- |||||||||| morphine sulphate / Generic mfg.
Journal, Surgery: Decreased Opioid Use and Equivalent Pain Score Outcomes After Robotic Urologic Surgery Using a Simplified Opioid Minimization Protocol: A Safety-Net Hospital Experience. (Pubmed Central) - Nov 17, 2023
Total opioids received within 30 days of surgery decreased by 68% in the OM vs OC cohort (median [IQR] 32.5 [7.5-65] vs 100 [30-173] Morphine Milligram Equivalents (MME), P < .001)...Pain severity did not differ between cohorts on POD2 (median [IQR]: OM=3/10 [2-5], OC=3.5/10 [2-6]; P = .5) or POD7 (median [IQR]: OM=2/10 [0-3], OC=1/10 [0-3]; P = .8), and POD7 satisfaction with pain management remained high for both cohorts (P = .8). Our simplified opioid minimization protocol decreased total opioid use after robotic urologic surgery by 68% without compromising pain or satisfaction.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Opioid Tapering in Older Cancer Survivors Does Not Increase Psychiatric or Drug Hospitalization Rates. (Pubmed Central) - Nov 17, 2023
Our simplified opioid minimization protocol decreased total opioid use after robotic urologic surgery by 68% without compromising pain or satisfaction. Opioid tapering in older cancer survivors does not appear to be linked to a higher risk of acute psychiatric or drug-related events, in contrast to prior research in the general population.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Effectiveness of Sublingual Buprenorphine for Pain Control in the ICU. (Pubmed Central) - Nov 17, 2023
Buprenorphine sublingual is as effective as oxycodone oral/enteral with regard to pain control and opioid consumption in the ICU. Buprenorphine sublingual is an appropriate option for patients in the ICU who are unable to take oral/enteral medications.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Mental health disorders and pain modulation in orthopedic shoulder patients. (Pubmed Central) - Nov 16, 2023
Other strategies are needed to reduce opioid doses while improving pain and function for patients who have been on LtOT for years with high levels of medical, mental health, and substance use comorbidity. Univariate analysis demonstrated significant differences between the MHD group and non-MHD group in average 90-day postoperative opioid scripts (2.10 vs. 1.55, respectively, P
- |||||||||| morphine sulphate / Generic mfg.
Journal, Metastases: Opiate use after total hip arthroplasty for metastatic bone disease. (Pubmed Central) - Nov 16, 2023
After THA in the setting of MBD, patients exhibit decreased post-operative opioid use. Future studies with larger cohorts should be conducted to characterize post-operative opioid use following joint arthroplasty in MBD patients.
- |||||||||| An Exotic Presentation: Managing Pain in a Patient with a Rare Axonal Variant of Guillain Barre Syndrome () - Nov 16, 2023 - Abstract #AAPMR2023AAPMR_901;
Current literature champions the use of gabapentin and carbamazepine as opposed to opioids in the management of GBS-related pain refractory to NSAIDs or Tylenol. When managing severe and intractable pain in patients with GBS, especially in patients with sensory nerve fiber involvement, utilizing a multimodal pharmacologic approach may be more efficacious than a single agent alone.
- |||||||||| morphine sulphate / Generic mfg., ibuprofen / Generic mfg.
Acute on Chronic Pain Management in Congenital Osteodystrophy () - Nov 16, 2023 - Abstract #AAPMR2023AAPMR_899;
Due to chronic fractures, patient took Tylenol #3 every 6 hours as needed (prn) and ibuprofen 600mg every 8 hours prn at home...Postoperatively, he was started on methocarbamol 500mg every 6 hours, acetaminophen 500mg every 6 hours prn, morphine 4mg every 4 hours prn, and Norco 5-325 every 4 hours prn which was later increased to Norco 7.5-325 to manage acute on chronic pain... Individualized approach to pain management is needed in patients with congenital osteodystrophy who suffer from acute on chronic fractures needing surgical and non-surgical intervention.
- |||||||||| Topical Ketamine for Post-amputation Phantom Limb Pain: A Case Series () - Nov 16, 2023 - Abstract #AAPMR2023AAPMR_891;
The efficacy of topical ketamine was assessed by averaging the self-reported pain ratings (scale from 0-10) documented by nursing staff every 3-6 hours as well as measured morphine milliequivalents (MME) of opioids taken on post-operative days one, two, three, and the day of discharge.Setting: Inpatient hospitalAssessment/ Topical ketamine administration allowed for dose reduction of multimodal opioid regimens for all three patients (Case 1 exhibited an 87.3% reduction in MME; Case 2 exhibited a 100% reduction in MME; Case 3 exhibited a 72.4% reduction in MME). The findings demonstrated in this case series may warrant prospective research for the use of topical ketamine for patients experiencing post-amputation phantom limb pain.
- |||||||||| morphine sulphate / Generic mfg.
A Rare Case of Pathologic Calcification Within an Intrathecal Pain Pump Pocket () - Nov 16, 2023 - Abstract #AAPMR2023AAPMR_872;
Pathologic calcification within the surgical pockets of ITP pumps and SCS are rare but can occur. More investigation into incidence, risk factors, and preventative strategies is warranted to explore pathologic calcification in the setting of ITP pumps and SCS.
- |||||||||| Bilateral Upper Extremity Paresthesia in Severe Burn Patient: A Case Report () - Nov 16, 2023 - Abstract #AAPMR2023AAPMR_746;
For neuropathic pain, he was initially prescribed gabapentin, but replaced with pregabalin with improved efficacy... Patients with axillary contractures experiencing transient forearm neuropathies elicited with dynamic movement should be evaluated with cervical spine MRI first to rule out urgent causes, and afterwards assessed for possible brachial plexopathy or other peripheral nerve entrapments.
- |||||||||| Spinraza (nusinersen) / Biogen, Ionis
Pod 2 - Improving your lumbar puncture skills (Learning Center in the Pavilion; In-Person) - Nov 16, 2023 - Abstract #AAPMR2023AAPMR_337;
Many physiatrists may have had limited exposure to this technique during their training. This workshop will improve the attendees confidence in performing this procedure.Lab Outline/Format:: Participants will rotate through each station - should take 10-15 minutes per stationStation 1:traditional lumbar puncture techniquesStation 2:Ultrasound guided lumbar puncture techniquesStation 3:Fluoroscopically guided lumbar puncture techniquesLearning Objectives: improve their LP performance using visual and palpation localization techniques through the use of LP simulation model.learn the sonographic appearance of spinal structures relative to ultrasound-guided lumbar punctures through the use of a gel ultrasound phantom.learn the radiographic appearance of spinal structures relative to fluoroscopically-guided lumbar puncture and execute this procedure through the use of virtual reality injection model.
- |||||||||| morphine sulphate / Generic mfg.
Impacts of morphine milligram equivalents in the 5 days prior to acute inpatient rehab (Research Hub in the Pavilion; In-Person) - Nov 16, 2023 - Abstract #AAPMR2023AAPMR_161;
MME in the days before rehab has no statistical significance on outcomes related to length of stay, 90 day readmission or disposition at discharge. Many factors may contribute to these outcome measures and further research is needed to investigate this.
- |||||||||| Dysport (abobotulinumtoxinA) / Ipsen
Live General Rehabilitation Original Research Presentations (Research Hub in the Pavilion; In-Person) - Nov 16, 2023 - Abstract #AAPMR2023AAPMR_148;
Don't miss this new opportunity to connect with researchers! The following research will be presented:Analyzing the Educational Value of Ankle Sprain-Related Videos on TikTokAn Evaluation of Craigslist as a Source of Durable Medical EquipmentA Cross-Sectional Survey of Cancer Rehabilitation Physiatrists Across the United States Regarding Outcome Measure CollectionA Review of Emergency Department and Inpatient Admissions of Adults with Spina Bifida followed by a Multidisciplinary ClinicBody Mass Index Impacts Postacute Rehabilitation Outcomes after Lower Limb AmputationClinical Utility of Bioimpedance Analysis for Upper Limb Lymphedema with Physiologic Surgical TreatmentDevelopment of rating scales of the stage of recovering self-leadership in patients with disability due to acquired brain injury: A pilot studyEconomic Hardship, Race, Language, Delirium, and Rehabilitation Outcomes in COVID-19Effects of inpatient rehabilitation on anxiety and depression in patients at an inpatient rehabilitation centerFunctional Status Outcomes in Adults Discharged from Inpatient Rehabilitation Facility to Skilled Nursing Facility: A Longitudinal Observational StudyIdentifying which patients are at risk of an unplanned transfer from an inpatient rehabilitation facility using the HOSPITAL score.Impact of hospital length of stay and %TBSA on functional outcome at inpatient rehabilitation facility following burn injuryImpacts of morphine milligram equivalents in the 5 days prior to acute inpatient rehabInpatient Rehabilitation Improves Physical Outcomes for Older Adults after Burn InjuryInpatient Rehabilitation Outcomes of Cancer Patients After Chimeric Antigen Receptor T-cell TherapyIntrasession test-retest reliability and minimal detectable change of an ergometer based repeated measures protocolLeg Activity Measure (LegA) Sensitivity to Change Following Treatment of Lower Limb Spasticity With a Single Cycle of AbobotulinumtoxinA in an Ambulant PopulationLongitudinal patterns of post-fracture outpatient physical/occupational therapy use and its association with 3-year mortality among adults with cerebral palsyLong-term changes in lymphoscintigraphy and its association with clinical parameters in secondary lymphedema after breast cancer surgeryLower Admission Key IRF-PAI Functional Scores Correspond to Higher Rate of Non-Home Discharge Among Lower Extremity AmputeesPoor Outcomes Following Hip Dislocation for Patients with Preexisting ComorbiditiesSafety and Feasibility of Integrating Tele-Exercise with Remote Monitoring Systems in People with Multiple SclerosisThe effect of regular aerobic exercise on radiation-induced pulmonary fibrosis: an animal studyThe Influence on Gait Speed of the Central Sensitization after Total Hip ArthroplastyUnderstanding the Relationship Between Social Risk Factors and Functional Limitation Among Stroke Survivors in the U.S.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Bacosides: a study of neurobiological activity, prospects for application (Pubmed Central) - Nov 15, 2023
The effects associated with the influence on the dopaminergic and serotonergic systems of the striatum are of interest for the therapy of morphine addiction. The theoretical justifications for the future use of bacosides as a multipurpose means of complex therapy of individual diseases in neurological and psychiatric practice are presented.
- |||||||||| Penthrox (methoxyflurane) / Medical Developments International, Instanyl (fentanyl) / Takeda
Trial completion, Trial completion date, Trial primary completion date, Head-to-Head: PreMeFen: A Comparison of Three Regimens of Acute Pain Management: Methoxyflurane; Intranasal Fentanyl; Intravenous Morphine (clinicaltrials.gov) - Nov 14, 2023
P3, N=338, Completed,
The enrolled patients incurred lower total medical expenses, but the difference between the two groups increased as the time to death shortened. Recruiting --> Completed | Trial completion date: Nov 2023 --> Apr 2023 | Trial primary completion date: Nov 2023 --> Apr 2023
- |||||||||| morphine sulphate / Generic mfg., hydromorphone hydrochloride / Generic mfg.
Observational data, Journal: Opioid Switch Dosing in Chronic Cancer Pain: A Prospective Longitudinal Study. (Pubmed Central) - Nov 13, 2023
Hydromorphone dose increased 2.5 times (IQR 1.0-3.6) above the original conversion factor used...Higher preswitch dosing may require higher dose conversion ratios. Dose reduction postswitch risks undertreatment and may not be always appropriate.
- |||||||||| morphine sulphate / Generic mfg.
Journal, Immunomodulating: Immunomodulatory properties of morphine and the hypothesised role of long-term opioid use in the immunopathogenesis of tuberculosis. (Pubmed Central) - Nov 13, 2023
Blockade of specific immune pathways involved in the host defence against TB by morphine may play a critical role in causing tuberculosis among chronic morphine users despite multiple confounding factors such as socioeconomic deprivation, Human immunodeficiency virus co-infection and malnutrition. In this review, we map out immune pathways involved when immune cells are co-stimulated with mycobacterial antigens and morphine to explore a potential immunopathological basis for TB amongst long-term opioid users.
- |||||||||| Retrospective data, Journal: The Impact of Non-opioid Analgesic Usage on Total Opioid Load During Traumatic Brain Injury Rehabilitation: A Retrospective Study. (Pubmed Central) - Nov 13, 2023
This study aimed to determine the association between non-opioid analgesic use and total opioid load, as measured using morphine milligram equivalents (MMEs), during inpatient rehabilitation for traumatic brain injury...Non-opioid medications that were reviewed in the study included acetaminophen, amitriptyline, baclofen, diclofenac, gabapentin, ibuprofen, lidocaine, methocarbamol, nortriptyline, and pregabalin...Results also showed that the mere presence of methocarbamol (regardless of daily or total dosage) had a significant effect on the ?MME. Conclusions Based on these findings, physicians may want to consider prescribing acetaminophen, gabapentin, or methocarbamol for patients admitted for inpatient rehabilitation following traumatic brain injury who require high amounts of opioids.
- |||||||||| morphine sulphate / Generic mfg.
Review, Journal: Opioid dose titration for cancer pain. (Pubmed Central) - Nov 10, 2023
Addition of ultrasound-guided PENG block to FICB did not improve postoperative analgesic or recovery outcomes in elderly patients undergoing hip fracture surgery. This review provides the most recent insights on the different modalities of opioid dose titration in cancer pain management.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Dissecting the innate immune recognition of morphine and its metabolites by TLR4/MD2: an in silico simulation study. (Pubmed Central) - Nov 9, 2023
These results indicate that the pivotal interactions at the dimerization interface between MD2 and TLR4* in M6G-bound (TLR4/MD2) were considerably weaker than those in M3G-bound (TLR4/MD2), which partially explains why M6G fails to activate TLR4 signaling. The discoveries from this study will offer valuable insights for the advancement of next-generation TLR4 small molecule modulators based on opioids.
- |||||||||| Olinvyk (oliceridine) / Trevena
Clinical, Journal: Neurocognitive effect of biased (Pubmed Central) - Nov 8, 2023
III. These data indicate that over the clinical concentration range, oliceridine is an analgesic with a favorable safety profile over morphine when considering analgesia and neurocognitive function.
- |||||||||| STR-324 / ArchiMed
Review, Journal: Enhancing Opiorphin's Metabolic Stability and Preserving its Potent Analgesic Effect: A Systematic Review. (Pubmed Central) - Nov 7, 2023
For OUD patients in need of acute pain management, the continuation of sublingual buprenorphine throughout hospitalization at a daily dose of >12 mg/d compared with ?12 mg/d did not confer a significant difference in daily average MME requirements. This paper presents the first systematic review discussing opiorphin and opiorphin analogs and identifies the most promising candidates for future research.
- |||||||||| morphine sulphate / Generic mfg.
Trial completion date, Trial primary completion date, Surgery: Comparative Study Between ESPB Versus IV Morphine as Postoperative Analgesia After Spine Surgeries . (clinicaltrials.gov) - Nov 7, 2023
P=N/A, N=60, Not yet recruiting,
This paper presents the first systematic review discussing opiorphin and opiorphin analogs and identifies the most promising candidates for future research. Trial completion date: Feb 2023 --> Jan 2024 | Trial primary completion date: Jan 2023 --> Dec 2023
- |||||||||| morphine sulphate / Generic mfg.
Journal: Quantification of ?9-tetrahydrocannabinol in urine as a marker of cannabis abuse. (Pubmed Central) - Nov 6, 2023
Sixty per cent of the total individuals tested positive for simply cannabinoids, 33 per cent for cannabinoids and sedatives, five per cent for cannabinoids and morphine and one for cannabis, morphine and cocaine. Assay characteristics included modest sample preparation, rapid chromatography, high specificity and small sample volume with a processing time of 12 h. The assay described here can be applied for diagnostic laboratories and in forensic settings as well.
- |||||||||| morphine sulphate / Generic mfg.
Journal: OralOpioids: Harnessing R Programming and Data Science to Combat Opioid Misuse. (Pubmed Central) - Nov 6, 2023
Moreover, it calculates the morphine equivalent dose (MED) for each DIN using the CDC table...Primarily targeting researchers, its scope extends to healthcare providers, insurers, and administrative boards, all of whom can leverage its potent capabilities for informed decision-making. Although currently centered on Canadian opioids, its flexible design is primed for future expansion, potentially capturing a global audience and catalyzing efforts against the opioid crisis.
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