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7 Diseases |  |
379 Trials |
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379 Trials |  |
12426 News |  |
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- | morphine sulphate / Generic mfg.
Preclinical, Journal: Acute morphine injection persistently affects the electrophysiological characteristics of rat locus coeruleus neurons. (Pubmed Central) - Jan 6, 2023
In addition, morphine treatment did not alter the rheobase current and first spike latency while affected the inhibitory postsynaptic currents elicited in response to orexin-A. In fact, single morphine exposure could inhibit the disinhibitory effect of orexin-A on LC neurons.
- | morphine sulphate / Generic mfg.
Preclinical, Journal: Nucleus accumbens circuit disinhibits lateral hypothalamus glutamatergic neurons contributing to morphine withdrawal memory in male mice. (Pubmed Central) - Jan 6, 2023
In the present study,our results showed that in male mice, during context-induced expression of morphine withdrawal memory, LH glutamatergic neurons played an important role; dopamine D1 receptor-expressing medium spiny neurons (D1-MSNs) projecting from the core of nucleus accumbens (NAcC) to the LH were an important upstream circuit to activate LH glutamatergic neurons; D1-MSNs projecting from the NAcC to the LH activated LH glutamatergic neurons through inhibiting LH local gamma-aminobutyric acid (GABA) neurons. These results suggest that disinhibited LH glutamatergic neurons by neural circuits from the NAcC importantly contribute to context-induced the expression of morphine withdrawal memory.
- | morphine sulphate / Generic mfg.
Journal, Metastases: Comparison of Opioids Prescribed by Advanced Practice Clinicians vs Surgeons After Surgical Procedures in the US. (Pubmed Central) - Jan 5, 2023
Linear regression was used to compare the total dosage of perioperative opioid prescriptions written by APCs vs surgeons measured in morphine milligram equivalents (MMEs)...In this cross-sectional analysis, one-fifth of perioperative opioid prescriptions and one-quarter of refill prescriptions were written by APCs. While surgeons wrote most perioperative opioid prescriptions that were intended for perioperative analgesia, higher total dosages from APCs suggest that opioid stewardship initiatives that support the role of APCs may be warranted.
- | morphine sulphate / Generic mfg.
Journal: Effects of epidural morphine combined with low-dose naloxone on the morphology and electrophysiology of intestinal interstitial cells of Cajal. (Pubmed Central) - Jan 5, 2023
While surgeons wrote most perioperative opioid prescriptions that were intended for perioperative analgesia, higher total dosages from APCs suggest that opioid stewardship initiatives that support the role of APCs may be warranted. No abstract available
- | morphine sulphate / Generic mfg., ropivacaine / Generic mfg.
Journal, Surgery: The Use of Unilateral Erector Spinae Plane Block in Minimally Invasive Cardiac Surgery. (Pubmed Central) - Jan 5, 2023
No abstract available Erector spinae plane catheter use may safely improve postoperative measures, including decreased opioid consumption and improved pain relief, as well as reductions in ICU and hospital lengths of stay in patients undergoing minimally invasive cardiac surgery.
- | morphine sulphate / Generic mfg.
Journal: Study protocol: hypnosis versus standard care for shoulder dislocation reduction in the emergency department - a multicentre, randomised, controlled study protocol. (Pubmed Central) - Jan 5, 2023
P=N/A
The primary endpoint will be the comparison of morphine equivalent analgesic consumption during a shoulder dislocation reduction manoeuvre...The results will be published in scientific articles and communicated in national and international conferences. ClinicalTrial.gov: NCT04992598; National Clinical trial no ID RCB : 2021-A01382-39.
- morphine sulphate / Generic mfg.
Naloxone Co-Prescribing for Emergency Medicine and Trauma Patients at High Risk for Opioid Overdose (Moscone Center South - 302) - Jan 4, 2023 - Abstract #SCCM2023SCCM_561;
High-risk patients were defined as those receiving opioid co-prescribed with benzodiazepine, opioid prescribed at a dose of at least 50 morphine milligram equivalents per day, or with opioid overdose history...The rate of naloxone co-prescribing to high-risk patients increased from 20.2% (n=16) to 80.3% (n=53), p < 0.001. CONCLUSIONS : Implementing a naloxone co-prescribing BPA into the EMR at the time of providers signing discharge prescriptions substantially increases naloxone co-prescribing to patients at high-risk for opioid overdose.
- morphine sulphate / Generic mfg., lorazepam / Generic mfg.
Palliative Medications at Terminal Extubation: A Secondary Analysis From DONATE Study Data (Moscone Center South - 302) - Jan 4, 2023 - Abstract #SCCM2023SCCM_503;
Time to death after TE is not associated with the dose of medication administered as part of comfort care. Providers should titrate analgesic and sedative/anxiolytic medications to patient comfort after terminal extubation
- | morphine sulphate / Generic mfg.
Journal: Role of the Orexinergic System Within the Ventral Tegmental Area in the Development of Sensitization to Morphine Induced by Lateral Hypothalamus Stimulation. (Pubmed Central) - Jan 3, 2023
Besides, the blockade of OX1 and OX2 receptors within the VTA before LH stimulation attenuated sensitization to the antinociceptive response of morphine. Therefore, the orexinergic system plays an important role in morphine sensitization and can be considered as one of the potential targets to increase the analgesic effect of morphine.
- | morphine sulphate / Generic mfg.
Journal, Surgery: Enhanced recovery after cardiac surgery protocol reduces perioperative opioid use. (Pubmed Central) - Jan 3, 2023
Opioid use was calculated as morphine milligram equivalents and compared between the 2 cohorts...Subgroup analysis of subjects with intravenous drug use history did not demonstrate a significant reduction in opioid use. Enhanced Recovery After Surgery protocols with an emphasis on multimodal pain management throughout perioperative care are associated with a significant reduction in the postoperative use of opioid analgesics.
- | fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
Retrospective data, Journal: Effects of opioids administered via intravenous or epidural patient-controlled analgesia after caesarean section: A network meta-analysis of randomised controlled trials. (Pubmed Central) - Jan 3, 2023
Considering the analgesic efficacy; opioid-induced nausea, vomiting, and sedation; and the well-being of breastfed infants, PCEA fentanyl may be the treatment of choice for post-caesarean section analgesia. The Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation (TCRD-TPE-111-27).
- | morphine sulphate / Generic mfg., ropivacaine / Generic mfg.
Journal, Video, Surgery: Programmed intermittent bolus infusion vs. continuous infusion for erector spinae plane block in video-assisted thoracoscopic surgery: A double-blinded randomised controlled trial. (Pubmed Central) - Jan 3, 2023
PIB for erector spinae plane block in video-assisted thoracic surgery resulted in a larger anaesthetised area and required a lower anaesthetic dose to maintain the analgesic effect. Therefore, it is more suitable for erector spinae plane block than continuous infusion.
- |||||| ketorolac PMB (NTM-001) / Neumentum
Enrollment open, Trial completion date, Trial primary completion date: Ketorolac Applied by Continuous IV Infusion for Treatment of Moderately Severe Postoperative Pain Following Bunionectomy (clinicaltrials.gov) - Jan 3, 2023
P3, N=360, Recruiting, Sponsor: NEMA Research, Inc.
Therefore, it is more suitable for erector spinae plane block than continuous infusion. Not yet recruiting --> Recruiting | Trial completion date: Apr 2023 --> Sep 2023 | Trial primary completion date: Jan 2023 --> Jun 2023
- ||| morphine sulphate / Generic mfg.
The number of times I have heard people say that they cannot give iv morphine as it will lead to hypotension but then want to give iv paracetamol. (Twitter) - Jan 2, 2023
- ||| morphine sulphate / Generic mfg., haloperidol / Generic mfg.
I don't understand why hospice use haldol in end of life care. I don't understand why morphine isn't the #1 choice for all agitation and pain. Stop with the haldol, it only blunts the goodbye. (Twitter) - Jan 2, 2023
- | morphine sulphate / Generic mfg.
Preclinical, Journal: Adolescent morphine exposure impairs dark avoidance memory and synaptic potentiation of ventral hippocampal CA1 during adulthood in rats. (Pubmed Central) - Jan 2, 2023
Therefore, adolescent morphine exposure has a durable effect on memory functions, synaptic activity, and plasticity of ventral hippocampal CA1. Adults with adolescent morphine exposures may experience maladaptive behaviors and cognitive disabilities.
- || fentanyl citrate / Generic mfg., ketamine / Generic mfg., isoflurane / Generic mfg.
Clinical, Journal, Combination therapy, Surgery: Influence of constant rate infusions of fentanyl alone or in combination with lidocaine and ketamine on the response to surgery and postoperative pain in isoflurane anesthetized dogs undergoing unilateral mastectomy: a randomized clinical trial. (Pubmed Central) - Jan 2, 2023
Postoperatively, the number of dogs requiring analgesic rescue was significantly lower in the FLK (0/11, 0%) than in the Fentanyl group (5/11, 45%). In dogs administered morphine and meloxicam as part of the anesthesia protocol, an intraoperative CRI of FLK abolished the requirement for postoperative analgesic rescue for 24 hours in dogs undergoing mastectomy.
- | morphine sulphate / Generic mfg.
Journal: Morphine use induces gastric microbial dysbiosis driving gastric inflammation through TLR2 signaling which is attenuated by proton pump inhibitor. (Pubmed Central) - Jan 1, 2023
In dogs administered morphine and meloxicam as part of the anesthesia protocol, an intraoperative CRI of FLK abolished the requirement for postoperative analgesic rescue for 24 hours in dogs undergoing mastectomy. This study attributes morphine-induced gastric acidity as a driver of gastric dysbiosis and pathology and proposes the therapeutic use of PPI as an inexpensive approach for the clinical management of morphine-associated pathophysiology.
- | morphine sulphate / Generic mfg.
Journal: Comparative investigation of analgesic tolerance to taurine, sodium salicylate and morphine: involvement of peripheral muscarinic receptors. (Pubmed Central) - Jan 1, 2023
Furthermore, the effect of this combination undergoes less analgesic tolerance during time. Combination of taurine and morphine is an effective strategy to attenuate both morphine analgesic tolerance and dependence and this also seems to depend on activity of muscarinic receptors, however through differential cellular mechanisms.
- ||| morphine sulphate / Generic mfg.
Jeremy Clarke, an Englishman living in rural France, offers a plucky description of the fatigue and disinterest associated with bone and liver metastases: I dropped a morphine capsule in my Moscow Mule https://t.co/f7YEzlNzJ8 (Twitter) - Dec 31, 2022
- | remifentanil / Generic mfg., morphine sulphate / Generic mfg.
Preclinical, Journal: Long-Term Exposure to Morphine Induces Cross-Tolerance to Acute Antinociceptive Effect of Remifentanil on Somatic and Visceral Stimuli in Rats. (Pubmed Central) - Dec 31, 2022
Our results indicate that morphine-tolerant rats exhibit cross-tolerance to remifentanil's acute antinociceptive effects on somatic and visceral stimuli. Cross-tolerance to remifentanil should be considered in the perioperative management of patients using morphine.
- | morphine sulphate / Generic mfg.
Journal, Surgery: Prospective analysis of home narcotic consumption and management of excess narcotic prescription following adolescent idiopathic scoliosis surgery. (Pubmed Central) - Dec 31, 2022
Cross-tolerance to remifentanil should be considered in the perioperative management of patients using morphine. Our study suggests that there are not a significant number of patient- or surgical-level factors predisposing patients to increased home narcotic usage following spinal fusion for adolescent idiopathic scoliosis.
- | morphine sulphate / Generic mfg., ropivacaine / Generic mfg.
Observational data, Journal, Surgery: Erector spinae plane block versus thoracic paravertebral block for the prevention of acute postsurgical pain in breast cancer surgery: A prospective observational study compared with a propensity score-matched historical cohort. (Pubmed Central) - Dec 31, 2022
P3
Our findings do not support the use of ESPB as the first-line regional anaesthesia for major breast cancer surgery. Randomized trials comparing ESPB and TPVB are needed.
- ||| fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
The @CDCgov has described #fentanyl as up to 50 times as potent as heroin and 100 times as potent as morphine. More than 71,000 people died in the U.S. of overdoses caused by synthetic opioids — primarily fentanyl — in 2021. https://t.co/hkZMFvZLKs (Twitter) - Dec 30, 2022
- | morphine sulphate / Generic mfg.
Journal: Chronic opioid users with dysphagia are indistinguishable from symptomatic nonusers on functional lumen imaging probe evaluation. (Pubmed Central) - Dec 30, 2022
Symptomatic chronic opioid users have FLIP diagnoses that are similar to nonusers, despite higher perceptive symptoms and worse quality of life. Dominant symptoms improve both in chronic opioid users and nonusers following treatment directed by FLIP.
- | morphine sulphate / Generic mfg., methadone / Generic mfg.
Journal: Conversion ratios for opioid switching: a pragmatic study. (Pubmed Central) - Dec 30, 2022
Patients receiving higher doses of opioids should be carefully monitored for individual and unexpected responses in an experienced palliative care unit, particularly those switched to methadone. Future studies should provide data regarding the profile of patients with difficult pain to be hospitalized.
- | Journal: A Comparison of Injury Patterns and Interventions among US Military Special Operations Versus Conventional Forces Combatants. (Pubmed Central) - Dec 30, 2022
SOF had consistently better medical documentation rates, more use of ketamine and fentanyl, less morphine administration, and lower threshold for use of blood products in both unadjusted and adjusted analyses. Our findings suggest lessons learned from the SOF medics should be extrapolated to the conventional forces for improved medical care.
- || fentanyl citrate / Generic mfg.
Review, Journal: Palliative Symptom Management in Malignant Pheochromocytoma: Safe Use of Fentanyl and a Review of Medications Used. (Pubmed Central) - Dec 30, 2022
Common opioid analgesics, dopamine-receptor antagonists, corticosteroids, and tricyclic antidepressants are medications known to precipitate a crisis. There is a lack of published research to support the safe prescribing of medications for these patients.
- || morphine sulphate / Generic mfg.
Clinical, Journal: Randomized Clinical Trial Comparing Quadratus Lumborum Block and Intrathecal Morphine for Postcesarean Analgesia. (Pubmed Central) - Dec 30, 2022
Quadratus lumborum block and intrathecal morphine are effective for analgesia after cesarean section. Patients undergoing QL block had lower postoperative pain scores without the undesirable side effects of opioids such as nausea, vomiting, and pruritus.
- | fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg., tramadol hydrochloride / Generic mfg.
Observational data, Journal: Plasma Brain-Derived Neurotrophic Factor and Opioid Therapy: Results of Pilot Cross-Sectional Study. (Pubmed Central) - Dec 30, 2022
Tramadol and buprenorphine exerted an important effect on BDNF levels in the examined patients. The BDNF level depends on duration of opioid therapy with buprenorphine, and age in tramadol therapy.
- || morphine sulphate / Generic mfg.
Retrospective data, Review, Journal, Surgery: Effects of ultrasound-guided regional anesthesia in cardiac surgery: a systematic review and network meta-analysis. (Pubmed Central) - Dec 30, 2022
However, it is still challenging to determine which is better, given the paucity of studies available in the literature. More randomized controlled trials are required to determine which regional anesthesia technique is better.
- | fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
Journal, Surgery: The impact of a postoperative multimodal analgesia pathway on opioid use and outcomes after cardiothoracic surgery. (Pubmed Central) - Dec 30, 2022
The MMA group was more likely to have mobility within one-day post-surgery. Patients in the MMA group were also more likely to have prolonged time to first BM and first zero RASS. Development and evaluation of a perioperative MMA pathway should be considered.
- | morphine sulphate / Generic mfg.
Journal: Transcutaneous electrical acupoint stimulation to reduce opioid consumption in patients undergoing inguinal hernia repair: protocol for a randomized controlled trial. (Pubmed Central) - Dec 30, 2022
Patients in the MMA group were also more likely to have prolonged time to first BM and first zero RASS. Development and evaluation of a perioperative MMA pathway should be considered. The results of this trial will determine whether TEAS with intensified stimulation protocol is a safe and effective option for reducing analgesic consumption and postoperative pain.
- | pethidine / Samaritan
Journal: Opioid Drug Detection in Hair Samples Using Polyoxometalate-Based Frameworks. (Pubmed Central) - Dec 29, 2022
Also, the ability of 1-4 (as the first polyoxomolybdate-containing frameworks) as sorbents for the extraction and quantitative determination of opioid drugs (morphine, methadone, and pethidine) was investigated by using dispersive micro-solid-phase extraction (D-μSPE) and high-performance liquid chromatography (HPLC). The method showed wide linear ranges in the range of 0.3 to 300 ng mg and low limits of detection (LODs) ranged from 0.1 to 0.2 ng mg of hair.
- | morphine sulphate / Generic mfg.
Journal: Neuroligin-3 in dopaminergic circuits promotes behavioural and neurobiological adaptations to chronic morphine exposure. (Pubmed Central) - Dec 29, 2022
This altered pattern of dopamine neuron activity may be driven by aberrant forms of opioid-evoked synaptic plasticity in the absence of NL3: dopamine neurons lacking NL3 showed weaker synaptic inhibition at baseline, which was subsequently strengthened after chronic morphine. In total, our study highlights neurobiological adaptations in dopamine neurons of the ventral tegmental area that correspond with increased behavioural sensitivity to opioids and further suggests that NL3 expression by dopamine neurons provides a molecular substrate for opioid-evoked adaptations in brain function and behaviour.
- | fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
Preclinical, Journal: Oral oxycodone self-administration leads to features of opioid misuse in male and female mice. (Pubmed Central) - Dec 29, 2022
In addition, a subset of animals demonstrate drug taking that is resistant to aversive consequences. This model is therefore translationally relevant and useful for studying the neurobiological substrates of prescription opioid abuse.
- morphine sulphate / Generic mfg., gemcitabine / Generic mfg.
Intra-operative Magnesium Sulfate is Associated with Decreased Anticholinergic Use after Urologic Procedures of the Bladder () - Dec 29, 2022 - Abstract #WSAUA2022WSAUA_74;
Endpoints of interest were use of AC/BO, maximum pain score, and morphine milligram equivalents (MME) in the PACU. Intravenous infusion of magnesium sulfate during endoscopic procedures of the bladder was found to decrease the use of AC/BO in the PACU.
- | morphine sulphate / Generic mfg.
Journal: Fluoroscopic anterior approach versus ultrasound guided superior hypogastric plexus neurolysis in cancer pelvic pain: a randomized controlled study. (Pubmed Central) - Dec 28, 2022
P2
Intravenous infusion of magnesium sulfate during endoscopic procedures of the bladder was found to decrease the use of AC/BO in the PACU. The fluoroscopic anterior approach SHPN was more superior than the US guided SHPN regarding the time of the procedure and patient satisfaction, while both technique were similar regarding the numeric rating scale and the complications during block.
- High perioperative opioid doses are associated with worse cancer-specific survival in patients undergoing radical cystectomy for urothelial carcinoma of the bladder (Pink Area, Coral 3) - Dec 27, 2022 - Abstract #EAU2023EAU_2615;
- Primary proximal hypospadias repair in in toilet-trained males is associated with a higher risk of post-operative complications and parental dissatisfaction (Pink Area, Coral 1) - Dec 27, 2022 - Abstract #EAU2023EAU_2475;
- Surgeon administered laparoscopic guided transversus abdominis plane block following robot-assisted laparoscopic radical prostatectomy (Pink Area, Coral 7) - Dec 27, 2022 - Abstract #EAU2023EAU_1608;
- Robot-assisted versus open kidney transplantation for end-stage kidney disease patients: A meta-analysis (Yellow Area, Amber 3) - Dec 27, 2022 - Abstract #EAU2023EAU_1301;
- Erector spinae plane blocks for analgesia after percutaneous nephrolithotomy: A pathway to reduce opiates (Yellow Area, Brown 3) - Dec 27, 2022 - Abstract #EAU2023EAU_1241;
- Ovastat (treosulfan) / Medac, Medexus
NURSES (Room 243) - Dec 27, 2022 - Abstract #EBMT2023EBMT_148;
The fluoroscopic anterior approach SHPN was more superior than the US guided SHPN regarding the time of the procedure and patient satisfaction, while both technique were similar regarding the numeric rating scale and the complications during block. The conditioning regimen consisted of ATG, thiotepa, fludarabine and treosulfan...Pain medication included paracetamol, tramadol, morphine and gabapentin...
- | morphine sulphate / Generic mfg.
Journal: Preparation and characterization of morphine gelatine microspheres. (Pubmed Central) - Dec 27, 2022
MGMs deliver sustained-release and long-action pharmacokinetics. It shows design goals of improving drug bioavailability, prolonging drug residence time in vivo, and maintaining stable blood drug concentration.
- | morphine sulphate / Generic mfg.
Journal: Multimodal analgesia is superior to opiates alone after tibial fracture in patients with substance abuse history. (Pubmed Central) - Dec 27, 2022
Morphine milligram equivalents (MMEs) dosed per patient were calculated each day...In patients with a history of substance abuse, multimodal analgesia not only decreases pain but also decreases length of stay and MMEs dosed to levels consistent with someone who does not have a substance abuse history. Level of Evidence: Therapeutic Level III.
- || morphine sulphate / Generic mfg.
Review, Journal: Impact of local anesthesia block on pain medication use and length of hospital stay in elderly indigenous patients in Alaska hospitalized for fragility fracture. (Pubmed Central) - Dec 27, 2022
However, receipt of PNB did not predict a reduction in postoperative morphine milligram equivalents opioid doses. Further study is required to determine whether one PNB method is superior to others based on individual-level characteristics.
- | tramadol hydrochloride / Generic mfg.
Journal: A randomized controlled study to compare analgesic efficacy of sublingual buprenorphine and intravenous tramadol in patients undergoing mastectomy. (Pubmed Central) - Dec 27, 2022
Analgesic efficacy of SL buprenorphine appears comparable to IV tramadol for managing postoperative pain after mastectomy. SL buprenorphine can be administered sublingually, which is an advantage.
- | morphine sulphate / Generic mfg.
Journal: A Novel Fat-Augmented Omentum-Based Construct for Unilateral and Bilateral Free-Flap Breast Reconstruction in Underweight and Normal Weight Women Receiving Nipple or Skin-Sparing Mastectomies. (Pubmed Central) - Dec 26, 2022
SL buprenorphine can be administered sublingually, which is an advantage. The O-FAFF is ideally suited for women of lower BMI and could dramatically increase the number of women who are candidates for autologous breast reconstruction.