morphine sulphate / Generic mfg. 
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  • ||||||||||  morphine sulphate / Generic mfg.
    Saliva miRNA biomarkers of neonatal opioid withdrawal syndrome () -  Mar 14, 2023 - Abstract #PAS2023PAS_4077;    
    Also, 53.8% of participants required morphine treatment. Saliva levels of miR-146a and miR-192 were decreased in the saliva of infants with NOWS compared to healthy infants (miR-146a, p = 0.0001, Cohen
  • ||||||||||  morphine sulphate / Generic mfg., methadone / Generic mfg.
    Predictors of Pharmacologic Treatment in Neonates with Prenatal Opioid Exposure () -  Mar 14, 2023 - Abstract #PAS2023PAS_4072;    
    Infants requiring pharmacotherapy received a median oral morphine dose of 0.073 mg/kg every three hours. Treated infants had a median of 71 morphine doses throughout admission, with median treatment duration of 15 days.
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
    Postnatal Management and Variation in Care Among Neonates in the RAFT Trial () -  Mar 14, 2023 - Abstract #PAS2023PAS_3534;    
    P1
    Choice of RRT varied, with centers using peritoneal dialysis (PD) (7), hemodialysis (HD) (5) and aquapheresis (3) alone or in combination. Minimum weight to offer RRT ranged from 1-2.5 kg and varied based on RRT modality available at each site.
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  Mitragynine, a primary constituent of kratom reinstates morphine-seeking behaviour in rats. (Pubmed Central) -  Mar 13, 2023   
    The present finding demonstrated that MG priming in a dose of 10 mg/kg resulted in the reinstatement of morphine-seeking behaviour, whereas the higher MG dose (30 mg/kg) tested suppressed the seeking response. This study indicated that exposure to a low MG dose may increase the likelihood of relapsing to opioids, suggesting that the potential of MG as a treatment for opioid management merits further scientific assessment of its ability to trigger relapse to opioid abuse.
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
    Observational data, Retrospective data, Journal:  Opioid prescribing and social deprivation: A retrospective analysis of prescribing for CNCP in Liverpool CCG. (Pubmed Central) -  Mar 13, 2023   
    Identification of fentanyl as a contributor to high dose prescribing resulted in changes to prescribing practice, and reports from NHS pain clinics that fewer patients require tapering from fentanyl. In conclusion, higher rates of high dose opioid prescribing continue to be evident in more socially deprived areas further increasing health inequalities.
  • ||||||||||  morphine sulphate / Generic mfg.
    Enabling Opioid Dose Reduction for Refractory Restless Legs Syndrome through Adjunctive Tonic Motor Activation (TOMAC) Therapy (Both in-person and online) -  Mar 12, 2023 - Abstract #AAN2023AAN_4135;    
    P=N/A
    Design/Methods We report interim analysis from an open-label multicenter clinical study (NCT04698343) recruiting adults taking a maximum of 60 morphine milligram equivalents (MME) to treat refractory RLS...Conclusions These preliminary results suggest that adjunctive TOMAC enables opioid dose reduction for patients with refractory RLS without increases to RLS symptoms. By enabling lower opioid doses, TOMAC could reduce the risks associated with long-term treatment of refractory RLS.
  • ||||||||||  Quantitative Pupillometry is Not Impacted By IV Opioid or Sedative Bolus Dosing (Both in-person and online) -  Mar 12, 2023 - Abstract #AAN2023AAN_3583;    
    Conclusions NPi does not significantly differ from before to after administration of bolus IV opioids or sedatives. Significant changes in NPi are unlikely to be related to medication administration and should be correlated clinically.
  • ||||||||||  levetiracetam / Generic mfg.
    High-Dose Levetiracetam: A Novel Post-Arrest Anti-Arrhythmic Medication? (Both in-person and online) -  Mar 12, 2023 - Abstract #AAN2023AAN_2891;    
    Significant changes in NPi are unlikely to be related to medication administration and should be correlated clinically. Design/Methods Case Description: A 17-month-old female presented in ventricular fibrillation arrest thought to be secondary to methamphetamine toxicity and a mitochondrial genetic mutation (discovered and confirmed later in her hospitalization)...Magnetic resonance imaging (MRI) on day 8 post-arrest was without evidence of diffusion restriction or T2-flair abnormalities and was thought to represent pseudonormalization in setting of hypoxic injury.
  • ||||||||||  Transient Perivascular Inflammation of the Carotid Artery (TIPIC) Syndrome after Breast Implant Surgery (Both in-person and online) -  Mar 12, 2023 - Abstract #AAN2023AAN_1384;    
    Acetaminophen, oxycodone, morphine and ketorolac provided moderate, short-lived relief...Her home medications were spironolactone, estradiol, aripiprazole, emtricitabine and tenofovir disoproxil fumarate...MRI showed enhancement surrounding the left as well as the right common carotid artery without luminal narrowing, suggestive of TIPIC.Neck pain resolved after a short course of oral prednisone...Reactivity against the left carotid plaque is an alternative cause, but it does not explain the inflammation around the right carotid artery where is no plaque. TIPIC syndrome should be differentiated from other causes of vasculitis and dissection.
  • ||||||||||  morphine sulphate / Generic mfg.
    Observational data, Retrospective data, Journal:  Evaluation of Naloxone Co-Prescribing Rates for Older Adults Receiving Opioids via a Meds-to-Beds Program. (Pubmed Central) -  Mar 11, 2023   
    The 144 patients included were primarily females with a median age of 69?years old and opioid prescriptions for 45 morphine milligram equivalents daily...Of the 65 prescribers included in our study, the incidence of naloxone co-prescribing (2/65, 3.1%) was no different from a previously-reported rate among prescribers (3/179, 1.7%), p?=?0.61. Naloxone co-prescribing for older adults receiving opioid prescriptions through a meds-to-beds program was low and opportunities for program enhancement exist.
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  Effect of selective lesions of nucleus accumbens  (Pubmed Central) -  Mar 11, 2023   
    There were no genotype differences in pain responses, morphine analgesia and tolerance, heroin self-administration, and relapse-related behaviors...After performing anatomical and behavioral validation experiments, we used the Oprm1-Cre knock-in rats to show that lesioning nucleus accumbens MOR-expressing cells had different effects on heroin self-administration in males and females. The new Oprm1-Cre rats can be used to study the role of brain MOR-expressing cells in animal models of opioid addiction, pain-related behaviors, and other opioid-mediated functions.
  • ||||||||||  morphine sulphate / Generic mfg., ropivacaine / Generic mfg.
    Journal, Surgery:  Quadratus Lumborum Blockade for Postoperative Analgesia in Infants and Children Following Colorectal Surgery. (Pubmed Central) -  Mar 10, 2023   
    The median opioid requirement in oral morphine milligram equivalents (MMEs) was 0.7, 0.5, and 0.3 MME/kg on the first, second, and third postoperative days, respectively...This retrospective review in a large cohort of pediatric patients demonstrates that the QLB can be performed safely and efficiently in children undergoing colorectal surgery. The QLB provides adequate postoperative analgesia, has a high success rate, may limit postoperative opioid consumption, and is associated with a limited adverse effect profile.
  • ||||||||||  morphine sulphate / Generic mfg., clonidine / Generic mfg.
    Enrollment closed, Enrollment change, Trial completion date, Trial primary completion date:  No-POPPY: Non-Opiate Treatment After Prenatal Opiate Exposure to Prevent Postnatal Injury to the Young Brain (clinicaltrials.gov) -  Mar 10, 2023   
    P3,  N=120, Active, not recruiting, 
    The QLB provides adequate postoperative analgesia, has a high success rate, may limit postoperative opioid consumption, and is associated with a limited adverse effect profile. Recruiting --> Active, not recruiting | N=200 --> 120 | Trial completion date: Feb 2023 --> Feb 2024 | Trial primary completion date: Feb 2023 --> Feb 2024
  • ||||||||||  morphine sulphate / Generic mfg.
    Trial completion date, Trial primary completion date:  Continuous Adductor Canal Infusion vs. Single-injection Adductor Canal Block for Total Knee Arthroplasty (clinicaltrials.gov) -  Mar 10, 2023   
    P=N/A,  N=80, Recruiting, 
    Recruiting --> Active, not recruiting | N=200 --> 120 | Trial completion date: Feb 2023 --> Feb 2024 | Trial primary completion date: Feb 2023 --> Feb 2024 Trial completion date: Dec 2022 --> Jun 2023 | Trial primary completion date: Dec 2022 --> May 2023
  • ||||||||||  remifentanil / Generic mfg., morphine sulphate / Generic mfg.
    Preclinical, Journal:  Probing pain aversion in rats with the  (Pubmed Central) -  Mar 9, 2023   
    Withdrawal from a brief systemic administration of remifentanil resulted in a long-lasting and robust increase in heat aversion, but no change in reflexive responses to heat. Taken together, these data demonstrate the utility of the HET paradigm as a novel tool in preclinical pain research.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Opioid Represcriptions After ACL Reconstruction in Adolescents are Associated With Subsequent Opioid Use Disorder. (Pubmed Central) -  Mar 9, 2023   
    Taken together, these data demonstrate the utility of the HET paradigm as a novel tool in preclinical pain research. In this cohort of patient ages 10 to 18 undergoing primary isolated ACL reconstruction, we found substantial variability in opiate prescribing patterns and higher initial opioid prescription volume, as well as opioid represcription within 6 weeks were predictive of the subsequent development of OUD.
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  The effects of the amount of weight bearing on articular cartilage early after ACL reconstruction in rats. (Pubmed Central) -  Mar 9, 2023   
    Rats were divided into groups according to the treatment received: untreated control, ACL reconstruction (ACLR), ACL reconstruction plus hindlimb unloading (ACLR?+?HU), and ACL reconstruction plus morphine administration (ACLR?+?M)...In the ACLR?+?M group, although chondrocyte density in the anterior region was increased, all other parameters were not significantly different from those in the ACLR group. Our results suggest that early weight bearing after ACL reconstruction is important to reduce cartilage degeneration.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Association of a Statewide Opioid Legislation with Opioid Prescribing Patterns in Facial Plastic and Reconstructive Procedures. (Pubmed Central) -  Mar 9, 2023   
    Objective: To compare opioid prescription rates and morphine milligram equivalents (MMEs) of opioid prescribed to patients undergoing various facial plastic and reconstructive surgery (FPRS) procedures before, during, and after legislation enactment...Regression analysis showed no change in MME prescribing in the year before legislation (p?=?0.70), followed by a decrease of 0.13 MME per day (p?=?0.00), with a subsequent stabilization of MME at a reduced rate for the remainder of the study period (p?=?0.74). Enactment of the Michigan Opioid Laws was temporally associated with a decrease in opioid prescriptions for common facial plastic surgery procedures.
  • ||||||||||  Nucynta (tapentadol) / Collegium Pharma, Grunenthal
    Review, Journal:  Systemic opioids versus other analgesics and sedatives for postoperative pain in neonates. (Pubmed Central) -  Mar 9, 2023   
    We are uncertain whether morphine reduces pain compared to paracetamol; none of the studies reported major neurodevelopmental disability, cognitive and educational outcomes in children more than five years old, all-cause mortality during initial hospitalization, retinopathy of prematurity, or intraventricular hemorrhage. We identified no studies comparing opioids versus non-pharmacological interventions.
  • ||||||||||  morphine sulphate / Generic mfg.
    Correlation between Length of Surgery and Opioid Overprescribing at Hospital Discharge () -  Mar 9, 2023 - Abstract #ISPOR2023ISPOR_668;    
    Factors such as duration of the procedure, age, and average pain score can influence this prescribing decision. Making information on opioid administration easily accessible to prescribers could increase the reliance on this measure for prescribing.