morphine sulphate / Generic mfg. 
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  • ||||||||||  morphine sulphate / Generic mfg., ketamine / Generic mfg., paracetamol / Generic mfg.
    Journal:  Preliminary investigation into isolation and extraction of DNA recovered from drug residues. (Pubmed Central) -  Jan 14, 2023   
    The amount of DNA collected was sufficient for further analysis in 86% of naked DNA samples, and 100% of blood samples, with all median APH values being over the 175 RFU standard. Chemical analysis showed that traces of the drug were still present in the samples after DNA extraction was performed. Therefore, this study demonstrates forensically useful DNA can be recovered from surfaces bearing drug residues, even when sampling directly from the samples of drugs.
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg., paracetamol / Generic mfg.
    Journal:  Pectoral Nerve Blocks for Transvenous Subpectoral pacemaker insertion in Children: Randomized Controlled Trial. (Pubmed Central) -  Jan 13, 2023   
    Post-procedure, pectoral nerve blocks reduced postprocedural pain scores, which was reflected in later first call for rescue analgesia, and lower postoperative morphine consumption, and did not increase rates of complications in children who underwent transvenous subpectoral pacemaker insertion. Ultrasound guided PECs have a good intraoperative hemodynamic profile, reduce postoperative pain scores, and lower total opioid usage in children who underwent transvenous subpectoral pacemaker placement.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Opioid dispensing 2008-18: a Queensland perspective. (Pubmed Central) -  Jan 13, 2023   
    ObjectiveThis study provides an overview of opioid dispensing in Queensland from 2008 to 2018 by recipient age, drug, oral morphine equivalent and remoteness.MethodsData were obtained from the Queensland Monitoring of Drugs of Dependence System database for 2008-18 and analysed using data from the Australian Bureau of Statistics to account for population growth...Prescriptions dispensed per 1000 population were 416 for major cities, 551 for inner regional and 445 for outer regional, and highlight that inner and outer regional areas have higher rates of prescriptions when compared to major cities (32 and 7% higher, respectively).ConclusionThis study highlights changes in opioid prescription dispensing by drug and OME, as well as the variation in dispensing rates when accounting for remoteness. Further studies to link statewide databases, and to better understand drivers for differences in dispensing by location, will provide valuable insights to further inform policy and service provision.
  • ||||||||||  morphine sulphate / Generic mfg.
    Enrollment change:  Analgesics in the Pre-hospital Setting: Implications on Hemorrhage Tolerance - Morphine (clinicaltrials.gov) -  Jan 12, 2023   
    P1/2,  N=44, Completed, 
    Rescued morphine within 24 h was significantly reduced and the SF-36 bodily pain dimension at 30 days after surgery was significantly improved. N=30 --> 44
  • ||||||||||  morphine sulphate / Generic mfg., aspirin / Generic mfg., indomethacin / Generic mfg.
    Journal:  Antinociceptive activity of doliroside B. (Pubmed Central) -  Jan 12, 2023   
    DBDS displayed antinociceptive activity by acting on both the peripheral and central nervous systems, which may act on multitargets. Further work is warranted for developing DBDS into a potential drug for the treatment of pain.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal, HEOR:  Pain Treatment and Cancer Patients: Are we Heeding Quality of Life? (Pubmed Central) -  Jan 12, 2023   
    Morphine with a mean dose of 49 Morphine Milligram Equivalent were used by 57% of them, and PMI was negative in 34% of the sample...Despite the substantial negative impact of pain on QOL, no association was found between the clinical factors assessed and QOL itself. This gap can be related to the persistence of high levels of sub-treatment, depression, and neuropathic pain associated with the use of low doses of opiates and adjuvant medications in the sample.
  • ||||||||||  morphine sulphate / Generic mfg., cyclosporine / Generic mfg.
    Review, Journal:  Immunotherapy as a treatment to confront the ongoing opioid epidemic- A review. (Pubmed Central) -  Jan 11, 2023   
    This monograph reviews preclinical studies of immunotherapy and experiments using treatments with three different immunomodifiers that were able to significantly attenuate the severity of opioid withdrawal symptoms in morphine dependent animals. These immunotherapy treatments are short, and will prevent relapse of opioid dependency and toxicity.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Pain management of newly diagnosed sarcoma patients at a single center. (Pubmed Central) -  Jan 11, 2023   
    Pain in children with newly diagnosed sarcoma was mainly moderate to severe, and the incidence of pain in sarcoma with bone invasion was higher, with greater intensity. Patients who received standardized pain assessment and regular analgesics reached pain relief quickly, and no serious adverse reactions were observed within the recommended dosage.
  • ||||||||||  morphine sulphate / Generic mfg.
    SOCIOECONOMIC STATUS AND POST-OPERATIVE OPIOID CONSUMPTION FOR CYSTECTOMY ERAS PATIENTS (Santa Maria) -  Jan 10, 2023 - Abstract #SESAUA2023SESAUA_46;    
    Our results indicate that there was no significant difference between SES and MME consumption postoperatively amongst patients undergoing cystectomy on an ERAS protocol. Further investigation is warranted to elucidate the individual risk for postoperative opioid consumption and whether ERAS protocols can have a mitigating effect.
  • ||||||||||  gabapentin / Generic mfg.
    REMOVAL OF GABAPENTIN AND KETORALAC FROM ERAS PATHWAY INCREASES PERIOPERATIVE OPIOID USE: A FOLLOW-UP ANALYSIS (Talbot DE) -  Jan 10, 2023 - Abstract #SESAUA2023SESAUA_31;    
    Our initial analgesia regimen included post-operative scheduled acetaminophen, ketorolac, and gabapentin...The morphine milligram equivalent (MME) was then compared using Chi Squared, Fisher’s Exact and Student’s T tests as appropriate...The clinical significance of this increase must be weighed with the risks and benefits of ketorolac and/or gabapentin administration. We hope to continue discussion regarding the value and optimization of ERAS protocols with non-narcotic medications in radical cystectomy patients.
  • ||||||||||  morphine sulphate / Generic mfg.
    Methylation Profile of Non-Small Cell Lung Cancer of Brazilian Patients (Grand Ballroom C3) -  Jan 10, 2023 - Abstract #LALCA2023LALCA_93;    
    We hope to continue discussion regarding the value and optimization of ERAS protocols with non-narcotic medications in radical cystectomy patients. These findings provide new insights about altered pathways in NSCLC and potential biomarkers of genes of the homeobox family based on differentially methylated genes for NSCLC Brazilian patients.
  • ||||||||||  morphine sulphate / Generic mfg.
    Enrollment open:  External Oblique Intercostal Plane Block for Laparoscopic Sleeve Gastrectomy (clinicaltrials.gov) -  Jan 10, 2023   
    P=N/A,  N=60, Recruiting, 
    Therefore, blockade of the XCL1-ITGA9 interaction may serve as an innovative strategy for the polypharmacotherapy of neuropathic pain in combination with opioids. Not yet recruiting --> Recruiting
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal, Adverse events, Surgery:  Association of CYP2D6 genotype predicted phenotypes with oxycodone requirements and side effects in children undergoing surgery. (Pubmed Central) -  Jan 10, 2023   
    We hypothesized that altered activity due to CYP2D6 polymorphisms will influence oxycodone requirements {relative oxycodone use [oxycodone morphine equivalents (MEq)/total MEq] to maintain analgesia} (primary outcome) and risk for oxycodone induced side-effects such as respiratory depression (RD) and emesis (secondary outcomes)...Genotype availability and guidance likely influence oral opioid prescription pattern after surgery. Our findings are limited by small sample size for UM/PM groups.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Upregulation of Brain's Calcium Binding Proteins in Mitragynine Dependence: A Potential Cellular Mechanism to Addiction. (Pubmed Central) -  Jan 10, 2023   
    Design and Six groups (n=6-8) of rats made up of negative control, positive control using morphine (10 mg/kg), and treatment groups at low (1mg/kg) and high doses of mitragynine (30 mg/kg) for 1 and 4 days...Among the proteins that were up-regulated in treatment groups were four calcium-binding proteins, namely calretinin, F-actin, annexin A3 and beta-centractin. Upregulation of calretinin acted as low Ca buffering upon the blockage of Ca ion channel by mitragynine in the brain, which subsequently caused a reduction of GABA released and inversely increased the dopamine secretions that contributed to dependence indicators.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal, Surgery:  Caudal Morphine in Pediatric Patients: A Comparison of Two Different Doses in Children Undergoing Infraumbilical Surgery - A Prospective, Randomized, Double-Blind Study. (Pubmed Central) -  Jan 10, 2023   
    Children with no analgesic requirement were 16.7% in Group A and 33.3% in Group B. The incidence of side effects was more in Group B (8 [26.7%] children with nausea and vomiting; 1 [3.3%] children with urinary retention) than in Group A (2 [6.6%] children with nausea and vomiting. From the above observations, it can be concluded that morphine of less dosage (20 μg.kg) when added to 0.2% ropivacaine for the caudal epidural block has better efficacy than morphine of higher dosage (30 μg.kg) as the duration of analgesia is similar with decreased incidence of side effects.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Post-Operative Order Set Decreases Opioid Prescriptions and Increases Efficiency. (Pubmed Central) -  Jan 10, 2023   
    A single 60 mg dose of DH administered 2 h before open radical cholecystectomy reduced total morphine consumption and improved VAS score postoperatively with no effect on PSS. The integration of a post-operative prescribing order set into our EMR substantially decreased opioid prescribing after MUO while streamlining the ordering process to improve efficiency.
  • ||||||||||  morphine sulphate / Generic mfg., methamphetamine / Generic mfg.
    Journal:  Pulverization is a crucial step-a comparative study of different pretreatments in hair drug testing. (Pubmed Central) -  Jan 9, 2023   
    The analytes we selected were those commonly encountered in traditional drug abuse cases: (±)-methamphetamine, (±)-amphetamine, morphine, 6-acetylmorphine, cocaine, benzoylecgonine, (-)-Δ9-tetrahydrocannabinol, ketamine, (±)-norketamine, and (±)3,4-methylenedioxymethamphetamine. The analysis method was liquid chromatography-tandem mass spectrometry.
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
    Journal:  Carfentanil Structural Analogs Found in Street Drugs by Paper Spray Mass Spectrometry and their Characterization by High Resolution Mass Spectrometry. (Pubmed Central) -  Jan 7, 2023   
    Literature and tandem mass spectrometry results were used to determine the identity of these potential new psychoactive substances, C H N O as desmethylcarfentanil amide, and C H N O as desmethylcarfentanil acid. μ-Opioid receptor binding modeling determined that the binding poses of these analogs were nearly identical to that of carfentanil with relative binding energy calculations of 0.544 kJ/mol (desmethylcarfentanil amide) and -0.171 kJ/mol (desmethylcarfentanil acid); these data suggest they may share the toxic effects of carfentanil and have similar potencies.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal, Surgery:  Lumbar spine surgery reduces postoperative opioid use in the veteran population. (Pubmed Central) -  Jan 7, 2023   
    Postoperative cumulative morphine milligram equivalents (MME) were tracked for each group and the paired Wilcoxon signed rank test was used to compare cumulative preoperative MME (days -365-0) to cumulative postoperative MME (days 91-455)...Even minimal exposure to opioids preoperatively resulted in a 2.69-time increase in risk of being on opioids at one year versus opioid naive patients. This study affirms that despite being a high-risk population, the veteran population has a similar response to lumbar spine surgery as the general population in regards to opioid dependence.
  • ||||||||||  fentanyl citrate / Generic mfg., fentanyl buccal / Generic mfg.
    Journal:  Predicting tolerability of high-dose fentanyl buccal tablets in cancer patients. (Pubmed Central) -  Jan 7, 2023   
    According to the dose relationship between the final FBT dose and the clinical features, three factors (sex, age, daily use of FBT) were independently associated with the final dose of FBT. Our risk score model could help predict tolerance to high-dose FBT and guide the titration plan for BTcP.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Postoperative Restrictive Opioid Protocols and Durable Changes in Opioid Prescribing and Chronic Opioid Use. (Pubmed Central) -  Jan 6, 2023   
    The ROPP implementation led to a 45% decrease in prescribed opioids after surgery (mean [SD], 157.22 [338.06] mean morphine milligram equivalents [MME] before ROPP vs 83.54 [395.70] MME after ROPP; P < .001)...The conversion rate to chronic opioid use decreased following ROPP implementation among both opioid-naive patients with cancer (11.3% [143 of 1267] to 4.5% [118 of 2645]; P < .001) and those without cancer (6.1% [19 of 310] to 2.7% [16 of 600]; P = .02). In this cohort study, prescribing an opioid supply of 3 or fewer days to surgical patients after hospital discharge was feasible for most patients, led to a significant decrease in the number of opioids prescribed after surgery, and was associated with a significantly decreased conversion to long-term opioid use without concomitant increases in refill requests or significant compromises in surgical recovery.