morphine sulphate / Generic mfg. 
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  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Biosynthesis of kratom opioids. (Pubmed Central) -  Jul 31, 2023   
    Mitragynine, an analgesic alkaloid from the plant Mitragyna speciosa (kratom), offers a safer alternative to clinical opioids such as morphine, owing to its more favorable side effect profile...Through these breakthroughs, we achieved the microbial biosynthesis of kratom opioids for the first time. The remarkable enzyme promiscuity suggests the possibility of generating derivatives and analogs of kratom opioids in heterologous systems.
  • ||||||||||  morphine sulphate / Generic mfg.
    Opioid-Induced Esophageal Dysfunction in Current and Former Opioid Users (Exhibit Hall) -  Jul 29, 2023 - Abstract #ACG2023ACG_3744;    
    Average age was 65.9 years, average BMI was 24.8, and 66.1% (156/236) were female (Table 1). 41.1% (97/236) were current opioid users, and 38.1% (90/236) had prior exposure to more than one opioid.
  • ||||||||||  morphine sulphate / Generic mfg.
    Review, Journal:  Narcotic analgesics. (Pubmed Central) -  Jul 29, 2023   
    The normalization of labs confirms the benign nature of SOD and can help explain recurrence. Charles Louis Derosne and Fredrich Wilhelm Adam Serturner isolated morphine from raw opium in 1802 and 1806 respectively, and it was Sert
  • ||||||||||  morphine sulphate / Generic mfg.
    Retrospective data, Journal:  Blended (Combined Spinal and General) vs. General Anesthesia for Abdominal Hysterectomy: A Retrospective Study. (Pubmed Central) -  Jul 29, 2023   
    Intrathecal administration of morphine with or without local anesthetic as a component of blended anesthesia is effective in improving postoperative pain control following laparoscopic or mini-laparotomic hysterectomy, in reducing intraoperative opioid consumption, in decreasing postoperative rescue analgesics consumption and the need for any additional analgesic technique. We recommend managing postoperative pain with a strategy tailored to the patient's physical status and the type of surgery, preventing and treating side effects of pain treatments.
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
    Journal:  Predictors of opioid requirement among patients receiving free flap reconstruction to the head and neck. (Pubmed Central) -  Jul 27, 2023   
    Preoperative opioid use was associated with higher postoperative opioid requirements. Multimodal pain management (MMPM) was not associated with a decreased opioid requirement; however, further studies are needed to investigate the hierarchy, dosing, and timing of MMPM in relation to opioid requirements and pain control.
  • ||||||||||  morphine sulphate / Generic mfg.
    Enrollment closed, Trial completion date, Adverse events:  Decreased Neuraxial Morphine After Cesarean Delivery (clinicaltrials.gov) -  Jul 27, 2023   
    P1,  N=87, Active, not recruiting, 
    Multimodal pain management (MMPM) was not associated with a decreased opioid requirement; however, further studies are needed to investigate the hierarchy, dosing, and timing of MMPM in relation to opioid requirements and pain control. Recruiting --> Active, not recruiting | Trial completion date: Jul 2023 --> Dec 2023
  • ||||||||||  morphine sulphate / Generic mfg.
    Observational data, Journal:  Longitudinal dose patterns among patients newly initiated on long-term opioid therapy in the United States, 2018 to 2019: an observational cohort study and time-series cluster analysis. (Pubmed Central) -  Jul 27, 2023   
    Patients were stratified into 4 categories based on their mean daily dosage during a 90-day baseline period (<50, 50-89, 90-149, and ?150 morphine milligram equivalent [MME]) and followed for a 270-day follow-up period...One cluster in each baseline dosage category comprised opioid dosage trajectories with decreases in dosage at the end of the follow-up period (80.7%, 98.7%, 98.7%, and 99.0%, respectively), discontinuation (58.5%, 80.0%, 79.3%, and 81.7%, respectively), and rapid tapering (50.8%, 85.8%, 87.5%, and 92.9%, respectively). These findings indicate multiple clusters of patients newly initiated on long-term opioid therapy who experience discontinuation and rapid tapering and highlight potential areas for clinician training to advance evidence-based guideline-concordant opioid prescribing, including strategies to minimize sudden dosage changes, discontinuation, or rapid tapering, and the importance of shared decision-making.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Acute Pain Management for Patients Maintained on Sublingual Buprenorphine as Medication for Opioid Use Disorder. (Pubmed Central) -  Jul 27, 2023   
    These findings indicate multiple clusters of patients newly initiated on long-term opioid therapy who experience discontinuation and rapid tapering and highlight potential areas for clinician training to advance evidence-based guideline-concordant opioid prescribing, including strategies to minimize sudden dosage changes, discontinuation, or rapid tapering, and the importance of shared decision-making. For OUD patients in need of acute pain management, the continuation of sublingual buprenorphine throughout hospitalization at a daily dose of >12 mg/d compared with ?12 mg/d did not confer a significant difference in daily average MME requirements.
  • ||||||||||  morphine sulphate / Generic mfg., methadone / Generic mfg.
    Journal:  Pragmatic, randomized, blinded trial to shorten pharmacologic treatment of newborns with neonatal opioid withdrawal syndrome (NOWS). (Pubmed Central) -  Jul 26, 2023   
    P3
    The proposed study is a pragmatic trial to determine whether a rapid-weaning intervention reduces the number of days of opioid treatment, compared to a slow-weaning intervention, and we powered the proposed study to detect a 2-day difference in the length of treatment. Hospitals will be able to use either morphine or methadone with the knowledge that we may find a positive treatment effect for both, one, or neither drugs.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Increase in Deltoid Compartment Pressures Immediately After Arthroscopic Rotator Cuff Repair (Pubmed Central) -  Jul 26, 2023   
    The pain journals were collected at the first postoperative visit, and opioid consumption was calculated based on morphine equivalents...No significant correlation between increase in individual or overall deltoid compartment pressures after ARCR and postoperative opioid consumption in the immediate postoperative period was found in this study. Level II, prospective cohort study.
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
    Review, Journal:  Old Drugs and New Challenges: A Narrative Review of Nitazenes. (Pubmed Central) -  Jul 24, 2023   
    These drugs pose a particular challenge since there is little experience in how to reverse a nitazene overdose or potential drug-drug or drug-alcohol interactions. Public health efforts are needed to better inform street drug consumers, first responders, healthcare professionals, and the general public about these "new old drugs" that are infiltrating the recreational drug supply.
  • ||||||||||  morphine sulphate / Generic mfg., hydromorphone hydrochloride / Generic mfg.
    Journal, Adverse events:  Paediatric harmful adverse drug events (PHADE). (Pubmed Central) -  Jul 24, 2023   
    Our prospective analysis and compilation of harmful medication errors in paediatric hospital practice, reported with denominators of opioid administrations, and patient bed days, is a new standard for comparison in the long-discussed problem of paediatric harmful adverse drug events. By focusing on identified problematic drugs, error types, and contributory factors, we identify opportunities for interventions, error prevention and harm reduction.
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
    Review, Journal:  Once again... breakthrough cancer pain: an updated overview. (Pubmed Central) -  Jul 22, 2023   
    Although oral opioids may still have specific indications, fentanyl products have been found to be more rapid and effective...In contrast, regulatory studies have suggested to use the minimal available dose to be titrated until the effective dose. Further large studies should definitely settle this never ended question.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  More Than 80% of the World's Morphine Goes to North America, Europe. (Pubmed Central) -  Jul 21, 2023   
    Direction from governing bodies is an important next step to incorporate these adjuncts into routine clinical practice to manage pain and reduce the amount of opioids prescribed and consumed after arthroscopic surgery. No abstract available
  • ||||||||||  morphine sulphate / Generic mfg.
    Trial completion date, Trial primary completion date:  Ultrasound Guided Erector Spinae Plane Block vs Intrathecal Morphine (clinicaltrials.gov) -  Jul 21, 2023   
    P4,  N=120, Recruiting, 
    No abstract available Trial completion date: Apr 2023 --> Aug 2023 | Trial primary completion date: Apr 2023 --> Aug 2023
  • ||||||||||  morphine sulphate / Generic mfg., ketamine / Generic mfg.
    Phase classification:  KLOE: Ketamine Low dOse Evaluation on Morphine Consumption in Traumatic Patient (clinicaltrials.gov) -  Jul 21, 2023   
    P3,  N=140, Recruiting, 
    Trial completion date: Apr 2023 --> Aug 2023 | Trial primary completion date: Apr 2023 --> Aug 2023 Phase classification: P4 --> P3
  • ||||||||||  morphine sulphate / Generic mfg.
    Intrathecal Administration Of Morphine Induces Itching Behavior, Which 5ht3 Receptor Antagonists Can Ameliorate. (Hall D-9) -  Jul 20, 2023 - Abstract #ASA2023ASA_3297;    
    Not yet recruiting --> Recruiting To assess the serotonergic involvement, the same experiment was performed against the pretreatment of serotonin-depleted toxin para-chlorophenylalanine (PCPA, 150 mg/kg for four days) and 5HT3 receptor antagonist ondansetron (OND: 0.05, 0.1, 0.5 mg/kg i.t. administration 1 hour before morphine administration)...However, GRPR antagonist RC3095 (1 nmol) co-administered with morphine did not suppress SBL behavior (morphine 30 nmol: 47.2
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
    Opiate Administration And Respiratory Events Overnight After Bariatric Surgery. (Hall D-11) -  Jul 20, 2023 - Abstract #ASA2023ASA_2941;    
    However, there was no significant difference in opioid use between OSA and non-OSA across all time points and in total across the 18 hr. Opiate administration cannot be invoked as a cause for the increased number of RE.
  • ||||||||||  morphine sulphate / Generic mfg.
    Electroencephalographic Insights Into A Dying Brain (Exhibit Hall) -  Jul 20, 2023 - Abstract #ASA2023ASA_2861;    
    The patient died 45 minutes after the end of therapy, with morphine supplementation in the presence of family members...Frontiers in Aging Neuroscience 2022; (3) Martial C, et al. Trends Cogn Sci 2020
  • ||||||||||  Maternal Cardiopulmonary Resuscitation (South: Hall D-7) -  Jul 20, 2023 - Abstract #ASA2023ASA_2622;    
    Your spinal dose consists of 12mg of 0.75% hyperbaric bupivacaine, 15mcg of fentanyl and 150mcg of preservative-free morphine...You administer 2 grams of intravenous cefazolin...After informing the obstetricians, you place a non-rebreather face mask at 8L/min, bolus 100mcg of phenylephrine, increase the infusion to 100mcg/min and give 50mg of diphenhydramine intravenously...1mg of epinephrine is given...The patient is transported to the ICU for cooling and recovery. Both the patient and her baby are discharged from the hospital two weeks later with no permanent sequelae.