morphine sulphate / Generic mfg. 
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  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Opioid Use Following Primary Unilateral Total Knee Arthroplasty Varies With Age. (Pubmed Central) -  Jun 12, 2025   
    Narcotic medications used in-house and in the 3 months following discharge were calculated and converted to morphine milligram equivalents (MMEs)...While age alone may not independently predict increased opioid consumption, these findings highlight the importance of identifying and managing modifiable risk factors to optimize pain control. Further research with larger cohorts is needed to better isolate the impact of age.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  A Collaborative Multimodal Pain Management Pathway Reduces Opiate Consumption After Total Hip and Knee Arthroplasty. (Pubmed Central) -  Jun 12, 2025   
    Primary outcome was postoperative morphine milligram equivalents (MMEs) per 24 hours...Our collaborative multimodal pain management pathway reduced opiate consumption for patients undergoing total hip and knee arthroplasty with a reduction in LOS, no difference in pain scores and was effective for patients with various levels of opiate requirements. Level III Therapeutic Study: retrospective comparative study.
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg., methadone / Generic mfg.
    Journal:  Intraoperative methadone for postoperative pain in adult patients undergoing tonsillectomy-a randomised controlled trial. (Pubmed Central) -  Jun 12, 2025   
    P4
    This study hypothesised that methadone would provide superior postoperative pain relief and reduced opioid consumption compared with fentanyl...Joint primary outcomes were pain intensity (numeric rating scale, 0-10) at swallowing upon postanaesthesia care unit (PACU) arrival and cumulative opioid consumption (oral morphine equivalents) over 5 postoperative days...Identifying risk factors for both severe postoperative pain and PONV may help guide patient selection for methadone use. NCT05445856, EudraCT ID 2022-002496-11.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Tolerance in thalamic paraventricular nucleus neurons following chronic treatment of animals with morphine. (Pubmed Central) -  Jun 11, 2025   
    Nearly all neurons in the anterior PVT (aPVT) neurons express opioid receptors, suggesting that this brain region likely contributes to affective and cognitive facets of opioid analgesia and dependence. Understanding the acute actions and adaptations induced by opioids in the PVT therefore provide insight into affective pain processing and potentially connect it to the affective withdrawal symptoms seen in opioid use disorder.
  • ||||||||||  morphine sulphate / Generic mfg.
    Reimbursement, US reimbursement, Journal:  De-prescribing opioids among Medicaid patients with long-term opioid use. (Pubmed Central) -  Jun 11, 2025   
    Clinical studies are warranted to validate their efficacy in rehabilitation centers for drug use disorder. Targeted provider-level interventions to support deprescribing for long-term opioid patients using opioids and other respiratory depressants may provide particularly high-value care.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Analgesia for living donor liver transplant: a systematic review of recent trials. (Pubmed Central) -  Jun 10, 2025   
    This does not support routine use of the more expensive intravenous form to improve recovery and accelerate discharge. Little new data are available since the last guidelines; regional anesthesia techniques appear to offer good pain management when part of a multimodal and balanced analgesic approach to liver transplant surgery.
  • ||||||||||  morphine sulphate / Generic mfg.
    Retrospective data, Journal:  Factors associated with chronic opioid use after minimally invasive lung resections. (Pubmed Central) -  Jun 10, 2025   
    Higher pre-discharge MMEs are associated with an increased likelihood of chronic opioid usage. Future studies should focus on whether preemptive early outpatient intercostal nerve blocks or cryoablations can decrease chronic narcotic usage in high-risk patients.
  • ||||||||||  morphine sulphate / Generic mfg., hydromorphone hydrochloride / Generic mfg.
    Journal, Head-to-Head:  Intrathecal Hydromorphone Versus Intrathecal Morphine for Postcesarean Delivery Analgesia: A Randomized Noninferiority Trial. (Pubmed Central) -  Jun 10, 2025   
    Future studies should focus on whether preemptive early outpatient intercostal nerve blocks or cryoablations can decrease chronic narcotic usage in high-risk patients. Intrathecally, hydromorphone is noninferior to morphine for analgesia after elective cesarean delivery when using the previously established ED90 for both opioids (morphine: 150
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
    Journal:  Endogenous Opioids and the Development of the Mammalian Respiratory Control Network. (Pubmed Central) -  Jun 10, 2025   
    Last, we propose clinical breathing conditions that may involve the endogenous opioid system. Given advances in tools for detecting endogenous opioid peptide release and the evidence reviewed herein, future research will yield new discoveries in the role of endogenous opioids in breathing across the lifespan.
  • ||||||||||  ketorolac / Generic mfg.
    Journal:  Early Utilization of Ketorolac in Cleft Palate Repair. (Pubmed Central) -  Jun 10, 2025   
    This has important consequences to help improve pain control with reduced opiates requirement as well as length of stay. Future prospective studies can help elicit the causative effect of Ketorolac on these parameters and can investigate whether use of Ketorolac has an effect on long term recovery and post-discharge opiate requirements as well.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Temporal Trends in Opioid-Related Care and Pain Among Veterans at the End of Life. (Pubmed Central) -  Jun 9, 2025   
    These findings suggest that important tradeoffs may exist between reducing opioid-related serious adverse events and undertreating patient pain in the last month of life. Opioid prescribing guidelines could consider incorporating prognosis into recommendations.
  • ||||||||||  Journal:  Evaluation of pharmacotherapy in sickle cell disease in an Afro- Colombian community: A cross-sectional analytical study in San Basilio de Palenque, Bol (Pubmed Central) -  Jun 9, 2025   
    The most commonly used medications included folic acid, analgesics (paracetamol, tramadol, naproxen, codeine, ibuprofen, morphine), L-glutamine, and enalapril...Notably, 62% of homozygous patients were not receiving baseline treatment with hydroxycarbamide, increasing their risk of complications...In conclusion, this research highlights the need for a multidisciplinary approach to optimize treatment and improve the quality of life of affected patients. Given its genetic significance, San Basilio de Palenque represents a unique setting for further studies on SCD.
  • ||||||||||  morphine sulphate / Generic mfg.
    Review, Journal:  Targeting Excitatory Glutamate Receptors for Morphine Tolerance: A Narrative Review. (Pubmed Central) -  Jun 9, 2025   
    Targeting excitatory glutamate receptors presents a promising therapeutic strategy for mitigating opioid tolerance. Future research should prioritize elucidating receptor-specific mechanisms, peripheral-central nervous system crosstalk, and translating preclinical findings into clinically viable.
  • ||||||||||  morphine sulphate / Generic mfg.
    Incident Opioid Use Disorder Among People with Long-Term Prescription Opioid Use: An Australian Nested Case-Control Study (Napoleon Ballroom CD, Third Floor) -  Jun 8, 2025 - Abstract #CPDD2025CPDD_799;    
    We applied conditional logistic regression to calculate odds ratios for OUD associated with five exposure metrics: (1) any opioid exposure; (2) strong opioid exposure; (3) long-term exposure (?60 consecutive days); and (4) peak or (5) average daily oral morphine equivalent (OME; mg)... Exposure to strong opioids and higher daily doses were strongly associated with OUD onset, particularly when exposure was maintained over time.
  • ||||||||||  methadone / Generic mfg.
    Trajectories of Heroin Users in Early Stages of Methadone Maintenance Treatment (Napoleon Ballroom CD, Third Floor) -  Jun 8, 2025 - Abstract #CPDD2025CPDD_684;    
    All participants underwent monthly urine morphine and amphetamine testing. Insufficient methadone dosing and concurrent methamphetamine use should be addressed among methadone entrants exhibiting unsatisfactory treatment responses.
  • ||||||||||  morphine sulphate / Generic mfg.
    Epigenetic and Transcriptomic Signatures of Morphine-Context Association in the Hippocampus (Napoleon Ballroom CD, Third Floor) -  Jun 8, 2025 - Abstract #CPDD2025CPDD_593;    
    ECM has been implicated in neuroplasticity in learning and memory and morphine-induced reorganization of the ECM at CA1 neurons may contribute to the formation of powerful and lasting memories between the drug experience and associated spatial context and cues. 2
  • ||||||||||  morphine sulphate / Generic mfg.
    Morphine Amplifies Traumatic Brain Injury Induced Neuroinflammation Via The Kynurenine Pathway (Napoleon Ballroom CD, Third Floor) -  Jun 8, 2025 - Abstract #CPDD2025CPDD_588;    
    These findings suggest that MOR treatment exacerbates TBI-induced elevations in chronic pain, neuroinflammation, and the central KP response, warranting future studies to explore the KP as a therapeutic target for post-TBI pain management. 2
  • ||||||||||  morphine sulphate / Generic mfg.
    Parabrachial CGRP Neurons Regulate Opioid Reinforcement and Withdrawal (Napoleon Ballroom CD, Third Floor) -  Jun 8, 2025 - Abstract #CPDD2025CPDD_577;    
    Given the availability of small-molecule CGRP receptor inhibitors as first-line treatments for migraine, these new results suggest that CGRPPBN neurons may be a novel, druggable target in OUD. 2
  • ||||||||||  morphine sulphate / Generic mfg.
    HIV-Tat Protein Expression and Morphine Synergize to Drive DNA Damage: The Role of AIM2 Inflammasome in HAND (Grand Ballroom B, Fifth Floor) -  Jun 8, 2025 - Abstract #CPDD2025CPDD_552;    
    Collectively, our data reveals that the phosphorylation of H2AX, the accumulation of DNA damage markers, DSBs, and altered DRPs may play a pivotal role in initiating neuroinflammation and contributing to the progression of HAND. These findings highlight potential therapeutic targets for mitigating neurodegeneration associated with HIV-1 Tat expression and chronic morphine exposure.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Behavioral Effects of Novel Para- And Ortho-Substituted Fentanyl Analogs (Napoleon Ballroom CD, Third Floor) -  Jun 8, 2025 - Abstract #CPDD2025CPDD_317;    
    These fentanyl analogs may have substantial potential to be used as substitutes for legal and illegal opioids. para-Bromofentanyl may be less dangerous as it was less potent than morphine in both assays.
  • ||||||||||  ANT-429 / Antyra
    Pharmacological Characterization of Substituted Nitazenes at Opioid Receptors (Grand Ballroom A, Fifth Floor) -  Jun 8, 2025 - Abstract #CPDD2025CPDD_302;    
    Nitazenes are appearing in drug samples seized by the DEA and have been 1 repeatedly identified in fatal and non-fatal intoxications around the world. The affinity, potency, and efficacy values reported herein for the nitazenes evaluated highlight key structure activity relationships, including newly described motifs that reduce selectivity for MOR versus KOR, conferring a more morphine-like pattern of binding and function at opioid receptors.
  • ||||||||||  morphine sulphate / Generic mfg.
    GPR55 and the Modulation of Opioid-Induced Behavioral Tolerance and Withdrawal (Grand Ballroom B, Fifth Floor) -  Jun 8, 2025 - Abstract #CPDD2025CPDD_294;    
    Male and female mice (8 per group) were given 5 day increasing doses of morphine every 12 hours... Given that both our GPR55 KO and KLS pretreated animals both saw reductions in adverse behaviors associated with opioids, we conclude that the mechanism is through GPR55 antagonism and that this receptor is a potential novel target that may increase the safety of opioid medications.
  • ||||||||||  morphine sulphate / Generic mfg.
    Eating A High Fat/High Carbohydrate Diet Enhances Morphine Tolerance, While Eating A Ketogenic Diet Mitigates Morphine Withdrawal in Male Rats (Napoleon Ballroom B3, Third Floor) -  Jun 8, 2025 - Abstract #CPDD2025CPDD_284;    
    Given that both our GPR55 KO and KLS pretreated animals both saw reductions in adverse behaviors associated with opioids, we conclude that the mechanism is through GPR55 antagonism and that this receptor is a potential novel target that may increase the safety of opioid medications. These results suggest that dietary intake can impact individual sensitivity to morphine, in ways that might be especially relevant for patients diagnosed with obesity, who are taking opioids for pain management.
  • ||||||||||  cebranopadol (TRN-228) / Tris Pharma
    Abuse Potential Assessment of Cebranopadol, a Novel Dual Nociceptin (NOP) and Mu Opioid (MOP) Receptor (NMR) Agonist: Implications for Scheduling (Napoleon Ballroom CD, Third Floor) -  Jun 8, 2025 - Abstract #CPDD2025CPDD_137;    
    In the drug discrimination procedure, cebranopadol showed dose-dependent generalization to morphine; however, effects were antagonized by naloxone (MOP antagonist) and enhanced by J-11397 (NOP antagonist), indicating NOP activity reduces its MOP agonist properties...In recreational opioid users, cebranopadol at doses up to 2.5 times the anticipated maximum therapeutic dose showed lower abuse potential compared with Schedule II (hydromorphone, oxycodone) and Schedule IV (tramadol) opioids... The overall abuse potential of cebranopadol is less than Schedule II and IV full and partial MOP agonists, suggesting a less restrictive schedule than Schedule II is appropriate.
  • ||||||||||  morphine sulphate / Generic mfg.
    A Multidimensional Model of the Opioid Withdrawal Syndrome in Male and Female Rats (Napoleon Ballroom CD, Third Floor) -  Jun 8, 2025 - Abstract #CPDD2025CPDD_62;    
    A robust multidimensional spontaneous withdrawal syndrome was produced in male and female rats with distinct time-dependent effects for somatic and psychological signs. Future studies will test classic and novel pharmacotherapeutics in this model.