 |
7 Diseases |  |
379 Trials |
|
379 Trials |  |
12426 News |  |
| «12...5960616263646566676869...216217» |
- | Relistor (methylnaltrexone bromide) / Ono Pharma, Bausch Health
Journal: Response Rates to Methylnaltrexone in Hospitalized Cancer Patients. (Pubmed Central) - Dec 25, 2022
Prior laxative use did not predict response at 24 hours whether these were osmotic laxatives (40.7% vs 47.1%, P = .52), stimulant laxatives (45.7% vs 45.2%, P > .99), or stool softeners (44.7% vs 46.1%, P = .89). Methylnaltrexone has a high response rate when used as treatment for OIC in hospitalized adult cancer patients, especially for patients taking ≥150 OME.
- | morphine sulphate / Generic mfg.
Journal: µ-Opioid Receptors Expressed by Intrinsically Photosensitive Retinal Ganglion Cells Contribute to Morphine-Induced Behavioral Sensitization. (Pubmed Central) - Dec 24, 2022
Morphine, however, did not acutely decrease the body temperature of MKO mice. These findings support the idea that MORs expressed by ipRGCs could contribute to opioid-related sleep/wake problems and thermoregulatory changes.
- | morphine sulphate / Generic mfg.
Retrospective data, Journal, Surgery: Opioid Dose, Pain, and Recovery following Abdominal Surgery: A Retrospective Cohort Study. (Pubmed Central) - Dec 24, 2022
High-intensity opioid use after elective abdominal surgery may not be sufficient for improving pain management or the quality of recovery compared to non-high-intensity use. Our results strengthen the argument for a multimodal approach that does not rely so heavily on opioids.
- || morphine sulphate / Generic mfg.
Review, Journal: Future Newborns with Opioid-Induced Neonatal Abstinence Syndrome (NAS) Could Be Assessed with the Genetic Addiction Risk Severity (GARS) Test and Potentially Treated Using Precision Amino-Acid Enkephalinase Inhibition Therapy (KB220) as a Frontline Modality Instead of Potent Opioids. (Pubmed Central) - Dec 24, 2022
The preferred first-line pharmacological treatment for NAS is opioid therapy, specifically morphine, and the goal is the short-term improvement in NAS symptomatology...In addition, genetic polymorphisms of the catechol-o-methyltransferase (COMT) and mu-opioid receptor (OPRM1) genes appear to affect the length of stay and the need for pharmacotherapy in newborns with prenatal opioid exposure. Therefore, based on this extensive literature and additional research, this team of coauthors suggests that, in the future, in addition to the current nonpharmacological therapies, patients with opioid-induced NAS should undergo genetic assessment (i.e., the genetic addiction risk severity (GARS) test), which can subsequently be used to guide DNA-directed precision amino-acid enkephalinase inhibition (KB220) therapy as a frontline modality instead of potent opioids.
- | morphine sulphate / Generic mfg.
Preclinical, Journal: Bifunctional Peptidomimetic G Protein-Biased Mu-Opioid Receptor Agonist and Neuropeptide FF Receptor Antagonist KGFF09 Shows Efficacy in Visceral Pain without Rewarding Effects after Subcutaneous Administration in Mice. (Pubmed Central) - Dec 24, 2022
We also demonstrated the absence of harmful effects caused by typical MOR agonists, i.e., rewarding effects (conditioned-place preference test) and sedation/locomotor impairment (open-field test), at a dose shown to be highly effective in inhibiting pain behavior. Consequently, KGFF09 displayed a favorable benefit/side effect ratio regarding these opioid-related side effects compared to conventional opioid analgesics, such as morphine, underlining the development of dual MOR agonists/NPFFR antagonists as improved treatments for various pain conditions.
- | remifentanil / Generic mfg., morphine sulphate / Generic mfg.
Journal: Erector spinae plane blocks for day-case medical thoracoscopy: a pilot clinical study. (Pubmed Central) - Dec 24, 2022
Average greatest depth of sedation using propofol was 1.92 (standard error of mean [SEM] 0.27), with remifentanil 2.52 (SEM 0.46)...Patients used an average of 3.33 mg oral morphine (SEM 2.35) in hospital, and 3 mg (SEM 2) on post-op day 1...Pain scores showed significant analgesic effect lasting several hours. The project showed pain outcomes and patient acceptability were good for the use of regional anaesthesia.
- | morphine sulphate / Generic mfg., hydromorphone hydrochloride / Generic mfg.
Journal, Head-to-Head: The efficacy and safety of epidural morphine/hydromorphone in the treatment of intractable postherpetic neuralgia: A single-center, double-blinded, randomized controlled, prospective, and non-inferiority study. (Pubmed Central) - Dec 24, 2022
For patients with VAS still greater than 50 mm after standard treatment, short-term application of EMO or EHM can ameliorate intractable pain, improve the quality of life, and have no obvious side effects. Short-term epidural opioid application will not lead to the appearance of OWS.
- | morphine sulphate / Generic mfg.
Journal: Changes in postoperative opioid prescribing across three diverse healthcare systems, 2010-2020. (Pubmed Central) - Dec 24, 2022
Trends in average daily discharge Morphine Milligram Equivalent (MME), postoperative pain and subsequent opioid prescription were compared using regression and likelihood ratio test statistics...In 2020, these systems achieved comparable opioid prescribing patterns and outcomes despite having very different populations. Acknowledging and incorporating these temporal distribution shifts into data learning models is essential for robust and generalizable models.
- | irinotecan / Generic mfg.
Preclinical, Journal: Opioid-induced microbial dysbiosis disrupts CPT-11 metabolism and increases gastrointestinal toxicity in a murine model. (Pubmed Central) - Dec 24, 2022
Gut microbiota play a significant role in opioid and chemotherapeutic agent drug-drug interactions. Inhibition of gut microbial glucuronidase may also prevent adverse GI effects of CPT-11 in patients on opioids.
- | morphine sulphate / Generic mfg.
Journal: Implementation of Multimodal Pain Protocol Associated With Opioid Use Reduction in Trauma Patients. (Pubmed Central) - Dec 24, 2022
Inhibition of gut microbial glucuronidase may also prevent adverse GI effects of CPT-11 in patients on opioids. A MMPP is associated with a reduction of opioids and increase in nonopioid analgesics with no difference in patient-reported pain scores.
- | Journal: Follow-Up: Effects of a Pandemic and Isolation on Alcohol and Psychoactive Medication Use in a Population of Rehabilitation and Pain Patients. (Pubmed Central) - Dec 24, 2022
In summary, these findings demonstrate relatively consistent drug use, with decreased positivity for high-risk drugs and dangerous drug combinations. We speculate that monitoring of these patients mitigates the possibility of drug misuse and potential overdose and is in concordance with the goals of these monitoring programs.
- | morphine sulphate / Generic mfg.
Journal, Surgery, Bariatric surgery: Does Liposomal Bupivacaine Decrease Postoperative Opioid Use in Conjunction with an Enhanced Recovery After Bariatric Surgery Pathway? A Prospective, Double-blind, Randomized Controlled Trial. (Pubmed Central) - Dec 24, 2022
We speculate that monitoring of these patients mitigates the possibility of drug misuse and potential overdose and is in concordance with the goals of these monitoring programs. In our study, liposomal bupivacaine did not significantly decrease postoperative opioid use either before implementation of ERAS or as part of an enhanced recovery after surgery program for minimally invasive bariatric surgery procedures.
- | morphine sulphate / Generic mfg., methadone / Generic mfg.
Journal: Regular, low-dose methadone for reducing breathlessness in people experiencing or at risk of neurotoxic effects from morphine: A single-center case series. (Pubmed Central) - Dec 23, 2022
All patients experienced a meaningful improvement in breathlessness intensity after methadone, by a median of 5 points (range 1-8) on the 0-10 numerical rating scale (NRS) in the whole group, and by 2 points (range 0-8) in those pretreated with other opioids, mainly morphine. Low-dose methadone can be considered an efficient alternative to morphine for reducing breathlessness in people experiencing neurotoxic effects or at risk of developing them following treatment with morphine.
- || morphine sulphate / Generic mfg., ropivacaine / Generic mfg.
Clinical, Journal: Analgesic effect of a new "cocktail" of local infiltration analgesia after total hip arthroplasty-A prospective randomized controlled study (Pubmed Central) - Dec 23, 2022
There was no significant difference in the incidence of complications such as nausea and vomiting, urine retention, fat liquefaction of incision, local hematoma, and large fluctuation of blood sugar between the two groups ( P>0.05). The new "cocktail" LIA with Diprospan can effectively reduce the early postoperative pain of THA, reduce the dosage of opioids, shorten the length of hospital stay, and is conducive to the early functional rehabilitation of patients.
- | morphine sulphate / Generic mfg.
New trial: External Oblique Intercostal Plane Block for Laparoscopic Sleeve Gastrectomy (clinicaltrials.gov) - Dec 23, 2022
P=N/A, N=60, Not yet recruiting, Sponsor: Istinye University
- | morphine sulphate / Generic mfg.
Journal: Cycles of addiction and loneliness. (Pubmed Central) - Dec 23, 2022
Dorsal raphe dynorphin neurons terminating in the nucleus accumbens suppress local serotonin release through kappa opioid receptors. These findings likely have important clinical implications.
- | morphine sulphate / Generic mfg.
Journal: The YTHDF1-TRAF6 pathway regulates the neuroinflammatory response and contributes to morphine tolerance and hyperalgesia in the periaqueductal gray. (Pubmed Central) - Dec 23, 2022
By reducing inflammatory markers such as IL-1β, IL-6, TNF-α and NF-κB, targeted reduction of YTHDF1 or suppression of TRAF6 activity in ventrolateral periaqueductal gray (vlPAG) slows the development of morphine analgesic tolerance and MIH. Our findings provide new insights into the mechanism of morphine analgesic tolerance and MIH indicating that YTHDF1 regulates inflammatory factors such as IL-1β, IL-6, TNF-α and NF-κB by enhancing TRAF6 protein expression.
- morphine sulphate / Generic mfg.
ACTIVATION OF MU-OPIOID RECEPTORS INDUCE TAU MISLOCALIZATION TO DENDRITIC SPINES AND CAUSE SYNAPTIC DYSFUNCTION (ONSITE - HALL F4+F5) - Dec 23, 2022 - Abstract #ADPD2023ADPD_349;
There was no significant difference between any experimental groups in mEPSC frequency. Conclusions Our novel findings suggest that tau KO neurons block morphine-induced electrophysiological deficits, supporting that the absence of tau prevents damaging effects of opioids on neurons.
- | morphine sulphate / Generic mfg.
Journal: Preemptive visceral analgesic effect of thoracic paravertebral block on postoperative opioid consumption in patients undergoing laparoscopic cholecystectomy: a prospective, randomized, assessor-blind study. (Pubmed Central) - Dec 22, 2022
The primary outcome was the total rescue analgesic consumption (morphine equianalgesic dose) during the 24 hours post-surgery...There were no adverse events associated with analgesics, RSB, or TPVB. Pre-incisional TPVB conferred a significant preemptive visceral analgesic effect in patients undergoing LC, and significantly reduced the amount of postoperative opioid consumption.
- | Journal: Opioids for pain. (Pubmed Central) - Dec 22, 2022
Pre-incisional TPVB conferred a significant preemptive visceral analgesic effect in patients undergoing LC, and significantly reduced the amount of postoperative opioid consumption. No abstract available
- | Journal: Comparison table: Some oral/transdermal opioid analgesics. (Pubmed Central) - Dec 22, 2022
No abstract available No abstract available
- | Chirocaine (levobupivacaine) / Purdue, AbbVie
Journal: Expression of Concern: Epidural Co-Administration of Dexmedetomidine and Levobupivacaine Improves the Gastrointestinal Motility Function after Colonic Resection in Comparison to Co-Administration of Morphine and Levobupivacaine. (Pubmed Central) - Dec 22, 2022
No abstract available No abstract available
- | morphine sulphate / Generic mfg.
Retrospective data, Journal: The Effect of Preemptive Local Infiltration on Postoperative Pain Following Vaginal Hysterectomy: a Retrospective Study. (Pubmed Central) - Dec 22, 2022
No abstract available Preemptive local infiltration of either Bupivacaine or Sodium-Chloride 0.9% reduced the use of morphine in the recovery unit, as well as the use of analgesics 24 hours after VH, compared to no infiltration at all.
- | morphine sulphate / Generic mfg.
Journal, Surgery, Bariatric surgery: How much narcotics are really needed after bariatric surgery: results of a prospective study. (Pubmed Central) - Dec 22, 2022
Preemptive local infiltration of either Bupivacaine or Sodium-Chloride 0.9% reduced the use of morphine in the recovery unit, as well as the use of analgesics 24 hours after VH, compared to no infiltration at all. An opioid-sparing protocol can be implemented after bariatric surgery with high overall satisfaction with pain control.
- | morphine sulphate / Generic mfg., ketamine / Generic mfg.
Enrollment change, Trial completion date, Trial termination, Trial primary completion date: KETAMORPH: Intravenous Subdissociative-dose Ketamine Versus Morphine for Prehospital Analgesia (clinicaltrials.gov) - Dec 21, 2022
P3, N=285, Terminated, Sponsor: Nantes University Hospital
N=496 --> 285 | Trial completion date: May 2022 --> Nov 2022 | Unknown status --> Terminated | Trial primary completion date: May 2022 --> Nov 2022; 285 patients have recruited instead on 496 but we don't want to continue to prolonge the study. Analysis will be performed on the data we have.
- | morphine sulphate / Generic mfg.
New P4 trial: Postoperative Pain After Caesarian Section (clinicaltrials.gov) - Dec 21, 2022
P4, N=108, Completed, Sponsor: Conrad Arnfinn Bjørshol
- || morphine sulphate / Generic mfg.
PK/PD data, Journal: Morphine in donkeys: antinociceptive effect and preliminary pharmacokinetics. (Pubmed Central) - Dec 21, 2022
Analysis will be performed on the data we have. The HDM treatment provided mechanical antinociception in donkeys with no significant adverse effects.
- || Olinvyk (oliceridine) / Trevena, Jiangsu NHWA Pharma
PK/PD data, Journal: Respiratory effects of biased-ligand oliceridine in older volunteers: a pharmacokinetic-pharmacodynamic comparison with morphine. (Pubmed Central) - Dec 21, 2022
The HDM treatment provided mechanical antinociception in donkeys with no significant adverse effects. Oliceridine and morphine differ in their respiratory pharmacodynamics with a more rapid onset and offset of respiratory depression for oliceridine and smaller magnitude of respiratory depression over time.
- || morphine sulphate / Generic mfg.
Retrospective data, Review, Journal: Perioperative Opioid Dispensing and Persistent Use after Benign Hysterectomy: A Systematic Review and Meta-Analysis. (Pubmed Central) - Dec 21, 2022
Perioperative opioid dispensing is significantly dependent on the route of hysterectomy, with the lowest dispensed MME of opioids for vaginal hysterectomy and the highest for abdominal hysterectomy. Nevertheless, hysterectomy route did not significantly predict persistent opioid use postoperatively, whereas younger age, smoking, alcohol use, back pain and fibromyalgia were significantly associated with persistent opioid use.
- | morphine sulphate / Generic mfg.
Journal: Preparation and identification of isoquinoline alkaloids with ATP citrate Lyase inhibitory activity from Dactylicapnos scandens. (Pubmed Central) - Dec 21, 2022
Three new isoquinoline alkaloids including a morphine derivative (1), two aporphine alkaloids (2-3), together with five known alkaloids (4-8) were obtained from the extract of Dactylicapnos scandens (D.Don) Hutch...Compounds 1-8 were evaluated for ATP Citrate Lyase (ACLY) inhibitory activity through an enzymatic assay. Among them, 2 and 3 showed the high ACLY inhibitory activity with an IC value of 10.48 ± 1.59 and 10.89 ± 4.89 μM.
- | metamizole / Generic mfg., morphine sulphate / Generic mfg., lignocaine / Generic mfg.
Trial completion, Enrollment change, Trial completion date, Trial primary completion date, Surgery: Impact of Intra- and Postoperative Continuous Infusion of Lidocaine on Analgesia in Vascular Anaesthesia (clinicaltrials.gov) - Dec 21, 2022
P4, N=87, Completed, Sponsor: ?ukasz Krzych
Among them, 2 and 3 showed the high ACLY inhibitory activity with an IC value of 10.48 ± 1.59 and 10.89 ± 4.89 μM. Suspended --> Completed | N=150 --> 87 | Trial completion date: Feb 2022 --> Jul 2022 | Trial primary completion date: Jan 2022 --> Jun 2022
- |||| morphine sulphate / Generic mfg., lorazepam / Generic mfg.
Clinical: Doing some research in regards to Ativan being given to patients with sepsis, it causes a decline, it is what I know for a fact cause my mother to become delirious She was 4 ft 10 Ativan, morphine, tied to a bed This is why my mom became delirious. (Twitter) - Dec 21, 2022
- | morphine sulphate / Generic mfg., methadone / Generic mfg.
Journal, HEOR: Resource utilization and convalescent care cost in neonatal opioid withdrawal syndrome. (Pubmed Central) - Dec 20, 2022
However, there may be a role for earlier transfer of a subset of infants at-risk for longer LOS as those exposed to methadone and/or benzodiazepines. Further studies exploring differences in resource utilization, convalescent care delivery and cost expenditure are recommended.
- | morphine sulphate / Generic mfg.
Trial completion, Trial completion date, Trial primary completion date, Head-to-Head: PENG Block vs Intrathecal Morphine in Total Hip Arthroplasty (clinicaltrials.gov) - Dec 20, 2022
P4, N=60, Completed, Sponsor: Kresimir Oremus, MD
Further studies exploring differences in resource utilization, convalescent care delivery and cost expenditure are recommended. Enrolling by invitation --> Completed | Trial completion date: Apr 2023 --> Dec 2022 | Trial primary completion date: Apr 2023 --> Dec 2022
- | morphine sulphate / Generic mfg.
Journal: The butterfly effect: How an outpatient quality improvement project affected inpatient opioid's prescribing habits. (Pubmed Central) - Dec 20, 2022
Opioids were converted to oral morphine equivalents (OME)...Of the 47 EGS patients who followed up in clinic post-ACS QI, 89.4% rated their pain management as excellent/good, 8.5% as fair, and 2.1% as poor. Implementation of a multifaceted approach to decrease opioid prescribing in the outpatient setting organically affected opioid prescribing habits at discharge for inpatients.
- | fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
Preclinical, Journal: A novel Oprm1-Cre mouse maintains endogenous expression, function and enables detailed molecular characterization of μ-opioid receptor cells. (Pubmed Central) - Dec 20, 2022
The latter allowed for cell type specific RNA sequencing via TRAP (Translating Ribosome Affinity Purification) of striatal MOR+ neurons following opioid withdrawal. The breadth of utility of this new tool will greatly facilitate the study of opioid biology under varying conditions.
- || morphine sulphate / Generic mfg.
Clinical, Journal, Head-to-Head: Postcesarean Analgesia With Epidural Morphine After Epidural 2-Chloroprocaine: A Randomized Noninferiority Trial. (Pubmed Central) - Dec 20, 2022
While designed as an exploratory study, initial epidural dosing with 3% CP and beginning subsequent redosing with LEB within 30 minutes of the initial CP bolus provided noninferior postcesarean analgesia with epidural morphine compared to initial epidural dosing and redosing with LEB. Previous observations of decreased analgesic efficacy of epidural morphine after epidural CP were likely due to a window period that may be mitigated by redosing with lidocaine; however, larger studies are necessary to confirm these findings.
- | methadone / Generic mfg.
Retrospective data, Journal: Exploring factors jointly associated with recurrent relapse and dropout of methadone maintenance treatment clients in Guangdong, China: A retrospective cohort study. (Pubmed Central) - Dec 20, 2022
It is common for clients to experience recurrent relapse and dropout. The findings suggest that MMT clinics should provide holistic interventions and appropriate methadone doses for clients to improve treatment compliance.
- || morphine sulphate / Generic mfg.
Morphine too ? (Twitter) - Dec 19, 2022
- | morphine sulphate / Generic mfg.
Journal: Efficacy of ultrasound-guided pericapsular nerve group (PENG) block combined with local infiltration analgesia on postoperative pain after total hip arthroplasty: a prospective, double-blind, randomized controlled trial. (Pubmed Central) - Dec 19, 2022
PENG block combined with LIA could improve postoperative pain relief, reduce opioid use, and enhance recovery in THA patients, without weakening the quadriceps muscle strength. This work justifies further trials to examine the safety and efficacy of the this block and to explore maximal effective volume of local anesthetic for motor-sparing PENG block.
- | morphine sulphate / Generic mfg.
Journal, HEOR: Liposomal Bupivacaine Vs. Continuous Nerve Block: Liposomal Bupivacaine may be non-inferior and more cost effective. (Pubmed Central) - Dec 19, 2022
This work justifies further trials to examine the safety and efficacy of the this block and to explore maximal effective volume of local anesthetic for motor-sparing PENG block. LB was found to be non-inferior to a pain pump, and the transition to this medication was associated with cost savings.
- || fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg., sevoflurane / Generic mfg.
I had Bupivacaine infiltrated to wound (appendix op) surely this provides quite long relief? Don't know why I was given Morphine & Fentanyl intra-op - sounds a bit over the top with all the other drugs incl Thiopentone & Sevoflurane & NMBs I was given, & relying on v old bloods. (Twitter) - Dec 18, 2022
- ||| fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
I know Morphine is an opioid, I think Fentanyl is too? Opiods affect breathing/heart? Thiopentone is a barbiturate (I think) what are the pros & cons of barbs & opioids please? Aren't Local anaesthetics made from Cocaine & if so why is there nobody rallying against them? Confused (Twitter) - Dec 18, 2022
- | morphine sulphate / Generic mfg.
Journal: Associations with daily opioid use during hospitalization following lumbar fusion: A contemporary cohort study. (Pubmed Central) - Dec 18, 2022
The maximum absolute opioid use was on POD1. We were able to quantify these trends on a daily gradient, which lays the conceptual groundwork to develop personalized algorithms which can model opioid use during hospitalization prior to surgery.
- | morphine sulphate / Generic mfg.
Journal: Divergent modulation of pain and anxiety by GABAergic neurons in the ventrolateral periaqueductal gray and dorsal raphe. (Pubmed Central) - Dec 18, 2022
Additionally, utilizing optogenetic technology, we observed that the pronociceptive effect arising from DR neuronal inhibition was reversed by the systemic administration of morphine. Our results collectively provide new insights into the modulation of pain and anxiety by specific midbrain GABAergic subpopulations, which may provide a basis for cell type-targeted or subregion-targeted therapies for pain management.
- | morphine sulphate / Generic mfg.
Journal: Evaluation of an opioid pain teleconsultation service to address the opioid overdose epidemic in Colorado: A Health First Colorado demonstration project. (Pubmed Central) - Dec 18, 2022
Our results collectively provide new insights into the modulation of pain and anxiety by specific midbrain GABAergic subpopulations, which may provide a basis for cell type-targeted or subregion-targeted therapies for pain management. Results indicate that provider-to-provider teleconsultation services with a pain specialist can be an effective intervention at reducing total inappropriate opioid use.
- || fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
This is cap brother. Weaponized/non regulated fentynal can me up to 24x more potent than morphine. For my job when we’re dealing w clandestine labs potentially manufacturing fentanyl we are in PPE to the gills. Depending on the potentcy / if you can see it it can kill u type sht (Twitter) - Dec 17, 2022
- | morphine sulphate / Generic mfg.
Journal: Comparing the safety and efficacy of intravenous naloxone administration in opioid-naive and opioid-tolerant hospitalized oncology patients. (Pubmed Central) - Dec 17, 2022
In opioid-tolerant patients, naloxone total doses required and response rates were similar to opioid-naïve patients. Use of opioid dosing history to identify potentially opioid-dependent patients should be considered prior to naloxone administration to guide dosing and reduce the risk for precipitating OWSs.
- | morphine sulphate / Generic mfg.
Journal: The effect of the COVID-19 pandemic on opioid prescribing for patients with pleuritic pain. (Pubmed Central) - Dec 17, 2022
During the first wave of the pandemic, COVID-19 patients with pleuritic pain were prescribed opioids less frequently than patients without COVID-19, while patients without COVID-19 were equally likely to be prescribed opioid pre- and intrapandemic. On the other hand, COVID-19 patients treated with opioids were given greater daily MMEs due to the greater utilization of opioid infusions.
- || morphine sulphate / Generic mfg.
Review, Journal: The impact of automatic physician review of prescription drug monitoring program data on opioid prescribing in a Maryland statewide hospital system. (Pubmed Central) - Dec 17, 2022
On the other hand, COVID-19 patients treated with opioids were given greater daily MMEs due to the greater utilization of opioid infusions. Automated PDMP review is associated with fewer prescriptions and smaller doses without decreasing appropriate use.