morphine sulphate / Generic mfg. 
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  • ||||||||||  morphine sulphate / Generic mfg.
    Biomarker, Journal:  Predictive Factors for Postoperative Opioid Use in Elective Endoscopic Endonasal Skull Base Surgery. (Pubmed Central) -  Feb 27, 2023   
    In patients undergoing EESBS, patient history of anxiety/depression, younger patient age, and nasoseptal flap use are associated with increased postoperative opioid use. Knowledge of these risk factors may guide perioperative prescribing patterns to both adequately control postoperative pain and reduce opioid use.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Postoperative opioid-prescribing practices in otolaryngology: Evidence-based guideline outcomes. (Pubmed Central) -  Feb 27, 2023   
    Prescribing guidelines led to an average reduction in prescribed morphine milligram equivalents (MME) per patient by: 48% (sialendoscopy), 63% (parotidectomy), 60% (para/thyroidectomy), and 42% (TORS)...Implementation of opioid-prescribing guidelines and the use of multimodal analgesia substantially reduced the amount of opioids prescribed across all procedures without impacting patient satisfaction. 2.
  • ||||||||||  morphine sulphate / Generic mfg., hydromorphone hydrochloride / Generic mfg.
    Trial completion date, Trial primary completion date:  NCI-2018-01139: Levorphanol as a Second Line Opioid in Reducing Pain in Patients With Cancer (clinicaltrials.gov) -  Feb 27, 2023   
    P1,  N=86, Active, not recruiting, 
    However, rectus sheath block provides inadequate postoperative analgesia in parturients who undergo caesarean delivery. Trial completion date: Dec 2022 --> Dec 2023 | Trial primary completion date: Dec 2022 --> Dec 2023
  • ||||||||||  morphine sulphate / Generic mfg., papaverine / Generic mfg.
    Review, Journal:  Papaver Plants: Current Insights on Phytochemical and Nutritional Composition Along with Biotechnological Applications. (Pubmed Central) -  Feb 24, 2023   
    Among other pharmacological properties, numerous preclinical studies have been published about the analgesic, anticancer, antimicrobial, antioxidant, and antidiabetic activities of Papaver plants. Although it highlights the significant impact of this genus for the treatment of a variety of diseases and conditions, as a future prospect, characterization works accompanying preclinical studies are required along with clinical and toxicology studies to establish a correlation between the scientific and traditional knowledge.
  • ||||||||||  Review, Journal, Surgery:  THE EFFECT OF REGIONAL VS. GENERAL ANESTHESIA ON THE IMMUNE RESPONSE IN BREAST CANCER SURGERY: A NARRATIVE REVIEW OF THE LITERATURE. (Pubmed Central) -  Feb 24, 2023   
    Regional anesthesia and its potential beneficial effects on the perioperative immune response and long-term outcome after surgery has been investigated as an alternative to general anesthesia in patients undergoing breast cancer surgery. In this paper, we present a review of literature aimed to assess the impact of regional anesthesia techniques on the immune response in patients undergoing breast cancer surgery and how it compares to general anesthesia.
  • ||||||||||  morphine sulphate / Generic mfg.
    Retrospective data, Review, Journal, Surgery:  Efficacy and safety of erector spinae plane block for postoperative analgesia in breast cancer surgery-A systematic review and meta-analysis. (Pubmed Central) -  Feb 24, 2023   
    In this paper, we present a review of literature aimed to assess the impact of regional anesthesia techniques on the immune response in patients undergoing breast cancer surgery and how it compares to general anesthesia. Compared to general anesthesia alone, ESPB combined with general anesthesia can effectively reduce the postoperative pain intensity within 48?h and opioid consumption within 24?h after breast cancer surgery, and reduce the incidence of opioid and nerve blocks related complications.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Opioid and benzodiazepine use in gynecologic oncology patients. (Pubmed Central) -  Feb 22, 2023   
    Opioid and benzodiazepine prescribing patterns differ for cervical, ovarian, and uterine cancer patients. Gynecologic oncology patients are overall at low risk for opioid misuse; however, patients with cervical cancer are more likely to have risk factors present for opioid misuse.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal, Stroma:  Insights in opiates toxicity: impairment of human vascular mesenchymal stromal cells. (Pubmed Central) -  Feb 14, 2023   
    The aim of this study was to assess the effect of in vitro morphine exposure on the physiological activity and maintenance of human vMSCs...Although confirmation studies are required on real fatal opiate intoxications, the approach based on morphological and immunofluorescence methodologies may have a high potential also as a useful tool or as a complementary method in forensic pathology. The application of these techniques in the future may lead to the identification of new markers and morphological parameters useful as complementary investigations for drug-related deaths.
  • ||||||||||  morphine sulphate / Generic mfg.
    Optimization of an Hsp90?-selective inhibitor to improve opioid therapy (Hall F-H (Indiana Convention Center)) -  Feb 14, 2023 - Abstract #ACSSp2023ACS_SP_12337;    
    Opioids such as morphine and oxycodone are commonly prescribed drugs for the treatment of chronic pain...Herein, we describe structure-activity relationship studies to improve such properties as aqueous solubility while maintaining this high selectivity. Our efforts have resulted in a lead compound that is ~100-fold more soluble and is active in a transgenic mouse model at 10 mg/kg p.o.
  • ||||||||||  morphine sulphate / Generic mfg.
    Development of a naloxone biosynthetic pathway using cell-free protein synthesis and deep learning (Cabinet (The Westin Indianapolis)) -  Feb 14, 2023 - Abstract #ACSSp2023ACS_SP_10400;    
    We also tested the single and multistep pipelines on known naturally occurring pathways, e.g., glycolysis, and produced a set of candidate pathways for naloxone from morphine...Several potential future directions will be discussed to improve the efficiency of the pipelines. Once we improve the computational framework, it could be used to guide the experimental synthesis of naloxone or other high-value small molecules.
  • ||||||||||  morphine sulphate / Generic mfg.
    Investigating the effects of morphine and cannabidiol on pain sensitivity (Hall F-H (Indiana Convention Center)) -  Feb 14, 2023 - Abstract #ACSSp2023ACS_SP_5237;    
    Once we improve the computational framework, it could be used to guide the experimental synthesis of naloxone or other high-value small molecules. Participant
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
    Computational study on binding affinity of opioids to the brain receptors versus opioid addiction (Hall F-H (Indiana Convention Center)) -  Feb 14, 2023 - Abstract #ACSSp2023ACS_SP_5037;    
    The study used AutoDock 4.2.6 software to find the binding sites and the binding energies. While stronger inter molecular interactions lead to higher binding energies, the study shows that the steric effect plays a major role in binding the ligand molecule to the receptor for most of the opioid that have been used for the study.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Towards a rapid electrochemical screening analysis of fentanyl and fentanyl analogs (Indiana Ballroom F (Indianapolis Marriott Downtown)) -  Feb 14, 2023 - Abstract #ACSSp2023ACS_SP_1981;    
    The analogs tested are commonly observed by the DEA, such as acetylfentanyl, acrylfentanyl, methoxyacetyl fentanyl, THF fentanyl, and furanyl fentanyl, along with medicinal fentanyl analogs such as sufentanil, alfentanil, and remifentanil. Additional fentanyl analogs will be characterized in the future to further demonstrate the universality of the proposed detection method of fentanyl and fentanyl analogs.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  The Impact of Hydrocodone Rescheduling on Utilization, Abuse, Misuse, and Overdose Deaths. (Pubmed Central) -  Feb 13, 2023   
    The net impact on hydrocodone and other opioid analgesic-involved misuse/abuse and fatal overdose was unclear. We did not detect an immediate impact on heroin abuse or overdose death rates; however, the dynamic nature of the crisis and data limitations present challenges to causal inference.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal, Surgery:  Surgical Opioid Stewardship for Orthopedic Surgery: A Quality Improvement Initiative. (Pubmed Central) -  Feb 13, 2023   
    There was a significant difference in morphine milligram equivalents per day and quantity prescribed when comparing the preintervention period with the postintervention period without significant increases in opioid refill requests or return visit rates...[Orthopedics. 202x;4x(x):xx-xx.].
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Opioid usage in lumbar disc herniation patients with nonsurgical, early, and late surgical treatments. (Pubmed Central) -  Feb 12, 2023   
    Inpatient opioid administration can be significantly reduced while maintaining comparable functional recovery and superior pain control. Early surgery in lumbar disc herniation patients is associated with lower long-term average daily MME, incidence of opioid use, and one-year cumulative MME burden compared to nonsurgical and late surgery treatment approaches.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Opioid-Induced Reductions in Amygdala Lateral Paracapsular GABA Neuron Circuit Activity. (Pubmed Central) -  Feb 12, 2023   
    Furthermore, in LPC neurons, abstinence from repeated morphine-exposure in vivo (10 mg/kg/day, 5 days, 2 days off) decrease the intrinsic membrane excitability, with a ~75% increase in afterhyperpolarization and ~40-50% enhanced adenylyl cyclase-dependent activity in LPC neurons. These data show that MORs in the BLA are a highly sensitive targets for opioid-induced inhibition and that repeated opioid exposure results in impaired LPC neuron excitability.