morphine sulphate / Generic mfg. 
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  • ||||||||||  morphine sulphate / Generic mfg.
    Reduction in Benzodiazepine Usage in Patients Born Less than 25-weeks' Gestation (Convention Center Exhibit Hall) -  Mar 16, 2024 - Abstract #PAS2024PAS_4553;    
    Post-intervention data for the DH (n=11) and RC (n=5) were compared to their respective baseline to assess the impact of implemented process changes. A Mann-Whitney U Test determined that the observed reduction of BZ doses in the first 90 days of life were statistically significant for both DH [U(Npre = 13, Npost = 5), z = 3.01, p< 0.05] and RC [U(Npre = 19, Npost = 5),z = 3.38, p< 0.001].
  • ||||||||||  Alfenta (alfentanil) / Abbott
    Premedication for Neonatal Rapid Sequence Intubation: A Network Meta-analysis (Convention Center Exhibit Hall) -  Mar 16, 2024 - Abstract #PAS2024PAS_4512;    
    Twenty-three RCTs enrolled 931 neonates (Figure 1). Pooled analysis identified that premedication with SAO+SH probably results in improved intubation success (network RR 2.54 [vs. placebo], 95% CI 1.02, 6.29; median rank 1, 95% CI 1-3; very low-certainty; Figure 2).
  • ||||||||||  morphine sulphate / Generic mfg., lorazepam / Generic mfg.
    Cumulative Exposure to Opioids and Benzodiazepines in Extremely Preterm Neonates (Convention Center Exhibit Hall) -  Mar 16, 2024 - Abstract #PAS2024PAS_4172;    
    The distribution of the cumulative exposure was highly right skewed for both drugs (Figure 1); however, 17% of infants received ?10 MME/kg and 9% received ?2 lorazepam equivalent mg/kg. Opioid exposure was inversely related to gestational age, with substantially higher median cumulative exposure in the most preterm neonates (Figure 2).
  • ||||||||||  morphine sulphate / Generic mfg., midazolam hydrochloride / Generic mfg., dexmedetomidine / Generic mfg.
    Protocolized Sedation Eliminates Disparities in Post-Operative Pain Control (Convention Center Exhibit Hall) -  Mar 16, 2024 - Abstract #PAS2024PAS_2487;    
    100% of patients received opioids, 42.5% benzodiazepines, and 85% dexmedetomidine. There were no differences in opioid, benzodiazepine, or dexmedetomidine doses according to patient race, ethnicity, or preferred language (Table 2 and 3).
  • ||||||||||  morphine sulphate / Generic mfg., clonidine / Generic mfg., dexmedetomidine / Generic mfg.
    Neurosedative Exposures in Hospitalized Infants with Grade 2/3 Bronchopulmonary Dysplasia (Convention Center Exhibit Hall) -  Mar 16, 2024 - Abstract #PAS2024PAS_2485;    
    Total cumulative daily neurosedative exposures for drug class remained stable over the study period, but alpha-agonist exposures (dexmedetomidine and clonidine) increased over time (Figure 2). Among 10,052 included subjects from 45 centers, a total of 987,858 cumulative daily neurosedative exposures were observed from birth to hospital discharge, with 676,384 (68%) occurring after 36 weeks
  • ||||||||||  gabapentin / Generic mfg.
    Gabapentin for Sedation and Pain Control in Neonates after Mandibular Distraction Osteogenesis (Convention Center Exhibit Hall) -  Mar 16, 2024 - Abstract #PAS2024PAS_2340;    
    Characteristics were similar between the two groups except for mean gestational age at birth (gabapentin group (GAB), 39.34 +/- 1.01 weeks, vs the no gabapentin (NoGAB) group, 37.70 +/- 2.24 weeks, p= 0.02). We found no difference in use of opioid infusions between GAB (38%) versus NoGAB (71%, p= 0.06), although the median duration of opioid infusion trended lower in the GAB group.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  The Effect of Kyphoplasty on Opioid Use in Patients With Vertebral Compression Fractures. (Pubmed Central) -  Mar 15, 2024   
    We found no difference in use of opioid infusions between GAB (38%) versus NoGAB (71%, p= 0.06), although the median duration of opioid infusion trended lower in the GAB group. Opioid measures, including the prescribed amount of morphine milliequivalents (MME) per day, number of opioid days, and total MME (MME per day x number of opioid days), in addition to numerical rating scale (NRS) pain scores, were analyzed pre- and post-KP...Conclusion Our findings suggest that KP may be associated with a reduction in both opioid use and pain scores in opioid-na
  • ||||||||||  morphine sulphate / Generic mfg.
    THE IMPACT OF CANNABIS USE ON POST-LIVER TRANSPLANT OPIOID REQUIREMENTS AND OUTCOMES (Hall A, Poster Hall - Walter E. Washington Convention Center) -  Mar 14, 2024 - Abstract #DDW2024DDW_7988;    
    Among those who underwent LT, cannabis use was associated with higher OMEs in the immediate postoperative period and was otherwise not associated with differences in post-LT outcomes. These findings support the growing evidence that cannabis may be a safe option to manage liver disease-related symptoms pre-LT with minimal impact on post-LT outcomes.
  • ||||||||||  morphine sulphate / Generic mfg.
    INVERSE RELATIONSHIP BETWEEN INTRAVENOUS "BREAKTHROUGH" NARCOTICS AND TEXTBOOK OUTCOMES FOLLOWING COLORECTAL SURGERY (206 - Walter E. Washington Convention Center) -  Mar 14, 2024 - Abstract #DDW2024DDW_2731;    
    These findings suggest that IV narcotic administration for 'breakthrough' at very early postoperative time intervals is related to adverse outcomes at later timepoints. Structured ERAS programing with multimodal non-narcotic analgesic alternatives should be prioritized for colorectal patients to reduce IV opioid requirements.
  • ||||||||||  morphine sulphate / Generic mfg.
    OUTCOMES AND QUALITY OF CARE OF TRANSFERRED AND NON-TRANSFERRED PATIENTS WITH ACUTE PANCREATITIS (Hall A, Poster Hall - Walter E. Washington Convention Center) -  Mar 14, 2024 - Abstract #DDW2024DDW_1037;    
    Though the quality of care was similar in both groups, transfer patients had more severe AP with more complications, more ICU admissions and longer LOS, but not a corresponding increase in mortality compared to patients admitted from the ED. This could possibly be due to the initial suboptimal resuscitation of transferred patients or may reflect referral bias where sicker patients were being transferred.
  • ||||||||||  morphine sulphate / Generic mfg.
    OPIOID USE IN HOSPITALIZED PATIENTS WITH ACUTE PANCREATITIS: RISK FACTORS AND OUTCOMES (Hall A, Poster Hall - Walter E. Washington Convention Center) -  Mar 14, 2024 - Abstract #DDW2024DDW_1036;    
    Although individuals experiencing more severe pain tended to use opioids more frequently, no significant association with any other identifiable risk factors, including ethnoracial factors, was noted. Longer time taken to transition from IV to PO opioids was associated with higher BMI, longer LOS, and greater severity of pain.
  • ||||||||||  Exparel (bupivacaine liposome injectable suspension) / Pacira
    INTRAPERITONEAL INFILTRATION OF EXPAREL REDUCES POSTOPERATIVE PAIN AND THE NEED FOR OPIOIDS FOLLOWING LAPAROSCOPIC HIATA HERNIA REPAIR WITH FUNDOPEXY (206 - Walter E. Washington Convention Center) -  Mar 14, 2024 - Abstract #DDW2024DDW_242;    
    The variables compared between the No-Exparel vs. Exparel group in the Post-Anesthesia Care Unit (PACU) included the number of patients with pain score of zero on arrival, pain scores on arrival, patients with pain scores of zero throughout the stay in PACU, patients who required opioids and Morphine Milligram Equivalent (MME), patients with pain scores of zero prior to discharge, pain scores prior to discharge and the need for Voltaren massages. Intraperitoneal infiltration of Exparel reduces the postoperative pain, increases the number of patients with zero pain in PACU, and decreases the number of patients requiring opioids and Voltaren massage to shoulders following laparoscopic hiatal hernia repair with fundopexy.
  • ||||||||||  morphine sulphate / Generic mfg.
    Review, Journal:  Take-Home Naloxone Access and Use among Older Adults Living with Pain: A Scoping Review. (Pubmed Central) -  Mar 14, 2024   
    Two of the studies highlighted patient-specific risk factors for opioid overdose, including concomitant use of benzodiazepines and/or gabapentinoids, mean morphine milligram equivalents per day of at least 50, and previous opioid overdose...The literature about THN for older adults living with pain is limited, and no literature was found on pharmacist-led initiatives in this area. Future research on THN provision for older adults, including pharmacist-led initiatives, could help to optimize care for older adults living with pain.
  • ||||||||||  morphine sulphate / Generic mfg., naltrexone / Generic mfg.
    Journal:  Characterization of a Nonselective Opioid Receptor Functional Antagonist: Implications for Development as a Novel Opioid Dependence Medication. (Pubmed Central) -  Mar 14, 2024   
    The administration of naltrexone, a potent pan-opioid receptor antagonist, to an individual dependent on opioids can trigger opioid withdrawal and induce severe side effects...Our in vivo work demonstrated that 1-10 mg/kg intraperitoneal administration of our compound produces moderate efficacy in antagonizing morphine-induced antiallodynia effects in the chemotherapy-induced peripheral neuropathy (CIPN) model...Furthermore, no organ toxicity was observed during the chronic administration of the compound over a 14-day period. Overall, we report a novel functional opioid antagonist holds promise for developing an opioid withdrawal therapeutic.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Pharmacological evaluation and phytochemical profiling of butanol extract of L. edodes with in- silico virtual screening. (Pubmed Central) -  Mar 13, 2024   
    GC-MS profiling of n-butanol extract depicted 34 potent biomolecules among those dimethyl; Morphine, 2TMS derivative; Benzoic acid, methyl ester 1-(2-methoxy-1-methylethoxy)-2-propanol were spotted at highest range...The current study showed that L. edodes might be used as potent drug molecules to cure multiple ailments. As mushrooms have high bioactivity, they can be used against different diseases and to develop antibacterial drugs based on the current situation in the world in which drug resistance is going to increase due to misuse of antibiotics so new and noval biological active compounds are needed to overcome the situation.
  • ||||||||||  morphine sulphate / Generic mfg.
    Enrollment open, Surgery:  High Versus Low Dose Serratus Anterior Plane Block After Minimally Invasive Valve Surgery. (clinicaltrials.gov) -  Mar 12, 2024   
    P=N/A,  N=100, Recruiting, 
    As mushrooms have high bioactivity, they can be used against different diseases and to develop antibacterial drugs based on the current situation in the world in which drug resistance is going to increase due to misuse of antibiotics so new and noval biological active compounds are needed to overcome the situation. Not yet recruiting --> Recruiting
  • ||||||||||  morphine sulphate / Generic mfg.
    History of Priapism Treatment in the 20th Century (206) -  Mar 12, 2024 - Abstract #AUA2024AUA_1407;    
    Some of the major developments in the first half of the 20th century included the use of heparin and the establishment of a relationship between testosterone and priapism. The second half of the 20th included treatment still in use today, such as carvenoglandular shunts and vasoconstrictive agents.
  • ||||||||||  morphine sulphate / Generic mfg.
    Pain and Post-operative Opioid Reduction with the Anterior Rectus Sheath Approach to Kidney Transplantation (301A) -  Mar 12, 2024 - Abstract #AUA2024AUA_1197;    
    In addition to less post-operative pain, patients receiving the ARS incision required only two-thirds of the cumulative post-operative opioid dose as those with a Gibson incision. The adoption of this technique in our practice has contributed to both improved post-operative recovery and a full day reduction in hospitalization.
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg., naltrexone / Generic mfg.
    Concise dearomative access to (-)-thebaine and its derivatives | Poster Board #1845 (In-person; Poster Board #1845; Hall C (Ernest N. Morial Convention Center)) -  Mar 12, 2024 - Abstract #ACSSp2024ACS_Sp_12745;    
    To date, five syntheses have been reported of thebaine, a biosynthetic precursor to morphine and codeine along with its semi-synthetic analogs such as the opioid antagonists naloxone and naltrexone...Some of the main drawbacks of naloxone are its metabolic half-life and decreased efficiency against stronger opioids such as fentanyl and carfentanyl...Additionally, the synthesis employs two separate dearomative steps and provides divergent access to three abiotic opioid derivatives. Finally, a formal enantioselective synthesis was designed that leverages a catalytic asymmetric dearomatization via anion-pairing catalysis.
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
    Efficacy modulation by semi-synthetic diversification of mitragynine pseudoindoxyl | Poster Board #746 (In-person; Poster Board #746; Hall C (Ernest N. Morial Convention Center)) -  Mar 12, 2024 - Abstract #ACSSp2024ACS_Sp_12621;    
    We have identified analogs with varying efficacies (60%-0%) with some lower than the parent natural product as well as some which are antagonists at the receptor. We hypothesize that the lower efficacy agonists, specially with intrinsic efficacy lower than 20% may be interest in developing safer analgesics Overall this work will emphasize that MP template can be used for efficacy modulation and to develop novel partial agonists having lower efficacy at the receptor and showing comparable analgesic effect as found in morphine but with minimized life-threatening side effects.