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7 Diseases |  |
379 Trials |
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379 Trials |  |
12426 News |  |
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- | morphine sulphate / Generic mfg.
Journal, Video: Efficacy of preemptive intercostal nerve block on recovery in patients undergoing video-assisted thoracic lobectomy. (Pubmed Central) - May 3, 2023
Pre- ICNB is equally efficacious in perioperative pain management as post-ICNB, and pre-ICNB significantly reduces intra-operative opioid consumption, providing faster recovery in PACU.
- | morphine sulphate / Generic mfg.
Journal: Associations of clinical personnel characteristics and controlled substance prescribing practices. (Pubmed Central) - May 3, 2023
After checking the PDMP, male physicians were more likely to alter their original prescription to include harm-reduction strategies. Optimizing the use of PDMP systems may serve to improve prescribing among US physicians.
- ||| morphine sulphate / Generic mfg.
@harshamd5 LA infiltration analgesia is significantly inferior to TAP blocks for C/S without intrathecal morphine. Please see the plot below 👇🏼 https://t.co/7BWpUlFzSE (Twitter) - May 3, 2023
- | morphine sulphate / Generic mfg.
Journal: N-substituted tetrahydro-beta-carboline as mu-opioid receptors ligands: in silico study; molecular docking, ADMET and molecular dynamics approach. (Pubmed Central) - May 3, 2023
The results showed that N-substituted tetrahydro-beta-carbolines with and without C6-methoxy group substitutions (THBC/6MTHBC) analogues of A1/B1 and A9/B9 have relatively acceptable affinity and within pocket-stability toward MOR compared to the reference compounds of morphine (agonist) and naloxone (antagonist)...In conclusion, the designed THBC analogues represent a good starting point for designing opioid receptor ligands other than morphinan scaffold, that have good synthetic accessibility which promotes feasible structural manipulation to tailor pharmacological effects with minimal side effects. Workflow rational in the discovery of potential Mu Opioid Receptor ligands.
- || morphine sulphate / Generic mfg.
Review, Journal: The Role of Opioid Receptors in Cancer. (Pubmed Central) - May 3, 2023
Workflow rational in the discovery of potential Mu Opioid Receptor ligands. Opioids such as morphine mediate clinically relevant effects primarily through the
- || morphine sulphate / Generic mfg.
Clinical, Journal, Surgery: Effect of perioperative high-dose transdermal nicotine patch on pain sensitivity among male abstinent tobacco smokers undergoing abdominal surgery: a randomized controlled pilot study. (Pubmed Central) - May 3, 2023
Opioids such as morphine mediate clinically relevant effects primarily through the Perioperative high-dose nicotine replacement therapy may help to relieve postoperative pain among male smoking-abstinent patients undergoing abdominal surgery.
- | morphine sulphate / Generic mfg.
Journal: Medical cannabis is effective for cancer-related pain: Quebec Cannabis Registry results. (Pubmed Central) - May 2, 2023
Real-world data from this large, prospective, multicentre registry indicate that MC is a safe and effective complementary treatment for pain relief in patients with cancer. Our findings should be confirmed through randomised placebo-controlled trials.
- | morphine sulphate / Generic mfg.
Journal: Optimizing opioid prescribing practices after minimally invasive lung resection through a quality-improvement intervention. (Pubmed Central) - May 2, 2023
After implementation of the CATS opioid guideline, there was a significant reduction in opioids prescribed at discharge and no increase in opioid prescription refills. Control charts are a valuable resource for monitoring outcomes on an ongoing basis and for assessing the effects of an intervention.
- | morphine sulphate / Generic mfg.
Preclinical, Journal: Effects of intrathecally administered interferon ? on chronic constriction injury model rats' mechanical pain threshold and G protein expression in the spinal cord. (Pubmed Central) - May 2, 2023
Control charts are a valuable resource for monitoring outcomes on an ongoing basis and for assessing the effects of an intervention. The intrathecal administration of both IFN-a and morphine can reduce the glutamate content in the cerebrospinal fluid (261.55
- || morphine sulphate / Generic mfg.
Review, Journal: "A Profound, Abiding Hatred": An Analysis of Hermann Goering's Alleged Morphine Addiction. (Pubmed Central) - May 1, 2023
His habit of ingesting paracodeine pills may have been a crude form of opioid maintenance therapy, similar to that of methadone today. Ultimately, his history of substance abuse had no significant impact on his capacity, ruthlessness, and leading role in Nazi crimes.
- | morphine sulphate / Generic mfg.
Retrospective data, Journal, Surgery: Intrathecal Morphine Injection for Postoperative Analgesia Following Gender-Affirming Pelvic Surgery: A Retrospective Case-Control Study. (Pubmed Central) - May 1, 2023
Their analgesic results were compared to a similar historical group of 13 patients who were not offered or declined intrathecal morphine. Conclusions Intrathecal morphine injection is a potent analgesic modality for patients presenting for gender-affirming pelvic surgery.
- | Retrospective data, Journal, Checkpoint inhibition: The Effect of Concomitant Usage of Analgesics on Immune Checkpoint Inhibitor-related Interstitial Lung Disease. (Pubmed Central) - May 1, 2023
Conclusions Intrathecal morphine injection is a potent analgesic modality for patients presenting for gender-affirming pelvic surgery. These results suggest that the concomitant use of narcotic analgesics is involved in the development of ICI-related ILD.
- | morphine sulphate / Generic mfg.
Retrospective data, Journal, PD(L)-1 Biomarker, IO biomarker, Metastases: The effect of opioids on the efficacy of immunotherapy in recurrent/metastatic squamous cell carcinoma of the head and neck. (Pubmed Central) - May 1, 2023
In our study cohort of anti-PD-1 mAb treatment in R/M HNSCC patients, higher opioids were associated with significantly lower PFS and OS and lower CD8 T cells in the tumor microenvironment. To our knowledge, this is the first analysis in R/M HNSCC patients and further research into the clinical and biologic effect of opioids is warranted.
- | morphine sulphate / Generic mfg.
Observational data, Retrospective data, Journal, Real-world evidence, Real-world: Real-World Observational Evaluation of Common Interventions to Reduce Emergency Department Prescribing of Opioid Medications. (Pubmed Central) - May 1, 2023
EHR-implemented solutions such as EPCS, pop-up alerts, and pill defaults had varying but significant effects on reducing ED opioid prescribing. Policy makers and quality improvement leaders might achieve sustainable improvements in opioid stewardship while balancing clinician alert fatigue through policy efforts promoting implementation of EPCS and default dispense quantities.
- | Biomarker, Journal: Do the lockdown-imposed changes in a wastewater treatment plant catchment's socio-demographics impact longitudinal temporal trends in psychoactive pharmaceutical use? (Pubmed Central) - May 1, 2023
The effects of the fluctuating socio-demographics of the catchment population were further evidenced by the different week-weekend pattern of PNMLs over the course of the sampling campaign. Mean parent/metabolite ratios (i.e., citalopram/norcitalopram, tramadol/O-desmethyltramadol, venlafaxine/O-desmethylvenlafaxine, and methadone/EDDP) remained relatively stable throughout the entire sampling campaign (RSD% below 25?% for all ratios, except for methadone/EDDP) and therefore were not affected by this population change.
- | morphine sulphate / Generic mfg., dexmedetomidine / Generic mfg.
Trial completion date, Trial primary completion date: Opioid-Sparing Multimodal Analgesia Versus Opioid Analgesia for Postoperative Pain After Elective Craniotomy (clinicaltrials.gov) - May 1, 2023
P=N/A, N=60, Completed, Sponsor: Zagazig University
Mean parent/metabolite ratios (i.e., citalopram/norcitalopram, tramadol/O-desmethyltramadol, venlafaxine/O-desmethylvenlafaxine, and methadone/EDDP) remained relatively stable throughout the entire sampling campaign (RSD% below 25?% for all ratios, except for methadone/EDDP) and therefore were not affected by this population change. Trial completion date: Oct 2022 --> Jan 2023 | Trial primary completion date: Sep 2022 --> Dec 2022
- | morphine sulphate / Generic mfg.
Retrospective data, Journal, Surgery: The Enhanced Recovery After Surgery pathway for posterior cervical surgery: a retrospective propensity-matched cohort study. (Pubmed Central) - Apr 29, 2023
Trial completion date: Oct 2022 --> Jan 2023 | Trial primary completion date: Sep 2022 --> Dec 2022 Implementing a novel ERAS protocol significantly improved length of stay, return of physiological function, home discharge, complications, and maximum pain score after posterior cervical surgery.
- | morphine sulphate / Generic mfg., ketamine / Generic mfg.
Journal, Surgery: Management of Anxiety for Ambulatory Hallux Valgus Surgery With a Virtual Reality Hypnosis Mask: Randomized Controlled Trial. (Pubmed Central) - Apr 29, 2023
In this study cohort undergoing percutaneous hallux valgus surgery, we found that use of a virtual reality hypnosis mask before surgery modestly reduced postoperative and predischarge anxiety as well as early postoperative consumption of higher-level analgesics in adults with significant preoperative anxiety. Level II, prospective cohort study.
- | morphine sulphate / Generic mfg.
Journal: Optogenetic stimulation in the medial prefrontal cortex modulates stimulus valence from rewarding and aversive to neutral states. (Pubmed Central) - Apr 28, 2023
This study addressed this issue and examined whether optogenetic ChR2 photostimulation in the cingulate, prelimbic, and infralimbic cortices of the mPFC regulated the valence of saccharin solution consumption from the rewarding property, the aversive property induced by morphine's conditioning, and the neutral states via saccharin extinction processes after morphine's conditioning...Notably, the change of valence was temporary alternation during light-on related to the light-off periods. However, the findings may provide insights in the development of novel treatments for addictive symptoms.
- | morphine sulphate / Generic mfg.
Journal: The trend of opioid prescriptions among cancer patients in a tertiary hospital: A multimethod quantitative study. (Pubmed Central) - Apr 28, 2023
Oral morphine equivalents (OME) were calculated using the standard conversion factors and the OME trend during the study period was assessed by a generalized additive model...Opioid use in cancer patients in this study is lower than the average global usage. Promoting opioid prescriptions for pain management through medical education can help doctors overcome opiophobia.
- | morphine sulphate / Generic mfg.
Retrospective data, Journal: Minimally Invasive Donors Right Hepatectomy versus Open Donors Right Hepatectomy: A Meta-Analysis. (Pubmed Central) - Apr 28, 2023
Promoting opioid prescriptions for pain management through medical education can help doctors overcome opiophobia. We concluded that MIDRH is a safe and feasible alternative to ODRH for living donators, especially in the PLDRH group.
- | morphine sulphate / Generic mfg.
Journal: Operative Management of Hip Fractures Within 24 Hours in the Elderly is Achievable and Associated With Reduced Opiate Use. (Pubmed Central) - Apr 27, 2023
We concluded that MIDRH is a safe and feasible alternative to ODRH for living donators, especially in the PLDRH group. Outcome measures were length of stay (LOS), oral morphine equivalents (OME) throughout hospitalization...Surgical treatment of geriatric hip/femur fractures in ?24
- | methadone / Generic mfg.
Enrollment change: Perioperative Methadone Use to Decrease Opioid Requirement in Pediatric Spinal Fusion Patients (clinicaltrials.gov) - Apr 27, 2023
P3, N=58, Completed, Sponsor: Medical College of Wisconsin
Outcome measures were length of stay (LOS), oral morphine equivalents (OME) throughout hospitalization...Surgical treatment of geriatric hip/femur fractures in ?24 N=44 --> 58
- morphine sulphate / Generic mfg.
Cancer pain in the emergency department: An EMR-based opioid dosing intervention and the effects on patient outcomes. () - Apr 26, 2023 - Abstract #ASCO2023ASCO_6934;
This EMR-based BPA intervention was associated with improved pain scores and decreased admission rates among cancer patients visiting the ED. The same intervention, however, was associated with increased ED return visits within 7 days, suggesting that pain management strategies may need to be implemented or modified upon ED discharge to assure that patients
- morphine sulphate / Generic mfg.
Adverse health effects of opioids in survivors of breast cancer after active cancer treatment. () - Apr 26, 2023 - Abstract #ASCO2023ASCO_6916;
We found statistically significant 1.6-2.1-fold increased risks of adverse events (falls, lung problems, fractures and CV events) associated with opioid use. Clinicians must weigh the risk and benefits of treating pain with opioids post-treatment.
- ketamine / Generic mfg.
Phase II study about efficacy and safety of the continuous intravenous infusion of ketamine as adjuvant to opioids in terminally ill cancer patients with refractory cancer pain. () - Apr 26, 2023 - Abstract #ASCO2023ASCO_6912;
P2
The CIVI of ketamine can be a useful tool in these patients considering limited treatment options. Further studies comparing usefulness of CIVI of ketamine and usual practice with opioids escalation are needed (NCT03362073).
- morphine sulphate / Generic mfg., tramadol hydrochloride / Generic mfg.
Use of Myeloma Patient Outcome Scale (MyPOS) to gauge the effectiveness of palliative management in patients with multiple myeloma: Experience from a large tertiary academic center in India. () - Apr 26, 2023 - Abstract #ASCO2023ASCO_6910;
Adequate pain management can significantly improve quality of life in MM patients. Use of standardized questionnaires such as MyPOS is a quintessential tool for the palliative specialist in order to gauge therapeutic efficacy.
- morphine sulphate / Generic mfg.
Opiate use after total hip arthroplasty for metastatic bone disease. () - Apr 26, 2023 - Abstract #ASCO2023ASCO_6907;
After THA in the setting of MBD, patients exhibit decreased postoperative opioid use. > MME, morphine milligram equivalent; IQR, interquartile range; *negative value in IQR denotes greater opioid use compared to preoperative opioid use; statistically significant p value is bolded.
- Opioid prescribing patterns for head and neck cancer radiation patients, with a comparison to breast cancer radiation patients. () - Apr 26, 2023 - Abstract #ASCO2023ASCO_5679;
Opioids are most prescribed before and during radiation and decrease by > 80% by 6 months after radiation started. 6% of HNC patients still require opioid prescriptions over 6 months after the start of radiation.
- morphine sulphate / Generic mfg.
Celiac plexus radiosurgery for pain management in advanced cancer: An international phase II trial, health-related quality of life (HRQOL) outcomes. () - Apr 26, 2023 - Abstract #ASCO2023ASCO_5258;
P2
The treatment appears to improve HRQOL. Clinical trial information: NCT03323489.
- Qarziba (dinutuximab beta) / Jazz
Single-agent activity of the anti-GD2 antibody dinutuximab beta given as a long-term infusion in relapsed and refractory neuroblastoma (APN311-304). (On Demand | Hall A; Poster Bd # 340) - Apr 26, 2023 - Abstract #ASCO2023ASCO_4042;
P2
Single-agent treatment with single agent dinutuximab beta given as long LTI without cytokines and without isotretinoin is effective and highly tolerable in R/R-NB. Clinical trial information: NCT02743429.
- pregabalin / Generic mfg., duloxetine / Generic mfg.
Phase III, international, multicentre, double-blind, dose increment, parallel-arm, randomised controlled trial of duloxetine versus pregabalin for opioid-unresponsive neuropathic cancer pain. (On Demand | Hall A; Poster Bd # 509b) - Apr 26, 2023 - Abstract #ASCO2023ASCO_3740;
Stage 3 (Day 8-14): Pregabalin (75 mg) 2 capsules (150 mg) twice a day (morning and bedtime). Clinical trial information: ACTRN12620000656932, jRCTs051190087.
- hydromorphone hydrochloride / Generic mfg., oxycodone controlled release / Generic mfg.
Patient-controlled subcutaneous analgesia with hydromorphone versus oral oxycodone for opioid titration of cancer pain: A prospective multicenter randomized trial. (On Demand | Hall A; Poster Bd # 492) - Apr 26, 2023 - Abstract #ASCO2023ASCO_3718;
Compared with oral oxycodone SR tablet, the use of PCSA with hydromorphone achieved faster pain relief and a shorter titration duration for patients with cancer pain without increasing adverse events. Clinical trial information: ChiCTR2000037845.
- || morphine sulphate / Generic mfg., methamphetamine / Generic mfg.
Review, Journal: Future perspectives of emerging novel drug targets and immunotherapies to control drug addiction. (Pubmed Central) - Apr 26, 2023
This article's main highlight is discussing the drug targets of SUDs and their associated mechanisms. Importantly, we have also discussed the scope of prophylactic measures to eliminate drug dependence.
- | morphine sulphate / Generic mfg., tramadol hydrochloride / Generic mfg.
Journal: What Changes Have Occurred in Opioid Prescriptions and the Prescribers of Opioids Before TKA and THA? A Large National Registry Study. (Pubmed Central) - Apr 26, 2023
More intradisciplinary collaboration seems important to limit the prescribing of preoperative opioids. Additionally, research is necessary to assess whether opioid cessation before surgery reduces the risk of adverse outcomes.
- ||| morphine sulphate / Generic mfg.
Clinical: Yes I have noticed that all Anglo-Saxon countries seem to think opioids in the spinal are essential. But we don’t. And our patients seem okay. We also stopped using PCA morphine post-op for sections because patients didn’t really use morphine. No silly TAP blocks either. (Twitter) - Apr 26, 2023
- | morphine sulphate / Generic mfg., methadone / Generic mfg.
Preclinical, Journal: Comparisons of stress-related neuronal activation induced by restraint in adult male rat offspring with prenatal exposure to buprenorphine, methadone, or morphine. (Pubmed Central) - Apr 25, 2023
Thus, stress-induced neuronal activation in the PVH and LC was well preserved in adult male rat offspring with prenatal exposure to Bu, but it was substantially lessened in those with prenatal exposure to Meth or Mor. Lowered neuronal activation found in the Meth or Mor exposure groups may be, at least in part, due to the reduction in the density of CRF neurons in the PVH.
- | morphine sulphate / Generic mfg.
Preclinical, Journal: VU0155041, a positive allosteric modulator of mGluR4, in the nucleus accumbens facilitates extinction and inhibits the reinstatement of morphine-induced conditioned place preference in male rats. (Pubmed Central) - Apr 25, 2023
Furthermore, the administration of VU0155041 into the NAc dose-dependently inhibited the reinstatement of CPP. The findings suggested that the mGluR4 in the NAc facilitates the extinction and inhibits the reinstatement of the morphine-induced CPP, which could be mediated by an increase in the release of extracellular glutamate.
- | morphine sulphate / Generic mfg.
Journal: Computational design and molecular modeling of morphine derivatives for preferential binding in inflamed tissue. (Pubmed Central) - Apr 24, 2023
This derivative exhibits a pKa reduction and enhanced ligand-protein interactions within the MOR. ?-fluorination decreased the overall pKa values of the morphine derivatives (pKa: 6.1-7.83) relative to morphine, reducing binding within healthy, central tissue.
- | morphine sulphate / Generic mfg., hydromorphone hydrochloride / Generic mfg.
Journal: Use of clinical phenotypes to characterize emergency department patients administered intravenous opioids for acute pain. (Pubmed Central) - Apr 24, 2023
Among patients who receive intravenous opioids in the emergency department, the experiences of pain relief and euphoria are highly variable. For many, pain relief is independent of intoxication.
- | morphine sulphate / Generic mfg.
Journal, Surgery: Impact of erector spinae plane block on the quality of recovery after lumbar spine decompression surgery: A comparative study between addicts and non-addicts. (Pubmed Central) - Apr 24, 2023
For many, pain relief is independent of intoxication. Time to first analgesic request was significantly longer in group N than in group A (mean
- | morphine sulphate / Generic mfg., ropivacaine / Generic mfg.
Retrospective data, Journal: Efficacy and safety of different doses of epidural morphine coadministered with low-concentration ropivacaine after cesarean section: A retrospective cohort study. (Pubmed Central) - Apr 24, 2023
No significant difference was found in the incidence and severity of PONV and pruritus, the rate of rescue analgesia and grading of motor block between RM3 and RM6 groups. Epidural 3
- | Preclinical, Journal: Evaluation of antinociceptive effect and pharmacological mechanisms of thiocyanoacetamide in rats. (Pubmed Central) - Apr 21, 2023
It may be concluded that Thm constitutes a promising antinociceptive drug including beta-adrenergic and serotoninergic targets. The present study warrants further investigation to determine the side effects of this compound.
- | morphine sulphate / Generic mfg.
Journal: Psychiatric risk factors for chronic high-dose opioid prescribing: register-based cohort study. (Pubmed Central) - Apr 20, 2023
Psychiatric disorders increase the risk of developing CHD opioid use in patients newly receiving prescription opioids. To reduce the public health burden of CHD opioid use, careful monitoring and optimal treatment of psychiatric conditions are advised when opioid therapy is initiated.
- | morphine sulphate / Generic mfg., paracetamol / Generic mfg.
Journal: Association of Patient-Reported Anxiety and Pain After Alveolar Bone Grafting. (Pubmed Central) - Apr 20, 2023
We identified an association for patient-reported anxiety and perioperative opioid use and pain in a CLP cohort undergoing ABG. Future considerations in preoperative patient and family consultation may be indicated in patients self-reporting higher anxiety in an effort to minimize perioperative opioid usage.
- | morphine sulphate / Generic mfg.
Journal, Head-to-Head: Comparison of two doses of intrathecal morphine in laparoscopic donor hepatectomy: A randomized double-blinded non-inferiority trial. (Pubmed Central) - Apr 20, 2023
Future considerations in preoperative patient and family consultation may be indicated in patients self-reporting higher anxiety in an effort to minimize perioperative opioid usage. For laparoscopic donor hepatectomy, preoperative ITM 300
- | Journal: Effects of magnesium sulfate on periarticular infiltration analgesia in total knee arthroplasty: a prospective, double-blind, randomized controlled trial. (Pubmed Central) - Apr 19, 2023
For laparoscopic donor hepatectomy, preoperative ITM 300 The addition of magnesium sulfate to the analgesic cocktail for PIA can prolong postoperative analgesia, decrease the consumption of opioids, and effectively alleviate early postoperative pain after TKA.
- | morphine sulphate / Generic mfg.
Journal: Heroin-induced osteoporosis presented with bilateral femoral neck insufficiency fractures in a male adult: a case report. (Pubmed Central) - Apr 19, 2023
The aim of this report is to highlight the laboratory and radiology findings in a case of osteoporosis caused by opioid addiction and discuss the potential pathway by which osteoporosis is induced by opioids. When an unusual osteoporosis presents with insufficiency fractures, heroin-induced osteoporosis should be considered.
- | morphine sulphate / Generic mfg.
Journal, Surgery: Analgesic effects of intrathecal morphine and bupivacaine during robotic-assisted surgery: A prospective randomized controlled study. (Pubmed Central) - Apr 19, 2023
Intrathecal morphine and bupivacaine to treat postoperative pain after robotic-assisted laparoscopic hysterectomy decrease total opioid consumption and NRS pain scores. This might be of great importance to diminish the rate of other serious disadvantages related to opioids.
- | methadone / Generic mfg.
Trial completion date, Trial primary completion date, Surgery: METASPINE: Methadone for Spinal Fusion Surgery. (clinicaltrials.gov) - Apr 18, 2023
P4, N=150, Recruiting, Sponsor: Aarhus University Hospital
This might be of great importance to diminish the rate of other serious disadvantages related to opioids. Trial completion date: Nov 2023 --> May 2024 | Trial primary completion date: Jul 2023 --> Feb 2024