- |||||||||| morphine sulphate / Generic mfg.
Retrospective data, Review, Journal, Surgery: Analgaesic efficacy of single-injection serratus anterior plane block for breast surgery: A systematic review, meta-analysis and trial sequential analysis of randomised controlled trials. (Pubmed Central) - Jun 12, 2023 The primary outcome was postoperative oral morphine equivalent (OME) consumption for up to 24 hours...Single-shot SAP reduced opioid consumption, prolonged analgaesia duration, lowered pain scores, and decreased the incidence of PONV compared to NBC. There was no statistically significant difference in the studied endpoints between SAP, PVB, and PECS blocks.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Sedation and Analgesia for Reduction of Pediatric Ileocolic Intussusception. (Pubmed Central) - Jun 11, 2023 The primary outcomes were opioid analgesia within 120 minutes of reduction based on the therapeutic window of IV morphine and sedation immediately before reduction of intussusception...This cross-sectional study of pediatric ileocolic intussusception found that more than two-thirds of patients received neither analgesia nor sedation. Neither was associated with intestinal perforation or failed reduction, challenging the widespread practice of withholding analgesia and sedation for reduction of ileocolic intussusception in children.
- |||||||||| Sativex (nabiximols) / Jazz, Cesamet (nabilone) / Bausch Health, Viatris
Review, Journal: Cannabis-based medicines and medical cannabis for adults with cancer pain. (Pubmed Central) - Jun 11, 2023 There is low-certainty evidence that a single dose of synthetic THC analogues is not superior to a single low-dose morphine equivalent in reducing moderate-to-severe cancer pain. There is low-certainty evidence that CBD does not add value to specialist palliative care alone in the reduction of pain in people with advanced cancer.
- |||||||||| morphine sulphate / Generic mfg.
The role of orexin type-1 receptors in the development of morphine tolerance in locus coeruleus neurons (Montreal Bonaventure Hotel (CAN meeting headquarters)) - Jun 10, 2023 - Abstract #CANACN2023CAN_ACN_706; There is low-certainty evidence that CBD does not add value to specialist palliative care alone in the reduction of pain in people with advanced cancer. This study showed that OX1R blockade by SB-334867 prevents the development of morphine tolerance in LC neurons.
- |||||||||| morphine sulphate / Generic mfg.
Dopamine modulation of morphine drug discrimination in male and female rats. (Montreal Bonaventure Hotel (CAN meeting headquarters)) - Jun 10, 2023 - Abstract #CANACN2023CAN_ACN_568; Background: One aspect of opioid use disorder is the elicitation of behaviours by drug cues. Our findings lend support to a mechanism of OS involving gating of CS-induced dopamine release by FP or FN drug states.
- |||||||||| morphine sulphate / Generic mfg.
Reduced cage-lid hanging behaviour in mouse: the role of endogenous opioid, cannabinoid, and corticosteroid systems (Montreal Bonaventure Hotel (CAN meeting headquarters)) - Jun 10, 2023 - Abstract #CANACN2023CAN_ACN_562; To investigate if opioidergic modulation participates in hanging behaviour, mice received morphine (1mg/Kg) or naloxone (3mg/Kg) IP, 30 minutes before assessing hanging behaviour...Animals under corticosterone treatment displayed a significant increase in immobility in the forced swim test on week 4, compatible with depression states, and a significant decrease in hanging (p<0.01; 2way ANOVA + Bonferroni). These findings suggest that hanging behaviour is modulated by opioidergic and endocannabinoid signaling, and its depression seems to be related to anhedonia.
- |||||||||| morphine sulphate / Generic mfg.
Clinical data, Journal: Preoperative Opioid Prescribers and Lumbar Fusion: Their Effect on Clinical Outcomes and Postoperative Opioid Usage. (Pubmed Central) - Jun 10, 2023 Multiple preoperative opioid prescribers predicted increased improvement in postoperative back pain, whereas preoperative involvement of a nonoperative spine provider predicted improvements in leg pain after surgery. The number of preoperative opioid prescriptions was a better metric for predicting poor postoperative outcomes and increased opioid consumption compared with the number of preoperative opioid prescribers.
- |||||||||| morphine sulphate / Generic mfg.
Journal, Surgery: Opioid Utilization after Scoliosis Surgery Is Greater in Marfan Syndrome than Adolescent Idiopathic Scoliosis. (Pubmed Central) - Jun 9, 2023 Together, these data suggest that male and female rats exposed to morphine during critical developmental periods are less motivated to participate in social play, potentially due to alterations in oxytocin-mediated reward signaling. Despite a similar intervention, patients with MFS and AIS seem to differ in their postoperative opioid usage after PSF, presenting an opportunity for further research to assist clinicians to better anticipate the analgesic needs of individual patients, particularly in light of the ongoing opioid epidemic.
- |||||||||| morphine sulphate / Generic mfg.
Preclinical, Journal: Ferulic acid-loaded nanostructure prevents morphine reinstatement: the involvement of dopamine system, NRF2, and ?FosB in the striatum brain area of rats. (Pubmed Central) - Jun 8, 2023 Morphine exposure increased the dopaminergic markers (D1R, D3R, DAT) and ?FosB immunoreactivity in the ventral striatum; however, FA-Nc treatment decreased D1R, D3R, and ?FosB and increased D2R, DAT, and NRF2. In conclusion, FA-Nc treatment prevented the morphine reinstatement, promoted antioxidant activity, and modified the dopaminergic neurotransmission, NRF2, and ?FosB, what may indicate a neuroprotective and antioxidant role of this nanoformulation.
- |||||||||| fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
Journal: Opioid prescribing patterns by drug type: The Pennsylvania experience. (Pubmed Central) - Jun 8, 2023 While fewer prescriptions were being prescribed overall, the breakdown of drug type being prescribed remained similar in 2020 compared to 2016. Fentanyl and hydrocodone saw the largest decrease between 2016 and 2020.
- |||||||||| morphine sulphate / Generic mfg.
Journal: New legislation in New Jersey reduced opioid use among trauma patients. (Pubmed Central) - Jun 8, 2023 Overall, opioid consumption was lower in 2018 without negatively affecting the quality of pain management. This suggests that the implementation of the new legislation has successfully reduced inpatient opioid use.
- |||||||||| dorsomorphin (Compound C) / EMD Serono
Preclinical, Journal: Mitochondrial-Derived Peptide MOTS-c Ameliorates Spared Nerve Injury-Induced Neuropathic Pain in Mice by Inhibiting Microglia Activation and Neuronal Oxidative Damage in the Spinal Cord via the AMPK Pathway. (Pubmed Central) - Jun 7, 2023 Accordingly, MOTS-c treatment produced pronounced dose-dependent antinociceptive effects in SNI mice; however, these effects were blocked by dorsomorphin, an AMPK inhibitor, but not naloxone, a nonselective opioid receptor antagonist...The antinociceptive effects of MOTS-c were retained even when microglia activation in the spinal cord was inhibited by minocycline pretreatment, indicating that spinal cord microglia are dispensable for the antiallodynic effects of MOTS-c...Finally, in contrast to morphine, i.t. administration of MOTS-c resulted in limited side effects relating to antinociceptive tolerance, gastrointestinal transit inhibition, locomotor function, and motor coordination. Collectively, the present study is the first to provide evidence that MOTS-c may be a promising therapeutic target for neuropathic pain.
- |||||||||| morphine sulphate / Generic mfg.
Journal, Surgery: Opioid-Sparing Protocol for Endocrine Surgery (OSPREY): A Prospective Study. (Pubmed Central) - Jun 7, 2023 An opioid-sparing treatment algorithm based on use of acetaminophen/ibuprofen may offer a safe and effective treatment algorithm compared to a primary opioid focused treatment pathway. Randomized adequately-powered studies are needed to confirm these findings.
- |||||||||| morphine sulphate / Generic mfg.
Journal, Adherence: Neurocognitive predictors of adherence to an online pain self-management program adjunct to long-term opioid therapy. (Pubmed Central) - Jun 6, 2023 A secondary analysis of a randomized controlled trial testing the impact of E-health (a 4-month subscription to the online Goalistics Chronic Pain Management Program) plus treatment as usual, relative to treatment as usual alone, on pain and opioid dose outcomes in adults receiving long-term opioid therapy of morphine equivalence dose ?20 mg; 165 E-health participants who completed an on-line neurocognitive battery were included in this sub-analysis...Future research to replicate and extend these findings seems warranted. NCT03309188.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Grit and postoperative opioid use after total joint arthroplasty. (Pubmed Central) - Jun 6, 2023 Those who completed their logs and a grit questionnaire had their average morphine equivalent dose (MED) and grit score calculated...There is not an apparent association between grit score and postoperative opioid consumption in the first 2?weeks after total joint arthroplasty. General psychological resiliency may not be an important predictor of postoperative opioid use with modern postoperative protocols.
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