- |||||||||| Journal: A Palliative Care Approach to Amyotrophic Lateral Sclerosis. (Pubmed Central) - Jan 24, 2024
Literature has shown that there are many advantages to the early inclusion of palliative care in ALS management, achieving effective symptom control and greater quality of life, but also reducing caregiver burden. However, in this study, we found that referrals to palliative care were late and included mostly cases of advanced disease with uncontrolled symptoms.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Clinical Impact of an Enhanced Recovery Program for Lower Extremity Bypass. (Pubmed Central) - Jan 23, 2024
However, in this study, we found that referrals to palliative care were late and included mostly cases of advanced disease with uncontrolled symptoms. This is the largest single center cohort study evaluating ERP in LEB, showing that ERP implementation is associated with shorter LOS and improved perioperative outcomes.
- |||||||||| morphine sulphate / Generic mfg., methamphetamine / Generic mfg.
Review, Journal: Vaccines to Treat Substance Use Disorders: Current Status and Future Directions. (Pubmed Central) - Jan 23, 2024
This review provides an overview of anti-drug vaccines, their mechanisms of action, and their potential impact on treatment for substance use disorders. Furthermore, this review summarizes recent advancements in vaccine development for each specific drug, offering insights for the development of more effective and personalized treatments capable of addressing the distinct challenges posed by various abused substances.
- |||||||||| Review, Journal: Novel Opioids in the Setting of Acute Postoperative Pain: A Narrative Review. (Pubmed Central) - Jan 23, 2024
On the other hand, dinalbuphine sebacate (DNS; semi-synthetic mu partial antagonist and kappa agonist), dual enkephalinase inhibitors (STR-324, PL37, and PL265), and endomorphin-1 analog (CYT-1010) have shown good efficacy in preclinical studies with future plans for clinical trials. Rather than relying solely on mu-opioid receptor agonism to relieve pain and risk opioid-related adverse events (ORAEs), novel opioids make use of alternative mechanisms of action to treat pain while maintaining a safer side-effect profile, such as lower incidence of nausea, vomiting, sedation, and respiratory depression as well as reduced abuse potential.
- |||||||||| Preclinical, Review, Journal: Fibromyalgia Animal Models Using Intermittent Cold and Psychological Stress. (Pubmed Central) - Jan 23, 2024
However, the pharmacotherapeutic treatment should be carried out 3 months after stress, which is stated in the FM guideline, and many preclinical studies, such as those analyzing molecular and cellular mechanisms, as well as additional evidence using different animal models, are required. Thus, the ICGP and IPGP models have the potential to help discover and characterize new therapeutic medicines that might be used for the radical treatment of FM, although there are several limitations to be overcome.
- |||||||||| morphine sulphate / Generic mfg.
Trial completion date, Trial primary completion date: Comparison of Local Anesthetic Dose in Ipack Block Performed in Knee Arthroplasty Operations (clinicaltrials.gov) - Jan 22, 2024
P=N/A, N=112, Recruiting,
Thus, the ICGP and IPGP models have the potential to help discover and characterize new therapeutic medicines that might be used for the radical treatment of FM, although there are several limitations to be overcome. Trial completion date: Nov 2023 --> Feb 2024 | Trial primary completion date: Nov 2023 --> Feb 2024
- |||||||||| morphine sulphate / Generic mfg.
Trial completion: Individualized Analgesia for Pediatric Adenotonsillectomy (clinicaltrials.gov) - Jan 22, 2024
P4, N=156, Completed,
Trial completion date: Nov 2023 --> Feb 2024 | Trial primary completion date: Nov 2023 --> Feb 2024 Recruiting --> Completed
- |||||||||| morphine sulphate / Generic mfg., hydromorphone hydrochloride / Generic mfg.
Journal: COVID-19 and End of Life in a Quaternary Australian Hospital: Referral for Palliative Care Consultation. (Pubmed Central) - Jan 22, 2024
Although the cause of this relationship is undetermined, it may represent the prescription patterns of the palliative care physicians during consultation or potentially higher symptom burden prompting referral. There was also a higher proportion of patients who received hydromorphone compared with other opioids, though the OMEDD was consistent with other published literature.
- |||||||||| Nucynta (tapentadol) / Collegium Pharma, Grunenthal
Journal: Declining but Pronounced State-Level Disparities in Prescription Opioid Distribution in the United States. (Pubmed Central) - Jan 22, 2024
Production quotas did not correspond with the distribution, particularly in the 2010-2016 period. Future research, focused on identifying factors contributing to the observed regional variability in opioid distribution, could prove valuable to understanding and potentially remediating the pronounced disparities in prescription opioid-related harms in the US.
- |||||||||| morphine sulphate / Generic mfg.
Preclinical, Journal: Simultaneous determination of sinomenine and its metabolites desmethyl-sinomenine and sinomenine N-oxide in rat plasma by liquid chromatography tandem mass spectrometry. (Pubmed Central) - Jan 22, 2024
Precursor-to-product transitions for detection were m/z 330.2 > 239.1 for sinomenine, m/z 316.2 > 239.1 for desmethyl-sinomenine, m/z 346.2 > 314.1 for sinomenine N-oxide and m/z 286.2 > 153.2 for morphine (internal standard), respectively...The validated method has been successfully applied to the pharmacokinetic study of sinomenine, desmethyl sinomenine, and sinomenine N-oxide in rat plasma after oral administration of sinomenine at a single dose of 5 mg/kg. The results suggested that sinomenine was rapidly metabolized into its metabolite desmethyl sinomenine and sinomenine N-oxide.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Evaluation of early effectiveness of local infiltration anesthesia with compound betamethasone in total knee arthroplasty (Pubmed Central) - Jan 20, 2024
Pain was assessed by visual analogue scale (VAS) score on the 1st, 2nd, and 3rd days after operation and morphine intake milligrames equivalent within 48 hours after operation...There was no poor wound healing and periprosthetic joint infection in the two groups, and there was no significant difference in the incidence of complications between the two groups ( P>0.05). The application of compound betamethasone in LIA during TKA is a safe and optimal strategy to promote the early postoperative rehabilitation of patients.
- |||||||||| tramadol hydrochloride / Generic mfg.
Review, Journal: Prevalence and health consequences of nonmedical use of tramadol in Africa: A systematic scoping review. (Pubmed Central) - Jan 18, 2024
However, the adverse health effects of tramadol use resulting from illicit trafficking, like those caused by fentanyl and methadone in North America, have not been well-documented in Africa...Future studies should focus on the social and economic costs of abuse on households to better understand the impact on well-being. Systematic review registration: Open Science Framework: https://osf.io/ykt25/.
- |||||||||| morphine sulphate / Generic mfg.
Journal, Surgery: Implementing an evidence-based guideline to decrease opioids after cardiac surgery. (Pubmed Central) - Jan 18, 2024
Our intervention increased the use of acetaminophen and decreased the overprescription of opioids in cardiac surgery patients at discharge. Further research is necessary to continue improving pain management to reduce the number of opioids prescribed at discharge.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Use of postoperative opioid therapy following Endoscopic Sleeve Gastroplasty (ESG). (Pubmed Central) - Jan 18, 2024
Further research is necessary to continue improving pain management to reduce the number of opioids prescribed at discharge. In patients undergoing ESG, postoperative opioid therapy should be individualized to attenuate opioid overprescription and the risk of opioid overuse.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Morphine concentrations in fatalities after palliative treatment of acute burn injury. (Pubmed Central) - Jan 17, 2024
Besides morphine, propofol, fentanyl, sufentanil, midazolam, diazepam, lorazepam, cefazolin, and rocuronium were detected in femoral blood...Further evidence of therapeutic concentrations of quetiapine, duloxetine, and melperone could be matched to preexisting medication of the individuals...However, this prediction is not sufficient to explain the high morphine concentrations in femoral blood measured here. It can be assumed that burn shock in particular leads to altered pharmacokinetics, namely decreased distribution of morphine.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Opioid Utilization After Primary Total Hip and Knee Arthroplasty Following Sequential Implementation of Statewide Legislation. (Pubmed Central) - Jan 17, 2024
A multivariate analyses of variance evaluated length of stay, morphine milligram equivalents (MMEs), age, body mass index and number of prescription refills...Despite a shift towards ambulatory surgery, opioid utilization decreased without compromising patient outcomes. These findings underscore the significance of both legislative and surgical practices influencing opioid prescribing habits among orthopaedic surgeons.
- |||||||||| Exparel (bupivacaine liposome injectable suspension) / Pacira
Journal, Surgery: Liposomal Bupivacaine Use During Orthognathic Surgery in Cleft Lip and Palate Patients. (Pubmed Central) - Jan 16, 2024
This study provides the first analysis of liposomal bupivacaine use in adolescent CLP patients undergoing orthognathic surgery, demonstrating a significant reduction in postoperative opioid consumption compared with controls. These results may guide future studies of liposomal bupivacaine within CLP patients, potentially as a component of enhanced recovery after surgery guidelines, as well as in cost-analysis studies.
- |||||||||| fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg., hydromorphone hydrochloride / Generic mfg.
Journal: British Columbia's Safer Opioid Supply Policy and Opioid Outcomes. (Pubmed Central) - Jan 16, 2024
Two years after its launch, the Safer Opioid Supply policy in British Columbia was associated with higher rates of safer supply opioid prescribing but also with a significant increase in opioid-related poisoning hospitalizations. These findings will help inform ongoing debates about this policy not only in British Columbia but also in other jurisdictions that are contemplating it.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Variation in Intraoperative Opioid Administration by Patient, Clinician, and Hospital Contribution. (Pubmed Central) - Jan 16, 2024
The rate of intraoperative opioid administration as a continuous measure of oral morphine equivalents (OMEs) normalized to patient weight and case duration was assessed...In this cohort study, clinician-, hospital-, and patient-level factors had important contributions to substantial variation of opioid administrations during surgical procedures. These findings suggest the need for a broadened focus across multiple factors when developing and implementing opioid-reducing strategies in collaborative quality-improvement programs.
- |||||||||| dexamethasone / Generic mfg., morphine sulphate / Generic mfg.
Retrospective data, Review, Journal: High dose glucocorticoids for treatment of postoperative pain: A systematic review of the literature and meta-analysis. (Pubmed Central) - Jan 15, 2024
High doses of glucocorticoids are one of the many possible tools available in multimodal postoperative analgesia, possibly reducing opioids consumption and recurrence of PONV but with no relevant effects in terms of reduction of postoperative VAS score. Available data show a safe therapeutic profile, without increase adverse events.
- |||||||||| morphine sulphate / Generic mfg.
Retrospective data, Journal, Surgery: 5-year Sustained Impact of a Thoracic Enhanced Recovery after Surgery Program. (Pubmed Central) - Jan 15, 2024
ERP for thoracic surgery is sustainable and has been demonstrated to improve patient outcomes, to decrease opioid use, and to lower hospital costs. Therefore, it has the potential to become the standard of care.
- |||||||||| Palexia RP (tapentadol extended release) / Assertio, J&J, Grunenthal, Collegium Pharma
Journal: Comparison of the effects of OPRM1 A118G polymorphism using different opioids: A prospective study. (Pubmed Central) - Jan 15, 2024
This study provides a novel therapeutic approach to reduce the side effects of MPH. Tapentadol and methadone may be more suitable than hydromorphone, oxycodone, and fentanyl for G-allele carriers due to their dual mechanism of action and low susceptibility to OPRM1 A118G polymorphism.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Naloxone Prescribing Practices in a Freestanding Rehabilitation Hospital. (Pubmed Central) - Jan 15, 2024
At this rehabilitation hospital, there was a low rate of naloxone prescribing by inpatient and outpatient providers, with a higher rate occurring in the outpatient than inpatient setting. More research is needed to understand this prescribing trend to determine potential interventions.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Evaluation of a pharmacist-led interprofessional chronic pain clinic in Canada. (Pubmed Central) - Jan 15, 2024
Of the 80 patients taking an opioid, 22.5% were switched to buprenorphine/naloxone and the remainder had their mean morphine-equivalent dose reduced by a mean of 41.7 mg/d...CGI-I data suggest that these patients, whose health status is typically very difficult to change, did not deteriorate but slightly improved after attending the clinic. The unique pharmacist-led, interprofessional model of care used by the University of Saskatchewan Chronic Pain Clinic may offer a viable alternative to traditional physician-led models.
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