morphine sulphate / Generic mfg. 
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  • ||||||||||  morphine sulphate / Generic mfg.
    Trial completion, Surgery:  Comparing Intrathecal Morphine With Erector Spina Plane Block in Open Gastrectomy Surgery (clinicaltrials.gov) -  Mar 28, 2024   
    P=N/A,  N=63, Completed, 
    Clinical and toxicological aspects, as well as pharmacogenetic and epigenetic research focusing on fetal and infant effects of opioid use during pregnancy together with their medico-legal implications are exposed and discussed. Recruiting --> Completed
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal, Combination therapy, MRI:  Comparison of Detomidine or Romifidine in Combination with Morphine for Standing Magnetic Resonance Imaging in Horses. (Pubmed Central) -  Mar 27, 2024   
    Any substantial differences were recorded between the two treatments in terms of HR, RR, and RT. In conclusion, at the doses used, a detomidine-morphine combination following a CRI of detomidine appears more suitable than a romifidine-morphine combination following a CRI of romifidine for maintaining an adequate depth of sedation and adequate immobility in horses undergoing standing MRI.
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  Differential Effect of Chronic Morphine on Neuronal Degeneration in Male vs. Female Mice. (Pubmed Central) -  Mar 27, 2024   
    Our data suggest that males are protected from demyelination by having a higher basal BDNF level. Altogether, our results suggest that males and females have different molecular signaling underlying their patterns in the development of morphine tolerance and drug-induced neuronal degeneration.
  • ||||||||||  morphine sulphate / Generic mfg.
    Review, Journal:  Progress in the study of intestinal microbiota involved in morphine tolerance. (Pubmed Central) -  Mar 27, 2024   
    Many research have previously shown that morphine has a variety of effects on the gastrointestinal tract, but none have determined the function of intestinal microbiota in morphine tolerance. This study reviewed the mechanisms of morphine tolerance from the perspective of dysregulation of microbiota-gut-brain axis homeostasis, by summarizing the possible mechanisms originating from the gut that may affect morphine tolerance and the improvement of morphine tolerance through the gut microbiota.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  THE EFFECTS OF DRAINAGE TUBE ON PAIN AND FUNCTIONAL RECOVERY AFTER UNICOMPARTMENTAL KNEE ARTHROPLASTY. (Pubmed Central) -  Mar 27, 2024   
    The ROM in the drainage group significantly increased at 3 days and 1 month post-surgery, with a statistically significant difference in morphine consumption between the two groups at 3 days (P<0.05)...The placement of a drainage tube in UKA may reduce the swelling of knee joint and pain, which not only reduces the use of Opioid but also facilitates early functional activities of the knee joint. Level of Evidence III; Retrospective Comparative Study.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Poller Screws and Post-Operative Pain Relief in Tibial Fractures. (Pubmed Central) -  Mar 26, 2024   
    Opioid medication data was collected and converted to "coverage" (days) and "strength" (morphine milligrams equivalent or MME)...The results highlight the importance of using poller screws alongside IM. This combination appears to be effective in improving post-operative pain management and enhancing overall patient outcomes.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal, Surgery:  Single Dose Intravenous Paracetamol versus Placebo in Postorthognathic Surgery Pain: A Randomized Clinical Trial. (Pubmed Central) -  Mar 25, 2024   
    The visual analogue pain scale (VAS) at 1-, 4-, 8-, 12-, 16-, 20-, and 24?-h postoperatively, morphine consumption, side effects from morphine, and patient satisfaction were analyzed...It provided significant benefits to patients, including reduced pain scores, decreased opioid consumption, reduced nausea and vomiting, and improved satisfaction. This trial is registered with TCTR20210908002.
  • ||||||||||  Journal:  Six-week postoperative opioid use and pain following a randomized controlled trial evaluating multimodal analgesia for head and neck free flap patients. (Pubmed Central) -  Mar 25, 2024   
    Arm A received scheduled acetaminophen and as-needed opioids, while Arm B received scheduled gabapentin, ketorolac, a regional nerve block at the donor site, scheduled acetaminophen, and as-needed opioids...Thirty patients participated, 14 in Arm A and 16 in Arm B. The average morphine milligram equivalents per day of filled prescriptions were not significantly different between Arm A and Arm B (7.23 vs. 7.88, p?=?.845)...To confirm these findings, a re-examination with strict measures of opioid use and scheduled pain assessments in a prospective manner is warranted. 4.
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  Determination of trace morphine and its metabolites in mouse urine using a TpBD functionalized bivalve magnetic nano-adsorbent. (Pubmed Central) -  Mar 25, 2024   
    By employing this methodology, we successfully obtained the temporal change curve of morphine and its metabolites in mouse urine through collection and measurement post intravenous administration of morphine. This approach not only presents a novel means for investigating pharmacokinetics and drug monitoring but also demonstrates significant potential in the fields of forensic toxicology and drug abuse surveillance.
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  Conditioned morphine tolerance promotes neurogenesis, dendritic remodelling and pro-plasticity molecules in the adult rat hippocampus. (Pubmed Central) -  Mar 24, 2024   
    In summary, we demonstrate that the acquisition of morphine tolerance promotes adult neurogenesis, dendritic remodelling and pro-plasticity molecules such as Bdnf/Trkb in the rat hippocampus. Indeed, the structural neuroplasticity of the hippocampus may underlie the newly formed aberrant memory and could provide the initial basis for understanding the neurobiological mechanisms of morphine-tolerance plasticity in the hippocampus.
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  Evidence for the induction of analgesic cross-tolerance between opioid and apelin/APJ systems in male rats. (Pubmed Central) -  Mar 22, 2024   
    Chronic administration of apelin or morphine induces analgesic cross-tolerance that may, in part, be mediated through receptor interactions and downregulation. The demonstrated efficacy of F13-A in these experiments highlights its potential as a novel target for improving pain management through the inhibition of the apelin/APJ signaling pathway, meriting further investigation.
  • ||||||||||  Journal:  Non-opioid analgesic combinations following total hip arthroplasty (RECIPE): a randomised, placebo-controlled, blinded, multicentre trial. (Pubmed Central) -  Mar 22, 2024   
    P4
    The demonstrated efficacy of F13-A in these experiments highlights its potential as a novel target for improving pain management through the inhibition of the apelin/APJ signaling pathway, meriting further investigation. In adults undergoing total hip arthroplasty, a combination of paracetamol, ibuprofen, and dexamethasone had the lowest morphine consumption within 24 h following surgery and the most favourable adverse event profile, with a lower incidence of serious and non-serious adverse events (primarily driven by differences in nausea, vomiting, and dizziness) compared with paracetamol plus ibuprofen.
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  Inhibition of spinal BRD4 alleviates pyroptosis and M1 microglia polarization via STING-IRF3 pathway in morphine-tolerant rats. (Pubmed Central) -  Mar 22, 2024   
    In adults undergoing total hip arthroplasty, a combination of paracetamol, ibuprofen, and dexamethasone had the lowest morphine consumption within 24 h following surgery and the most favourable adverse event profile, with a lower incidence of serious and non-serious adverse events (primarily driven by differences in nausea, vomiting, and dizziness) compared with paracetamol plus ibuprofen. This study demonstrated for the first time that spinal BRD4 contributes to pyroptosis and switch of microglia polarization via STING-IRF3 signaling pathway during the development of morphine tolerance, which extend the understanding of the neuroinflammation mechanism of morphine tolerance and provide an alternative strategy for the precaution against of this medical condition.
  • ||||||||||  ketorolac / Generic mfg.
    Trial completion, Enrollment change, Trial completion date, Trial primary completion date:  Effect of Ketorolac on Post Adenotonsillectomy Pain (clinicaltrials.gov) -  Mar 21, 2024   
    P4,  N=63, Completed, 
    This study demonstrated for the first time that spinal BRD4 contributes to pyroptosis and switch of microglia polarization via STING-IRF3 signaling pathway during the development of morphine tolerance, which extend the understanding of the neuroinflammation mechanism of morphine tolerance and provide an alternative strategy for the precaution against of this medical condition. Recruiting --> Completed | N=120 --> 63 | Trial completion date: Sep 2024 --> Aug 2023 | Trial primary completion date: Sep 2024 --> Aug 2023
  • ||||||||||  morphine sulphate / Generic mfg., ropivacaine / Generic mfg.
    Trial completion, Phase classification, Surgery:  Suprascapular Nerve Block as Postoperative Analgesia After Artroscopic Shoulder Surgery (clinicaltrials.gov) -  Mar 21, 2024   
    P=N/A,  N=40, Completed, 
    Recruiting --> Completed | N=120 --> 63 | Trial completion date: Sep 2024 --> Aug 2023 | Trial primary completion date: Sep 2024 --> Aug 2023 Unknown status --> Completed | Phase classification: P4 --> PN/A
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  Preconception opioids interact with mouse strain to alter morphine withdrawal in the next generation. (Pubmed Central) -  Mar 20, 2024   
    Regardless of strain or sex, morphine-dependent Mor-F1 mice had significantly lower levels of withdrawal-induced corticosterone but significantly higher glucose levels when compared to Sal-F1 controls. In contrast, both strain- and preconception opioid exposure effects on physical signs of morphine dependence were observed.
  • ||||||||||  morphine sulphate / Generic mfg.
    Effective pain management in chest trauma: should we go regional? () -  Mar 18, 2024 - Abstract #ISICEM2024ISICEM_1021;    
    RA, mainly TE, is feasible, safe and offers a meaningful reduction in opioid consumption in CT patients despite no significant impact on other outcomes. Choice of analgesia strategy demands thoughtful patient -specific risk consideration.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  The effects of green and chemically-synthesized copper oxide nanoparticles on the production and gene expression of morphinan alkaloids in Oriental poppy. (Pubmed Central) -  Mar 17, 2024   
    The comparison of treatments revealed that utilizing a lower concentration of CuO NPs (20 mg/L) and extending the duration of cell suspension incubation (up to 48 h) play a more influential role in inducing the expression of the BIAs biosynthesis pathway genes (PsWRKY, TYDC, SalSyn, SalR, SalAT, T6ODM, COR and CODM) and increasing the production of morphinan alkaloids (thebaine, codeine, and morphine). The overarching results indicate that the concentration of CuO NPs and the duration of cell treatment have a more significant impact than the nature of CuO NPs in inducing oxidative stress and stimulating the expression of the BIAs pathway genes.
  • ||||||||||  phenobarbital / Generic mfg.
    Pharmacokinetics of Phenobarbital in Ex-vivo Extracorporeal Membrane Lung (San Diego Convention Center, Area L (Hall H, Ground Level)) -  Mar 17, 2024 - Abstract #ATS2024ATS_8926;    
    These results suggest that phenobarbital is extracted rapidly and to a high degree by the oxygenator in the ECMO circuit, which may result in decreased drug availability in-vitro. Further study is needed to demonstrate reproducibility and assess the impact of priming circuit with blood as opposed to PlasmaLyte.
  • ||||||||||  morphine sulphate / Generic mfg.
    Phoenix Children's provider opioid prescribing review following 2022 CDC opioid prescribing guidelines update (Convention Center Exhibit Hall) -  Mar 16, 2024 - Abstract #PAS2024PAS_5344;    
    Objective: The primary objective is to assess provider compliance with CDC opioid prescribing guidelines; specifically to evaluate opioid prescriptions given for more than 50 morphine milligram equivalents per day and quantities of more than 3 days of opioid supply...Epidemiologic data of patients receiving opioid prescriptions and prescribers of opioids will also be summarized. IRB approval has been granted and data analysis is expected to be completed by March 1, 2024.
  • ||||||||||  dexmedetomidine / Generic mfg.
    The Burden of Opioids, Benzodiazepines, and Dexmedetomidine for Neonates with Complex Care: A Point Prevalence Study (Convention Center Exhibit Hall) -  Mar 16, 2024 - Abstract #PAS2024PAS_5167;    
    The total cumulative dose mg/kg (by current weight) will be calculated for each class of medication in morphine, midazolam, and dexmedetomidine equivalent doses. This is an ongoing project with data collected in 32/60 patients for the point of prevalence study; further data will be collected as a prospective observational study for one year starting November 2023