morphine sulphate / Generic mfg. 
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  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
    Journal:  Structures of drug-specific monoclonal antibodies bound to opioids and nicotine reveal a common mode of binding. (Pubmed Central) -  Dec 16, 2022   
    Structural analysis showed a critical convergent hydrogen bonding mode that is dependent on a glutamic acid residue in the mAbs' heavy chain and a tertiary amine of the ligand. Characterizing drug-mAb complexes represents a significant step toward rational antibody engineering and future manufacturing activities to support clinical evaluation.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Preoperative Cannabis Use Associated With an Increased Rate of Reoperation and Postoperative Opioid Use Following Anterior Cervical Decompression and Fusion. (Pubmed Central) -  Dec 16, 2022   
    Groups were compared based on outcomes including the rate of emergency department visits six months postoperatively, rate of readmissions one year postoperatively, rate of reoperation two years postoperatively, and daily postoperative opioid use measured in milligram morphine equivalents (MMEs) at 0-6 months and 6-12 months postoperatively.  Results Of the 198 patients included in this study, 13 (6.6%) were active cannabis users, 11 (5.6%) were former users, and 174 (87.8%) were nonusers...For chronic opioid users, acute users, and nonusers, the average daily opioid use in MMEs 6-12 months postoperatively was 39.9, 18.4, and 5.7, respectively (p<.0001). Conclusions History of cannabis use is associated with increased postoperative opioid use and increased rate of reoperation following elective ACDF.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  A Fatal Case Report Resulting from the Abuse of the Designer Benzodiazepines Clonazolam and Flualprazolam in Conjunction with Dried Opium Poppy Pods. (Pubmed Central) -  Dec 16, 2022   
    Based on the concentrations measured in femoral blood in particular, we assume that the deceased had taken a lethal dose of the designer benzodiazepines flualprazolam (0.74 mg/L) and clonazolam (2.08 mg/L), an extremely high dose of the opiates thebaine (0.81 mg/L), codeine (0.23 µg/mL) and morphine (0.13 µg/mL) and a high dose of the synthetic cannabinoid CUMYL-4CN-BINACA (0.01 mg/L). Besides postmortem concentrations, we also present electron impact (EI) and electrospray ionization (ESI) mass spectra of compounds found in the vicinity of the decedent, namely the tryptamines 4-HO-MIPT, 4-HO-MET and 4-ACO-DET, the amphetamines 3-FEA and 2-FMA, and the arylcyclohexylamines O-PCE, 3-MeO-PCP and 3-MeO-PCE.
  • ||||||||||  morphine sulphate / Generic mfg., alprazolam / Generic mfg., methamphetamine / Generic mfg.
    Retrospective data, Journal:  Exploring substance use disorder discussions in Native American communities: a retrospective Twitter infodemiology study. (Pubmed Central) -  Dec 16, 2022   
    These results may assist in the future design and detection of infodemiology trends and early warning signs that can better facilitate intervention specific to the ongoing Tribal opioid epidemic. While all data were collected from the public domain, additional care should be given to individual and community privacy.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Use of topical morphine gel in epidermolysis bullosa wounds-A series of case studies. (Pubmed Central) -  Dec 16, 2022   
    The purpose of this paper is to demonstrate the efficacy of topical morphine gel used in a variety of EB wounds as well as patient reported reduction in pain through a series of case studies. The case studies suggest a positive effect of topical morphine gel on painful wounds across a spectrum of EB subtypes.
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  Adolescent kratom exposure affects cognitive behaviours and brain metabolite profiles in Sprague-Dawley rats. (Pubmed Central) -  Dec 16, 2022   
    Male Sprague-Dawley rats (Postnatal day, PND31) were given vehicle, morphine (5 mg/kg), mitragynine (3, 10, or 30 mg/kg), or LKD (equivalent dose of 30 mg/kg mitragynine) for 15 consecutive days...Several pathways that may be involved in the effects of kratom exposure include arachidonic acid, pantothenate and CoA, and tryptophan pathways, with several potential biomarkers identified. These findings suggest that adolescent kratom exposure can cause cognitive behavioural deficits that may be associated with changes in the brain metabolite profiles.
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg., hydromorphone hydrochloride / Generic mfg.
    Review, Journal:  Recurrent Persistent Hiccups on Opioid Treatment: A Case Report and Literature Review. (Pubmed Central) -  Dec 16, 2022   
    Individual susceptibility probably plays a central role in the development of opioid-related hiccups. Opioid rotation is a promising strategy in the management of opioid-related hiccups, particularly when the mere discontinuation of the opioid is not a viable option, such as in the oncology and palliative care field.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Determinants of long-term opioid use in hospitalized patients. (Pubmed Central) -  Dec 16, 2022   
    Several patient-level characteristics associated with an increased risk of ≥ 60 days of cumulative opioid use. The results could be used to help identify patients who are at high-risk of continuing opioids beyond guideline recommendations and inform policies to curb excessive opioid prescribing.
  • ||||||||||  morphine sulphate / Generic mfg.
    Chronic Opioid Use Is Associated with Inferior Survival in Myeloma Patients Undergoing Autologous Transplant (World Center Marriott Royal; In-Person) -  Dec 16, 2022 - Abstract #TCTASTCTCIBMTR2023TCT_ASTCT_CIBMTR_1287;    
    Daily opioid doses were converted to morphine milligram milliequivalents (MME; ≥ 20 mg/day correlates with risk for overdose events)...These data highlight the need to improve the understanding and management of pain in MM. Finally, non-opioid analgesic strategies that correlate with lower risk of COU may be appropriate in managing pain effectively and safely.
  • ||||||||||  morphine sulphate / Generic mfg.
    Avascular Necrosis after Allogeneic Stem Cell Transplant () -  Dec 16, 2022 - Abstract #TCTASTCTCIBMTR2023TCT_ASTCT_CIBMTR_810;    
    Finally, non-opioid analgesic strategies that correlate with lower risk of COU may be appropriate in managing pain effectively and safely. With this information, we will utilize the Triple Aim Theory to identify ways to maximize quality of life, improve patient care, and decrease healthcare associated costs as they relate to the diagnosis of avascular necrosis after allogeneic stem cell transplant.
  • ||||||||||  morphine sulphate / Generic mfg.
    Lived by general practitioners in supporting palliative care patients (Display area) -  Dec 14, 2022 - Abstract #CPLF2023CPLF_771;    
    The main difficulties encountered were the prescription of the morphine, communication with the patient and his entourage and the psychological weight of this care...Conclusion The increase in life expectancy of the population and the constant progress of medicine reveals new ethical questions with more and more complex medical ends. According to our study, doctors' training, the development of extra-hospital care and city-hospital collaboration are the areas to be improved.
  • ||||||||||  morphine sulphate / Generic mfg.
    Sleep disorders in patients followed for primitive bronchopulmonary cancer (Display area) -  Dec 14, 2022 - Abstract #CPLF2023CPLF_326;    
    Forty percent of the patients were under morphine with an average dose of 56 mg...Conclusion Sleep disorders are well answered in patients followed for CBP They can alter their quality of life. Adequate management is necessary and must appear in the therapeutic management of the CBP.
  • ||||||||||  morphine sulphate / Generic mfg., paclitaxel / Generic mfg.
    Journal, IO biomarker:  Morphine counteracts the effects of paclitaxel in triple-negative breast cancer cells. (Pubmed Central) -  Dec 14, 2022   
    Our data suggest that morphine promotes breast cancer cell viability at clinically relevant plasma concentrations and reduces the apoptotic effect of paclitaxel. This interaction may be very important in clinical settings; however, more studies are needed to explore the plausible mechanisms of interaction and to correlate such findings through in vivo animal studies as well as clinically.
  • ||||||||||  methylphenidate tablet / Generic mfg., morphine sulphate / Generic mfg., dextroamphetamine immediate release / Generic mfg.
    Journal:  Psychostimulant drugs activate cell-type specific and topographic cFos expression in the lumbar spinal cord. (Pubmed Central) -  Dec 13, 2022   
    Psychostimulant drugs, such as cocaine, d-amphetamine and methylphenidate, alter a wide range of behaviors including locomotor activity and somatosensory perception...Similar expression patterns were observed in response to cocaine and methylphenidate, but not following morphine and dozilcipine administration...Our work provides evidence that cFos expression can be activated in lumbar spinal cord in response to acute psychostimulants administration. Running title: Psychostimulant-evoked neuronal ensembles in spinal cord.
  • ||||||||||  morphine sulphate / Generic mfg.
    Retrospective data, Review, Journal:  Opioid Free Anesthesia in Thoracic Surgery: A Systematic Review and Meta Analysis. (Pubmed Central) -  Dec 12, 2022   
    (4) Although intrathecal administration of morphine is similarly effective in the treatment of pain after knee replacement surgery as a single femoral triangle nerve block, it is associated with a higher incidence of cumbersome side effects, primarily nausea and pruritus. Opioid-free anesthesia in thoracic surgery is associated with lower postoperative complications, and less opioid demand with better postoperative analgesia at 48 h compared to opioid-based anesthesia.
  • ||||||||||  Nucynta (tapentadol) / Collegium Pharma, Grunenthal
    Journal:  Effects of Different Opioid Drugs on Oxidative Status and Proteasome Activity in SH-SY5Y Cells. (Pubmed Central) -  Dec 12, 2022   
    In fact, while prolonged morphine exposure significantly increased the proteolytic activity of both subunits and β5 mRNA levels, buprenorphine and tapentadol either reduced or did not alter these parameters. These results, showing different actions of the selected opioid drugs on the investigated parameters, suggest that a low µ receptor intrinsic efficacy could be related to a smaller oxidative stress and proteasome activation and could be useful to shed more light on the role of the investigated cellular processes in the occurrence of these opioid drug side effects.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Survival Outcomes Associated With the Size of Opioid Prescriptions in the Management of Chronic Pain Related to Advanced Nasopharyngeal Carcinoma. (Pubmed Central) -  Dec 10, 2022   
    These results, showing different actions of the selected opioid drugs on the investigated parameters, suggest that a low µ receptor intrinsic efficacy could be related to a smaller oxidative stress and proteasome activation and could be useful to shed more light on the role of the investigated cellular processes in the occurrence of these opioid drug side effects. In patients with newly diagnosed ANC experiencing palliative care, a high opioid prescription size may be associated with shorter OS than a low opioid prescription size.
  • ||||||||||  morphine sulphate / Generic mfg., clonidine / Generic mfg.
    Preclinical, Journal:  Understanding the effects of opioids vs non-opioids in the treatment of neonatal abstinence syndrome, an in vitro model. (Pubmed Central) -  Dec 10, 2022   
    Recently, a non-opioid agent, clonidine (CD) has also been used with potentially favorable short- and long-term outcomes in infants...The PFC is vital in controlling higher-order executive functions such as behavioral flexibility, learning and working memory. Therefore, our finding is consistent with executive function problems in children with prenatal opioid exposure.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal, PD(L)-1 Biomarker, IO biomarker:  Morphine suppresses the immune function of lung cancer by up-regulating MAEL expression. (Pubmed Central) -  Dec 9, 2022   
    We propose that MOR agonists including morphine in the early phase after peripheral nerve trauma might delay the axonal regeneration of the primary afferent neurons but prevent the development of neuropathic pain. Morphine activated MAEL in lung cancer cells by Nrf2/PTEN pathway and regulated the immune factors, thereby promoting tumor immune escape.