- |||||||||| morphine sulphate / Generic mfg.
Preclinical, Journal: Adolescent morphine exposure changes the endogenous vlPAG opioid response to inflammatory pain in rats. (Pubmed Central) - Dec 26, 2023
Additionally, the nociceptive score significantly increased following naloxone but not saline microinjection into the vlPAG of the saline-treated group during adolescence, rather than the morphine-treated one. These findings indicate that AME has long-lasting effects on the endogenous opioid system in the vlPAG, which can consequently alter behaviors related to inflammatory pain in adulthood.
- |||||||||| morphine sulphate / Generic mfg.
Preclinical, Journal: Small G-Protein Rheb gates mTOR signaling to regulate morphine tolerance in mice. (Pubmed Central) - Dec 26, 2023
These findings indicate that AME has long-lasting effects on the endogenous opioid system in the vlPAG, which can consequently alter behaviors related to inflammatory pain in adulthood. This study suggests spinal Rheb as a key molecular factor for regulating mTOR signaling.
- |||||||||| fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg., ketamine / Generic mfg.
Journal: Analgosedation for less-invasive surfactant administration: Variations in practice. (Pubmed Central) - Dec 26, 2023
However, there are considerable variations regarding the use of analgosedation. More evidence is required to guide clinicians seeking to safely and effectively deliver surfactant via a thin catheter to spontaneously breathing preterm infants.
- |||||||||| tegileridine (SHR8554) / Jiangsu Hengrui Pharma
Trial completion, Surgery: A Study of SHR8554 Injection for the Treatment of Pain After Orthopedic Surgery (clinicaltrials.gov) - Dec 26, 2023
P2/3, N=320, Completed,
Over the 10 years studied, there was a changing pattern of opioid prescribing following colectomy, with a decrease in the proportion of opioid-naive patients prescribed postdischarge opioids. Active, not recruiting --> Completed
- |||||||||| morphine sulphate / Generic mfg., warfarin / Generic mfg.
Journal: Hemodynamic Instability After Axillary Artery Rupture Following Inferior Glenohumeral Joint Dislocation: A Case Report. (Pubmed Central) - Dec 25, 2023
The patient had a medical history of stroke, and thus had a daily intake of 10 mg Warfarin...The shoulder reduction was conducted under general anaesthesia after reduction with intravenous morphine sedation...The diagnostic modalities of CT scan with contrast or arteriogram should be performed with a low threshold of suspicion after reduction. With symptoms such as enlarging hematoma in the axilla, diminished radial and ulnar pulse, sudden pain from the axilla, or signs of hemodynamic instability after reduction, diagnostic modalities should be considered.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Different projection neurons of basolateral amygdala participate in the retrieval of morphine withdrawal memory with diverse molecular pathways. (Pubmed Central) - Dec 25, 2023
The present results showed that (1) BLA neurons projecting to the prelimbic cortex (BLA) and BLA neurons projecting to the nucleus accumbens (BLA) participated in context-induced retrieval of morphine withdrawal memory; (2) there was an increase in the expression of Arc and pERK in BLA neurons, but not in BLA neurons during context-induced retrieval of morphine withdrawal memory; (3) pERK was the upstream molecule of Arc, whereas D1 receptor was the upstream molecule of pERK in BLA neurons during context-induced retrieval of morphine withdrawal memory; (4) D1 receptors also strengthened AMPA receptors, but not NMDA receptors, -mediated glutamatergic input to BLA neurons via pERK during context-induced retrieval of morphine withdrawal memory. These results suggest that different projection neurons of the BLA participate in the retrieval of morphine withdrawal memory with diverse molecular pathways.
- |||||||||| morphine sulphate / Generic mfg.
Review, Journal: The effect of cannabinoid type 2 receptor agonist on morphine tolerance. (Pubmed Central) - Dec 25, 2023
The CB2 receptor may modulate the effect of morphine through a pathway that is common to the MOR, since both receptors are G protein-coupled receptors (GPCRs). This study introduces the potential mechanism of morphine tolerance and the effect of CB2 receptor agonists on reducing morphine tolerance, which can provide new ideas for researchers studying morphine and provide beneficial effects for patients suffering from morphine tolerance.
- |||||||||| morphine sulphate / Generic mfg.
Journal, Surgery: Physician Characteristics Associated With Opioid Prescribing After Same-Day Breast Surgery in Ontario, Canada: A Population-Based Cohort Study. (Pubmed Central) - Dec 25, 2023
The primary outcome was current high opioid prescribing defined as >75th percentile of the mean oral morphine equivalents (OME; milligrams)...Prescriber characteristics associated with a higher likelihood of high current opioid prescribing were family practice (risk ratio [RR], 1.56; 95% confidence interval [CI], 1.35-1.79 compared to general surgery), larger community practice setting (RR, 1.34; 95% CI, 1.05-1.71 compared to urban), and a previous high opioid prescribing behavior (RR, 2.28; 95% CI, 2.06-2.52). While most studies examine surgeon opioid prescribing, our data suggest that other specialties contribute to opioid overprescribing in surgical patients and identify characteristics of physicians likely to overprescribe.
- |||||||||| morphine sulphate / Generic mfg.
MULTIMODAL PREHABILITATION MAY IMPROVE SURGICAL OUTCOMES FOR PATIENTS WITH INFLAMMATORY BOWEL DISEASE (Bellagio Ballroom - Bellagio Las Vegas) - Dec 24, 2023 - Abstract #CCCongress2024CCCongress_193;
Multimodal prehabilitation may improve select surgical outcomes in IBD, including length of stay and opioid use after surgery. Larger, prospective, controlled studies may help to further clarify the impact of PH on surgical outcomes for IBD, including complications, readmissions, and functional status.
- |||||||||| morphine sulphate / Generic mfg., ropivacaine / Generic mfg., Chirocaine (levobupivacaine) / Purdue, AbbVie
Retrospective data, Review, Journal, Surgery: The impact of timing, type, and method of instillation of intraperitoneal local anaesthetic in laparoscopic abdominal surgery: a systematic review and network meta-analysis. (Pubmed Central) - Dec 23, 2023
While aerosolised bupivacaine instilled at the end of surgery but before deflation of the pneumoperitoneum minimises postoperative opioid consumption, pain scores up to 24 h did not differ between the different modalities of delivering IPLA. The generalisability of these results is limited by the lack of utilisation of non-opioid analgesics in most trials.
- |||||||||| ketorolac / Generic mfg.
Retrospective data, Review, Journal, Surgery: Ketorolac in neonates and infants following congenital heart surgery: a retrospective review. (Pubmed Central) - Dec 22, 2023
The generalisability of these results is limited by the lack of utilisation of non-opioid analgesics in most trials. If validated prospectively, these findings suggest that a ketorolac regimen 0.5 mg/kg/dose every 6 hours in neonates and infants post-cardiac surgery may be safe with regard to renal function and bleeding risk, and effective regarding opioid-sparing capacity.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Neural network connectivity following opioid dependence is altered by a common genetic variant in the mu-opioid receptor, OPRM1 A118G. (Pubmed Central) - Dec 20, 2023
Mice with the equivalent Oprm1 variant, A112G, demonstrate sex-specific alterations in the rewarding properties of morphine and heroin...We also identified six (predominantly cortical) brain regions that strongly influence the transition to an opioid-dependent brain state. These data suggest potential brain regions that may be targeted using non-invasive therapeutic approaches such as repetitive Transcranial Magnetic Stimulation (rTMS) and could be useful to inform personalized treatment.
- |||||||||| fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
Journal: Comprehensive, Evidence-Based, Consensus Guidelines for Prescription of Opioids for Chronic Non-Cancer Pain from the American Society of Interventional Pain Physicians (ASIPP). (Pubmed Central) - Dec 20, 2023
These guidelines were developed based upon a comprehensive review of the literature, consensus among expert panelists, and in alignment with patient preferences, and shared decision-making so as to improve the long-term pain relief and function in patients with chronic non-cancer pain. Consequently, it was concluded - and herein recommended - that chronic opioid therapy should be provided in low doses with appropriate adherence monitoring and understanding of adverse events only to those patients with a proven medical necessity, and who exhibit stable improvement in both pain relief and activities of daily function, either independently or in conjunction with other modalities of treatments.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Early palliative care for the management of breathlessness in pulmonary diseases (Pubmed Central) - Dec 20, 2023
These measures are more effective if offered early in the holistic management of the patient. This article illustrates and describes, with the help of a clinical situation, these treatments options and the collaborations established between the palliative care and pneumology divisions.
- |||||||||| morphine sulphate / Generic mfg., midazolam hydrochloride / Generic mfg.
Journal: Optimizing burn wound procedural pain control, efficiency, and satisfaction through integrated nurse and physician education. (Pubmed Central) - Dec 20, 2023
Demographics, opioid dose prescribed (oral morphine equivalents), midazolam use, timing of administration, and adverse events were collected. Patients' pain management satisfaction rating did not change, but the number of subjects rating their pain management as excellent tended to increase (36.4% vs. 20%, p
- |||||||||| morphine sulphate / Generic mfg.
Journal: Enhancing Protective Antibodies against Opioids through Antigen Display on Virus-like Particles. (Pubmed Central) - Dec 19, 2023
The antibodies induced exhibited strong binding toward multiple heroin/morphine derivatives that have the potential to be abused, while binding weakly to medications used for OUD treatment and pain relief. Furthermore, vaccination effectively reduced the impacts of morphine on mice in both ambulation and antinociception assays, highlighting the translational potential of the mQ?-6-AmHap conjugate to mitigate the harmful effects of drugs of abuse.
- |||||||||| morphine sulphate / Generic mfg., aspirin / Generic mfg.
Preclinical, Journal: Analgesic effect of the flavonoid herbacetin in nociception animal models. (Pubmed Central) - Dec 18, 2023
Accordingly, L-CYSee and analogs may be a novel class of therapeutics that ameliorate the development of physical dependence on opioids in humans. Herbacetin possesses antinociceptive activity in adult mice that is mediated through both central and peripheral pathways.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Long-term postoperative opioid use in orthopaedic patients. (Pubmed Central) - Dec 18, 2023
This study assessed long-term postoperative opioid use in a full breadth orthopaedic population using patient reported measures, making conclusions much more robust. The prevalence of long-term postoperative opioid use in this study was 12.5%.
- |||||||||| Instanyl (fentanyl) / Takeda, Nucynta (tapentadol) / Collegium Pharma, Grunenthal
Review, Journal: Opioid analgesics for nociceptive cancer pain: A (Pubmed Central) - Dec 18, 2023
The interpretation of study results, however, was complicated by the heterogeneity in the study populations evaluated. Given the limited quality and quantity of research, there is a need to reappraise the clinical utility of opioids in people with cancer pain, particularly those who are not at the end of life, and to further explore the effects of opioids on immune system function and quality of life in these individuals.
- |||||||||| morphine sulphate / Generic mfg.
Trial completion, Trial completion date, Trial primary completion date, Surgery: AGORA: Evaluation of the Benefit of Non-opioid General Anaesthesia on Postoperative Pain in Laparoscopic Colonic Surgery (clinicaltrials.gov) - Dec 18, 2023
P=N/A, N=160, Completed,
In patients undergoing elective Caesarean section under spinal anaesthesia without intrathecal morphine, both QLB and ESPB provided superior analgesia and quality of recovery compared to the standard care, without significant difference between the two blocks. Recruiting --> Completed | Trial completion date: Jan 2022 --> Feb 2023 | Trial primary completion date: Jan 2022 --> Feb 2023
- |||||||||| morphine sulphate / Generic mfg.
Clinical data, Retrospective data, Journal: Post-operative Opioid Reduction Protocol Reduces Racial Disparity in Clinical Outcomes in Children. (Pubmed Central) - Dec 18, 2023
Prior to the protocol, there was a racial disparity in clinical variables associated with prolonged opioid use including length of stay, TPN use, and intubation length. The clinical protocol reduced variability in opioid prescribing patterns in all racial groups which was associated with a reduction in variability in associated clinical variables.
- |||||||||| morphine sulphate / Generic mfg.
Trial completion date, Trial primary completion date: CMP: Cannabidiol, Morphine, Pain (clinicaltrials.gov) - Dec 15, 2023
P1, N=40, Recruiting,
There was no difference between ODT and standard ticagrelor tablets in terms of post-LD residual platelet reactivity, percentage of platelet inhibition or safety regardless to morphine use. Trial completion date: Dec 2022 --> May 2024 | Trial primary completion date: May 2022 --> May 2024
- |||||||||| Review, Journal: Barriers and Best Practices on the Management of Opioid Use Disorder. (Pubmed Central) - Dec 15, 2023
This is followed by a description of barriers to treatment and best practices for management with a discussion on recent updates and their potential impact on this patient population. This is followed by a description of barriers to treatment and best practices for management with a discussion on recent updates and their potential impact on this patient population.
- |||||||||| morphine sulphate / Generic mfg.
Trial completion: Intrathecal Morphine for Robotic-assisted Laparoscopic Hysterectomy. (clinicaltrials.gov) - Dec 13, 2023
P=N/A, N=100, Completed,
Opioid analgesics other than morphine should be chosen preferentially in adult patients with high risk of HA-AKI when treating moderate-to-severe pain. Recruiting --> Completed
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