morphine sulphate / Generic mfg. 
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 7 Diseases   379 Trials   379 Trials   12426 News 


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  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg., tramadol hydrochloride / Generic mfg.
    PROGNOSTIC IMPACT OF OPIOID USE PRIOR TO DIAGNOSIS OF MULTIPLE MYELOMA (Poster area) -  May 12, 2023 - Abstract #EHA2023EHA_1112;    
    In conclusion, the opioid analogue hierarchy may be a valuable prognostic tool indicating that MM patients in pain have shorter OS independent of ISS. Prognostic factor, Multiple myeloma, Bone disease
  • ||||||||||  morphine sulphate / Generic mfg., prednisone / Generic mfg.
    Thyroid cancer mimicking acute coronary syndrome (ENDOExpo) -  May 11, 2023 - Abstract #ENDO2023ENDO_2529;    
    Even though imaging to look for metastasis is usually not part of the protocol before radioactive iodine ablation, it could be considered in patients with high-risk features on the surgical pathology report. This could prevent possible complications related to thyrotropin-alpha by identifying patients at risk.
  • ||||||||||  nitroprusside / Generic mfg.
    Comparison of Sodium Nitroprusside and Urapidil in Laparoscopic Adrenalectomy for Pheochromocytoma (ENDOExpo) -  May 11, 2023 - Abstract #ENDO2023ENDO_795;    
    This data shows that to stabilize patient blood pressure in adrenalectomy for pheochromocytoma, preparation with ?1-blockers is significant. The use of Sodium Nitroprusside and Urapidil is equally effective for managing BP during adrenalectomy, however, Urapidil shows to have advantages due to its lower side effects compared to Nitroprusside.
  • ||||||||||  TARGETING MINIMAL CUMULATIVE OPIOID REQUIREMENTS IN BARIATRIC SURGERY (Room S503) -  May 11, 2023 - Abstract #SSAT2023SSAT_51;    
    Patients were retrospectively stratified based on adherence to a target aspect of the protocol: Group 1 received preoperative acetaminophen and gabapentin, as well as intraoperative ketorolac and ketamine, while Group 2 was characterized by non-adherence to at least 1 of the 4 medications perioperatively... Cumulative perioperative opioid use following elective bariatric surgery can be safely minimized by adherence to a multifaceted non-narcotic analgesic protocol.
  • ||||||||||  morphine sulphate / Generic mfg.
    Trial completion date, Trial primary completion date, Surgery:  Erector Spinae Plane Block Versus General Anesthesia in Breast Cancer Surgeries (clinicaltrials.gov) -  May 9, 2023   
    P=N/A,  N=120, Recruiting, 
    Including LB in multimodal pain management protocols proved effective in reducing opioid use while increasing mobilization in the immediate postoperative period. Trial completion date: Apr 2023 --> Jul 2023 | Trial primary completion date: Mar 2023 --> Jun 2023
  • ||||||||||  naloxone injection / Generic mfg., fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
    Journal:  Operational definition of precipitated opioid withdrawal. (Pubmed Central) -  May 8, 2023   
    People (N = 106) with opioid use disorder maintained on morphine received 0.4 mg intramuscular naloxone and completed self-report (Subjective Opiate Withdrawal Scale, SOWS), visual analog scale (VAS), Bad Effects and Sick, and observer ratings (Clinical Opiate Withdrawal Scale, COWS)...Data suggested that a change of 10 (15% MPE) and 6 (12% MPE) points on the SOWS and COWS, respectively, that occurred within 60 min of antagonist administration was identified by participants as a clinically meaningful increase in symptom severity. These data provide a method to begin examining precipitated opioid withdrawal.
  • ||||||||||  morphine sulphate / Generic mfg., aspirin / Generic mfg.
    Journal:  Lysionotin exerts antinociceptive effects in various models of nociception induction. (Pubmed Central) -  May 8, 2023   
    Thus, lysionotin exhibited peripheral and central antinociception through the modulation of vanilloid receptors, opioid receptors, and the glutamatergic system. Lysionotin possesses antinociceptive activity on adult mice that is mediated through both central and peripheral pathways.
  • ||||||||||  morphine sulphate / Generic mfg., methadone / Generic mfg.
    Trial completion date, Trial primary completion date:  Trial to Shorten Pharmacologic Treatment of Newborns With Neonatal Opioid Withdrawal Syndrome (NOWS) (clinicaltrials.gov) -  May 8, 2023   
    P3,  N=502, Recruiting, 
    Ketofol was determined to be a clinically acceptable combination for TIVA in premedicated rabbits. Trial completion date: Aug 2025 --> Dec 2025 | Trial primary completion date: Aug 2023 --> Dec 2023
  • ||||||||||  morphine sulphate / Generic mfg.
    Review, Journal:  Opium alkaloids, biosynthesis, pharmacology and association with cancer occurrence. (Pubmed Central) -  May 7, 2023   
    The extraction of pharmaceutically important alkaloids like morphine and codeine from poppy plant reflects the need for the most suitable and standard methods...Many evidence-based reviews suggest that opium consumption is directly linked or acts as a risk factor for different cancers. In this review, we highlight significant efforts related to research which have been done over the past 5 decades and the complete information on Papaver somniferum including its phytochemistry, pharmacological actions, biosynthetic pathways and analytical techniques of opium alkaloid extraction and the link between opium consumption and cancer-related updates.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal, Surgery:  Preoperative Activity Level and Postoperative Pain After Pelvic Reconstructive Surgery. (Pubmed Central) -  May 7, 2023   
    Factors associated with non-DMARD use represent a window of opportunity for intervention to improve pain-related quality of life in patients living with RA. A higher preoperative activity level among patients undergoing urogynecologic surgery was not associated with lower pain scores nor decreased opioid use.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Effect of Training on Physicians' Palliative Care-Related Knowledge and Attitudes in Vietnam. (Pubmed Central) -  May 7, 2023   
    Our basic palliative care course in Vietnam resulted in significant and enduring improvements among physicians in palliative care-related knowledge, attitudes, and self-assessed competence. To respond to the enormous unmet need for palliative care in LMICs, primary care providers and physician-specialists in many fields, among others, should receive palliative care training of proven effectiveness, receive ongoing mentoring or refresher training, and be given the responsibility and opportunity to practice what they learn.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Embedding a State-Wide Prescription Drug Monitoring Program into the Electronic Health Record. (Pubmed Central) -  May 6, 2023   
    The intervention automatically performs MME (morphine milligram equivalent) calculations, highlights unsafe thresholds, while also presenting controlled-substance medications each patient is using...This work has also led to accruing five bonus points from the Medicare promoting interoperability attestation program. This initiative, and others like it, have helped Intermountain Healthcare decrease controlled substance pills by nearly 11 million, in the past five years.
  • ||||||||||  morphine sulphate / Generic mfg., ketamine / Generic mfg.
    Trial completion date, Trial primary completion date, Surgery:  Annie-Dimitra: Morphine Versus Ketamine as Adjuvants in Paravertebral Blocks (clinicaltrials.gov) -  May 6, 2023   
    P=N/A,  N=90, Active, not recruiting, 
    This initiative, and others like it, have helped Intermountain Healthcare decrease controlled substance pills by nearly 11 million, in the past five years. Trial completion date: Apr 2023 --> Apr 2024 | Trial primary completion date: Apr 2023 --> Apr 2024
  • ||||||||||  morphine sulphate / Generic mfg., nefopam / Generic mfg., paracetamol / Generic mfg.
    Trial completion:  Nonopioid Analgesics and Cholecystectomy (clinicaltrials.gov) -  May 6, 2023   
    P3,  N=90, Completed, 
    Trial completion date: Apr 2023 --> Apr 2024 | Trial primary completion date: Apr 2023 --> Apr 2024 Recruiting --> Completed
  • ||||||||||  Relistor (methylnaltrexone bromide) / Ono Pharma, Bausch Health
    Journal:  Methylnaltrexone for Opioid-Induced Dysmotility in Critically Ill Infants and Children: A Pilot Study. (Pubmed Central) -  May 4, 2023   
    The results suggest that neither the type of articulation or constraint used for primary TKA has a significant impact on immediate post-operative pain and opioid consumption. Methylnaltrexone may be an effective treatment for opioid-induced dysmotility in critically ill pediatric patients with low risk of adverse effects.