morphine sulphate / Generic mfg. 
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  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Influence of chronic administration of morphine and its withdrawal on the behaviour of zebrafish. (Pubmed Central) -  Sep 8, 2023   
    In essence, this study offers a zebrafish model to comprehensively examine changes in behaviour of animals on opiate dependence and its withdrawal. The present study also reported that in zebrafish, the influence of chronic exposure of morphine modulates key gene targets involved in behaviour, neuroinflammation, and autophagy, which directly or indirectly are associated with morphine addiction in a chronic morphine model.
  • ||||||||||  morphine sulphate / Generic mfg.
    Observational data, Journal:  Efficacy of opioid-free anesthesia in modified radical mastectomy: a cross-sectional observational study. (Pubmed Central) -  Sep 7, 2023   
    We noticed morphine sparing at T0 and T12 with statistically significant differences P=0.043 and P=0.006, respectively. OFA could be considered in modified radical mastectomy management in female patients; nerve block seemed to act as morphine sparing in operative and postoperative settings by providing significantly less time to extubate with less postoperative morphine requirement.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Peripheral Nerve Catheter Reduces Postoperative Opioid Consumption and Pain in Revision Total Knee Arthroplasty. (Pubmed Central) -  Sep 7, 2023   
    To assess the primary outcome of opiate consumption, nursing documented opiate administration events were converted into morphine milligram equivalents per 24-hour interval...In rTKA patients, PNC can significantly reduce inpatient opioid consumption while maintaining a comparable functional recovery and superior pain control. Retrospective Cohort Study.
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  Distinctive roles of L-type calcium channels subtypes within the dorsal hippocampus in formation of morphine withdrawal-induced aversion in rats. (Pubmed Central) -  Sep 7, 2023   
    Firstly, we injected the non-specific LTCCs antagonist verapamil into the DH of morphine-dependent rats before conditioning an environment with naloxone-precipitated withdrawal...In morphine-dependent rats, conditioning with withdrawal increased Ca1.2 expression in the membrane, while only acute naloxone injection increased the membrane expression of Ca1.3...Ca1.2 siRNA, but not Ca1.3 shRNA, inhibited the acquirement of CPA and relieved somatic withdrawal symptoms. Together, our findings reveal that Ca1.2, but not Ca1.3 plays an important role in mediating morphine withdrawal, suggesting this subtype may serve as a potential therapeutic target for the treatment of negative effects in opiate dependence.
  • ||||||||||  morphine sulphate / Generic mfg.
    Trial completion, Trial primary completion date, Surgery, Bariatric surgery:  Benefits of Opioid Free Anesthesia on Morphine Consumption in Gastric Bypass (clinicaltrials.gov) -  Sep 5, 2023   
    P=N/A,  N=183, Completed, 
    Preoperative ITM administration resulted in a significantly lower incidence of moderate-to-severe pain within 24 postoperative hours after laparoscopic donor hepatectomy than after open donor hepatectomy. Recruiting --> Completed | Trial primary completion date: Dec 2022 --> Sep 2022
  • ||||||||||  morphine sulphate / Generic mfg.
    Trial initiation date, Surgery:  Postoperative pain and outcomes using spinal analgesia in hepatobiliary-pancreatic surgery (EUDRACT) -  Sep 2, 2023   
    P=N/A,  N=273, Completed, 
    Altered social behaviors in male morphine-sired adolescents indicate that the changes in drug-taking behavior in adults sired by morphine-exposed sires may be due to more complex factors not yet fully assessed. Initiation date: Apr 2000 --> Apr 2022
  • ||||||||||  morphine sulphate / Generic mfg.
    Reimbursement, US reimbursement, Journal, Medicare:  Approach-Based Complication Rates of Total Hip Arthroplasty in the Medicare Population. (Pubmed Central) -  Sep 1, 2023   
    The DAA to THA resulted in shorter surgical time, length-of-stay, and increased likelihood of discharge to HHA or self-care when compared with the PA. There were no differences in opioid consumption and complications leading to 90-day readmission.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal, Surgery:  Variability in Opioid Prescribing Among Plastic Surgery Residents After Bilateral Breast Reduction. (Pubmed Central) -  Aug 31, 2023   
    Excessive and variable opioid prescriptions among plastic surgery residents highlight the need for opioid prescribing education early in surgical training and improved oversight and communication with attending surgeons. Furthermore, implementation of evidence-based opioid-conscious analgesic protocols after common surgical procedures may improve patient safety by standardizing postoperative analgesic prescriptions.
  • ||||||||||  metamizole / Generic mfg., morphine sulphate / Generic mfg.
    Retrospective data, Journal:  Opioid versus non-opioid postoperative pain management in otolaryngology. (Pubmed Central) -  Aug 30, 2023   
    HMC demonstrated a significantly more permissive approach to both prescribing and consuming opioid medications for postoperative pain management than SMC for similar, common otolaryngological surgeries. Non-opioid alternatives and examining the cultural and medical practice-based differences contributing to the opioid epidemic should be discussed and reevaluated.
  • ||||||||||  morphine sulphate / Generic mfg., ketamine / Generic mfg., dexmedetomidine / Generic mfg.
    Trial completion date, Trial primary completion date, Surgery:  Dexmedetomidine and Ketamine in VATS Surgery (clinicaltrials.gov) -  Aug 30, 2023   
    P=N/A,  N=120, Recruiting, 
    Recruiting --> Completed Trial completion date: Jul 2024 --> Jul 2025 | Trial primary completion date: Dec 2023 --> Dec 2024
  • ||||||||||  morphine sulphate / Generic mfg., tramadol hydrochloride / Generic mfg.
    Journal, Surgery:  Opioid dispensing in relation to arthroscopic knee surgery in Denmark from 2006 to 2018. (Pubmed Central) -  Aug 29, 2023   
    The incidence of opioids dispensed increased for all investigated procedures from 2006 to 2018. In the same period, the average amount of opioids dispensed within the first seven days after discharge decreased.
  • ||||||||||  morphine sulphate / Generic mfg., gabapentin / Generic mfg.
    Review, Journal:  Spinal Nerve Root Stimulation for Chronic Pain: A Systematic Review. (Pubmed Central) -  Aug 29, 2023   
    SNRS led to a mean 44% reduction in pain intensity, with a low level of certainty. In addition, there is some evidence to suggest that using SNRS is associated with reduced use of analgesics, including morphine and gabapentin.
  • ||||||||||  acetylcysteine solution / Generic mfg.
    Preclinical, Journal:  The potential protective effect of melatonin and N-acetylcysteine alone and in combination on opioid-induced testicular dysfunction and degeneration in rat. (Pubmed Central) -  Aug 28, 2023   
    Methadone (Met) is the most common treatment for opioid addiction...The present study aimed to evaluate the effect of melatonin and N-acetylcysteine (N) on morphine and Met-induced oxidative stress, apoptosis, suppression of blood sexual hormones, impairment in sperm parameters, and sexual dysfunction...Melatonin and N alone and particularly, in combination with each other improved testicular degeneration, sex hormone suppression, and testicular function mediated by increasing the testicular antioxidant capacity and inhibition of the apoptosis pathway. It's suggested that oral administration of antioxidants may be an effective treatment for attenuating some opioid-related testicular dysfunction and degeneration.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Multi-omics analysis revealing the interplay between gut microbiome and the host following opioid use. (Pubmed Central) -  Aug 27, 2023   
    This study presents for the first time ever an interactive view of morphine-induced changes in microbial metabolism, strain level gut microbiome analysis and comprehensive view of changes in gut transcriptome. We also identified areas of potential therapeutic interventions to limit microbial dysbiosis and present a unique resource to the opioid research community.
  • ||||||||||  morphine sulphate / Generic mfg.
    Review, Journal:  Pharmacological Treatments and Therapeutic Drug Monitoring in Patients with Chronic Pain. (Pubmed Central) -  Aug 26, 2023   
    Specifically, we focus our attention on therapeutic drug monitoring (TDM), a tool that could help clinicians select the most suitable drug and dose to be used for each patient. The actual potential of using TDM to optimize and personalize opioid-based pain treatments is finally discussed based on recent scientific reports.
  • ||||||||||  Instanyl (fentanyl) / Takeda
    Retrospective data, Review, Journal:  Intranasal analgesia for acute moderate to severe pain in children - a systematic review and meta-analysis. (Pubmed Central) -  Aug 23, 2023   
    Our review suggests that intranasal analgesics are probably a good alternative to intramuscular analgesics in children with acute moderate to severe pain; and may be an alternative to intravenous administration. Intranasal ketamine gives similar pain relief to fentanyl, but causes more sedation, which should inform the choice of intranasal agent.
  • ||||||||||  Idiopathic Scoliosis Correction In An Adolescent Patient With OTC Deficiency (South: Hall F) -  Aug 23, 2023 - Abstract #ASA2023ASA_6193;    
    We believe that, in the face of our experience, TIVA-TCI techniques with propofol infusions are a legitimate first-line option for patients with OTC deficiency who are to undergo long surgeries, in detriment of balanced anesthesia techniques. Locoregional anesthesia techniques, such as the erector spinae block, are also a safe and desirable option for these patients.
  • ||||||||||  baclofen / Generic mfg.
    Chemical Meningitis from Baclofen Intrathecal Pump (South: Hall F) -  Aug 23, 2023 - Abstract #ASA2023ASA_6184;    
    Chemical meningitis is a diagnosis of exclusion. Life-threatening causes should be ruled out first in these patients.
  • ||||||||||  Bilateral Erector Spinae Plane Blocks for Ventral Hernia Repair in a Morbidly Obese Patient with Chronic Pain (South: Hall F) -  Aug 23, 2023 - Abstract #ASA2023ASA_6163;    
    Preoperatively, ultrasound-guided single-shot bilateral erector spinae plane blocks using liposomal bupivacaine/bupivacaine mixture were performed at T10 and T12 with significant pain relief lasting 60 hours postoperatively. She was briefly on a ketamine drip, received hydromorphone 16mg total via IV PCA, and required no breakthrough IV medications prior to her uneventful discharge on postoperative day 4.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Neurotoxicity Associated to Fentanyl: A Case Report (Exhibit Hall) -  Aug 23, 2023 - Abstract #ASA2023ASA_6045;    
    This would not require monitoring per guidelines of longer than 2 hours, and would allow same day discharge with excellent analgesia. A 44-year-old man with severe pain from pelvic necrotizing fasciitis, osteomyelitis, and type 2 diabetes was initially treated with intravenous morphine (40-60mg/day) and buprenorphine (1200