- |||||||||| morphine sulphate / Generic mfg., buprenorphine/naloxone sublingual film / Generic mfg.
Retrospective data, Journal: Outpatient cross-titration to buprenorphine for chronic pain: A retrospective analysis. (Pubmed Central) - Jan 12, 2024
However, other variables may also play a role in opioid utilization. The University of Washington's buprenorphine cross-titration protocol for chronic pain was successful in about half of included patients undergoing conversion from chronic full
- |||||||||| morphine sulphate / Generic mfg., dexmedetomidine / Generic mfg.
Trial completion date, Trial primary completion date: Dexmedetomidine Plus Low Dose Morphine Versus Standard Dose of Morphine in PCA in Children . (clinicaltrials.gov) - Jan 11, 2024
P=N/A, N=60, Recruiting,
Procedural deep sedation can be safely and effectively administered to single ventricle patients by intensivist-led sedation teams in selective case. Trial completion date: Aug 2023 --> Mar 2024 | Trial primary completion date: Aug 2023 --> Mar 2024
- |||||||||| morphine sulphate / Generic mfg.
Retrospective data, Review, Journal, Surgery: Intrathecal Morphine and Post-Operative Pain Relief in Robotic Surgeries: A Systematic Review and Meta-Analysis. (Pubmed Central) - Jan 11, 2024
Significant pain score reductions were observed both at rest (MD = -27.15; 95% CI [-43.97, -10.33]; I = 95%; p = 0.002) and on exertion (MD = -25.88; 95% CI [-37.03, -14.72]; I = 79%; p = 0.0003) 24 h postoperatively in the ITM groups, accompanied by a notable decrease in postoperative IV morphine equivalent consumption at 24 h (MD = -20.13; 95% CI [-30.74, -9.52]; I = 77%; p = 0.0002). ITM improved pain scores both at rest and on exertion at 24 and 48 h intervals, concurrently reducing the need for postoperative opioid consumption, but at the cost of an increased incidence of adverse events.
- |||||||||| ibuprofen / Generic mfg.
Review, Journal: Ibuprofen for acute postoperative pain in children. (Pubmed Central) - Jan 9, 2024
Ibuprofen likely results in a reduction in adverse events compared to morphine, and in little to no difference in bleeding when compared to paracetamol. We remain mostly uncertain about the safety of ibuprofen compared to other drugs.
- |||||||||| morphine sulphate / Generic mfg.
Preclinical, Journal: Sensitization of Human and Rat Nociceptors by Low Dose Morphine is TLR4-dependent. (Pubmed Central) - Jan 9, 2024
We found that low concentration (100 nM) of morphine reduced rheobase in human (by 36%) and rat (by 26%) putative C-type nociceptors, an effect of morphine that was markedly attenuated by preincubation with LPS-RS Ultrapure. Our findings support the suggestion that in humans, as in rodents, OIH is mediated by the direct action of opioids at TLR4 on nociceptors.
- |||||||||| morphine sulphate / Generic mfg.
Median Sternotomy Versus Clamshell Thoracotomy for Bilateral Lung Transplantation (Board #240; Poster Hall) - Jan 9, 2024 - Abstract #ISHLT2024ISHLT_1403;
Primary outcome was total morphine equivalents used in the first 14 days after transplantation...Although there was a slightly increased risk of postoperative wound infection with sternotomy at 30 days, the difference was less pronounced at 90 days. These findings should be investigated in larger multicenter cohorts or prospective cohorts.
- |||||||||| morphine sulphate / Generic mfg.
Is Cold Gold? Equivalence Between Intercostal Nerve Cryoablation and Multimodal Analgesia with Regional Nerve Blocks in Less Invasive LVAD Implantation (Board #94; Poster Hall) - Jan 9, 2024 - Abstract #ISHLT2024ISHLT_1066;
There were no differences in overall postoperative pain scores or opioid use measured by morphine equivalents, at postoperative day 7...There was a significant increase in total operating room time (CA 435 min [375-542] vs non-CA 393 min [326-447.5], p = 0.026).Conclusion While previous studies have shown that cryoablation decreases postoperative pain scores and opioid use after thoracotomy, there was no significant difference in opioid use, pain scores, or pulmonary recovery after LVAD placement in our study population. Prospective, randomized trials are needed to further evaluate these findings, cost analysis, and patient reported outcomes after discharge.
- |||||||||| morphine sulphate / Generic mfg.
Journal, Surgery: Efficiency of the Local Infi ltration Analgesia Method in Total Knee Artroplasty Surgeries. (Pubmed Central) - Jan 9, 2024
4...For TKA patients where post-operative exercise is particularly important, we recommend the easy-to-use LIA method for a pain-free and unrestricted postoperative period. total knee arthroplasty, local infi ltration analgesia, postoperative analgesia, knee fl exion angle, opioid consumption.
- |||||||||| morphine sulphate / Generic mfg., ropivacaine / Generic mfg.
Journal, HEOR, Cost-effectiveness, Cost effectiveness: Cost-effectiveness analysis of epidural morphine/ropivacaine treatment in patients with cancer pain. (Pubmed Central) - Jan 9, 2024
A value judgement to decide whether the incremental benefit associated with the use of the new intervention is worth the extra cost will have to be made by the healthcare provider. Interventions that can relieve cancer pain symptoms should be investigated continuously, in search of evidence to support clinical practice and promote better quality of life for patients.
- |||||||||| morphine sulphate / Generic mfg.
Retrospective data, Journal: Single-Port Versus Multiport Robot-Assisted Partial Nephrectomy: A Meta-Analysis. (Pubmed Central) - Jan 8, 2024
There were no significant differences in other outcomes between the two approaches, including the intraoperative complication, minor postoperative complication (Clavien-Dindo I-II), major postoperative complication (Clavien-Dindo III-V), conversion to radical nephrectomy, pain score at day #1, pain score on discharge, morphine milligram equivalent (MME) usage, hospital stay, positive surgical margins and postoperative eGFR. Conclusions Initial studies have demonstrated that SP-RAPN is a safe and feasible approach to performing partial nephrectomy, albeit with inferior outcomes for ischemia time and blood transfusion rates.
- |||||||||| Nucynta (tapentadol) / Collegium Pharma, Grunenthal
Journal, Adverse events: A systematic analysis and data mining of opioid-related adverse events submitted to the FAERS database. (Pubmed Central) - Jan 8, 2024
On the contrary, the hierarchical clustering analysis further categorized the 13 opioid classes into two groups by comparing the full profiles of presence/absence of AEs. The results of network analysis and hierarchical clustering analysis were not only consistent and cross-validated each other but also provided a better and deeper understanding of the associations and relationships between the 13 opioid groups with respect to their adverse effect profiles.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Morphine manifesto seeks to boost access to oral morphine. (Pubmed Central) - Jan 8, 2024
The results of network analysis and hierarchical clustering analysis were not only consistent and cross-validated each other but also provided a better and deeper understanding of the associations and relationships between the 13 opioid groups with respect to their adverse effect profiles. No abstract available
- |||||||||| methylphenidate tablet / Generic mfg.
Preclinical, Journal: Methylphenidate attenuates signs of evoked neuropathic pain in animal model. (Pubmed Central) - Jan 7, 2024
Methyphenidate suppressed mechanical and cold hyperalgesia/allodynia, while had no effect on thermal one. Therefore, methylphenidate seems to be a new potential pharmacotherapy for the treatment of neuropathic pain.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Continuous wound infusion catheter as part of a multimodal analgesia regimen for post-Caesarean delivery pain: a quality improvement impact study. (Pubmed Central) - Jan 5, 2024
Opioid consumption (continuous wound infusion catheter group 11.3 [7.5-61.9] mg morphine equivalents vs control group 30.0 [11.3-48.8] mg morphine equivalents), pain scores (except 24 h resting pain scores which were higher in the control group 2 [1-3] vs 1.5 [0-3] in the continous wound infusion catheters group; P=0.05), side-effects, length of stay, and complications were similar between groups...The addition of continuous wound infusion catheters to a multimodal analgesia regimen for post-Caesarean delivery pain management demonstrated minimal clinically significant analgesic benefits. Future studies are needed to explore the use of continuous wound infusion catheters in populations that may benefit most from this intervention.
- |||||||||| ondansetron / Generic mfg., morphine sulphate / Generic mfg., methadone / Generic mfg.
Journal: Advances in the Care of Infants With Prenatal Opioid Exposure and Neonatal Opioid Withdrawal Syndrome. (Pubmed Central) - Jan 5, 2024
Fourth, maternal, infant, environmental, and genetic factors that have been found to be associated with NOWS severity are highlighted. Finally, emerging recommendations on postdelivery hospitalization follow-up and developmental surveillance are presented, along with highlighting ongoing and needed areas of research to promote infant and family well-being for families impacted by opioid use.
- |||||||||| morphine sulphate / Generic mfg.
Review, Journal: The Role of the Cerebellum in Drug Reward: A Review. (Pubmed Central) - Jan 4, 2024
Unlike previous studies, this article focuses on the influence of alcohol, nicotine, morphine, cannabis, and cocaine on the cerebellum from multiple viewpoints, including imaging and behavioral changes, molecular signals, neurotransmitters, and synaptic transmission...Finally, we discuss the limitations and prospects of drug reward research on the cerebellum to provide novel insights into studying the cerebellum and its role in addiction. We recommend that future addiction network models should include the cerebellum to provide new therapeutic targets for treating addiction.
- |||||||||| ketorolac / Generic mfg., gabapentin / Generic mfg.
Journal: Does preoperative gabapentin or intraoperative ketorolac influence postoperative pain following hip arthroscopy? (Pubmed Central) - Jan 3, 2024
Females had higher first PACU VAS pain score (6.05 versus 5.15 P?=?0.0026), final PACU VAS pain score (4.43 versus 3.90, P?=?0.0045), final VAS pain score prior to discharge (3.87 versus 3.03, P?<?0.001) and average postoperative pain score (4.60 versus 4.03, P?<?0.001), but no difference in VAS pain score on follow-up call following surgery. Gabapentin or ketorolac was not associated with decreased VAS pain scores or time to discharge after hip arthroscopy.
- |||||||||| morphine sulphate / Generic mfg.
Journal, Surgery: The Impact of Florida Law HB21 on Opioid Prescribing Patterns After Outpatient Hand Surgery. (Pubmed Central) - Jan 2, 2024
The following variables were evaluated with retrospective chart review before and after implementation of HB21: type of opioid, number of pills, morphine milligram equivalents (MMEs), emergency department visits, and readmissions...There was an association between preoperative opioid prescriptions filled and prolonged opioid use (odds ratio 6.438, P = .003). Florida law HB21 resulted in significantly fewer pills prescribed per patient, suggesting that legislation likely changed prescriber behavior and/or patient demand regarding postoperative opioid prescriptions after outpatient hand and upper extremity surgery.
- |||||||||| fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg., methadone / Generic mfg.
The clinical relevance of Mu-opioid receptor gene (OPRM1) expression in breast cancer () - Dec 29, 2023 - Abstract #SSO2024SSO_203;
These results may be because the OPRM1 gene expression signal in a bulk human breast cancer was from T-cells and endothelial cells and not from cancer cells. Learning Objectives: describe the association of OPRM1 with survival in breast cancer patients.
- |||||||||| ketorolac / Generic mfg., morphine sulphate / Generic mfg., dexmedetomidine / Generic mfg.
Retrospective data, Journal, Surgery: Application of Butorphanol versus Sufentanil in Multimode Analgesia via Patient Controlled Intravenous Analgesia After Hepatobiliary Surgery: A Retrospective Cohort Study. (Pubmed Central) - Dec 29, 2023
The occurrence of postoperative vomiting was lower in group B (1.4% vs 3.0%, P=0.025) than in group S. However, more patients in group B experienced dizziness (0.9% vs 0.1%, P=0.019). Compared with sufentanil, the application of butorphanol in multimodal analgesia combined with dexmedetomidine and ketorolac via PCIA ameliorated postoperative pain after hepatobiliary surgery, with reduced opioid consumption and shorter postoperative hospital length of stay.
- |||||||||| Review, Journal: Pain Management Throughout Pediatric Laparoscopic Appendectomy: A Systematic Review. (Pubmed Central) - Dec 29, 2023
However, the reliance on opioids remained significant in some cases, particularly among patients with peritonitis who required more morphine...The findings from this study highlight the potential benefits of non-opioid analgesics, nerve blocks, and alternative methods for managing postoperative pain in <18 appendectomy patients. Further research and standardization of pain management protocols are needed to ensure optimal patient outcomes and minimize the risk of opioid-related complications.
- |||||||||| morphine sulphate / Generic mfg.
Review, Journal: Oxycodone, an opioid like the others? (Pubmed Central) - Dec 28, 2023
The aim of this review is to focus on the genomic and epigenetic regulatory features of oxycodone compared with other opioid agonists. Our aim is to initiate a discussion of perceptible differences in the pharmacological response observed with these various opioids, particularly after repeated administration in preclinical models commonly used to study drug dependence potential.
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