- |||||||||| Clinical, Review, Journal: Treatment and Prevention of Post-dural Puncture Headaches: A Systematic Review. (Pubmed Central) - Feb 16, 2024
On the other hand, neither neuraxial morphine nor epidural dexamethasone showed promising results...Epidural blood patches remain the more invasive but the gold standard and ultimate solution in patients resisting medical therapy. This study highlights the need for larger research to define the best approach to prevent and treat PDPH.
- |||||||||| morphine sulphate / Generic mfg., tramadol hydrochloride / Generic mfg.
Observational data, Journal: Variations in opioid prescribing after total joint arthroplasty: An Observational study. (Pubmed Central) - Feb 16, 2024 This study highlights the need for larger research to define the best approach to prevent and treat PDPH. Generalized linear models accounting for within-person correlations were used to model the association between patient age, prescriber, etiology, opioid category, and mean morphine milligram equivalent (MME) prescribed...Hydrocodone and oxycodone prescriptions had significantly higher MMEs than tramadol prescriptions (CI 446.33, 719.52; p
- |||||||||| morphine sulphate / Generic mfg.
Enrollment open: ITM: The Contribution of Intrathecal Morphine Administration to Postoperative Patient Satisfaction During Cesarean Delivery (clinicaltrials.gov) - Feb 16, 2024 P=N/A, N=60, Recruiting, Generalized linear models accounting for within-person correlations were used to model the association between patient age, prescriber, etiology, opioid category, and mean morphine milligram equivalent (MME) prescribed...Hydrocodone and oxycodone prescriptions had significantly higher MMEs than tramadol prescriptions (CI 446.33, 719.52; p Not yet recruiting --> Recruiting
- |||||||||| ketorolac / Generic mfg., morphine sulphate / Generic mfg., hydromorphone hydrochloride / Generic mfg.
Trial completion date, Trial primary completion date: PATIENCE: Initial Pain Management in Pediatric Pancreatitis: Opioid vs. Non-Opioid (clinicaltrials.gov) - Feb 15, 2024 P2, N=50, Recruiting, Not yet recruiting --> Recruiting Trial completion date: Dec 2023 --> Jun 2024 | Trial primary completion date: Dec 2023 --> Jun 2024
- |||||||||| morphine sulphate / Generic mfg.
Journal, Surgery: Risk Factors for Rescue Opioid Prescription After Cubital Tunnel Surgery. (Pubmed Central) - Feb 15, 2024 The median postoperative opioid prescription amount was 90 morphine equivalent units (MEU) for the total cohort, 77.5 MEU for in situ ulnar nerve decompression, and 112.5 MEU for ulnar nerve decompression with transposition...While most patients do not require additional rescue opioid prescriptions after cubital tunnel surgery, chronic pain patients and patients with pain sensitivity syndromes are at risk for requiring additional rescue opioid prescriptions. For these high-risk patients, preoperative collaboration of a multidisciplinary team may be beneficial for developing a perioperative pain management plan that is both safe and effective.
- |||||||||| fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg., tramadol hydrochloride / Generic mfg.
NUTRITIONAL TRACKING IN PEDIATRIC BONE MARROW TRANSPLANT RECOVERY (ePoster area) - Feb 14, 2024 - Abstract #EBMT2024EBMT_2110; The most common cause of malnutrition in transplanted children is the prolonged occurrence of mucositis, necessitating long-term administration of parenteral nutrition. Additionally, the early recognition of total body weight changes, data collection, and monitoring serum protein and albumin values are crucial for timely identification and prevention of malnutrition.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Prescription Opioid Exposure During Pregnancy and Risk of Spontaneous Preterm Delivery. (Pubmed Central) - Feb 14, 2024 Conditional logistic regression was used to estimate the association between spontaneous preterm birth and total opioid morphine milligram equivalents (MME) dispensed, adjusting for parity, prepregnancy body mass index, education level, tobacco use, hepatitis infections, and pain indications...In this case-control study, a positive association was found between total prescription opioid dose dispensed and the odds of spontaneous preterm birth. These findings support guidance to minimize opioid exposure during pregnancy and prescribe the lowest dose necessary.
- |||||||||| Journal: N-desethyl isotonitazene detected in polydrug users admitted to hospital in Birmingham, United Kingdom. (Pubmed Central) - Feb 14, 2024
Although these features are also consistent with the known effects of N-desethyl isotonitazene, in only one case is it possible to attribute the patient's features to N-desethyl isotonitazene toxicity alone. This case series highlights the need for toxicovigilance in the illicit drug market as patterns of substance misuse evolve and novel psychoactive substances continue to emerge.
- |||||||||| morphine sulphate / Generic mfg.
Review, Journal: Erector spinae plane block for postoperative pain. (Pubmed Central) - Feb 12, 2024 Further research is required to study the possibility of extending the duration of analgesia. We identified 37 new studies in the updated search and there are three ongoing studies, suggesting possible changes to the effect estimates and the certainty of the evidence in the future.
- |||||||||| morphine sulphate / Generic mfg.
Journal, Epigenetic controller: DNA methylation and transcriptome analysis reveal epigenomic differences among three macaque species. (Pubmed Central) - Feb 12, 2024 Functional enrichment analyses showed the DMR-related genes were enriched in developmental processes and neurological functions, such as the growth hormone-related pathway, insulin secretion pathway, thyroid hormone synthesis pathway, morphine addiction, and GABAergic synapses...Our study provides one of the first genome-wide comparisons of genetic, gene expression, and epigenetic variations across different macaques. Our results should facilitate further research on comparative genomic and genetic differences in macaque species.
- |||||||||| ketamine / Generic mfg.
Journal, Surgery: Ketamine infiltration improves analgesia after thyroid surgery. (Pubmed Central) - Feb 9, 2024 The incidence of nausea and vomiting was similar in both groups. Ketamine wound infiltration is an efficient modality to reduce postoperative opioid consumption compared to a placebo after thyroid surgery.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Morphine exposure modulates dimensional bias and set formation in anthropoids. (Pubmed Central) - Feb 9, 2024 These findings indicate that significant dimensional biases and set formation are evolutionarily preserved in humans' and monkeys' cognition and that repeated exposure to morphine interacts with their manifestation. Shared neural mechanisms might be involved in the long-lasting effects of morphine and expression of dimensional biases and set formation in anthropoids.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Differences in heroin overdose deaths in Australia by age, 2020-2022: Disease and estimated survival times. (Pubmed Central) - Feb 9, 2024 The proportion of cases in which blood 6-acetyl morphine (6AM) was detected, as a measure of survival time...Compared to the youngest group, cases aged ?50 years were more likely to be diagnosed with cardiomegaly (44.0 v 16.7 %), coronary artery disease (46.0 v 15.0 %), emphysema (35.0 v 5.1 %), hepatic steatosis (15.4 v 3.4 %), hepatic fibrosis (17.6 v 3.4 %), and cirrhosis (19.8 v 0.0 %). Older cases of heroin overdose had more extensive heart, lung, and liver disease, and appeared more likely to have shorter survival times.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Prescription opioids induced microbial dysbiosis worsens severity of chronic pancreatitis and drives pain hypersensitivity. (Pubmed Central) - Feb 8, 2024 Opioids, such as morphine and oxycodone, are widely used for pain management associated with chronic pancreatitis (CP); however, their impact on the progression and pain sensitivity of CP has never been evaluated...Together, these analyses revealed that opioids worsen the severity of CP and induce significant alterations in pain sensitivity and the gut microbiome in a caerulein CP mouse model. Microbial dysbiosis plays an important role in sensitizing the host to pancreatic inflammation.
- |||||||||| morphine sulphate / Generic mfg.
Journal: The Effect of Marijuana on Postoperative Spine Patients' Emergency Department Visits, Readmission Rates, and Opioid Consumption. (Pubmed Central) - Feb 7, 2024 To compare postoperative opioid consumption with patients who tested negative for tetrahydrocannabinol (THC) preoperatively with those who were THC-positive and patients who were positive for THC and any other drug and to compare 90-day rates of postoperative emergency department (ED) visits and 90-day readmission rates, using morphine milligram equivalents (MMEs), for those three patient populations...The THC patients to be cautious toward are the multidrug user. Although not statistically significant, multidrug patients were noted for a trend toward increased ED visits and readmissions.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Xeroform Stick-Down Dressing: A Novel Treatment for Pediatric Partial-Thickness Burns. (Pubmed Central) - Feb 6, 2024 Further research is needed to explore the long-term outcomes and optimal treatment regimens for different patient populations. The Xeroform stick-down dressing has equivalent clinical outcomes to that of standard Silvadene dressings for the treatment of pediatric partial-thickness burns with the major advantages of decreasing dressing change frequency, minimizing patient distress and pain, and streamlining clinical care.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Treatment of patients with chronic malignant pain with intrathecal morphine. (Pubmed Central) - Feb 6, 2024 As argued in this review, in these patients, continuous intrathecal infusion of pain medicine by a programmable subcutaneously placed pump enables good pain relief, less systemic side effects, and better life quality. Intrathecal pain treatment should therefore be considered in patients with a proper performance score and suitable estimated life expectancy.
- |||||||||| morphine sulphate / Generic mfg.
Preclinical, Journal, Metastases: J-2156, a small molecule somatostatin type 4 receptor agonist, alleviated hindpaw hypersensitivity in the streptozotocin-induced rat model of painful diabetic neuropathy but with a 2-fold decrease in potency at an advanced stage in the model, mimicking morphine. (Pubmed Central) - Feb 6, 2024 When compared to control, ITM patients had superior analgesia while using fewer opioids In the intervals, 8-12-weeks (morphine-sensitive phase; Phase 1) and 16-18-weeks (morphine-hyposensitive phase; Phase 2) post-STZ, rats received a single dose of intraperitoneal (i.p.) J-2156 (10, 20, 30
- |||||||||| morphine sulphate / Generic mfg.
Retrospective data, Journal, Surgery: Opioid prescribing practices in breast oncologic surgery-A retrospective cohort study. (Pubmed Central) - Feb 5, 2024 In a tertiary care center, the operating surgeon had the greatest influence on opioid prescribing practices, and trainees tended to prescribe less MME. These findings support the need for a standardized approach to optimize prescribing and reduce opioid-related harms after oncologic breast surgery.
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