- |||||||||| morphine sulphate / Generic mfg.
Journal: Tapering of opioid-based pain treatment for chronic pain patients in an outpatient setting (Pubmed Central) - Jun 21, 2023
Opioid treatments above 50 milligrams morphine equivalents (MME) per day are associated with an increased risk of morbidity and mortality...Inability to taper may require further reassessment of opioid dependence. Temporary increases in pain may occur at the start of tapering, but pain may improve or remain unchanged upon completion of tapering.
- |||||||||| Review, Journal: Recent advances in the detection of drugs of abuse by Dried Blood Spots. (Pubmed Central) - Jun 21, 2023
The most recent, innovative and fully validated methods for the qualitative and/or quantitative detection of common drugs of abuse are reported, including alprazolam, clonazepam, diazepam, 3,4-methylenedioxymethamphetamine (MDMA), 3,4-methylenedioxyamphetamine (MDA), 3,4-methyl- enedioxyethylamphetamine (MDEA), amphetamine, methamphetamine, cocaine, tetrahydrocannabinol (THC), 6-monoacetylmorphine, morphine, codeine, hydromorphone, hydrocodone, oxycodone, noroxycodone, tramadol, methadone, buprenorphine, fentanyl, ketamine and their respective metabolites and ?-hydroxybutyric acid (GHB). DBS proved to be extremely promising for routine analysis of forensic cases, although large-scale experiments on real samples need to be performed to confirm the emerging advantages of the technique and remove the potential limitations still affecting its widespread application.
- |||||||||| morphine sulphate / Generic mfg.
DELAYED GASTRIC EMPTYING FOLLOWING PANCREATIC RESECTION: RISK FACTORS AND CLINICAL IMPACT AT A HIGH VOLUME INSTITUTION () - Jun 20, 2023 - Abstract #APCM2023APCM_174;
The average amount of opioids calculated as morphine milligram equivalent (MME) administered per day during the first post-operative week was similar in the 2 groups (20.9 MME [SD 12.6] vs. 19.1 MME [SD 14.3])... DGE remains an important and insidious clinical entity after PR and is associated with increased morbidity and prolonged hospitalization; in our experience we could not identify any strong modifiable factor related to it; continued investigation is desirable to help to better predict this complication, tailor clinical pathways accordingly and reduce relative costs.
- |||||||||| morphine sulphate / Generic mfg., tramadol hydrochloride / Generic mfg.
ASSOCIATION OF POSTOPERATIVE OPIOID USE WITH PANCREATIC FISTULA RATES AFTER DISTAL PANCREATECTOMY (Adams) - Jun 20, 2023 - Abstract #APCM2023APCM_32;
Early postoperative opioid use in the 3 days after distal pancreatectomy is associated with increased odds of CR-POPF, while other reported risk factors failed to show an association. Decreasing perioperative opioid use through standardized, opioid-minimizing care pathways is a low-cost and generalizable approach that may reduce rates of CR-POPF.
- |||||||||| morphine sulphate / Generic mfg.
Journal, Surgery: SLIM: Single Long-Incision Minimally Invasive Surgery. (Pubmed Central) - Jun 20, 2023
Decreasing perioperative opioid use through standardized, opioid-minimizing care pathways is a low-cost and generalizable approach that may reduce rates of CR-POPF. SLIM has similar operative time to PSF and is technically similar to PSF, while maintaining the surgical and post-operative outcome advantages of 3MIS.
- |||||||||| Prialt (ziconotide) / Jazz
Review, Journal: Intrathecal drug delivery in the management of chronic pain. (Pubmed Central) - Jun 20, 2023
In pain management, off-label use of medication and combination therapy is often reported. The specific action of the intrathecal drugs, the efficacy and safety, is described, as well as the modalities for trialing intrathecal drug delivery and the implantation methods.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Assessment of high-risk opioid use metrics among individuals with spinal cord injury: A brief report. (Pubmed Central) - Jun 19, 2023
Outcomes included: percentage of individuals prescribed chronic opioids, high-dose chronic opioid therapy (daily morphine milligram equivalents (MME) ?50 and ?90), and chronic concurrent opioids and benzodiazepines, sedatives, or hypnotics (BSH)...While the number of individuals receiving high-risk opioid prescriptions may not be large, it is a concerning number of prescriptions. The findings suggest a need for more cautious opioid prescribing and monitoring of high-risk use in adults with chronic SCI.
- |||||||||| simvastatin / Generic mfg., morphine sulphate / Generic mfg., pravastatin / Generic mfg.
Journal, Heterogeneity: MultiDS-MDA: Integrating multiple data sources into heterogeneous network for predicting novel metabolite-drug associations. (Pubmed Central) - Jun 19, 2023
Additionally, MultiDS-MDA showed outstanding performance compared with similar approaches. Case studies for three metabolites (cholesterol, thromboxane B2 and coenzyme Q10) and three drugs (simvastatin, pravastatin and morphine) also demonstrated the reliability and efficiency of MultiDS-MDA, and it is anticipated that MultiDS-MDA will serve as a powerful tool for future exploration of metabolite-drug interactions and contribute to drug development and drug combination.
- |||||||||| morphine sulphate / Generic mfg.
Preclinical, Journal: Buprenorphine reduces somatic withdrawal in a mouse model of early-life morphine exposure. (Pubmed Central) - Jun 19, 2023
Lastly, neonatal morphine exposure elevated mRNA expression of KOR, and reduced mRNA expression of corticotropin-releasing hormone (CRH) in the periaqueductal gray when measured on PND 14. Altogether, this data provides support for the therapeutic effects of acute low-dose buprenorphine treatment in a mouse model of neonatal opioid exposure and withdrawal.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Comparing Inpatient Management of Chronic Pelvic Pain Flares Before and After the COVID-19 Pandemic. (Pubmed Central) - Jun 19, 2023
Women with CPP received significantly more inpatient morphine, pain team reviews and were more likely to be discharged with strong opioids...Inpatient resource use for women with CPP remains high, investigations have low diagnostic yield and frequent instigation of opiates on discharge may risk dependence. Improved community care of CPP is needed to reduce emergency gynaecology resource utilisation.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Physical and Psychosocial Symptoms of Young Adult Patients Referred to the Supportive Care Mobile Team. (Pubmed Central) - Jun 19, 2023
We compared medical, psychosocial history, Morphine Equivalent Daily Dose (MEDD), Edmonton Symptom Assessment Scale (ESAS) scores, and Eastern Cooperative Oncology Group (ECOG) scores at the time of initial inpatient consultation with supportive care...Importantly, YAs with children was associated with higher ratings of pain, sleep difficulties, and financial distress. Overall, results suggest YAs may benefit from specialized services to address their unique psychosocial needs.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Pelvic ring injuries after alpine ski and snowboard accidents. (Pubmed Central) - Jun 19, 2023
Overall, results suggest YAs may benefit from specialized services to address their unique psychosocial needs. The majority of pelvic ring injuries from alpine ski and snowboard accidents were LC1 injuries, half of which were unstable, resulting in longer hospital stays, time to PT clearance/ambulation, and opioid use.
- |||||||||| Trial completion date, Trial primary completion date: Project 1 Aim 2, Adaptations of the Brain in Chronic Pain With Opioid Exposure (clinicaltrials.gov) - Jun 18, 2023
P2, N=80, Recruiting,
The majority of pelvic ring injuries from alpine ski and snowboard accidents were LC1 injuries, half of which were unstable, resulting in longer hospital stays, time to PT clearance/ambulation, and opioid use. Trial completion date: Apr 2023 --> Aug 2023 | Trial primary completion date: Mar 2023 --> Aug 2023
- |||||||||| morphine sulphate / Generic mfg., hydromorphone hydrochloride / Generic mfg.
Trial completion, Enrollment change, Trial completion date, Trial primary completion date: NCI-2018-01139: Levorphanol as a Second Line Opioid in Reducing Pain in Patients With Cancer (clinicaltrials.gov) - Jun 18, 2023
P1, N=43, Completed,
N=132 --> 0 | Not yet recruiting --> Withdrawn Active, not recruiting --> Completed | N=86 --> 43 | Trial completion date: Dec 2023 --> Jun 2023 | Trial primary completion date: Dec 2023 --> Jun 2023
- |||||||||| morphine sulphate / Generic mfg.
Exploring secondary breathlessness outcomes: the Morphine vs Placebo trial (PS-1 in poster area) - Jun 17, 2023 - Abstract #ERS2023ERS_4260;
Active, not recruiting --> Completed | N=86 --> 43 | Trial completion date: Dec 2023 --> Jun 2023 | Trial primary completion date: Dec 2023 --> Jun 2023 Palliative care; General respiratory patient care; Pulmonary function testing; Cell and molecular biology; Epidemiology; Public health; Imaging
- |||||||||| morphine sulphate / Generic mfg.
Pathophysiology and treatment of cough in ILD (Purple) - Jun 17, 2023 - Abstract #ERS2023ERS_4168;
In this presentation, the speaker will discuss the most recent insights in cough pathogenesis and update the audience on new evidence regarding pharmacological treatment of cough in ILD and ongoing trials. He will also update us on the PaciFy cough trial, an innovative RCT on the efficacy of morphine for cough in pulmonary fibrosis.; General respiratory patient care; Palliative care; Pulmonary rehabilitation
- |||||||||| morphine sulphate / Generic mfg.
Morphine for breathlessness in COPD (Silver) - Jun 17, 2023 - Abstract #ERS2023ERS_1338;
He will also update us on the PaciFy cough trial, an innovative RCT on the efficacy of morphine for cough in pulmonary fibrosis.; General respiratory patient care; Palliative care; Pulmonary rehabilitation This presentation will review the effect of regular, low-dose, extended-release morphine for chronic breathlessness in COPD, highlighting the study published by the speaker in JAMA.; Epidemiology; General respiratory patient care
- |||||||||| morphine sulphate / Generic mfg., tramadol hydrochloride / Generic mfg.
Biomarker, Journal: Long-term deprescription in chronic pain and opioid use disorder patients: Pharmacogenetic and sex differences. (Pubmed Central) - Jun 16, 2023
More than half of patients with opioid use disorder for chronic non-cancer pain (CNCP) reduced their dose through a progressive opioid withdrawal supported by a rotation to buprenorphine and/or tramadol...Effectiveness (< 50 mg per day of morphine equivalent daily dose without any aberrant opioid use behaviour) and safety (number of side-effects) were analysed in relation to sex differences and pharmacogenetic markers impact [OPRM1 genotype (rs1799971) and CYP2D6 phenotypes]...Long-term deprescription was successful in half of the cases. Understanding sex and gender interaction plus a genetic impact could help to design more individualized strategies for opioid deprescription.
- |||||||||| morphine sulphate / Generic mfg.
Review, Journal: Intrathecal opioids for the management of post-operative pain. (Pubmed Central) - Jun 16, 2023
This study focuses on intrathecal morphine (ITM) which is the only US Food and Drug Administration-approved opioid for intrathecal administration and remains the most commonly used as well as extensively studied...Patients receiving low-dose ITM can be nursed in regular surgical wards. The monitoring recommendations from societies such as the European Society of Regional Anaesthesia and Pain Therapy (ESRA), the American Society of Regional Anesthesia and Pain Medicine and the American Society of Anesthesiologists need to be updated so that the requirements for extended or continuous monitoring at postoperative care units (PACUs), step-down units, high-dependency units, and intensive care units can be eliminated, thereby reducing additional costs and inconvenience and making this simple, versatile and highly effective analgesia technique available to a wider patient population in resource-limited settings.
- |||||||||| morphine sulphate / Generic mfg.
Journal: BDNF-TrkB signaling pathway-mediated microglial activation induces neuronal KCC2 downregulation contributing to dynamic allodynia following spared nerve injury. (Pubmed Central) - Jun 16, 2023
Dynamic allodynia is insensitive to morphine treatment and is transmitted through the spinal dorsal horn by a specific neuronal pathway, which is different from that for punctate allodynia, leading to difficulties in clinical treatment...Finally, the BDNF-TrkB pathway mediated by activated microglial affected SNI-induced dynamic allodynia through neuronal KCC2 downregulation. Overall, our findings revealed that activation of microglia through the BDNF-TrkB pathway affected neuronal KCC2 downregulation, contributing to dynamic allodynia induction in an SNI mouse model.
- |||||||||| morphine sulphate / Generic mfg., hydromorphone hydrochloride / Generic mfg.
Journal: Rational Engineering of (S)-Norcoclaurine Synthase for Efficient Benzylisoquinoline Alkaloids Biosynthesis. (Pubmed Central) - Jun 14, 2023
Therefore, we identified vital NCS rate-enhancing mutations through the rational transition-state macrodipole stabilization method at the Quantum Mechanics/Molecular Mechanics (QM/MM) level. The results are a step forward for obtaining NCS variants able to biosynthesize (S)-norcoclaurine on a large scale.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Association between Opioid Requirement and Overall Survival in Patients with Spinal Metastases. (Pubmed Central) - Jun 13, 2023
Patients given opioids were divided into two groups: the opioid requirement group [?5 mg oral morphine equivalent (OME)/day] and the nonopioid group (<5 mg OME/day)...For patients with spinal metastases, opioid requirement was associated with shorter survival, independently of known prognostic factors. The patients were also more likely to have tumor-related spinal instability than those in the nonopioid group.
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