morphine sulphate / Generic mfg. 
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  • ||||||||||  Rituxan (rituximab) / Roche
    CENTRAL NEUROGENIC HYPERVENTILATION IN A PATIENT WITH MULTIPLE SCLEROSIS: A CASE REPORT (Convention Center Exhibit Hall: Rapid Fire Area 3D) -  Sep 11, 2024 - Abstract #CHEST2024CHEST_6920;    
    Intervention and management require careful monitoring, as the bicarbonate buffer system requires time to achieve homeostasis. Although correcting the underlying cause of CNH is the most beneficial treatment available, monitored treatment of respiratory alkalosis and symptoms with opioids has proven to be a beneficial and temporizing measure.
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  N-palmitoylethanolamide attenuates negative emotions induced by morphine withdrawal in mice. (Pubmed Central) -  Sep 10, 2024   
    In summary, PEA demonstrates a significant positive effect on negative emotions associated with morphine withdrawal, accompanied with the reduction in levels of monoamine neurotransmitters in key brain regions. These insights could be valuable for managing negative emotions arising from morphine withdrawal.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  The autoimmune nature of morphine addiction. (Pubmed Central) -  Sep 9, 2024   
    The immunological nature of morphine addiction is the reason for lifelong changes in the body's reactivity to the drug. An addict can be cured if he gets rid of B- and T-memory cells, which specifically react to ORs.
  • ||||||||||  morphine sulphate / Generic mfg.
    Observational data, Journal:  Design and Implementation of an Opioid Scorecard for Hospital System-Wide Peer Comparison of Opioid Prescribing Habits: Observational Study. (Pubmed Central) -  Sep 9, 2024   
    Poisson regression demonstrated a 1.6% quarterly reduction in opioid prescribing, and chi-square analysis demonstrated pre-post reductions in the proportion of prescriptions longer than 5 days' duration and a morphine equivalent daily dose of >50...By sharing this process for designing the metrics and the process of distribution, the authors hope to influence other health systems to attempt to curb the opioid pandemic through peer comparison. Future research examining the effects of this intervention could demonstrate significant reductions in opioid prescribing, thus potentially reducing the progression of individual patients to opioid use disorder and the associated increased risk of morbidity and mortality.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Retrospective data, Journal:  Robotic colorectal resections are associated with less postoperative pain, decreased opioid use, and earlier return to work as compared to the laparoscopic approach. (Pubmed Central) -  Sep 9, 2024   
    Future research examining the effects of this intervention could demonstrate significant reductions in opioid prescribing, thus potentially reducing the progression of individual patients to opioid use disorder and the associated increased risk of morbidity and mortality. In this retrospective, cohort study, we compare postoperative opioid requirements, reported as morphine milligram equivalents (MME), postoperative average and highest pain scores across postoperative days (POD) 0-5, and return to work in patients who underwent robotic versus laparoscopic colorectal resections...Patients in the robotic arm had earlier return to work (2.1 vs 3.8
  • ||||||||||  morphine sulphate / Generic mfg., methamphetamine / Generic mfg.
    Review, Journal:  The Impact of Potent Addictive Substances on Angiogenic Behavior: A Comprehensive Review. (Pubmed Central) -  Sep 9, 2024   
    The addictive substances addressed in this review are nicotine, opioids such as morphine and heroin, alcohol, cocaine, methamphetamine, and cannabinoids. An accurate assessment of the influence of these substances on the angiogenic process may help to construct a potentially effective therapeutic protocol to control and treat several angiogenesis-related diseases.
  • ||||||||||  morphine sulphate / Generic mfg.
    Retrospective data, Journal:  Intravenous Sedation and Analgesia in a Pediatric Emergency Department: A Retrospective Descriptive Study. (Pubmed Central) -  Sep 9, 2024   
    The drugs used for sedation and analgesia were ketamine (99.2%, n=610), midazolam (95.8%, n=589), propofol (1.6%, n=10), and morphine (0.5%, n=3)...Children were sedated by a pediatric intensivist in 68.1% (n=419), by a general pediatrician in 26.7% (n=164), and by a pediatric resident in 2% (n=12). Conclusions The results of this study demonstrate that intravenous sedoanalgesia, particularly the combination of ketamine and midazolam, is a safe method for sedation in pediatric patients, with a low rate of adverse events.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Concise Total Synthesis of (-)-Codeine. (Pubmed Central) -  Sep 7, 2024   
    Codeine and morphine are among the few natural products that are used directly as drugs for medical treatment...Following that, an oxidation followed by global reduction leads to the formation of (-)-codeine. Our synthesis relies on simple and classical reactions to address the opium alkaloids and will serve as an efficient route to access the other morphinans.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Distance to Burn Center Does Not Impact Long-term Anxiety and Depression Risk Following Burn Injury. (Pubmed Central) -  Sep 6, 2024   
    Total body surface area burned (P = .02) and a prior psychiatric history (P = .02) predicted postinjury depression. The distance between a patient's home and the treating burn center does not alter anxiety and depression rates following burn injury, further supporting the transfer of patients to specialized centers.
  • ||||||||||  morphine sulphate / Generic mfg.
    Retrospective data, Review, Journal:  Fascia iliaca catheters for donor site pain after split-thickness skin grafting for acute burn injury: a retrospective review. (Pubmed Central) -  Sep 6, 2024   
    Oral morphine equivalent (OME) administration was significantly lower in the FI group than the control group, starting with POD 0, which is the day of the FI catheter insertion (188 vs 327 mg, P < .001)...There was a significant difference in OME administered between the FI group and the control group on POD 5 (159.5 vs 209.2mg, p<0.05). Our retrospective study evaluating the role of fascia iliaca catheters in burn patients undergoing split thickness skin grafting surgery showed significantly lower opioid consumption on postoperative days 1-5 compared to patients without a fascia iliaca catheter.
  • ||||||||||  Prialt (ziconotide) / Jazz
    Retrospective data, Journal, Real-world evidence, Real-world:  Real-World Prescription Data for Intrathecal Drug Delivery: A Retrospective Analysis in 32,784 Patients. (Pubmed Central) -  Sep 4, 2024   
    Despite the prevalence of IDDS for managing chronic, intractable pain, minimal data exist on real-world prescription practices. Our study found that FDA-approved IT formulations accounted for the minority of prescriptions, indicating significant practice variation, with off-label prescriptions being common.
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  Mapping functional traces of opioid memories in the rat brain. (Pubmed Central) -  Sep 4, 2024   
    For this, we developed a morphine-conditioned place preference protocol that allows contextual stimuli presentation inside a magnetic resonance imaging scanner and investigated differences in activity and connectivity at context recall...We have identified functional maps of acquisition and retrieval of drug-related memory that may support the relapse-triggering ability of opioid-associated sensory and contextual cues. These findings may clarify the inter-individual sensitivity and vulnerability seen in addiction to opioids found in humans.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal, IO biomarker:  Impact of Morphine withdrawal on genes related to the TLR2 pathway expressed in the Prefrontal Cortex. (Pubmed Central) -  Sep 4, 2024   
    Morphine withdrawal induced gene expression was attenuated in a whole body TLR2 knockout model. These results provide more support that TLR2 plays an integral role in morphine withdrawal mechanisms and could be a potential therapeutic target to minimize opioid withdrawal associated co-morbidities.
  • ||||||||||  Instanyl (fentanyl) / Takeda
    Journal:  Intranasal Fentanyl Versus Morphine in Fracture Reduction in a Pediatric Trauma Center. (Pubmed Central) -  Sep 3, 2024   
    INF reduces the time to obtain sufficient analgesia and time of care, with good effectiveness maintained during the procedure in fracture reduction, allowing the extension to lower limb fractures. Thus, this rapid and efficient analgesia facilitates orthopaedic care in the pediatric ED that would otherwise require to be reduced in the operating room under general anesthesia.
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  Pronociceptive role of spinal Cav2.3 (R-type) calcium channels in a mouse model of postoperative pain. (Pubmed Central) -  Sep 2, 2024   
    Mortality risk was monotonically associated with morphine milligram equivalents in patients with kidney failure who received long-term opioid prescriptions. Our results demonstrate that Cav2.3 has a pronociceptive role in the induction of postoperative pain, indicating that it is a potential target for the development of therapeutic approaches for the treatment of postoperative pain.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Signaling Modulation Mediated by Ligand Water Interactions with the Sodium Site at ?OR. (Pubmed Central) -  Sep 2, 2024   
    In mice, RO76 was systemically active in tail withdrawal assays and showed reduced liabilities compared to those of morphine. In summary, we show that targeting water molecules in the sodium binding pocket may be an avenue to modulate signaling properties of opioids, and which may potentially be extended to other G-protein coupled receptors where this site is conserved.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Baicalein isolated from Oroxylum indicum acts as a potent  (Pubmed Central) -  Sep 1, 2024   
    The acute dose of 3 (20?mg/kg) and pan opioid receptor antagonist naloxone (20?mg/kg) block the morphine-induced antinociception and the paw withdrawal latency decreases up to 8.3?s and 9.6?s, respectively. The in silico studies also support our in vitro data that compound 3 binds with MOR and KOR.
  • ||||||||||  morphine sulphate / Generic mfg., methadone / Generic mfg.
    Journal:  Opioid Dosing Deviation and Dose Banding Development in Young Hospitalized Children. (Pubmed Central) -  Sep 1, 2024   
    A total of 20% of opioid doses prescribed to children ?24 months of age are outside the recommended ranges. Dose banding represents a promising method for simplifying opioid prescribing in the pediatric inpatient setting.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Morphine-responsive neurons that regulate mechanical antinociception. (Pubmed Central) -  Sep 1, 2024   
    Among these, forced activation or silencing of excitatory RVMBDNF projection neurons mimicked or completely reversed morphine-induced mechanical antinociception, respectively, via a brain-derived neurotrophic factor (BDNF)/tropomyosin receptor kinase B (TrkB)-dependent mechanism and activation of inhibitory spinal galanin-positive neurons. Our results reveal a specific RVM-spinal circuit that scales mechanical nociception whose function confers the antinociceptive properties of morphine.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Opioid circuit opens path to pain relief. (Pubmed Central) -  Sep 1, 2024   
    Our results reveal a specific RVM-spinal circuit that scales mechanical nociception whose function confers the antinociceptive properties of morphine. Manipulation of neural circuits targeted by morphine enables pain relief without opioids.
  • ||||||||||  morphine sulphate / Generic mfg., methadone / Generic mfg.
    Journal:  Analysis of crude wastewater from two treatment plants in South Wales for 35 new psychoactive substances and cocaine, and cannabis. (Pubmed Central) -  Sep 1, 2024   
    An additional experiment employing enzymatic hydrolysis revealed the presence of morphine, an increased presence of codeine, and 11-Nor-9-Carboxy-THC (THC-COOH) post-hydrolysis. These findings underscore the significant presence of illicit substances and medicinal compounds in wastewater systems with the absence of NPS within the South Wales area, highlighting the necessity for enhanced monitoring and treatment strategies to address public health and environmental concerns.