- |||||||||| morphine sulphate / Generic mfg.
Review, Journal: Impact of Sternal Fixation on Patient Outcomes: A Case Matched Review. (Pubmed Central) - Feb 3, 2023
Continued research should examine additional or alternative regional block procedures, as well as financial cost and potential long-term impact of PVBs. Despite similarities in pain scores, ICU, and hospital LOS SF was associated with decreased opioid requirements and improved respiratory function at discharge in this study.
- |||||||||| morphine sulphate / Generic mfg.
Trial completion date, Trial primary completion date: Postoperative Analgesia in Patients Undergoing Elective Lumbar Fusion Operations Under General Anesthesia (clinicaltrials.gov) - Feb 2, 2023
P4, N=120, Recruiting,
Despite similarities in pain scores, ICU, and hospital LOS SF was associated with decreased opioid requirements and improved respiratory function at discharge in this study. Trial completion date: Nov 2022 --> Mar 2023 | Trial primary completion date: Nov 2022 --> Mar 2023
- |||||||||| morphine sulphate / Generic mfg.
Journal: Activation of HSP90/HSF1 Signaling as an Adaptive Response to an Electrophilic Metabolite of Morphine. (Pubmed Central) - Feb 2, 2023
MO exposure caused S-modification of HSP90 (determined using biotin-PEAC-maleimide labeling) and nuclear translocation of transcription factor HSF1, thereby up-regulating its downstream genes encoding B-cell lymphoma 2-associated anthanogene 3 and heat shock 70 kDa protein 1. However, dihydromorphinone, a non-electrophilic metabolite of morphine, had little effect on HSF1 activation or upregulation of these genes, suggesting that covalent modification plays a role in this process and that the HSP90/HSF1 pathway is a redox-signaled adaptive response to morphine metabolism.
- |||||||||| morphine sulphate / Generic mfg.
Trial completion date, Trial primary completion date: Ultrasound Guided Erector Spinae Plane Block vs Intrathecal Morphine (clinicaltrials.gov) - Feb 2, 2023
P4, N=120, Recruiting,
These results suggest that covalent modification is crucial in the Keap1/Nrf2 pathway activation and that this pathway is a redox signaling-associated adaptive response to MO metabolism. Trial completion date: Nov 2022 --> Feb 2023 | Trial primary completion date: Nov 2022 --> Feb 2023
- |||||||||| morphine sulphate / Generic mfg.
Journal, Surgery: Feasibility of opioid-free surgery for inflammatory bowel disease. (Pubmed Central) - Feb 1, 2023
Trial completion date: Nov 2022 --> Feb 2023 | Trial primary completion date: Nov 2022 --> Feb 2023 In the era of modern enhanced recovery protocols and minimally invasive techniques, we show that early postoperative opioid avoidance is feasible in a limited number of inflammatory bowel disease patients after colorectal surgery.
- |||||||||| Journal: Does Facial Fracture Management Require Opioids? A Pilot Trial of a Narcotic-Minimizing Analgesia Protocol for Operative Facial Trauma. (Pubmed Central) - Jan 31, 2023
Postoperatively, patients received intravenous (IV) ketorolac, scheduled acetaminophen, ibuprofen, and gabapentin...At all recorded postoperative intervals, narcotic-minimizing subjects reported less pain (vNRS) than controls (0-8 h, 7.7 versus 8.1; 8-16 h, 4.4 versus 8.0; 16-24 h 4.3 versus 6.9); significance was achieved at the 8 to 16-hour time point (P = 0.006). A multimodal, opioid-sparing analgesia protocol significantly reduces opioid use in perioperative facial trauma management without sacrificing satisfactory pain control for patients.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Changes in Prescribed Opioid Dosages Among Patients Receiving Medical Cannabis for Chronic Pain, New York State, 2017-2019. (Pubmed Central) - Jan 31, 2023
The main outcome was opioid dosage, measured by mean daily morphine milligram equivalent (MME)...Among individuals in the nonexposure group, daily MME was reduced by only 4% in the lowest stratum, 9% in the middle stratum, and 14% in the highest stratum. In this cohort study of patients receiving LOT, receiving MC for a longer duration was associated with reductions in opioid dosages, which may lower their risk of opioid-related morbidity and mortality.
- |||||||||| morphine sulphate / Generic mfg.
Journal, Surgery: Rapid Adoption of Telemedicine Increases Opioid Prescribing in Orthopedic Surgery. (Pubmed Central) - Jan 31, 2023
Prescriptions were converted into daily milligram morphine equivalents (MMEs) to facilitate direct comparison...In addition, significantly higher MME were prescribed by mid-level prescribers compared with DOs or MDs. Institutions should ensure these prescribers are involved during creation of opioid prescribing protocols after orthopedic surgery.
- |||||||||| morphine sulphate / Generic mfg.
Preclinical, Journal: Modulation of the inflammatory response by pre-emptive administration of IMT504 reduces postoperative pain in rats and has opioid-sparing effects. (Pubmed Central) - Jan 29, 2023
Various groups of rats were prepared for pain-like behaviour analyses, including subgroups receiving morphine or naloxone, as well as for flow-cytometry or quantitative RT-PCR analyses of the spleen and hindpaws (for analysis of inflammatory phenotype)...Also, IMT504 treatment targeted the spleen, with upregulated or downregulated transcript expressions, 6 h after incision, of interleukin-10 and interleukin-1β, respectively. Altogether, pre-emptive or postoperative IMT504 provides protection against postincisional pain, through participation of significant immunomodulatory actions, and exhibiting opioid-sparing effects.
- |||||||||| morphine sulphate / Generic mfg.
Journal, Surgery: Opioid use following pelvic reconstructive surgery: a predictive calculator. (Pubmed Central) - Jan 29, 2023
Altogether, pre-emptive or postoperative IMT504 provides protection against postincisional pain, through participation of significant immunomodulatory actions, and exhibiting opioid-sparing effects. Patients undergoing surgery for pelvic floor disorders use far fewer opioids than they are prescribed.
- |||||||||| morphine sulphate / Generic mfg., paracetamol / Generic mfg.
New trial, Surgery: ESP Block in Robotic Cardiac Surgery (clinicaltrials.gov) - Jan 27, 2023
P=N/A, N=50, Recruiting,
- |||||||||| morphine sulphate / Generic mfg.
Journal: Opioid Use Disorder from Poppy Seed Tea Use: A Case Report. (Pubmed Central) - Jan 27, 2023
Poppy seeds can be purchased in an unwashed or unprocessed form, and these seeds can be contaminated with the opium alkaloids morphine, codeine, and thebaine on their surfaces...CONCLUSIONS Poppy seeds in their unwashed and unprocessed form can be misused and could lead to an opioid use disorder. This disorder can be treated with buprenorphine/naloxone products.
- |||||||||| morphine sulphate / Generic mfg.
Retrospective data, Journal, Surgery: Multimodal Pain Control Reduces Narcotic Use after Outpatient Abdominoplasty: Retrospective Analysis in an Ambulatory Surgery Practice. (Pubmed Central) - Jan 27, 2023
The treatment cohort was prescribed two-thirds less oral narcotic than the control (251 versus 787 mean morphine milligram equivalents P < 0.001)...Optimally utilizing multimodal medications effectively reduces narcotic consumption while effectively managing postoperative pain from abdominoplasty in a private practice, ambulatory surgery setting. Surgeons must change their prescribing habits if we are going to make progress in the war against the opioid crisis.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Racial Differences in Postoperative Opioid Prescribing Practices in Spine Surgical Patients. (Pubmed Central) - Jan 27, 2023
In a large cohort of opioid-naive postoperative neurosurgical patients, this study demonstrates higher inpatient and outpatient postoperative opioid usage among White patients. Increasing physician awareness to the effect of race on inpatient and outpatient pain management would allow for a modified opioid prescribing practice that ensures limited yet effective opioid dosages void of implicit biases.
- |||||||||| morphine sulphate / Generic mfg., ropivacaine / Generic mfg.
Journal: Laparoscopic transversus abdominis plane block is useful in pain relief after laparoscopic stapled repair of diastasis recti and ventral hernia. (Pubmed Central) - Jan 26, 2023
All patients received 24 h infusion of 20 mg morphine; pain was checked at 6, 24 and 48 h after surgery by numeric rating scale (NRS) score...Laparoscopic-guided TAP-block can be considered safe and effective in the management of post-operative pain and in the reduction of analgesic need in patients undergoing laparoscopic repair of diastasis recti and ventral hernias. The non-randomised nature of the study and the lack of a consistent series of patients require further evaluations.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Emergence of restless legs syndrome during opioid discontinuation. (Pubmed Central) - Jan 25, 2023
In many cases, symptoms appear to be self-limited, although a minority develop persistent symptoms. Our results may have implications for successful opioid tapering, but future confirmatory studies with structured clinician interview are needed to establish that these symptoms truly represent restless legs syndrome given the potential for RLS-mimicking symptoms in individuals with chronic pain syndromes.
- |||||||||| morphine sulphate / Generic mfg.
EVALUATION OF DISCHARGE OPIOID PRESCRIBING IN MECHANICALLY VENTILATED ICU PATIENTS () - Jan 25, 2023 - Abstract #SCCM2023SCCM_1985;
Our study found 25% of opioid-naïve patients undergoing IMV were discharged from the hospital on opioids and the daily CPOT score did not correlate with MME and dose titration. It is unclear why 25% of opioid-naïve patients who underwent IMV in a MICU required opioids at hospital discharge and is an area that warrants further investigation.
- |||||||||| ketamine / Generic mfg.
EVALUATION OF SUBDISSOCIATIVE-DOSE KETAMINE FOR PROCEDURAL SEDATION IN THE EMERGENCY DEPARTMENT () - Jan 25, 2023 - Abstract #SCCM2023SCCM_1812;
However, patients receiving SDK required less median lorazepam milligram equivalents (0 [IQR 0-0 mg] vs 0 [IQR 0-0.5 mg], p< 0.001)... Sub-dissociative dose ketamine administration for PSA in the ED provided comparable procedural sedation and analgesia success at lower doses compared to dissociative dose ketamine along with a significant reduction in adverse events.
- |||||||||| RISK FACTORS FOR ICU AND HOSPITAL LENGTH OF STAY IN ICU PATIENTS RECEIVING IV OPIOIDS () - Jan 25, 2023 - Abstract #SCCM2023SCCM_1760;
All hospital opioids doses were converted to morphine milligram equivalent (MME)... Requirement of tracheostomy, development of delirium, use of dexmedetomidine, and history of substance abuse had effects on ICU LOS, while admission weight, requirement of tracheostomy, development of delirium, increased hospital opioid use, dexmedetomidine use, history of substance abuse, increased APACHE II score at admission, and use of midazolam had effects on hospital LOS.
- |||||||||| fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
RISK FACTORS FOR 30-DAY HOSPITAL READMISSION IN CRITICALLY ILL PATIENTS RECEIVING IV OPIOID THERAPY () - Jan 25, 2023 - Abstract #SCCM2023SCCM_1759;
In mechanically ventilated ICU patients receiving IV opioid therapy, having an ICD code for substance abuse, tracheostomy placement and hospital length of stay were all risk factors that predict 30-day hospital readmission. Conversely, admission age, delirium, gender, race, ICD code for obstructive sleep apnea, total hospital opioid dose and APACHE score were not found to be associated risk factors for 30-day hospital readmission.
- |||||||||| morphine sulphate / Generic mfg.
PRACTICES AND OUTCOMES ASSOCIATED WITH BUPRENORPHINE USE IN A CRITICALLY ILL POPULATION () - Jan 25, 2023 - Abstract #SCCM2023SCCM_1757;
Secondary outcomes included difference in morphine milligram equivalents (MME) before and after reaching the target dose in patients who received low-dose initiation and incidence of precipitated withdrawal... Buprenorphine can be safely used in critically ill patients and is associated with a decrease in full-agonist opioid exposure for patients receiving a low-dose initiation.
- |||||||||| morphine sulphate / Generic mfg., lorazepam / Generic mfg.
EVALUATION OF SEDATION REQUIREMENTS IN CRITICALLY ILL TRAUMA PATIENTS WITH HISTORY OF SUBSTANCE USE () - Jan 25, 2023 - Abstract #SCCM2023SCCM_1615;
Among critically ill trauma patients with a HOSU, there was an increased sedation and analgesia requirement compared to those without a HOSU. Understanding substance use history in this patient population is necessary in order to set realistic expectations for managing sedation and analgesia.
- |||||||||| morphine sulphate / Generic mfg.
A PERFECT STORM OF SICKLE CELL HEPATOPATHY () - Jan 25, 2023 - Abstract #SCCM2023SCCM_1252;
This case illustrates the rapid and life threatening nature of SCIC and the importance of prompt initiation of exchange transfusion therapy. While SCIC is a challenging given its non-specific constellation of symptoms with significant overlap with several other hepatic processes, nevertheless it should be high on the differential in patients with SCD who develop hepatic abnormalities during vaso-occulsive crisis.
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