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- morphine sulphate / Generic mfg.
Low-Dose Short-Term Scheduled Ketorolac Reduces Opioid Use and Pain in Orthopaedic Polytrauma Patients: A Randomized Clinical Trial (West, Room 2020) - Nov 22, 2023 - Abstract #AAOS2024AAOS_1593;
The results support the use of scheduled low-dose, short-term IV ketorolac for acute pain control among orthopaedic polytrauma patients. Future studies are needed to delineate lasting clinical effects and potential long-term effects, such as fracture healing.
- duloxetine / Generic mfg.
A Randomized Controlled Trial Evaluating Duloxetine on Postoperative Outcomes following Primary Total Knee Arthroplasty (South, Esplanade Ballroom 155) - Nov 22, 2023 - Abstract #AAOS2024AAOS_1443;
Patients taking duloxetine felt significantly more well rested immediately following TKA and had superior KOOS scores at 6 weeks, although this difference may not be clinically important. Further research is required to investigate the benefit of duloxetine and SNRIs following TKA in patients without central sensitization.
- morphine sulphate / Generic mfg.
Does Melatonin Improve Subjective Sleep Quality after Total Knee Arthroplasty? A Randomized, Placebo-Controlled Trial (South, Esplanade Ballroom 155) - Nov 22, 2023 - Abstract #AAOS2024AAOS_1442;
Poor sleep quality was associated with worse physical function and pain. Our results do not support the routine use of melatonin supplementation after TKA.
- morphine sulphate / Generic mfg.
Single Shot Interscalene Block with Liposomal Bupivacaine versus Bupivacaine in Shoulder Arthroplasty (West, Room 2001) - Nov 22, 2023 - Abstract #AAOS2024AAOS_1354;
LBIB and NLIB showed similar patient reported pain scores postoperatively. LBIB patients were more likely to be opioid free postoperatively compared to NLIB however there was no statistically significant difference in total morphine equivalents consumed, daily mean morphine equivalents, or in 30- and 90-day ED visits and readmission rates.
- Bridion (sugammadex) / Merck (MSD)
Risk Factors for Postoperative Urinary Retention after Lumbar Fusion Surgery: Anesthetics and Surgical Approach (South, Room 210) - Nov 22, 2023 - Abstract #AAOS2024AAOS_1242;
Several studies have assessed the association between neostigmine, glycopyrrolate, sugammadex, and POUR without demonstrating consistent results. Our study adds to the literature by being the first to demonstrate that sugammadex is protective against POUR after spinal fusion surgery.
- morphine sulphate / Generic mfg.
Inpatient Opioid Consumption Since the Implementation of a Rapid Recovery Protocol for Posterior Spinal Fusion of Adolescent Idiopathic Scoliosis (South, Room 210) - Nov 22, 2023 - Abstract #AAOS2024AAOS_1127;
Our study demonstrates that older age, preoperative pain, more levels of fusion, and surgery length all correlate with increased hospital opioid use. Awareness of these factors is important for optimizing pain control for AIS-PSF patients because we also show there are strong relationships between use of pain medications in the hospital and pain levels and medication needs after discharge.
- morphine sulphate / Generic mfg., diazepam / Generic mfg.
The Role of Liposomal Bupivacaine in Multimodal Pain Management in Adolescent Idiopathic Scoliosis Patients Undergoing Posterior Spinal Fusion (South, Room 210) - Nov 22, 2023 - Abstract #AAOS2024AAOS_1114;
LB was associated with decreased total opioid use, improved ambulation, and shorter length of stay in AIS patients undergoing PSF. Including LB in multimodal pain management protocols proved effective in reducing opioid use while increasing mobilization in the immediate postoperative period.
- morphine sulphate / Generic mfg.
Comparison of Opioid-Free versus Traditional Opioid-Containing Postoperative Pain Management Pathways for Idiopathic Scoliosis (South, Room 210) - Nov 22, 2023 - Abstract #AAOS2024AAOS_1112;
The results of this study support that an OF pathway following instrumented PSF for idiopathic scoliosis results in equivalent LOS and fewer opioids prescribed at discharge compared with an OC pathway. To our knowledge, this is the first study to show that OF pain management is possible in this population.
- morphine sulphate / Generic mfg., aspirin / Generic mfg.
Impact of Counseling and Education on Opioid Consumption after Anterior Cruciate Ligament Reconstruction (CARE): A Randomized Controlled Trial (West, Room 2007) - Nov 22, 2023 - Abstract #AAOS2024AAOS_976;
The instruction to take oxycodone only as a last resort if the pain was unbearable resulted in less opioid use but was not associated with a significant difference in patient-reported postoperative pain and sleep quality. Patient counseling may be an effective method of minimizing the amount of opioid taken postoperatively after ACL reconstruction, without jeopardizing patient pain control and patient-reported outcomes measures.
- morphine sulphate / Generic mfg.
Opioid-Sparing Nonsteroidal Anti-Inflammatory Drugs Protocol in Patients Undergoing Intramedullary Nailing of Tibial Shaft Fractures: A Randomized Controlled Trial. (OrthoLive, West Hall) - Nov 22, 2023 - Abstract #AAOS2024AAOS_872;
Among patients undergoing intramedullary nailing for closed tibial shaft fractures, using an NSAID-based postoperative pain protocol led to a decrease in opioid consumption without affecting pain scores in the postoperative period. Due to the minimal risk of short-term NSAID use, there is a role in the postoperative management of tibia shaft fractures.
- morphine sulphate / Generic mfg.
Perioperative Regional Anesthesia Does Not Increase Risk of Missed Acute Compartment Syndrome following Tibia Fractures (OrthoLive, West Hall) - Nov 22, 2023 - Abstract #AAOS2024AAOS_832;
Regional anesthesia does not increase the rate of missed ACS in patients with operative tibial shaft or plateau injuries but does decrease postoperative opioid requirements. Heightened awareness should be used in patients receiving catheters as this remains a challenging diagnosis.
- Past History of Opioid Use and Prior Surgery, but Not Resilience or Anxiety, Predict Outcomes Up to 1 Year following Anterior Cruciate Ligament Reconstruction (OrthoLive, West Hall) - Nov 22, 2023 - Abstract #AAOS2024AAOS_762;
Following surgery, patients were provided an analgesic cocktail of acetaminophen, meloxicam, tramadol, and gabapentin in addition to 10 tablets of oxycodone...Postoperative rescue oxycodone use was measured cumulatively in morphine milligram equivalents (MME) at 48-72 hours, 2 weeks, and 6 weeks... Orthopaedic surgeons should be mindful that patients with a history of opioid use
- morphine sulphate / Generic mfg.
Opioid Prescribing Patterns following Rotator Cuff Repair: A Multicenter Retrospective Analysis (OrthoLive, West Hall) - Nov 22, 2023 - Abstract #AAOS2024AAOS_723;
On average, patients under the age of 65 receive more MMEs per day than patients 65-years and older. Biological sex and BMI are not associated with a statistically significant difference in average daily MMEs.
- morphine sulphate / Generic mfg.
The Effect of Marijuana on Postoperative Spine Patients' Emergency Room Visits, Readmission Rates, and Opioid Consumption (OrthoLive, West Hall) - Nov 22, 2023 - Abstract #AAOS2024AAOS_595;
Operative spine patients who test positive for THC preoperatively are more likely to consume higher amounts of narcotics postoperatively compared to a control group. The return to ED rates are similar between THC positive and negative patients, and while not statistically significant, there is a trend that THC positive patients are likely to return to the ED sooner.
- morphine sulphate / Generic mfg.
Opioid-Free Pain Management in Anterior Cervical Spine Surgery: A Randomized Controlled Trial (OrthoLive, West Hall) - Nov 22, 2023 - Abstract #AAOS2024AAOS_593;
Specifically, average postoperative pain levels at 6 and 24 hours reported by patients in the OF group were statistically non-inferior to pain levels reported by patients in the OC group. In addition, postoperative comfort levels at 12 and 24 hours reported by patients in the OF group were significantly higher than comfort levels reported by patients in the OC group.
- morphine sulphate / Generic mfg.
The Effects of Surgical Site Infiltrate of Liposomal Bupivacaine along with Bupivacaine in Postoperative Opioid Use and Pain Score in Patients Undergoing Major Hip Surgeries (OrthoLive, West Hall) - Nov 22, 2023 - Abstract #AAOS2024AAOS_565;
Local wound infiltration of Liposomal Bupivacaine in combination with Bupivacaine HCl was associated with significantly less opioid use (average daily MME) yet comparable VAS pain scores compared to PCA alone or PCA with Bupivacaine infiltration. These benefits were seen in patients throughout their hospital course with an average hospital stay of 4 days.
- morphine sulphate / Generic mfg.
Liposomal Bupivacaine in Postoperative Pain Control after Foot and Ankle Procedures: A Prospective Randomized Controlled Study (OrthoLive, West Hall) - Nov 22, 2023 - Abstract #AAOS2024AAOS_537;
The duration of effect of perineural block is significantly extended with addition of LB to the block mixture. Consideration should be given to the use of LB blocks in foot and ankle surgical procedures to reduce patient postoperative narcotic requirements.
- morphine sulphate / Generic mfg.
Rapid Recovery Pathway Utilizing Intrathecal Morphine Improves Quality of Care in Adolescent Idiopathic Scoliosis and Decreases Overall Hospital Costs (OrthoLive, West Hall) - Nov 22, 2023 - Abstract #AAOS2024AAOS_472;
Our RRP pathway, which integrates micro dose ITM injections at the time of surgery, allows for optimal perioperative management, improved costs, and overall better outcomes than the conventional PCA approach. This is crucial considering growing concerns about opioid dependence and rising hospital costs.
- morphine sulphate / Generic mfg.
The Relationship Between Preoperative PROMIS Pain Interference and Pain Intensity Scores and Early Postoperative Pain and Opioid Consumption after Lumbar Fusion (OrthoLive, West Hall) - Nov 22, 2023 - Abstract #AAOS2024AAOS_469;
After risk adjustment, increased baseline PROMIS Pain Interference, but not Pain Intensity, scores were associated with increased opioid use on postoperative days 0 and 1, although not to clinically significant levels. These results suggest that both the intensity of pain and level of life disruption from pain should be considered when identifying patients at risk for increased pain and opioid consumption after PLF.
- morphine sulphate / Generic mfg.
Percutaneous Versus Open Pedicle Screw Fixation for the Management of Metastatic Spine Disease: A Matched-Cohort Study (OrthoLive, West Hall) - Nov 22, 2023 - Abstract #AAOS2024AAOS_464;
Findings from the study indicate that percutaneous pedicle screw fixation is associated with less blood loss and shorter surgical time. Additionally, both palliative procedures are effective in improving physical function and reducing pain and depression.
- morphine sulphate / Generic mfg.
Anterior Cervical Discectomy and Fusion Reduces Postoperative Opioid Use in the Veteran Population (OrthoLive, West Hall) - Nov 22, 2023 - Abstract #AAOS2024AAOS_435;
Following ACDF surgery there was a significant reduction in median postoperative MME in both the low and high preoperative opioid cohorts. In those na
- Non-Opioid Multimodal Analgesia for Total Shoulder Arthroplasty Demonstrates Significant Reductions in Opioid Prescriptions without Increased Complications: A Retrospective Comparative Study (OrthoLive, West Hall) - Nov 22, 2023 - Abstract #AAOS2024AAOS_383;
The non-opioid cohort included patients from late 2020 to 2022 and consisted of preoperative oral analgesics (Celecoxib, Pregabalin, and Tramadol); intraoperative IV Dexamethasone and Acetaminophen, and local infiltration of Ropivacaine, Epinephrine, and Ketorolac; and postoperative oral Dexamethasone and oral analgesics (Pregabalin, Tizanidine, Magnesium, Ibuprofen, and Acetaminophen)...Opioid consumption (preoperative, and 10-days, 6-weeks, and 3-months postoperative) using Morphine Milligram Equivalents (MME) were compared and analyzed using the nonparametric Wilcoxon rank-sum test for both cohorts... A non-opioid multimodal postoperative regimen for patients undergoing anatomic or reverse TSA significantly reduces opioid prescriptions with similar patient-reported outcomes, subjective pain scores, and without increased complication rates compared to an opioid only regimen.
- morphine sulphate / Generic mfg.
Mental Health Disorders and Pain Modulation in Orthopaedic Shoulder Patients (OrthoLive, West Hall) - Nov 22, 2023 - Abstract #AAOS2024AAOS_344;
Our findings support our hypothesis and emphasize the clinical importance of recognizing mental health disease while navigating postoperative pain control expectations. Given the rising prevalence of mental health disorders nationwide, considering the effect of these comorbidities on postoperative pain in RCR, TSA, and RTSA patients will be essential to enhance postoperative counseling and management by orthopaedic surgeons.
- morphine sulphate / Generic mfg., hydrocodone/paracetamol / Generic mfg.
Opioid Prescription Patterns 30 Days after Pediatric Supracondylar Humerus Fracture Closed Reduction and Percutaneous Pinning (OrthoLive, West Hall) - Nov 22, 2023 - Abstract #AAOS2024AAOS_277;
Furthermore, 22-98% of patients did not take any narcotics in these studies. The average 6-year-old should be prescribed no more than 25.2 MME total, based on these studies' recommendations.
- morphine sulphate / Generic mfg.
Bipolar Sealer Hemostasis: Pain and Opioid Use Reduction in the Immediate Postoperative Phase following Primary Total Knee Arthroplasty (OrthoLive, West Hall) - Nov 22, 2023 - Abstract #AAOS2024AAOS_211;
Our study revealed statistically significant differences in pain and narcotic consumption on patients operated with bipolar sealing technology. This study suggests that there are substantial merits of its use to decrease pain and narcotic consumption in unilateral TKAs using strict multimodal treatment protocols.
- morphine sulphate / Generic mfg., heparin sodium injection / Generic mfg., tramadol hydrochloride / Generic mfg.
Computer Assisted Cryotherapy Reduce Opioids Use after Total Knee Arthroplasty: A Safe Postoperative Pain Management (OrthoLive, West Hall) - Nov 22, 2023 - Abstract #AAOS2024AAOS_115;
Moreover CAC seems to be a safe procedure with no adverse effect registered in our series. In conclusion, CAC is a safe and effective procedure following primary TKA resulting in less experienced pain and opioids use in the first postoperative days.
- morphine sulphate / Generic mfg.
Does a Pericapsular Nerve Group Block Reduce Perioperative Opioid Consumption among Patients Undergoing Anterior or Posterior Total Hip Arthroplasty? (OrthoLive, West Hall) - Nov 22, 2023 - Abstract #AAOS2024AAOS_79;
Since the PENG block is directed at the sensory fibers of the anterior hip capsule, a larger benefit was expected in patients undergoing anterior THA. We found a statistically significant reduction in PACU MMEs among those who received a PENG block for anterior THA; this difference was not observed among posterior approach THA patients, which supported our hypothesis.
- ketamine / Generic mfg.
Low-Dose Ketamine following Periacetabular and/or Femoral Osteotomy is Associated with a Significant Reduction in Postoperative Opioid Requirements (OrthoLive, West Hall) - Nov 22, 2023 - Abstract #AAOS2024AAOS_38;
Patients who received postoperative ketamine following PAO and/or DFO had a significant decrease in MME when compared to a control group of patients who did not receive ketamine. Surgeons should consider adding ketamine to their postoperative multimodal pain control protocol to decrease opioid consumption, while adequately addressing postoperative pain.
- | Enrollment change: Recommendations of Enhanced Recovery Interventions for Patient's Clinical Team and Collection of Associated Data (clinicaltrials.gov) - Nov 21, 2023
P3, N=2500, Recruiting, Sponsor: Jennifer Holder-Murray
Surgeons should consider adding ketamine to their postoperative multimodal pain control protocol to decrease opioid consumption, while adequately addressing postoperative pain. N=35485 --> 2500
- || morphine sulphate / Generic mfg.
Clinical, Journal: Combined Infraclavicular-Suprascapular Nerve Blocks Compared With Interscalene Block for Arthroscopic Rotator Cuff Repair: A Prospective, Randomized, Double-blind, and Comparative Clinical Trial. (Pubmed Central) - Nov 21, 2023
N=35485 --> 2500 The employment of the costoclavicular block in combination with the suprascapular block may provide a comparable analgesic potency to the sole use of the standard ISB with no HDP.
- | morphine sulphate / Generic mfg.
Retrospective data, Journal: Impact of opioid law on prescriptions and satisfaction of pediatric burn and orthopedic patients: An epidemiologic study. (Pubmed Central) - Nov 21, 2023
Discharge opioids prescribed for pediatric burn and knee arthroscopy procedures has decreased from 2015-2019. Caregivers varied greatly in their satisfaction with pain control and the amount of opioid prescribed.
- | morphine sulphate / Generic mfg.
Journal: The effectiveness of erector spina plane, quadratus lumborum blocks, and intrathecal morphine for analgesia after cesarean: a randomized study. (Pubmed Central) - Nov 21, 2023
Caregivers varied greatly in their satisfaction with pain control and the amount of opioid prescribed. All three methods, including intrathecal morphine, erector spinae plane block, and quadratus lumborum block, are efficacious and comparable in providing postoperative analgesia after cesarean under spinal anesthesia.
- | hydroxyzine hydrochloride / Generic mfg., morphine sulphate / Generic mfg.
Journal: Effect of intravenous administration of hydroxyzine hydrochloride on intrathecal morphine-induced pruritus after cesarean section. (Pubmed Central) - Nov 21, 2023
All three methods, including intrathecal morphine, erector spinae plane block, and quadratus lumborum block, are efficacious and comparable in providing postoperative analgesia after cesarean under spinal anesthesia. No abstract available
- | morphine sulphate / Generic mfg., nefopam / Generic mfg.
Journal: The effect of the addition of nefopam to intraoperative ketoprofen and acetaminophen on postoperative morphine requirements after laparoscopic cholecystectomy: a randomized controlled trial. (Pubmed Central) - Nov 21, 2023
No abstract available Adding nefopam to ketoprofen and acetaminophen before the end of laparoscopic cholecystectomy provides a reduction in morphine consumption with superior analgesia in PACU.
- | morphine sulphate / Generic mfg.
Journal: Urine and (Pubmed Central) - Nov 21, 2023
There was no clear trend toward increasing urinary opiate concentrations over the course of the study. Hair drug test The hair samples of two participants produced quantifiable codeine (41?pg/mg and 51?pg/mg), but no sample reached a common reporting threshold of 200?pg/mg for codeine or morphine.
- | Journal: Evaluation of Atypical Antipsychotics for the Facilitation of Weaning Sedation in Mechanically Ventilated Critically Ill Patients. (Pubmed Central) - Nov 21, 2023
AAP use was associated with a significant reduction in sedatives/analgesics doses. Future studies are warranted to confirm the results.
- || morphine sulphate / Generic mfg.
Retrospective data, Review, Journal: PATIENT-CONTROLLED ANALGESIA FOR THE MANAGEMENT OF ADULTS WITH ACUTE TRAUMA IN THE EMERGENCY DEPARTMENT: A SYSTEMATIC REVIEW & META-ANALYSIS. (Pubmed Central) - Nov 21, 2023
This study did not demonstrate a significant improvement in pain relief or patient satisfaction using PCA for trauma in the ED. Clinicians wishing to use PCA to treat acute trauma pain in adult patients in the ED are advised to consider the available resources in their own practice settings and to implement protocols for monitoring and responding to potential adverse events.
- | morphine sulphate / Generic mfg.
Journal: Chronic morphine induces adaptations in opioid receptor signaling in a thalamo-striatal circuit that are location-dependent, sex-specific and regulated by mu opioid receptor phosphorylation. (Pubmed Central) - Nov 21, 2023
Instead, prior morphine exposure increased morphine effects at thalamic terminals in the dorsomedial striatum only in male mice, but decreased morphine effects at medial thalamic cell bodies in both sexes. In mice lacking phosphorylation sites on MOR, chronic morphine treatment decreased, rather than increased, morphine effects at thalamic terminals in the dorsomedial striatum, implicating receptor phosphorylation in driving adaptations observed in wild-type mice.
- | morphine sulphate / Generic mfg.
Journal, Adherence: Opioid dose risk, clinician and patient characteristics, and adherence to opioid prescribing recommendations in chronic non-cancer pain. (Pubmed Central) - Nov 20, 2023
This study documented that higher MEDD was associated with risks of worse health outcomes without improved adherence to opioid prescribing guideline recommendations. Enhanced clinician awareness of factors associated with MEDD has the potential to mitigate LTOT risks and improve overall patient care.
- | morphine sulphate / Generic mfg.
Retrospective data, Journal: New Persistent Opioid Use After Childbirth. (Pubmed Central) - Nov 20, 2023
Among people who filled an opioid prescription after delivery, about 1% displayed evidence of persistent opioid use in the subsequent year. Initial prescriptions for large quantities of opioids and a concurrent benzodiazepine prescription may be important modifiable risk factors to prevent new persistent opioid use after delivery.
- | morphine sulphate / Generic mfg.
Journal: Enhancement of neuronal excitability in the medial prefrontal cortex following prenatal morphine exposure. (Pubmed Central) - Nov 20, 2023
Moreover, the sag voltage ratio was significantly decreased in the prenatal morphine group. Our results suggest that the changes observed in the electrophysiological properties of mPFC neurons indicate an elevation in neuronal excitability following prenatal exposure to morphine.
- || morphine sulphate / Generic mfg., ropivacaine / Generic mfg.
Clinical, Journal: Peri-Incisional Infiltration and Intraperitoneal Instillation of Local Anesthetic for Reducing Pain After Laparoscopic Donor Nephrectomy: A Prospective, Randomized, Double-Blind Control Trial. (Pubmed Central) - Nov 19, 2023
Our results suggest that the changes observed in the electrophysiological properties of mPFC neurons indicate an elevation in neuronal excitability following prenatal exposure to morphine. Peri-incisional infiltration and intraperitoneal instillation of ropivacaine did not reduce postoperative pain or analgetic consumption.
- | morphine sulphate / Generic mfg.
Journal: Inpatient opioid use and pain control after robotic versus laparoscopic sleeve gastrectomy. (Pubmed Central) - Nov 19, 2023
Peri-incisional infiltration and intraperitoneal instillation of ropivacaine did not reduce postoperative pain or analgetic consumption. There is no difference in inpatient opioid use or pain scores between patients undergoing laparoscopic and robotic sleeve gastrectomy.
- | morphine sulphate / Generic mfg.
Journal: A 1:1 matched comparison of posterior retroperitoneal and lateral transabdominal adrenalectomy using a robotic platform. (Pubmed Central) - Nov 19, 2023
There is no difference in inpatient opioid use or pain scores between patients undergoing laparoscopic and robotic sleeve gastrectomy. Perioperative outcomes of lateral transperitoneal adrenalectomy, including those related to recovery, were similar to those of posterior retroperitoneal adrenalectomy when matched for tumor and patient anthropometric parameters.
- | morphine sulphate / Generic mfg.
Journal, Surgery: Impact of Limited Enhanced Recovery Pathway for Cardiac Surgery: A Single-Institution Experience. (Pubmed Central) - Nov 19, 2023
Patients additionally experienced less postoperative pain despite decreased opioid use. Implementation of ERP, even in a limited format, is a promising approach to improving outcomes in patients undergoing cardiac surgery.
- | morphine sulphate / Generic mfg.
Enrollment open, Surgery: Intrathecal Morphine for Analgesia in Video-assisted Thoracic Surgery (clinicaltrials.gov) - Nov 18, 2023
P4, N=90, Recruiting, Sponsor: University of Chicago
Implementation of ERP, even in a limited format, is a promising approach to improving outcomes in patients undergoing cardiac surgery. Not yet recruiting --> Recruiting
- || morphine sulphate / Generic mfg.
Review, Journal: A Critical Review of the Neuropharmacological Effects of Kratom: An Insight from the Functional Array of Identified Natural Compounds. (Pubmed Central) - Nov 18, 2023
The most prevalent compounds, mitragynine and 7-hydroxy mitragynine, are reported to display agonist morphine-like effects on human ?-opioid receptors and antagonists at ?- and ?-opioid receptors with multimodal effects at other central receptors...Additionally, its anti-inflammatory, antioxidative, antibacterial, and gastroprotective effects are well-cited. In this context, this review focuses on the research gap to resolve ambiguities about the neuronal effects of kratom and demonstrate its prospects as a therapeutic target for neurological disorders associated with other pharmacological effects.
- || Review, Journal: Periarticular infiltration used in total joint replacements: an update and review article. (Pubmed Central) - Nov 18, 2023
Each medication's mode of action, duration, ideal dosage, contraindications, side effects and effectiveness have been summarized in the review article. This article will help the clinician to make an informed evidence-based decision about which medications to include in their ideal cocktail.
- | morphine sulphate / Generic mfg.
Journal: Aitongping patch could alleviate cancer pain via suppressing microglia activation and modulating the miR-150-5p/CXCL12 signaling. (Pubmed Central) - Nov 18, 2023
This article will help the clinician to make an informed evidence-based decision about which medications to include in their ideal cocktail. Aitongping patch could alleviate cancer pain via suppressing microglia activation, and the downregulation of miR-150-5p, as well as the upregulation of CXCL12 mRNA and protein, induced by tumor implantation or lipopolysaccharide stimulation, was restored by Aitongping treatment.
- | morphine sulphate / Generic mfg.
Journal, Surgery: Early observations with an ERAS pathway for thyroid and parathyroid surgery: Moving the goalposts forward. (Pubmed Central) - Nov 17, 2023
This study demonstrates a significant benefit from Enhanced recovery after surgery pathways for thyroidectomies and parathyroidectomies, even with initial data and a staggered roll-out plan. Further directions include a follow-up study once we reach a higher level of institutional compliance with all components of the Enhanced Recovery After Surgery pathway and a prospective trial to identify the relative significance of different portions of the Enhanced Recovery after Surgery pathway, particularly the superficial cervical plexus block.