morphine sulphate / Generic mfg. 
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  • ||||||||||  morphine sulphate / Generic mfg.
    EFFICACY OF DROPERIDOL FOR THE TREATMENT OF NAUSEA, VOMITING, OR ABDOMINAL PAIN () -  Jan 25, 2023 - Abstract #SCCM2023SCCM_1243;    
    Administration of droperidol did not appear to influence patients’ ED length of stay. The amount of opioid administered was found to be statistically significantly reduced in patients who received droperidol as compared to when not administered.
  • ||||||||||  Entereg (alvimopan) / Merck (MSD)
    MEDICATION USE EVALUATION OF ALVIMOPAN IN A TEACHING HOSPITAL () -  Jan 25, 2023 - Abstract #SCCM2023SCCM_1232;    
    There were no safety concerns associated with the use of alvimopan. Furthermore, about $90,000 of the cost is attributable to low-quality evidence dosing strategy.
  • ||||||||||  Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
    DROPERIDOL UNDERMINING GASTROPARESIS SYMPTOMS (DRUGS) IN THE EMERGENCY DEPARTMENT () -  Jan 25, 2023 - Abstract #SCCM2023SCCM_1229;    
    Studies of ED patients with gastroparesis presenting with abdominal pain, nausea, and vomiting have shown that haloperidol reduces pain and nausea while reducing the amount of morphine equivalents administered and reducing admission rates... In patients with gastroparesis presenting to the ED, droperidol has the potential to reduce opioid use, antiemetic use, symptoms, cost, and length of stay.
  • ||||||||||  methadone / Generic mfg.
    METHADONE VERSUS OXYCODONE TO FACILITATE WEANING OF PARENTERAL OPIOIDS IN CRITICALLY ILL PATIENTS () -  Jan 25, 2023 - Abstract #SCCM2023SCCM_1044;    
    This was a single-center, retrospective, cohort chart review of adult patients in an intensive care unit (ICU) who received a continuous infusion of IV fentanyl or hydromorphone for > 72 hours and an enteral weaning strategy using either methadone or oxycodone from January 1, 2020 through December 31, 2021...Differences between groups such as COVID-19 status, scheduled midazolam, oral opioid titration, and total IV morphine equivalents prior to the start of weaning were controlled for using Cox Proportional Hazards (CPH)... Compared to oxycodone, patients who received enteral methadone had a shorter duration of IV opioids without differences in length of stay or safety outcomes.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Proteomics and Metabolomics Analysis Reveals the Toxicity of ZnO Quantum Dots on Human SMMC-7721 Cells. (Pubmed Central) -  Jan 24, 2023   
    ZnO QDs significantly modified metabolic pathways, including purine metabolism, ferroptosis, morphine addiction, alcoholism, cGMP-PKG signaling, and Cushing syndrome...The KEGG analyses of the metabolomics and proteomics data both enriched the alcoholism and Cushing syndrome pathways. These results provide an experimental basis for future research on the safe use of nanomaterials.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Opportunistic salpingectomy during robotic sacrocolpopexy: Data to support a widely accepted practice. (Pubmed Central) -  Jan 24, 2023   
    Narcotics administered during the immediate post-operative period until discharge was collected for each patient and converted to morphine milligram equivalents (MME) via multiplying the administered dose by the CDC established evidence-based conversion factor...Due to the exploratory nature of this analysis, there were no corrections applied for multiple comparisons. This data can be used as a basis for researchers to build upon when assessing ovarian cancer primary prevention strategies and associated treatment modalities.
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg., ketamine / Generic mfg.
    Journal:  Comparing the Effects of Low-Dose Ketamine, Fentanyl, and Morphine on Hemorrhagic Tolerance and Analgesia in Humans. (Pubmed Central) -  Jan 24, 2023   
    These experimental data demonstrate that morphine reduces tolerance to simulated hemorrhage while fentanyl and ketamine do not affect tolerance. Thus, these laboratory-based data, captured via simulated hemorrhage, suggest that morphine should not be used for a hemorrhaging individual in the prehospital setting.
  • ||||||||||  morphine sulphate / Generic mfg.
    Slow-release oral morphine as MOUD: used internationally but why not the USA? (Potomac 4-6, Ballroom Level) -  Jan 23, 2023 - Abstract #ASAM2023ASAM_82;    
    Upon completion, participants will be able to demonstrate knowledge about the clinical evidence for the use of slow-release oral morphine in methadone inductions, MOUD switches to buprenorphine, and as monotherapy for OUD. Upon completion, participants will be able to describe the regulatory and policy issues that impact the use of slow-release oral morphine in the USA.
  • ||||||||||  metamizole / Generic mfg., morphine sulphate / Generic mfg.
    Journal:  Quantitative cardiac autonomic outcomes of hydrotherapy in women during the first stage of labor. (Pubmed Central) -  Jan 21, 2023   
    The findings of this study provide quantitative support for using warm shower hydrotherapy during labor via point-of-care testing. The dependability of hydrotherapy as a non-pharmacological treatment is linked to the completion of more clinical research demonstrating quantitative evidence via outcome biomarkers to support indications on stress and birth progress.
  • ||||||||||  morphine sulphate / Generic mfg.
    Magnetic resonance imaging as a non-invasive tool to assess gastric emptying in mice (Tiffany/Shah – Hilton Antwerp Old Town) -  Jan 21, 2023 - Abstract #BWG2023BWG_165;    
    The ability of MRI to detect delayed gastric emptying was evaluated in a model of morphine-induced gastroparesis (5mg/kg, sc) and compared to the standard [13C] octanoic acid breath test...In diabetic mice, gastric volume assessed by MRI at t = 60 min (control: 23 ± 2 mm3; n = 14 vs diabetic: 26 ± 5 mm3; n = 18; p = 0.014) but not at t = 120 min (control: 21 ± 3 mm3; n = 13 vs diabetic: 18 ± 5 mm3; n = 18; p = 0.115) was significantly increased compared to nondiabetic mice. Conclusions Our data indicate that MRI is a reliable and reproducible tool to assess gastric emptying in mice and may represent a useful technique to study gastroparesis in disease models or for evaluation of pharmacological compounds.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Long-term opioid therapy and mental health comorbidity in chronic pain patients. (Pubmed Central) -  Jan 21, 2023   
    This study shows that mental health comorbidity is highly prevalent but that the prescribed opioid dosage is independent of it in the clinical setting of this study. The concept of liaison psychiatric care may have essentially contributed to the "detachment" of opioid prescription and psychiatric conditions but cannot be isolated from other potentially contributing factors within this single-center observational study.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Review, Journal:  Atypical Fentanyl Transdermal Patch Consumption and Fatalities: Case Report and Literature Review. (Pubmed Central) -  Jan 21, 2023   
    Fentanyl consumption presumably took place by chewing of a transdermal patch, with subsequent aspiration of the protective film. The pathophysiology of death can be identified as combined respiratory failure-both central suppression and a fentanyl-induced increase in muscular stiffness; a further minor contribution may be identified in the mechanical airflow obstruction caused by the presence of the protective film at the bronchial level.
  • ||||||||||  morphine sulphate / Generic mfg.
    New P3 trial:  Regional Block for Upper Abdominal Surgeries (clinicaltrials.gov) -  Jan 20, 2023   
    P3,  N=120, Not yet recruiting, 
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Chronic and Sustained High-Dose Opioid Use in an Integrated Health System. (Pubmed Central) -  Jan 20, 2023   
    The pathophysiology of death can be identified as combined respiratory failure-both central suppression and a fentanyl-induced increase in muscular stiffness; a further minor contribution may be identified in the mechanical airflow obstruction caused by the presence of the protective film at the bronchial level. Implementing evidence-based prescribing guidelines was associated with a decrease in chronic and sustained high-dose prescription opioid use.
  • ||||||||||  Nucynta (tapentadol) / Collegium Pharma, Grunenthal
    Observational data, Journal, Real-world evidence, Real-world:  Therapeutic alliance impact on analgesic outcomes in a real-world clinical setting: An observational study. (Pubmed Central) -  Jan 19, 2023   
    Further efforts are needed to improve communication strategies for pain management. Future directions of research should include the analysis of the role of the pharmacist in poly-professional consultations as related to the advice of patients about their medication, and the mutual trust with the patients.
  • ||||||||||  morphine sulphate / Generic mfg., ketamine / Generic mfg.
    Trial completion date, Trial primary completion date:  Postpartum Perineal Pain After Obstetric Anal Sphincter Injuries (clinicaltrials.gov) -  Jan 19, 2023   
    P4,  N=160, Recruiting, 
    Future directions of research should include the analysis of the role of the pharmacist in poly-professional consultations as related to the advice of patients about their medication, and the mutual trust with the patients. Trial completion date: Apr 2023 --> Dec 2024 | Trial primary completion date: Dec 2022 --> Dec 2023
  • ||||||||||  methadone / Generic mfg.
    Enrollment change, Trial completion date, Trial withdrawal, Trial primary completion date:  Study of LYN-014 in Individuals With Opioid Use Disorder Who Are Stable on Methadone Therapy (clinicaltrials.gov) -  Jan 19, 2023   
    P1,  N=0, Withdrawn, 
    Trial completion date: Apr 2023 --> Dec 2024 | Trial primary completion date: Dec 2022 --> Dec 2023 N=16 --> 0 | Trial completion date: May 2023 --> Dec 2022 | Recruiting --> Withdrawn | Trial primary completion date: Apr 2023 --> Dec 2022
  • ||||||||||  morphine sulphate / Generic mfg.
    Trial completion:  Evaluation of Peripheral Itch Mechanisms Following Injection of Morphine (clinicaltrials.gov) -  Jan 18, 2023   
    P=N/A,  N=26, Completed, 
    N=16 --> 0 | Trial completion date: May 2023 --> Dec 2022 | Recruiting --> Withdrawn | Trial primary completion date: Apr 2023 --> Dec 2022 Recruiting --> Completed
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Review, Journal:  Systemic opioid regimens for postoperative pain in neonates. (Pubmed Central) -  Jan 17, 2023   
    We are uncertain whether continuous opioid infusion reduces pain compared with intermittent opioid boluses; none of the studies reported the other primary outcomes of this review, i.e. all-cause mortality during initial hospitalization, significant neurodevelopmental disability, or cognitive and educational outcomes among children older than five years old. Only one small study reported on morphine infusion with parent- or nurse-controlled analgesia.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  A fast and simple protocol to anaesthesia in chicken embryos. (Pubmed Central) -  Jan 16, 2023   
    In a group treated with xylazine-morphine, the heart rate did not decrease, but the movement decreased after the stimulus. As the best results were the combinations of ketamine-midazolam-morphine and ketamine-xylazine, we recommend these associations for use in embryos in the final third of embryonic development in experimental protocols and euthanasia.
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg., hydromorphone hydrochloride / Generic mfg.
    Observational data, Journal, Real-world evidence, Real-world:  Systemic opioids for dyspnea in cancer patients: A real-world observational study. (Pubmed Central) -  Jan 15, 2023   
    As the best results were the combinations of ketamine-midazolam-morphine and ketamine-xylazine, we recommend these associations for use in embryos in the final third of embryonic development in experimental protocols and euthanasia. Regular systemic opioids were effective for dyspnea in real-world cancer patients.
  • ||||||||||  tramadol hydrochloride / Generic mfg.
    Journal:  Tramadol regulates the activation of human platelets via Rac but not Rho/Rho-kinase. (Pubmed Central) -  Jan 14, 2023   
    Not morphine or reboxetine, but duloxetine, fluvoxamine and sertraline attenuated the synergistic effect of the combination on the platelet aggregation (30 μM of fluvoxamine, 67.3% decrease, p<0.05; 30 μM of sertraline, 67.8% decrease, p<0.05)...The Rac1-GEF interaction inhibitor NSC23766 suppressed the platelet activation and the phosphorylation of p38 MAPK and HSP27 induced by the combination of collagen and CXCL12...Suppression of the platelet aggregation after the duloxetine administration was observed in 2 of 5 patients in pain clinic. These results suggest that tramadol negatively regulates the combination of subthreshold collagen and CXCL12-induced platelet activation via Rac upstream of p38 MAPK.