- |||||||||| morphine sulphate / Generic mfg., ketamine / Generic mfg.
Journal: Evaluating a unique enhanced recovery protocol in laparoscopic donor nephrectomy: A single center experience. (Pubmed Central) - Oct 22, 2023
After laparoscopic gastrectomy, this was generally achieved without epidural analgesia and with fewer opioids. A protocol pairing lidocaine and ketamine with a comprehensive approach to preoperative PO intake, premedication, intraoperative fluid management and postoperative pain control is associated with reduced opioid consumption in LDN.
- |||||||||| morphine sulphate / Generic mfg.
PK/PD data, Journal: Comparative pharmacokinetics of nalbuphine nasal spray and solution for injection in healthy volunteers. (Pubmed Central) - Oct 22, 2023
A protocol pairing lidocaine and ketamine with a comprehensive approach to preoperative PO intake, premedication, intraoperative fluid management and postoperative pain control is associated with reduced opioid consumption in LDN. The similarity of PK parameters of IM-injected nalbuphine solution and the nasal spray allows us to assume the latter is a feasible alternative to intramuscular nalbuphine injections appropriate for self-administration and field environments for managing moderate and severe pain of various aetiologies.
- |||||||||| morphine sulphate / Generic mfg., naltrexone / Generic mfg.
Journal: Oxycodone: A Current Perspective on its Pharmacology, Abuse and Pharmacotherapeutic Developments. (Pubmed Central) - Oct 22, 2023
Although thebaine cannot be used therapeutically due to the occurrence of convulsions at higher doses, it has been converted to a number of other widely used compounds that include naloxone, naltrexone, buprenorphine, and oxycodone...Several concerns were expressed as early as the 1940s that oxycodone had significant abuse potential similar to heroin and morphine...Oxycodone emerged as a drug with wide-spread abuse. This article brings together an integrated, detailed review of the pharmacology of oxycodone, preclinical and clinical studies of pain, abuse, and also covers recent advances to identify potential opioid analgesics without abuse liability.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Management of cancer pain in pregnancy: can opioids be used? (Pubmed Central) - Oct 22, 2023
Opioids such as morphine may be considered for the management of severe cancer pain during pregnancy...Further research is needed. In this review article we describe the challenges of managing cancer pain in pregnant woman and the current approach of opioids management for cancer pain in these patients using a case report.
- |||||||||| morphine sulphate / Generic mfg.
Clinical, Journal: Noninvasive Bioelectronic Treatment of Postcesarean Pain: A Randomized Clinical Trial. (Pubmed Central) - Oct 20, 2023
The primary outcome was inpatient postoperative opioid use, measured in morphine milligram equivalents (MME)...In this randomized clinical trial of postoperative patients following cesarean delivery, use of a high-frequency electrical stimulation device as part of a multimodal analgesia protocol decreased opioid use in the immediate postoperative period and opioids prescribed at discharge. These findings suggest that the use of this device may be a helpful adjunct to decrease opioid use without compromising pain control after cesarean delivery.
- |||||||||| morphine sulphate / Generic mfg.
Preclinical, Journal: In (Pubmed Central) - Oct 17, 2023
Combining PhOX photoactivation with optical recording of extracellular dopamine revealed adaptations in the opioid sensitivity of mesolimbic dopamine circuitry in response to chronic morphine administration. This work establishes a general experimental framework for using in
- |||||||||| morphine sulphate / Generic mfg.
Journal: Associations Between Management Pathway and Opioid Prescriptions for Patients Entering the Emergency Department With Neck and Back Pain. (Pubmed Central) - Oct 16, 2023
Within 12 months after the index ED visit, 58.0% (n=10,949) were prescribed an opioid, with most patients prescribed an opioid within the first week (average daily morphine milligram equivalents of 6.8 mg (SD 9.6 mg)...Compared with the ED to primary care provider pathway, the relative risk of opioid prescription between 7 days and 12 months after the index ED visit was similar for the ED to physical therapy pathway, higher for both the ED to hospital admission or repeat ED visit pathway (30% increase; relative risk (RR), 1.3; 95% CI, 1.17-1.44) and the ED to specialist pathway (19% increase; RR, 1.19; 95% CI, 1.07-1.33), and lower in the ED with no follow-up visits pathway (41% decrease; RR, 0.59; 95% CI, 0.54-0.65). In general, more conservative care was associated with lower opioid prescription rates, and escalated care was associated with higher opioid prescription rates.
- |||||||||| morphine sulphate / Generic mfg., methadone / Generic mfg.
Journal: Trends in deaths following drug use in England before, during, and after the COVID-19 lockdowns. (Pubmed Central) - Oct 16, 2023
For people who use drugs, the impact of the restrictions due to the COVID-19 pandemic was greater than that of infection from the virus itself. The health and social care strategy for these people needs to be pre-emptively adapted to mitigate against the specific risk factors for fatal drug overdose associated with future emergency scenarios.
- |||||||||| fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
Journal: Perioperative Analgesia and Patients' Satisfaction in Spinal Anesthesia for Cesarean Section: Fentanyl Versus Morphine. (Pubmed Central) - Oct 14, 2023
On the other hand, fentanyl had significantly fewer non-life-threatening side effects, such as high-intensity pruritus (Mann-Whitney U test, p < 0.001), nausea (OR = 0.324; p = 0.019), vomiting and dizziness upon first mobilization (OR = 0.256; p < 0.001). It remains for future clinical trials to help establish doses that will tilt the scale to one side or the other.
- |||||||||| morphine sulphate / Generic mfg., ropivacaine / Generic mfg.
Trial completion, Trial completion date: Thoracic Paravertebral Blocks in Open Nephrectomy (clinicaltrials.gov) - Oct 13, 2023
P2, N=60, Completed,
It remains for future clinical trials to help establish doses that will tilt the scale to one side or the other. Unknown status --> Completed | Trial completion date: Feb 2021 --> Feb 2023
- |||||||||| morphine sulphate / Generic mfg.
Journal: A pharmacist integrated into a general practice in Australia: an evolving model of care in medicines optimization. (Pubmed Central) - Oct 12, 2023
Opioid-related data included dose changes from baseline, at 6 and 9 months, standardized to oral morphine equivalents...General practice provides opportunities for medicine optimization and deprescribing. This study has demonstrated a GPP model of care that achieved functional deprescribing to reduce potential harm in a population at risk and addressed recognized barriers.
- |||||||||| morphine sulphate / Generic mfg.
Clinical, Journal, Surgery: The effect of transversus abdominis plane block application on postoperative analgesia quality and patient satisfaction after varicocele surgery: a randomized clinical trial. (Pubmed Central) - Oct 11, 2023
To compare the effect of spinal anesthesia + transversus abdominis plane (TAP) block application on postoperative analgesia quality and patient satisfaction with spinal anesthesia + intrathecal morphine (ITM) application...There was no statistically significant difference in terms of VAS values at 0 h, 2 h, 6 h, 12 h, and 18 h. When the factors affecting postoperative patient satisfaction were evaluated, feeling fatigue after the surgery (r = -0.811, P = 0.001) and postoperative complications such as nausea, vomiting, and itching (r = -0.831, P = 0.001) were found to have a negative effect on patient satisfaction. Due to low complication rates, TAP block is an effective application for postoperative analgesia management in varicocele operations that increases patient satisfaction postoperatively.
- |||||||||| tegileridine (SHR8554) / Jiangsu Hengrui Pharma
Enrollment closed, Surgery: A Study of SHR8554 Injection for the Treatment of Pain After Orthopedic Surgery (clinicaltrials.gov) - Oct 10, 2023
P2/3, N=320, Active, not recruiting,
A caudal block with ropivacaine and morphine could provide a satisfactory analgesic effect for 24 h postoperatively without additional adverse effects after total laparoscopic hysterectomy. Recruiting --> Active, not recruiting
- |||||||||| morphine sulphate / Generic mfg.
Review, Journal: Erector spinae plane block for postoperative pain. (Pubmed Central) - Oct 9, 2023
Further research is required to study the possibility of extending the duration of analgesia. We identified 37 new studies in the updated search and there are three ongoing studies, suggesting possible changes to the effect estimates and the certainty of the evidence in the future.
- |||||||||| morphine sulphate / Generic mfg.
Journal, Surgery: Achieving opioid-free discharge following robotic thoracic surgery: A single-institution experience. (Pubmed Central) - Oct 9, 2023
Demographics, operative outcomes, postoperative opioid dispensed (morphine milligram equivalent), and opioid discharge status were collected...Optimized opioid-sparing ERATS protocols are highly effective in reducing opioid prescription on the day of discharge. We observed a very low rate of new persistent or chronic opioid use in our cohort, further highlighting the role ERATS protocols in combating the opioid epidemic.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Effects of early rehabilitation on enhanced recovery after caesarean section. (Pubmed Central) - Oct 8, 2023
Our protocol was based on neuraxial anaesthesia with intrathecal morphine, multimodal analgesia, with oral analgesics postoperatively, prevention of postoperative nausea and vomiting (PONV), rapid demedicalization, refeeding and mobilisation...Early rehabilitation after caesarean section is quite applicable to the Algerian context. It offers a quick functional recovery with patient satisfaction, as well as a reduction of the length of stay.
- |||||||||| morphine sulphate / Generic mfg.
Retrospective data, Journal: Racial, Ethnic, and Language-Based Inequities in Inpatient Opioid Prescribing by Diagnosis from Internal Medicine Services, a Retrospective Cohort Study. (Pubmed Central) - Oct 6, 2023
We conducted a negative binomial regression analysis to determine how average administered daily opioids, measured as morphine milligram equivalents (MMEs), were associated with race, ethnicity, and language, while adjusting for additional patient demographics, hospitalization characteristics, medical comorbidities, prior opioid therapy, and substance use disorders...There are notable inequities in opioid prescribing based on patient race, ethnicity, and language status for those admitted to inpatient internal medicine services across all conditions and in the subcohorts of the six most frequent hospital conditions and three pain-associated conditions. This represents an institutional and societal opportunity for quality improvement initiatives to promote equitable pain management.
- |||||||||| morphine sulphate / Generic mfg., hydromorphone hydrochloride / Generic mfg.
Observational data, Journal: Intrathecal Opioid Use in Kidney Transplantation: An Observational Cohort Study. (Pubmed Central) - Oct 6, 2023
Intrathecal opioid administration was associated with improved pain outcomes in patients undergoing kidney transplantation, including lower opioid requirements and pain scores through 72 hours. However, this was accompanied by an increased risk of PONV.
- |||||||||| morphine sulphate / Generic mfg., indomethacin / Generic mfg.
Preclinical, Journal: Evaluation of Antinociceptive Activity of Ficus Religiosa Root Extract in Swiss Albino Mice. (Pubmed Central) - Oct 5, 2023
The activity of Ficus religiosa extract at doses of 50 and 100 mg/kg was equipotent to Standard control (Morphine and Indomethacin) used in different test models. Conclusion The extract of Ficus religiosa possesses both central and peripheral analgesic activity thus validating the traditional use of this plant in the management of pain.
- |||||||||| gabapentin / Generic mfg.
Journal: Gabapentin as Adjunctive Therapy in Neonatal Opioid Withdrawal Syndrome: A Case Series. (Pubmed Central) - Oct 5, 2023
Conclusion The extract of Ficus religiosa possesses both central and peripheral analgesic activity thus validating the traditional use of this plant in the management of pain. Gabapentin appeared to facilitate successful morphine weans in six patients with NOWS who were previously unable to wean despite the initiation of clonidine.
- |||||||||| morphine sulphate / Generic mfg., methadone / Generic mfg.
Clinical, Journal: Individual-Level Risk Prediction of Return to Use During Opioid Use Disorder Treatment. (Pubmed Central) - Oct 4, 2023
All participants received 1 of 3 medications for opioid use disorder: methadone, buprenorphine, or extended-release naltrexone...The final model based on 4 predictors at treatment entry (heroin use days, morphine- and cocaine-positive UDS results, and heroin injection in the past 30 days) yielded an area under the receiver operating characteristic curve (AUROC) of 0.67 (95% CI, 0.62-0.71)...The prediction model described in this study may be a universal risk measure for return to opioid use by treatment week 3. Interventions to prevent return to regular use should focus on this critical early treatment period.
- |||||||||| morphine sulphate / Generic mfg.
Biomarker, Journal: Salivary cortisol as a biomarker of stress in surgical patients. (Pubmed Central) - Oct 4, 2023
The first group (MI - morphine intermittently) included patients given morphine doses 0.1 mg/kg/6h s.c. intermittently. The second group (MPCA - morphine patient-controlled analgesia) included patients who received morphine via the PCA system - intravenous administration of morphine adjusted to a dose of 1 mg per shot and a lockout interval of 6 minutes.
- |||||||||| morphine sulphate / Generic mfg.
Journal, Surgery: Prospective evaluation of postoperative pain and opioid use after minor urologic surgery. (Pubmed Central) - Oct 3, 2023
Based on our data, we suggest that a prescription for 39 OME would adequately treat postoperative pain in 95% of patients undergoing minor urologic procedures. Education around pain management with non-narcotic modalities is imperative, and practice changes are warranted to address the opioid crisis within our specialty.
- |||||||||| morphine sulphate / Generic mfg.
Trial completion: Ultrasound Guided Erector Spinae Plane Block vs Intrathecal Morphine (clinicaltrials.gov) - Oct 3, 2023
P4, N=120, Completed,
We therefore do not recommend the use of intravenous lidocaine as part of an ERP multimodal pain management strategy in abdominal surgery patients. Recruiting --> Completed
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