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379 Trials |  |
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- | morphine sulphate / Generic mfg.
Journal: Preoperative Mental Health Disorders Affect Opioid Consumption and Perioperative Complications After Total Shoulder Arthroplasty. (Pubmed Central) - Sep 23, 2024
Patients with a MHD had higher mean hospital costs ($75,984
- morphine sulphate / Generic mfg.
Feasibility Study of a Randomized Controlled Trial Investigating Renal Denervation as a Possible Treatment Option in Patients with Loin Pain Hematuria Syndrome (Exhibit Hall, Convention Center) - Sep 23, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_3430;
This is the first randomized controlled study that shows that RDN is associated with improvement in pain and quality of life. Our results suggest that percutaneous catheter-based radiofrequency energy delivery is a safe, rapid treatment option for all patients with LPHS.CharacteristicsRoll in (n=3)RDN (n=5)Sham (n=5)Cross-over (n=3)Mean age (years)43.33
- morphine sulphate / Generic mfg.
Unsafe Opioid Prescribing among Patients with ESKD in 2020 (Exhibit Hall, Convention Center) - Sep 23, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_1170;
The results demonstrate that unsafe opioid prescribing impacted 1 in 6 HD patients and about 1 in 7 PD patients. Given the high need for symptom management for patients with kidney failure, the results underscore the need to improve access to alternative pain management strategies and to monitor unsafe opioid prescribing for this population.
- | morphine sulphate / Generic mfg., resatorvid (TAK-242) / Takeda, Akaza Bioscience
Journal, IO biomarker: Morphine induces inflammatory responses via both TLR4 and cGAS-STING signaling pathways. (Pubmed Central) - Sep 21, 2024
Morphine activates the cGAS-STING pathway in macrophage cell types. Inhibition of the STING pathway can be an additional method to overcome immune cell inflammation-related morphine tolerance and opioid-induced hyperalgesia.
- | morphine sulphate / Generic mfg.
Journal, Metastases: Opioid Access among Advanced Cancer Patients in Low- and Middle-Income Countries in Asia. (Pubmed Central) - Sep 21, 2024
Study findings emphasize the importance of palliative care training-even a minimal amount-in supporting access to opioids for advanced cancer patients. This study also highlights pragmatic site-level policies, such as extended morphine prescription durations, enabling access.
- | morphine sulphate / Generic mfg.
Journal: Is general practitioner involvement in the initiation of opioids for chronic non-cancer pain associated with opioid dose and concurrent drug use? (Pubmed Central) - Sep 21, 2024
Main outcome measures 1) Total opioid dose in daily oral morphine equivalents (OMEQ)...Conclusions GP involvement in the initiation of opioid medication for CNCP was associated with a lower opioid dose being prescribed. Implications GP involvement in the initiation of opioid prescriptions may facilitate safer prescribing.
- | morphine sulphate / Generic mfg.
Journal: Morphine-specific IgE testing in the diagnosis of neuromuscular blocking agent allergy: proper use and interpretation. (Pubmed Central) - Sep 21, 2024
Implications GP involvement in the initiation of opioid prescriptions may facilitate safer prescribing. No abstract available
- || morphine sulphate / Generic mfg.
Retrospective data, Review, Journal: Non-pulmonary complications of intrathecal morphine administration: a systematic review and meta-analysis with meta-regression. (Pubmed Central) - Sep 21, 2024
No abstract available Intrathecal morphine significantly increased postoperative nausea and vomiting, pruritus, and urinary retention after surgery or labour in a dose-independent manner.
- | Pavacol-D (pholcodine) / Alliance
Journal: Pholcodine and allergy to neuromuscular blocking agents. Comment on Br J Anaesth 2024; 132: 457-60. (Pubmed Central) - Sep 21, 2024
Intrathecal morphine significantly increased postoperative nausea and vomiting, pruritus, and urinary retention after surgery or labour in a dose-independent manner. No abstract available
- | morphine sulphate / Generic mfg.
Enrollment change: Intraosseous Morphine in Primary TKA (clinicaltrials.gov) - Sep 20, 2024
P4, N=65, Completed, Sponsor: The Methodist Hospital Research Institute
No abstract available N=48 --> 65
- || Chirocaine (levobupivacaine) / Purdue, AbbVie
Review, Journal: Gene polymorphism impact on opioid analgesic usage. (Pubmed Central) - Sep 20, 2024
From those articles, we reviewed the impact of gene polymorphism on pain management and drug pharmacokinetics. Based on this systematic review, we concluded that gene polymorphism of gene affects analgesic, specifically opioid mechanisms.
- | morphine sulphate / Generic mfg.
Journal: Comparison of patient-controlled epidural analgesia and epidural morphine for post-cesarean section analgesia: experience from a tertiary center in China. (Pubmed Central) - Sep 20, 2024
The use of PCEA was an independent protective factor for supplementary analgesia during the post-cesarean section. Prophylactic antiemetic therapy may reduce the side effects of post-cesarean analgesia.
- | pilocarpine / Generic mfg., ivermectin topical / Generic mfg.
Preclinical, Journal: Ivermectin Exerts Anticonvulsant Effects Against Status Epilepticus Induced by Lithium-Pilocarpine in Rats via GABAA Receptor and Neuroinflammation Modulation: Possible Interaction of Opioidergic Pathways and KATP Channel with Nitrergic System. (Pubmed Central) - Sep 20, 2024
following SE, while increased the reduced expression of GABAA receptors. Overall, these findings suggest that ivermectin has anti-seizure effects in a SE seizure which may be mediated by the modulation of GABAergic, opioidergic, and nitrergic pathways and KATP channels.
- | morphine sulphate / Generic mfg.
Trial completion, Trial completion date, Trial primary completion date: A Randomized Controlled Trial Comparing Intrathecal Morphine with Quadratus Lumborum Block for Post-cesarean Delivery Analgesia (clinicaltrials.gov) - Sep 20, 2024
P=N/A, N=60, Completed, Sponsor: Nova Scotia Health Authority
Overall, these findings suggest that ivermectin has anti-seizure effects in a SE seizure which may be mediated by the modulation of GABAergic, opioidergic, and nitrergic pathways and KATP channels. Recruiting --> Completed | Trial completion date: Dec 2021 --> Apr 2024 | Trial primary completion date: Dec 2021 --> Oct 2023
- | morphine sulphate / Generic mfg.
Retrospective data, Journal: Cordotomy for pain control and opioid reduction in cancer patients: A cancer center 11-year experience. (Pubmed Central) - Sep 20, 2024
PLCC is a valuable therapeutic intervention for patients experiencing cancer pain that is unresponsive to conservative treatments. The anticipated analgesic outcomes are generally favorable, particularly in cases where the pain is localized unilaterally in the abdomen or lower body segments.
- | morphine sulphate / Generic mfg., metoclopramide / Generic mfg.
Observational data, Journal: Prevention of postoperative nausea and vomiting after cesarean delivery under neuraxial anesthesia and postpartum analgesia in Japan: A cross-sectional study. (Pubmed Central) - Sep 20, 2024
The anticipated analgesic outcomes are generally favorable, particularly in cases where the pain is localized unilaterally in the abdomen or lower body segments. The online survey showed that the physicians using neuraxial opioids for CD had a higher proportion of multimodal PONV management involving two or more agents.
- | clonidine / Generic mfg.
Observational data, Journal: Oral Clonidine-based Strategy to Reduce Opiate Use during Cooling for Neonatal Encephalopathy: An Observational Study. (Pubmed Central) - Sep 20, 2024
The online survey showed that the physicians using neuraxial opioids for CD had a higher proportion of multimodal PONV management involving two or more agents. Our CLON protocol is noninferior to MOR, maintaining perceived effectiveness and hemodynamic safety, with an apparently reduced need for opiates and inotropes.
- | morphine sulphate / Generic mfg.
New P1 trial: Comparison Between Epidural Analgesia and Intrathecal Opioid Analgesia for Pain Management in Open Nephrectomy (clinicaltrials.gov) - Sep 19, 2024
P1, N=40, Not yet recruiting, Sponsor: University Hospital of Split
- | morphine sulphate / Generic mfg.
Enrollment change, Trial withdrawal: Intrathecal Morphine vs. Intrathecal Morphine and Regional Anesthesia After Cesarean Section. (clinicaltrials.gov) - Sep 19, 2024
P4, N=0, Withdrawn, Sponsor: University of Miami
Our CLON protocol is noninferior to MOR, maintaining perceived effectiveness and hemodynamic safety, with an apparently reduced need for opiates and inotropes. N=100 --> 0 | Suspended --> Withdrawn
- ||||||| ketorolac PMB (NTM-001) / Neumentum
Trial completion: Ketorolac Applied by Continuous IV Infusion for Treatment of Moderately Severe Postoperative Pain Following Bunionectomy (clinicaltrials.gov) - Sep 19, 2024
P3, N=341, Completed, Sponsor: NEMA Research, Inc.
N=100 --> 0 | Suspended --> Withdrawn Recruiting --> Completed
- | morphine sulphate / Generic mfg.
Trial completion date, Trial primary completion date, Surgery: Intrathecal Morphine for Analgesia in Video-assisted Thoracic Surgery (clinicaltrials.gov) - Sep 19, 2024
P4, N=90, Recruiting, Sponsor: University of Chicago
Recruiting --> Completed Trial completion date: Dec 2024 --> Mar 2026 | Trial primary completion date: Sep 2024 --> Jan 2026
- | morphine sulphate / Generic mfg.
Preclinical, Journal: The effects of eating a traditional high fat/high carbohydrate or a ketogenic diet on sensitivity of female rats to morphine. (Pubmed Central) - Sep 18, 2024
However, eating a ketogenic diet may have beneficial effects on opioid withdrawal-related weight loss. Individuals diagnosed with obesity taking opioids for pain-related conditions might therefore consider adopting a ketogenic diet when opioid administration is discontinued to potentially mitigate withdrawal-related weight loss.
- | morphine sulphate / Generic mfg., gabapentin / Generic mfg.
Journal: Postoperative Opioid Consumption Patterns Diverge Between Propensity Matched Patients Undergoing Traumatic and Elective Cervical Spine Fusion. (Pubmed Central) - Sep 18, 2024
Preoperative opioid use was also a risk factor for higher consumption in the short-term postoperative period. These results may aid physicians in further understanding patients' postoperative care needs based on presenting injury characteristics and highlights the need for enhanced follow-up care for traumatic cervical spine injury patients after fusion surgery.
- | morphine sulphate / Generic mfg.
Journal, HEOR, Real-world evidence, Surgery, Real-world: Effects of Liposomal Bupivacaine on Opioid Use and Healthcare Resource Utilization After Outpatient Spine Surgery: a Real-world Assessment. (Pubmed Central) - Sep 18, 2024
ED visit rates were significantly lower at 60 days after discharge. These findings support reduced cost and improved quality metrics in patients treated with LB versus non-LB analgesia for outpatient spine surgery.
- || Clinical, Journal: Effects of a Modified Long-Acting Cocktail on Analgesia and Enhanced Recovery After Total Hip Arthroplasty: A Double-Blinded Randomized Clinical Trial. (Pubmed Central) - Sep 18, 2024
These findings support reduced cost and improved quality metrics in patients treated with LB versus non-LB analgesia for outpatient spine surgery. The modified cocktail with a new adjuvant can prolong the duration of postoperative analgesia, reduce the dosage of rescue analgesics, and accelerate early postoperative functional recovery in patients undergoing THA.
- | morphine sulphate / Generic mfg.
Observational data, Retrospective data, Journal: Effect of Morphine Used to Relieve Dyspnea Due to Heart Failure on Delirium. (Pubmed Central) - Sep 18, 2024
Morphine, which is used to relieve dyspnea due to heart failure, had minimal effect on the incidence of delirium. This information is likely to be beneficial for the future use of morphine in the management of dyspnea in patients with heart failure.
- | morphine sulphate / Generic mfg.
Journal: Disruption of relapse to cocaine and morphine seeking by LiCl-induced aversive counterconditioning following memory retrieval. (Pubmed Central) - Sep 15, 2024
In addition, the effect of LiCl-induced aversive counterconditioning could last for about 14?days. These results suggest that aversive counterconditioning during the reconsolidation of cocaine or morphine memory can prevent the re-seeking of cocaine or morphine, presumably by updating or replacing cocaine or morphine memories with aversive information.
- | morphine sulphate / Generic mfg.
Retrospective data, Journal: Intrathecal Morphine Enhances Postoperative Analgesia and Recovery in Robotic-Assisted Laparoscopic Partial Nephrectomy: A Retrospective Study of 272 Patients. (Pubmed Central) - Sep 15, 2024
CONCLUSIONS Our findings indicate that ITM provided superior pain control during the early period following RAPN, with reduced postoperative opioid requirements. Moreover, ITM improved patient satisfaction with recovery.
- || morphine sulphate / Generic mfg.
Review, Journal: Orlando Veterans Affairs Stratification Tool for Opioid Risk Mitigation (STORM) Very High Risk Interdisciplinary Team Review: A Brief Report. (Pubmed Central) - Sep 15, 2024
A reduction in MEDD, increase in SUD treatment, and improved risk mitigation was observed. The central role of clinical pharmacy and expanded process for continued follow-up warrants further study.
- | morphine sulphate / Generic mfg., methadone / Generic mfg.
Retrospective data, Journal, Surgery: Intravenous Methadone versus Intrathecal Morphine as Part of an Enhanced Recovery After Cardiac Surgery Protocol on Postoperative Pain and Outcomes: A Retrospective Cohort Study. (Pubmed Central) - Sep 15, 2024
Methadone can be considered as a safe and effective alternative to ITM for ERACS protocols. Future large prospective studies are needed to validate this finding and further improve analgesia and safety.
- | morphine sulphate / Generic mfg.
Retrospective data, Journal, Surgery: Association Between Single-Injection Regional Analgesia and Postoperative Pain in Cardiac Surgery Patients: A Single-Center Retrospective Cohort Study. (Pubmed Central) - Sep 15, 2024
Future large prospective studies are needed to validate this finding and further improve analgesia and safety. In this retrospective study, the implementation of single-shot chest wall nerve blocks with liposomal bupivacaine was not associated with decreased postoperative pain scores or opioid consumption at 72 hours in select cardiac surgical patients at one institution.
- || dexmedetomidine / Generic mfg.
Clinical, Journal: Analgesic Effect and Sleep Quality of Low-Dose Dexmedetomidine in Cardiac Surgical Patients After Ultrafast-Track Extubation: A Randomized Clinical Trial. (Pubmed Central) - Sep 15, 2024
In this retrospective study, the implementation of single-shot chest wall nerve blocks with liposomal bupivacaine was not associated with decreased postoperative pain scores or opioid consumption at 72 hours in select cardiac surgical patients at one institution. Sedation with low-dose dexmedetomidine infusion for ultra-fast track extubation following cardiac surgery enhances sleep duration and quality.
- || morphine sulphate / Generic mfg.
Retrospective data, Review, Journal: Efficacy and safety of intrathecal diamorphine: a systematic review and meta-analysis with meta-regression and trial sequential analysis. (Pubmed Central) - Sep 15, 2024
Sedation with low-dose dexmedetomidine infusion for ultra-fast track extubation following cardiac surgery enhances sleep duration and quality. There is very low level of evidence that intrathecal diamorphine provides effective analgesia after surgery, while increasing postoperative nausea and vomiting with doses >?200??g.
- | morphine sulphate / Generic mfg.
Preclinical, Journal, Immunomodulating: Comparison of Morphine and Endomorphin Analog ZH853 for Tolerance and Immunomodulation in a Rat Model of Neuropathic Pain. (Pubmed Central) - Sep 15, 2024
PERSPECTIVE: Neuropathic pain is generally undertreated, resistant to available medications, and opioid treatment is limited by side-effects. Here, we show that, compared to an equiantinociceptive dose of a stereotypical
- | morphine sulphate / Generic mfg.
Journal: Pain Assessment and Analgesic Requirements after Sleeve Gastrectomy: A Comparison Study of Robotic versus Laparoscopic Approaches. (Pubmed Central) - Sep 14, 2024
These findings suggest that RSG may lead to reduced immediate postoperative pain and lower opioid requirements compared to the laparoscopic approach, despite longer operative times. Further randomized controlled trials are needed to confirm these observations and evaluate long-term outcomes.
- | morphine sulphate / Generic mfg.
Journal, Surgery: Cryo-Pneumatic Compression Results in a Significant Decrease in Opioid Consumption After Shoulder Surgery: A Multicenter Randomized Controlled Trial. (Pubmed Central) - Sep 14, 2024
P=N/A
Narcotic use was evaluated by the number of oral morphine milligram equivalents consumed during the postoperative period, as well as the time to cessation of narcotic use...In patients undergoing unilateral shoulder surgery, the use of cryotherapy with pneumatic compression, when compared with standard care, resulted in significantly decreased opioid consumption as well as increased function at 2 weeks. NCT04185064 (ClinicalTrials.gov identifier).
- || morphine sulphate / Generic mfg., methamphetamine / Generic mfg.
Review, Journal: Structural and Functional Dysregulation of the Brain Endothelium in HIV Infection and Substance Abuse. (Pubmed Central) - Sep 14, 2024
We summarize evidence from human and animal studies, in vitro studies, and associated mechanisms. We further summarize evidence of synergy or lack thereof between commonly abused substances (cocaine, methamphetamine, alcohol, tobacco, opioids, and cannabinoids) and HIV- or viral protein-induced BBB injury and dysfunction.
- || Review, Journal, Tumor cell: Pain Management in Animals with Oncological Disease: Opioids as Influencers of Immune and Tumor Cellular Balance. (Pubmed Central) - Sep 14, 2024
Cancer pain management searches to ascertain analgesic protocols that enhance patient well-being by minimizing or abolishing pain and reducing its impact on the immune system and cancer cells. Due to their ability to reduce nerve sensitivity, opioids are the mainstay for managing moderate and severe acute pain; however, despite their association with tumor progression, specific opioid agents have immune-protective properties and are considered safe alternatives to analgesia for cancer patients.
- | morphine sulphate / Generic mfg.
Journal: Determination of Opium Alkaloid Content in Poppy Seeds Using Liquid Chromatography Coupled with a Mass Spectrometer with a Time-of-Flight Analyzer (UPLC-TOF-HRMS). (Pubmed Central) - Sep 14, 2024
Both groups showed similar levels of morphine content as well as other OAs, which significantly exceeded the permissible limit of 20 mg/kg set by the European Commission (EU) 2023/915. These results indicate that the presence of morphine and other opium alkaloids in poppy seeds exceeds permissible levels, posing a serious health issue and necessitating further research and improvement in processing methods.
- | morphine sulphate / Generic mfg.
Journal: Sustained acoustic medicine treatment of discogenic chronic low back pain: A randomized, multisite, double-blind, placebo-controlled trial. (Pubmed Central) - Sep 13, 2024
Daily, home-use SAM treatment significantly improves the clinical symptoms of chronic lower back pain, improves physical mobility, and reduces daily medication use. SAM treatment is well-tolerated by patients and may be considered a safe, non-invasive treatment option for chronic discogenic, lower back pain.
- | morphine sulphate / Generic mfg.
Journal: Comparing Post-operative Pain and Other Outcomes in Carotid Endarterectomy Versus Transcarotid Artery Revascularization. (Pubmed Central) - Sep 13, 2024
Differences in pain and post-operative narcotic use may be of less importance when deciding between TCAR and CEA. Total non-opioid protocols may be feasible in both approaches.
- | morphine sulphate / Generic mfg.
Journal: Operative treatment of clavicle fractures results in more opioids prescribed as compared to non-operative management. (Pubmed Central) - Sep 13, 2024
Clavicles treated operatively receive substantially more opiates than those treated non-operatively, despite data suggesting that operative treatment makes clavicle fractures less painful. The total amount of narcotic analgesics obtained by operatively treated patients was over three times that obtained by non-operatively managed patients, which equates to 55 5
- | morphine sulphate / Generic mfg., ketamine / Generic mfg.
Journal: Comparison of thoracic epidural catheter and continuous peripheral infusion for management of traumatic rib fracture pain. (Pubmed Central) - Sep 13, 2024
The maximal benefit of TEC therapy appears to be on days 3 and 4. Prospective, randomized comparison between groups is necessary to evaluate the magnitude of the treatment effect.
- || morphine sulphate / Generic mfg.
Review, Journal: Caenorhabditis elegans for opioid addiction research. (Pubmed Central) - Sep 12, 2024
Prospective, randomized comparison between groups is necessary to evaluate the magnitude of the treatment effect. Opioids, such as morphine, are thought to cause addiction-like behavior by activating dopamine nerves in C.
- | morphine sulphate / Generic mfg., methadone / Generic mfg.
Retrospective data, Journal: Intraoperative methadone administration for total mastectomy: A single center retrospective study. (Pubmed Central) - Sep 12, 2024
Opioids, such as morphine, are thought to cause addiction-like behavior by activating dopamine nerves in C. Our study suggests that the unique pharmacological properties of methadone, including a short onset of action when given intravenously, long-acting pharmacokinetics, and multimodal effects, are associated with better acute pain management after a total mastectomy.
- || morphine sulphate / Generic mfg.
Retrospective data, Review, Journal, Surgery: Analgesic efficacy and safety of erector spinae plane block in pediatric patients undergoing elective surgery: A systematic review and Meta-analysis of randomized controlled trials. (Pubmed Central) - Sep 12, 2024
Our study suggests that the unique pharmacological properties of methadone, including a short onset of action when given intravenously, long-acting pharmacokinetics, and multimodal effects, are associated with better acute pain management after a total mastectomy. ESPB provides effective and safe perioperative analgesia in pediatric patients undergoing elective surgery under general anesthesia.
- || morphine sulphate / Generic mfg.
Retrospective data, Review, Journal: Characterization of Oral Ketamine Use: A Retrospective Review. (Pubmed Central) - Sep 12, 2024
Secondary outcomes included oral Morphine Milligram Equivalents (MMEs), buprenorphine dose, minimum and maximum pain scores on the first and last day of therapy...Oral ketamine was administered safely for analgesia, with patients receiving ketamine doses that were on the lower end of the established therapeutic range. Evaluation of the efficacy and safety of oral ketamine use for analgesia should be further studied.
- | morphine sulphate / Generic mfg.
Observational data, Journal, Surgery: Discharge Opioid Prescription and Consumption Following Surgery: The POPCORN Observational Study. (Pubmed Central) - Sep 12, 2024
The median dose prescribed was 10 opioid pills (75.0 morphine milligram equivalents)...More than half of all prescribed pills were unused. Protocols implementing specific prescribing strategies warrant further investigation to evaluate their potential impact on opioid prescription and consumption.
- | morphine sulphate / Generic mfg.
Journal: Chronic Morphine Treatment Induces Sex- and Synapse-Specific Cellular Tolerance on Thalamo-Cortical Mu Opioid Receptor Signaling. (Pubmed Central) - Sep 11, 2024
Furthermore, it suggests this tolerance may be driven by MOR phosphorylation. Overall, these findings improve our understanding of how chronic opioid exposure alters cellular signaling in ways that may contribute to opioid analgesic tolerance.
- | morphine sulphate / Generic mfg.
Retrospective data, Journal: Intrathecal Drug Delivery System in Prepontine Cistern for Patients with Intractable Craniofacial Cancer Pain: A Multicenter Retrospective Study. (Pubmed Central) - Sep 11, 2024
Placing the catheter tip of an intrathecal morphine pump into the prepontine cistern could effectively relieve refractory craniofacial cancer pain with an extremely low total morphine dose requirement and few adverse events. This procedure could be considered in patients with severe refractory craniofacial cancer pain.