morphine sulphate / Generic mfg. 
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 7 Diseases   379 Trials   379 Trials   12426 News 


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  • ||||||||||  Journal:  Oral Cavity Fluid as an Alternative Postmortem Matrix: Comparison to Simultaneously Collected Blood and Urine Specimens. (Pubmed Central) -  Jul 7, 2023   
    Notable findings were benzoylecgonine (24 cases), ethyl sulfate (23 cases), acetaminophen (21 cases), morphine (21 cases), naloxone (21 cases), gabapentin (20 cases), fentanyl (17 cases), and 6-acetylmorphine (15 cases), which were detected more frequently in OCF than in blood (heart, femoral, or body cavity) or urine. This study suggests that OCF is a suitable matrix for detecting and quantifying analytes in postmortem subjects compared with traditional matrices, particularly when other matrices are limited or difficult to collect because of body condition or putrefaction.
  • ||||||||||  morphine sulphate / Generic mfg.
    Total pancreatectomy with islet auto-transplantation (TPIAT): Improving quality of life for patients with chronic pancreatitis at OHSU (Indigo 204) -  Jul 7, 2023 - Abstract #IPITAIXACTRMS2023IPITA_IXA_CTRMS_144;    
    Pain outcome was measured as the requirement of morphine equivalent units per day...Auto-transplantation of the Islets of Langerhans helps minimize post-surgical brittle diabetes; 73% of our patients demonstrate insulin independence or partial graft function. Though it is considered a highly invasive surgical procedure, it can provide significant pain relief, narcotic independence, and restoration of quality of life for chronic pancreatitis patients.
  • ||||||||||  morphine sulphate / Generic mfg., phenobarbital / Generic mfg.
    Review, Journal:  Neonatal Abstinence Syndrome: A Review of Treatment in the Neonatal Intensive Care Unit. (Pubmed Central) -  Jul 6, 2023   
    The common finding of polysubstance antenatal exposure, involving predominantly opioids, was associated with scheduled morphine pharmacotherapy for the majority of patients, prolonged hospitalization, and frequent adverse events. Pharmacotherapy for NAS was associated with levels of sedation that interfered with feeding in neonates.
  • ||||||||||  morphine sulphate / Generic mfg., alprazolam / Generic mfg.
    Trial completion date, Trial primary completion date:  MAP: Opioid/Benzodiazepine Polydrug Abuse: Aim 3 (clinicaltrials.gov) -  Jul 6, 2023   
    P2,  N=24, Recruiting, 
    Pharmacotherapy for NAS was associated with levels of sedation that interfered with feeding in neonates. Trial completion date: Dec 2024 --> Oct 2025 | Trial primary completion date: Aug 2024 --> Aug 2025
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  The effects of weight bearing after ACL reconstruction on joint contracture in rats. (Pubmed Central) -  Jul 5, 2023   
    Our results suggest that morphine administration improves myogenic contractures in parallel with an increase in the amount of weight bearing. Unloading after ACL reconstruction is effective in reducing both myogenic and arthrogenic contractures.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Effects of U.S. State Medical Cannabis Laws on Treatment of Chronic Noncancer Pain. (Pubmed Central) -  Jul 3, 2023   
    Proportion of patients receiving any opioid prescription, nonopioid prescription pain medication, or procedure for chronic noncancer pain; volume of each treatment type; and mean days' supply and mean morphine milligram equivalents per day of prescribed opioids, per patient in a given month...This study did not identify important effects of medical cannabis laws on receipt of opioid or nonopioid pain treatment among patients with chronic noncancer pain. National Institute on Drug Abuse.
  • ||||||||||  morphine sulphate / Generic mfg.
    Review, Journal:  Peripheralization Strategies Applied to Morphinans and Implications for Improved Treatment of Pain. (Pubmed Central) -  Jul 2, 2023   
    Among clinically used analgesics, opioids from the class of morphinans (i.e., morphine and structurally related analogues) are of utmost clinical importance as analgesic drugs activating the mu-opioid receptor...The preclinical and clinical research activities have allowed for the characterization of a variety of compounds that show low central nervous system penetration, and therefore an improved side effect profile, yet maintaining the desired opioid-related antinociceptive activity. Such peripheral opioid analgesics may represent alternatives to presently available drugs for an efficient and safer pain therapy.
  • ||||||||||  morphine sulphate / Generic mfg., methamphetamine / Generic mfg.
    Review, Journal:  Microglia NLRP3 Inflammasome and Neuroimmune Signaling in Substance Use Disorders. (Pubmed Central) -  Jul 2, 2023   
    Various types of abused drugs (cocaine, methamphetamine, alcohol, opiate-like drugs, marijuana, etc.) can modulate the activation status of microglia and neuroinflammation levels which are involved in the pathogenesis of SUDs...The research on this topic is still at an infant stage; however, the readily available findings suggest that NLRP3 inflammasome could be a common downstream effector stimulated by various types of abused drugs and play critical roles in determining abused-drug-mediated biological effects through enhancing glia-neuron communications. NLRP3 inflammasome might serve as a novel target for ameliorating the development of SUDs.
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  Evaluation of tarsal injuries in C57BL/6J male mice. (Pubmed Central) -  Jun 30, 2023   
    When tested just after being given morphine, the affected mice performed more similarly to unaffected mice, suggesting there is a pain sensation to this disease process. This highlights the importance of further characterizing inbred mouse mutations, as they may impact research programs or specific study goals.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal, Surgery:  Erector Spinae Plane (ESP) Block for Postoperative Pain Management after Open Oncologic Abdominal Surgery. (Pubmed Central) -  Jun 30, 2023   
    Accordingly, patients in the ESP group required less morphine from 60?minutes to 12?hours after surgery, but they required increased non-opioid postoperative analgesia management at 4, 8, and 12?hours after surgery (p from 0.002 to <0.001) compared to the control group. In this study, we found ESP blocks to be a safe, technically simple, and effective treatment for postoperative pain management after elective oncologic abdominal procedures.
  • ||||||||||  morphine sulphate / Generic mfg.
    PK/PD data, Preclinical, Journal:  Morphine pharmacokinetics and opioid transporter expression at the blood-retina barrier of male and female mice. (Pubmed Central) -  Jun 30, 2023   
    In addition, fluorescence extravasation studies revealed that chronic morphine treatment did not alter the permeability of either the BBB or BRB. Together, these data suggest that reduced P-gp expression mediates retinal morphine accumulation upon systemic delivery, and in turn, potential effects on circadian photoentrainment.
  • ||||||||||  morphine sulphate / Generic mfg.
    Retrospective data, Journal:  A retrospective analysis of pain and opioid usage in head and neck free flap reconstruction. (Pubmed Central) -  Jun 29, 2023   
    Data captured included demographics, postoperative inpatient pain, pain at postoperative visits, morphine equivalent doses (MEDs) administration, medication history, and comorbidities...We found a poor association between MEDs administered and patient-reported pain scores, which suggests that standardized protocols aimed at optimizing analgesia while reducing opioid administration may be warranted. Level of Evidence: 3 (Retrospective cohort study).
  • ||||||||||  Avastin (bevacizumab) / Roche
    Journal:  Postoperative Pain Following Coblation of Sinonasal Hereditary Hemorrhagic Telangiectasias. (Pubmed Central) -  Jun 28, 2023   
    This is a longitudinal, prospective cohort study of adult patients undergoing endoscopic endonasal coblation for treatment of HHT lesions with or without bevacizumab injection between November 2019 and March 2020 at a single academic university hospital...Opioids were ordered on discharge in 4 cases and the average morphine milligram equivalent prescribed on discharge was 41...Postoperative pain was mild to moderate and most patients stopped using opioid medications by POD 4, although the majority of patients solely used acetaminophen. Future studies with increased sample size will be useful to further identify predictors of need for analgesics postoperatively and other non-opioid adjuncts for pain control.
  • ||||||||||  Journal:  A Novel UHPLC-MS/MS Method for the Quantification of Seven Opioids in Different Human Tissues. (Pubmed Central) -  Jun 28, 2023   
    Future studies with increased sample size will be useful to further identify predictors of need for analgesics postoperatively and other non-opioid adjuncts for pain control. Results in terms of linearity, accuracy, precision, recovery and matrix effect fitted the recommendations of FDA and EMA guidelines, and the sensitivity was high enough to allow successful application on human autoptic specimens from an ethically approved clinical study, confirming its eligibility for post-mortem pharmacological/toxicological studies.
  • ||||||||||  phenytoin / Generic mfg.
    Preclinical, Journal:  Phenytoin Decreases Pain-like Behaviors and Improves Opioid Analgesia in a Rat Model of Neuropathic Pain. (Pubmed Central) -  Jun 28, 2023   
    This is the first study to report that phenytoin improves morphine-induced antinociceptive effects and influences microglia/macrophage activity at the spinal cord and dorsal root ganglion levels in a neuropathic pain model. Our findings support the hypothesis that phenytoin may represent an effective strategy for neuropathic pain management in clinical practice, particularly when combination with opioids is needed.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  IPAC integrates rewarding and environmental memory during the acquisition of morphine CPP. (Pubmed Central) -  Jun 27, 2023   
    A projection from the VTA GABAergic neurons (VTA) to the IPAC lateral region GABAergic neurons (IPACL) mediated the effect of morphine rewarding, whereas the pathway from NAcSh dopamine receptor 1-expressing neurons (NAcSh) to the IPAC medial region GABAergic neurons (IPACM) was involved in the acquisition of environmental memory. These findings demonstrated that the distinct IPAC circuits VTA?IPACL and NAcSh?IPACM were attributable to the rewarding and environmental memory during the acquisition of morphine CPP, respectively, and provided the circuit-based potential targets for preventing and treating opioid addiction.
  • ||||||||||  fentanyl citrate / Generic mfg., remifentanil / Generic mfg., morphine sulphate / Generic mfg.
    Review, Journal:  Opioids for procedural pain in neonates. (Pubmed Central) -  Jun 27, 2023   
    The evidence is very uncertain about the effect of opioids on any outcome when compared to non-pharmacological interventions or to other analgesics. We identified no studies comparing opioids to other opioids or comparing different routes of administration of the same opioid.
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg., methadone / Generic mfg.
    PK/PD data, Review, Journal:  Long-Acting Opioid Analgesics for Acute Pain: Pharmacokinetic Evidence Reviewed. (Pubmed Central) -  Jun 27, 2023   
    Because of its safety profile and regulatory status, buprenorphine is more accessible than morphine, methadone, and fentanyl. This review of PK studies coupled with the well-established safety profile of buprenorphine suggests that the accelerated approval pathways may be available for this new family of LAI veterinary pharmaceuticals.
  • ||||||||||  morphine sulphate / Generic mfg.
    PACAP as a therapeutic target for Medication Overuse Headache () -  Jun 26, 2023 - Abstract #ANA2023ANA_126;    
    We found that the PACAP-PAC1 receptor antagonist, M65, reversed chronic allodynia in a model which combines morphine with the migraine trigger, nitroglycerin...Furthermore, in situ hybridization studies show a clear overlap between the mu opioid receptor and PACAP or PAC1 in migraine processing regions. This work suggests that the PACAPergic system facilitates the transition to chronic headache following opioid use, and strategies targeting this system may be particularly beneficial for MOH.
  • ||||||||||  morphine sulphate / Generic mfg., dexmedetomidine / Generic mfg.
    Journal:  Effect of common sedation agents on feline splenic size determined via ultrasonography. (Pubmed Central) -  Jun 22, 2023   
    Sedation with IM dexmedetomidine and morphine did not change splenic size, whereas acepromazine or alfaxalone and morphine increased it regardless of the degree of sedation. Where splenomegaly is identified in a cat sedated with acepromazine or alfaxalone, the effects of the sedation protocol could be considered as a possible cause.