morphine sulphate / Generic mfg. 
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  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Medical Cannabis in the Treatment of Parkinson's Disease. (Pubmed Central) -  May 20, 2023   
    The MC may improve motor and nonmotor symptoms in patients with PD and may allow for reduction of concomitant opioid medication use. Large, placebo-controlled, randomized studies of MC use in patients with PD are required.
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  Brain glucose metabolism and dopamine transporter changes in rats with morphine-induced conditioned place preference. (Pubmed Central) -  May 19, 2023   
    DAT expression alterations were only observed in the long-term morphine compared with the short-term morphine group. This study shows that cerebral glucose metabolism significantly altered during morphine administration and CPP process mainly in the mPFC, striatum and hippocampus, which indicates that the function of these brain regions is involved in cue-induced craving and memory retrieval.
  • ||||||||||  morphine sulphate / Generic mfg., dexamethasone injection / Generic mfg.
    Journal:  Perioperative Dexamethasone Associated With Decreased Length of Stay After Total Hip and Knee Arthroplasty. (Pubmed Central) -  May 19, 2023   
    Perioperative dexamethasone was associated with reduced LOS and decreased postoperative complications including PONV, pulmonary embolism, deep vein thrombosis, acute kidney injury, and urinary tract infection after TJA. Although perioperative dexamethasone was not associated with notable reductions in postoperative opioid utilization, this study supports the use of dexamethasone to decrease LOS through multifactorial mechanisms beyond decreased pain.
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  Multi-view image-based behavior classification of wet-dog shake in Kainate rat model. (Pubmed Central) -  May 18, 2023   
    The wet-dog shake behavior (WDS) is a short-duration behavior relevant to the study of various animal disease models, including acute seizures, morphine abstinence, and nicotine withdrawal...With three cameras, we achieved a precision of 0.91 and a recall of 0.86. Our multi-view animal behavior detection system represents the first system capable of detecting WDS and has potential applications in various animal disease models.
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  Behavioral mechanisms of oxycodone's effects in female and male rats: Reinforcement delay and impulsive choice. (Pubmed Central) -  May 18, 2023   
    ?-Opioid agonists (e.g., morphine) typically increase impulsive choice, which has been interpreted as an opioid-induced increase in sensitivity to reinforcement delay...However, drug-induced changes in impulsive choice could be related to at least two potential behavioral mechanisms: reinforcement delay and/or reinforcement magnitude. Effects of oxycodone on sensitivity to reinforcement magnitude remain to be fully characterized.
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal, IO biomarker:  Daphnetin alleviates neuropathic pain in chronic constrictive injury rats via regulating the NF-?B dependent CXCL1/CXCR2 signaling pathway. (Pubmed Central) -  May 17, 2023   
    Male Sprague-Dawley rats were divided into six groups: Control, Model, Sham, morphine (0.375?mg/kg), and daphnetin (0.0625 and 0.025?mg/kg)...Daphnetin decreased the expression of toll-like receptor 4 (TLR4) (0.47-fold), phosphorylated inhibitor of NF-?B (p-IKB?) (0.29-fold), nuclear factor kappaB (NF-?B) (0.48-fold), glial fibrillary acidic protein (GFAP) (0.42-fold), CXC chemokine ligand type 1 (CXCL1) (0.84-fold), CXC chemokine receptor type 2 (CXCR2) (0.78-fold) in the spinal cord. Daphnetin alleviates NP by inhibiting inflammation and astrocyte activation in the spinal cord, providing theoretical support for the extensive clinical treatment of NP.
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  Phosphorylation of Neurofilament Light Chain in the VLO Is Correlated with Morphine-Induced Behavioral Sensitization in Rats. (Pubmed Central) -  May 17, 2023   
    We found that although both chronic and acute morphine-induced behavioral sensitization were accompanied by an increase of p-CREB/p-NF-L, TSA exhibited opposing effects on behavioral phenotype and molecular changes at different addiction contexts. Thus, our findings revealed a novel role of NF-L in morphine-induced behavioral sensitization, and therefore provided some correlational evidence of the involvement of NF-L in opiate addiction.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal, Surgery:  A Standardized Protocol for Opioid Prescribing After Surgery Decreases Total Morphine Equivalents Prescribed. (Pubmed Central) -  May 17, 2023   
    Implementation of a standardized protocol for opioid prescribing after surgery decreases the total MME prescribed. Compliance with our protocol significantly reduced this disparity, which has the potential for decreasing abuse, misuse, and diversion of opioids by better estimating actual postoperative analgesic requirements.
  • ||||||||||  morphine sulphate / Generic mfg.
    Interdisciplinary Pain Rehabilitation Treatment Outcomes for Oncological Patients With Chronic Pain (Hall B Foyer, Exhibition Level Moscone South) -  May 17, 2023 - Abstract #APA2023APA_1267;    
    Our study demonstrates improvements in physical and psychological function across several pain-related measures among patients with a cancer history. IPRP treatment presents an additional patient care option for cancer survivors for whom chronic pain is functionally disruptive, stable, and not an indication of disease progression.
  • ||||||||||  morphine sulphate / Generic mfg., methadone / Generic mfg.
    Whats Cooking in the Kitchen? Drawing Parallels Between Two Newer Substances of Abuse, Kratom and Krokodil (Hall B Foyer, Exhibition Level Moscone South) -  May 17, 2023 - Abstract #APA2023APA_1206;    
    She remained seriously ill, yet threatened to discharge against medical advice if IV Morphine was not given...This poster aims to heighten awareness, which would help screen, diagnose and treat individuals using these substances earlier, as the eye does not see what the mind does not know. Knowledge of potential consequences of these substances can also help physicians educate their patients, particularly when a harm reduction approach is indicated.
  • ||||||||||  morphine sulphate / Generic mfg.
    The Prevalence and Predictors of Long-Term Opioid Use After Pelvic Fracture Secondary to Trauma (Hall B Foyer, Exhibition Level Moscone South) -  May 17, 2023 - Abstract #APA2023APA_634;    
    We can conclude that total and daily inpatient opioid use were each significantly associated with 60-90OP and 30-60OP, where there is a higher likelihood of post-discharge opioid use for patients who received >50 MME/inpatient day. Identifying the prevalence and risk factors for long-term opioid use after pelvic fractures requiring opioids for pain management is vital for informing clinical decision making to prevent adverse outcomes.
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  Intravenous Injection of GluR2-3Y Inhibits Repeated Morphine-Primed Reinstatement of Drug Seeking in Rats. (Pubmed Central) -  May 16, 2023   
    Pretreatment with GluR2-3Y altered the ability of LTD induction to the level of that in the naive group, while pretreatment with GluR2-3S had no effects on LTD. Our results demonstrated that the intravenous injection of GluR2-3Y, to block the endocytosis of AMPA receptors, inhibited the reinstatement of morphine-seeking behavior, which may be induced by modulating the neuronal plasticity in the NAc shell of rats.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Opioid: Plenitude versus pittance. (Pubmed Central) -  May 15, 2023   
    Millions of patients in LMICs, suffering from life-modifying cancer pain, do not have access to morphine and other essential opioids, due to restrictive opioid policies. Attention will be needed to improve opioid availability in large parts of the world, even though the opioid crisis has led to control the licit medical use in the USA.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Does a hip fracture mean we should we operate on a concomitant proximal humerus fracture? (Pubmed Central) -  May 15, 2023   
    There were no differences in inpatient LOS, ICU need, discharge location, or readmissions. Future larger, multicenter studies are needed to further delineate if operative repair of concomitant proximal humerus fractures provides a benefit in the geriatric population.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal, Surgery:  Opioid Prescribing Patterns in Body Contouring Surgery. (Pubmed Central) -  May 15, 2023   
    Our data provides information on opioid prescribing patterns in the body contouring population, with focused review of comorbid conditions and complications on opioid prescribing patterns. We hope that the data will improve opioid prescription habits among plastic surgeons in the setting of a global opioid crisis.
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  Probing different paradigms of morphine withdrawal on sleep behavior in male and female C57BL/6J mice. (Pubmed Central) -  May 15, 2023   
    We find that sleep deprivation dysregulates sleep in mice that had previous opioid withdrawal experience. Our data suggest that the 3-day precipitated withdrawal paradigm has the most profound effects on opioid-induced sleep dysregulation and further validates the construct of this model for opioid dependence and OUD.
  • ||||||||||  Rexulti (brexpiprazole) / Lundbeck, Otsuka
    Preclinical, Journal:  Preclinical evidence for the use of the atypical antipsychotic, brexpiprazole, for opioid use disorder. (Pubmed Central) -  May 15, 2023   
    However, brexpiprazole treatment did prevent the expression of opioid-induced hyperalgesia in a tail-withdrawal assay, while failing to improve somatic withdrawal symptoms. Altogether, these results provide preclinical evidence for the efficacy of brexpiprazole as a modulator of dopamine-dependent behaviors during opioid use and withdrawal.
  • ||||||||||  morphine sulphate / Generic mfg., chlorpromazine / Generic mfg.
    Journal:  Factors associated with euphoria in a large subset of cases using propofol sedation during gastrointestinal endoscopy. (Pubmed Central) -  May 14, 2023   
    The mean Pentobarbital-Chlorpromazine-Alcohol Group (PCAG) score before the procedure and after 30 min of the procedure was 3.24 and 6.22, respectively...There are several risk factors for the development of propofol addiction, including dreaming, propofol dose, duration of anesthesia, and etomidate dose. These findings suggest that propofol may have a euphoric effect and may have the potential for drug addiction and abuse.
  • ||||||||||  morphine sulphate / Generic mfg., hydromorphone hydrochloride / Generic mfg.
    Journal:  Managing opioid waste, cost, and opportunity for drug diversion in the emergency department. (Pubmed Central) -  May 13, 2023   
    As hospitals continue to seek strategies to reduce costs and mitigate the harms of opioid diversion amidst the opioid epidemic, this study shows that optimizing the dose of the stock vial to minimize waste using provider ordering patterns, could mitigate risk while also reducing cost. Limitations included the use of data from EDs within a single health system, drug shortages that affected stock vial availability, and finally, the actual cost of stock vials, used for cost calculations, can differ based on a variety of factors.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Naloxone could limit morphine hypersensitivity: Considering the molecular mechanisms. (Pubmed Central) -  May 13, 2023   
    Limitations included the use of data from EDs within a single health system, drug shortages that affected stock vial availability, and finally, the actual cost of stock vials, used for cost calculations, can differ based on a variety of factors. This study suggests that BDNF and KCC2 may be candidate molecules for decreased morphine tolerance and hyperalgesia.
  • ||||||||||  morphine sulphate / Generic mfg., oxycodone controlled release / Generic mfg.
    OPIOID USE REDUCTION BY OXYCODONE MORPHINE FORMULARY SWITCH () -  May 12, 2023 - Abstract #EHA2023EHA_3151;    
    Switching from oxycodone to morphine as the preferred oral opioid for hemato-oncology patients with pain reduces both the oral opioid use during admission and the number of patients with an oral opioid prescription at discharge. Since the reduction in opioid use resulted in no differences in overall pain control, the oxycodone morphine switch warrants further implementation.Figure 1: number of clinical prescriptions for opioids at the hematology ward Drug interaction, Side effects, Quality of life
  • ||||||||||  morphine sulphate / Generic mfg.
    ASSESSING ADHERENCE TO EMERGENCY DEPARTMENT PROTOCOLS FOR SICKLE CELL DISEASE: IMPLICATIONS FOR QUALITY OF CARE (Poster area) -  May 12, 2023 - Abstract #EHA2023EHA_1763;    
    Since the reduction in opioid use resulted in no differences in overall pain control, the oxycodone morphine switch warrants further implementation.Figure 1: number of clinical prescriptions for opioids at the hematology ward Drug interaction, Side effects, Quality of life The median cumulative morphine dose was 7.5 mg (IQR 5.0