported cannabinoid analgesic Δ9-tetrahydrocannabinol (0.01-2.0 mg/kg) did not...Overall these results suggest that burrowing is a valid, functional index of inflammatory pain in both sexes, and training on the burrowing procedure is not necessary. However, females are more avid burrowers than males, which should be considered when both sexes are used in inflammatory pain testing.
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg., tramadol hydrochloride / Generic mfg.
    Retrospective data, Journal, Real-world evidence:  Real-world patterns of opioid therapy initiation in Spain, 2012-2018: A population-based, retrospective cohort study with 957,080 patients and 1,509,488 initiations. (Pubmed Central) -  Dec 6, 2022   
    When compared to tramadol, patients initiating with short-acting, long-acting and ultrafast opioids were more likely to be older and had more comorbidities, whereas initiators with codeine were more prone to be healthier and younger...19.55% of initiators with ultrafast fentanyl received more than 120 daily Morphine Milligram Equivalents (MME), and 16.12% of patients initiating with long-acting opioids were prescribed more than 90 daily MME (p < 0.001)...In subsequent initiations, 55.48% of treatments included three or more prescriptions (vs. 17.60% in baseline initiations) and risk of overlap was also increased. Opioids are initiated for a vast array of non-oncological indications, and, despite clinical guidelines, short-acting opioids are used marginally, and a significant number of patients is exposed to potentially high-risk patterns of initiation, such as treatments lasting more than 14 days, treatments surpassing 50 daily MMEs, initiating with long-acting opioids, or hazardous overlapping with other therapies.
  • ||||||||||  morphine sulphate / Generic mfg.
    Review, Journal:  Perioperative and oncologic outcomes of single-port versus conventional robotic-assisted partial nephrectomy: an evidence-based analysis of comparative outcomes. (Pubmed Central) -  Dec 6, 2022   
    There were no significant differences in operative time (p = 0.19), transfusion rates (p = 0.11), off-clamp (p = 0.32), total perioperative milligram morphine equivalents (MME) (p = 0.44), intraoperative complications (p = 0.60), major complications (p = 0.84), overall complications (p = 0.90), positive surgical margins (PSM) (p = 0.75) and local recurrence (p = 0.50) between SP-RAPN and Con-RAPN...However, SP-RAPN had longer warm ischemia time compared to Con-RAPN (WMD 3.42 min, 95% CI 1.71, 5.13; p < 0.0001). The results of this study demonstrated that SP-RAPN provided similar effectiveness and safety to Con-RAPN, while SP-RAPN might be associated with a marginally shorter length of hospital stay and less blood loss.
  • ||||||||||  pethidine / Samaritan
    Journal:  A nationwide study on consumption of opioid analgesics in Iran from 2000 to 2018. (Pubmed Central) -  Dec 6, 2022   
    Despite considerable growth in the consumption of opioid analgesics in Iran over nearly two decades, the consumption amount remained low, which might signal sub-optimal pain management. On the other hand, misuse and abuse seem to be the main reason behind significant increases in the consumption of opioid analgesics with less controlled distribution.
  • ||||||||||  morphine sulphate / Generic mfg., methadone / Generic mfg.
    Enrollment change, Trial initiation date, Trial withdrawal:  METHADOPT: Methadone for 'Adenocarcinopathic' Pain Treatment (clinicaltrials.gov) -  Dec 5, 2022   
    P3,  N=0, Withdrawn, 
    Adult patients undergoing THA under spinal anaesthesia with bupivacaine and 0.2 mg morphine had superior analgesia to patients who received spinal analgesia with bupivacaine or bupivacaine and 0.1 mg morphine. N=40 --> 0 | Initiation date: Jun 2022 --> Sep 2022 | Not yet recruiting --> Withdrawn
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal, Patient reported outcomes:  Association of Preoperative Opioid Use With Postoperative Opioid Use and Patient-Reported Outcomes in Ankle Fracture Fixation Patients. (Pubmed Central) -  Dec 3, 2022   
    Multiple linear regression was used to examine the influences of age, sex, body mass index (BMI), fracture characteristics, medical comorbidities, and preoperative opioid use (OU) on postoperative opioid morphine milligram equivalent (MME) amount and FAAM scores...However, only age, BMI, bimalleolar fractures, and postoperative MME amount were associated with lower FAAM scores postoperatively. Level III, retrospective cohort study.
  • ||||||||||  ketorolac / Generic mfg., morphine sulphate / Generic mfg., ketamine / Generic mfg.
    Journal:  Benefits of Implementing an Enhanced Recovery After Surgery Protocol in Ambulatory Surgery. (Pubmed Central) -  Dec 2, 2022   
    All domains showed significant improvements for both the ACL and the ACL plus meniscal repair cohorts, with the exception of pain at discharge in the ACL plus meniscal repair group. The study findings suggest that an enhanced recovery pathways protocol that includes a standardized intraoperative periarticular bupivacaine, ketamine, and ketorolac injection improves pain scores in the immediate postoperative window, decreases opioid consumption, and reduces recovery time in the PACU for patients undergoing ACL reconstruction.
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg., hydromorphone hydrochloride / Generic mfg.
    Review, Journal:  Opioid Management of Dyspnea at End of Life: A Systematic Review. (Pubmed Central) -  Dec 2, 2022   
    Challenges persist in conducting end-of-life research, preventing consensus on standardization of opioid treatment for dyspnea within this specific palliative time frame. Future robust prospective trials using specific, accurate assessment with reassessment of dyspnea/respiratory distress, and consideration of opioid tolerance, polypharmacy, and comorbidities are required.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Medical Marijuana Legalization and Opioid- and Pain-Related Outcomes Among Patients Newly Diagnosed With Cancer Receiving Anticancer Treatment. (Pubmed Central) -  Dec 2, 2022   
    Having 1 or more days of opioids, 1 or more days of long-acting opioids, total morphine milligram equivalents of any opioid dispensed to patients with 1 or more opioid days, and 1 or more pain-related emergency department visits or hospitalizations (hereafter, hospital events) during the 6 months after a new cancer diagnosis...Findings of this cross-sectional study suggest that medical marijuana legalization implemented from 2012 to 2017 was associated with a lower rate of opioid dispensing and pain-related hospital events among some adults receiving treatment for newly diagnosed cancer. The nature of these associations and their implications for patient safety and quality of life need to be further investigated.
  • ||||||||||  morphine sulphate / Generic mfg., midazolam hydrochloride / Generic mfg.
    Trial completion date, Trial initiation date, Trial primary completion date:  Pharmacokinetics-pharmacodynamics of Morphine With or Without Midazolam Administered by Continuous Infusion in Neonatal Intensive Care (clinicaltrials.gov) -  Dec 2, 2022   
    P=N/A,  N=180, Not yet recruiting, 
    Enhanced guidance is needed to support prescribers in implementing opioid therapy tapering strategies with consideration of OUD and OAT status. Trial completion date: Dec 2024 --> Jul 2025 | Initiation date: Sep 2022 --> Apr 2023 | Trial primary completion date: Dec 2024 --> Jul 2023
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  CircRalgapa1 facilitates morphine tolerance via miR-873a-5p/A20 axis in mice. (Pubmed Central) -  Dec 2, 2022   
    In conclusion, chronic morphine administration-mediated down-regulation of circRalgapa1 in the spinal cord contributes to morphine tolerance via miR-873a-5p/A20 axis in mice. Overexpression of circRalgapa1 may be a promising RNA-based therapy for morphine tolerance.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Status of Palliative Care Services in Tamil Nadu - A Descriptive Report. (Pubmed Central) -  Dec 1, 2022   
    PCCs in Tamil Nadu were identified from the National Health Mission directory, online sources and from morphine license annexure of drug control department...The number of PCCs is disproportionate, in which majority of the centres are clustered in urban areas. Integrating PC services into the existing health system is the way forward.
  • ||||||||||  morphine sulphate / Generic mfg.
    PK/PD data, Journal, Real-world evidence:  Pharmacokinetic/Pharmacodynamic Modeling and Simulation of the Analgesic Effects of Pentazocine Using Perioperative Real-World Data. (Pubmed Central) -  Dec 1, 2022   
    It should be administered at appropriate dosing intervals not only because of its morphine-like side effects but also because frequent inappropriate dosing can lead to dependence...Additional doses should be considered every 8-12 h in postoperative patients with Pain NRS of 5 weighing 40-80 kg. Simulation using the PK/PD model developed in this study may provide useful information for determining the analgesic effects and timing of the dosing interval after PTZ administration in perioperative patients.
  • ||||||||||  morphine sulphate / Generic mfg., aspirin / Generic mfg.
    Journal:  Anti-Inflammatory and Analgesic Activity of Methanolic Root Extract of Verbascum sinaiticum Benth. (Pubmed Central) -  Nov 30, 2022   
    Furthermore, in carrageenan and formalin induced anti-inflammatory test both VS200 and VS400 were shown to produce significant (p< 0.05) anti-inflammatory effect at the later hours and days. The findings from this study suggest that 80% methanol root extract of V. sinaiticum possesses peripheral and central analgesic as well as anti-inflammatory activity, possibly emanating from the phytochemicals present in the hydroalcoholic crude extract.