morphine sulphate / Generic mfg. 
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  • ||||||||||  morphine sulphate / Generic mfg.
    The efficacy of ketamine for pain management in patients with cancer: A systematic review. () -  Apr 24, 2024 - Abstract #ASCO2024ASCO_4827;    
    The use of intrathecal ketamine demonstrates significant improvement in post-op oncological pain and refractory cancer pain, resulting in lowered pain scores and decreased morphine requirements. Further research is essential to ascertain the extent to which incorporating ketamine with opioids in cancer pain treatment can enhance pain outcomes, especially in morphine-tolerant patients.
  • ||||||||||  morphine sulphate / Generic mfg.
    Opioid use in impending versus pathologic proximal femur fractures. () -  Apr 24, 2024 - Abstract #ASCO2024ASCO_4815;    
    Future studies should examine postoperative opioid use with careful consideration of concurrent pain management pain therapies and tumor characteristics. >IQR, interquartile range; MME, morphine milliequivalent.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Quantitative analysis of noninvasive deep temporal interference stimulation: A simulation and experimental study. (Pubmed Central) -  Apr 24, 2024   
    Additionally, steering the interfering region to the left motor cortex leads to noticeable contralateral movement of the right hand while no movement was observed in the right hand during the stimulation of the right motor cortex. This technique of stimulation for the deep regions of the brain is a promising tool to noninvasively treat various neurological and psychiatric disorders such as morphine dependence in addicted rats.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  The Correlation of Surgical Setting With Perioperative Opioid Prescriptions for Wide-Awake Carpal Tunnel Release. (Pubmed Central) -  Apr 24, 2024   
    Compared with patients with surgery in the operating room, fewer patients with office-based surgery filled opioid prescriptions (45% vs 62%), and those prescriptions had lower morphine milligram equivalents (MMEs, median 130 vs 188)...This likely reflects patient and provider attitudes about pain control and opioid utilization. Further patient- and provider-level investigation may provide additional insights that could aid in efforts to reduce perioperative opioid utilization across surgical settings.
  • ||||||||||  morphine sulphate / Generic mfg., 2R,6R-hydroxynorketamine hydrochloride ((2R,6R)-HNK) / National Institute of Mental Health
    Preclinical, Journal:  Effects of (2R,6R)-hydroxynorketamine in assays of acute pain-stimulated and pain-depressed behaviors in mice. (Pubmed Central) -  Apr 23, 2024   
    Intermittent administration of (2R,6R)-HNK also did not produce antinociceptive effects in the hot plate or pain-depressed locomotor activity assays. These results suggest that (2R,6R)-HNK is unlikely to have efficacy in treating acute pain; however, the efficacy of (2R,6R)-HNK in chronic pain states should continue to be evaluated.
  • ||||||||||  morphine sulphate / Generic mfg.
    Trial completion, Enrollment change:  Ilioinguinal Iliohypogastric Nerve Block as Adjunct to Spinal Anesthesia for Cesarean Section (clinicaltrials.gov) -  Apr 23, 2024   
    P=N/A,  N=90, Completed, 
    In ITC analyses, oliceridine significantly reduced the incidence of nausea and/or vomiting or the need for antiemetics in orthopedic surgery compared with hydromorphone and a non-significant trend toward reduced risk versus fentanyl. Not yet recruiting --> Completed | N=30 --> 90
  • ||||||||||  morphine-6-glucuronide (M6G) / PAION
    Review, Journal, Adverse events:  Incidence of drug-related adverse events related to the use of high-alert drugs: A systematic review of randomized controlled trials. (Pubmed Central) -  Apr 22, 2024   
    The most reported drug classes in the articles included that were related to incidence of drug-related adverse events in use of high-alert medications: morphine, M6G-glucuronide, haloperidol, promethazine, ivabradine, digoxin, warfarin, ximelagatran, cyclophosphamide, cyclosporine, and ATG. The formulate protocols for the use of these medications, with importance placed on evaluating, among the classes, the medication that causes the least harm.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Review, Journal:  Fentanyl and its derivatives: Pain-killers or man-killers? (Pubmed Central) -  Apr 22, 2024   
    In this review, the properties, general pharmacology, and overdose death cases associated with fentanyl and selected derivatives are presented. Moreover, current opioid epidemic in the US, Moscow theatre hostage crisis, and potential misuse of fentanyl and its derivatives as a chemical weapon are disclosed.
  • ||||||||||  Exparel (bupivacaine liposome injectable suspension) / Pacira
    INTRAPERITONEAL INFILTRATION OF EXPAREL REDUCES POSTOPERATIVE PAIN AND THE NEED FOR OPIOIDS FOLLOWING LAPAROSCOPIC HIATA HERNIA REPAIR WITH FUNDOPEXY (Room 206) -  Apr 21, 2024 - Abstract #SSAT2024SSAT_52;    
    The variables compared between the No-Exparel vs. Exparel group in the Post-Anesthesia Care Unit (PACU) included the number of patients with pain score of zero on arrival, pain scores on arrival, patients with pain scores of zero throughout the stay in PACU, patients who required opioids and Morphine Milligram Equivalent (MME), patients with pain scores of zero prior to discharge, pain scores prior to discharge and the need for Voltaren massages. Intraperitoneal infiltration of Exparel reduces the postoperative pain, increases the number of patients with zero pain in PACU, and decreases the number of patients requiring opioids and Voltaren massage to shoulders following laparoscopic hiatal hernia repair with fundopexy.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Source Apportionment of Morphine in Wastewater (Pubmed Central) -  Apr 21, 2024   
    The different sources varied in these months due to the COVID-19 and influenza A outbreaks, in which the use of drugs containing poppy straws and codeine was the main source, whereas the use of morphine analgesics remained relatively stable. Inventory analysis further demonstrated the reliability of the source contributions from the PMF model, and morphine was not abused in this city.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Incidence and risk factors for potential drug-drug interactions in outpatients receiving opioid analgesics. (Pubmed Central) -  Apr 20, 2024   
    The combination of oxycodone with morphine had the most frequent occurrence of 229 times, and its adverse effects mainly related to exacerbate central respiratory depression...Outpatients taking opioid analgesics had a higher incidence of pDDIs. As consequently, optimized monitoring and management of patients taking opioid analgesics is recommended in order to ensure patient medication safety.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Pudendal Block at the Time of Transvaginal Prolapse Repair: A Randomized Controlled Trial. (Pubmed Central) -  Apr 19, 2024   
    As consequently, optimized monitoring and management of patients taking opioid analgesics is recommended in order to ensure patient medication safety. Because pain satisfaction after transvaginal surgery in the era of ERAS is high, with overall low opioid requirements, PNB provides no additional benefit.
  • ||||||||||  morphine sulphate / Generic mfg., ibuprofen / Generic mfg.
    Journal:  WITHANICANDRIN ISOLATED FROM Datura Ferox PROMOTES ANTINOCICEPTION BY MODULATING THE ASICS AND TRPS CHANNELS AND ANTI-INFLAMMATION IN ADULT ZEBRAFISH. (Pubmed Central) -  Apr 19, 2024   
    As a result, withanicandrin reduced nociceptive behavior by capsaicin at a dose of 40 mg/kg and by acid saline at doses of 4 and 40 mg/kg, through neuromodulation of TRPV1 channels and ASICs, identified through blocking the antinociceptive effect of withanicandrin by the antagonists capsazepine and naloxone. Furthermore, withanicandrin caused an anti-inflammatory effect through the reduction of abdominal edema, absence of leukocyte infiltrate in the liver tissue and reduction of ROS in thel liver tissue and presented better affinity energy compared to control morphine (TRPV1) and ibuprofen (COX-1 and COX-2).
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Factors Affecting Upper Limb Fracture Opioid Requirements. (Pubmed Central) -  Apr 19, 2024   
    The use of intravenous parecoxib is effective in improving rehabilitation indices and provides decreased postoperative pain scores after TKA. Post-injury opioid prescriptions in the first post-injury year were calculated every month up to six months and then grouped from the seventh to the 12th month and converted to morphine milligram
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal, Surgery:  The Efficacy of Systemic Transdermal Diclofenac Patch for Postoperative Pain after Lumbar Spinal Surgery. (Pubmed Central) -  Apr 19, 2024   
    Post-injury opioid prescriptions in the first post-injury year were calculated every month up to six months and then grouped from the seventh to the 12th month and converted to morphine milligram Systemic transdermal DP may potentially offer safe and effective postoperative analgesia, especially in less invasive procedures such as non-fusion lumbar spinal surgery.
  • ||||||||||  ketorolac / Generic mfg.
    Retrospective data, Journal, Surgery:  Ketorolac Dosing and Outcomes in Neonates Following Congenital Heart Surgery: A Retrospective Analysis. (Pubmed Central) -  Apr 18, 2024   
    If validated prospectively, these findings suggest that a ketorolac regimen of 0.5?mg/kg/dose every 6 hours in neonates postcardiac surgery may be safe with regard to renal function and bleeding risk. Additional randomized studies would be needed to determine efficacy with regard to opioid-sparing capacity.
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  In Vitro and In Vivo Pharmacological Profiles of LENART01, a Dermorphin-Ranatensin Hybrid Peptide. (Pubmed Central) -  Apr 17, 2024   
    In mice, LENART01 produced dose-dependent antinociceptive effects in formalin-induced inflammatory pain, with increased potency than morphine...LENART01 is the first peptide-based MOR-D2R ligand known to date and the first dual MOR-dopamine D2R ligand for which in vivo pharmacology is reported with antinociceptive efficacy and reduced opioid-related side effects. Our current findings may pave the way to new pain therapeutics with limited side effects in acute and chronic use.
  • ||||||||||  morphine sulphate / Generic mfg.
    Review, Journal:  Analgesic Peptides: From Natural Diversity to Rational Design. (Pubmed Central) -  Apr 17, 2024   
    The procedures employed in prolonged drug delivery of emerging compounds are also discussed. The work summarizes the conditions leading to the development of potential morphine replacements.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Evaluating the Effect of Maternal Opioid Maintenance Dose on the NOWS-COS Outcome Criteria: A Pilot Study. (Pubmed Central) -  Apr 17, 2024   
    Maternal dose was converted into morphine milligram equivalents (MMEs) and stratified into high- (MME >1000 mg) and low-dose groups (MME ?1000 mg)...Maternal MME did not predict need for NOWS treatment. Higher MME-exposed infants should have optimized nonpharmacologic interventions for consolation and be increasingly observed for signs of developmental delay.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Pain Assessment Following Opioid Administration in Aneurysmal Subarachnoid Hemorrhage Associated Headache. (Pubmed Central) -  Apr 17, 2024   
    In symptomatic patients with STEMI who underwent primary PCI after ticagrelor pretreatment and who received intravenous opioids, we found a dose-dependent relationship between the administration of intravenous fentanyl, but not morphine, and ticagrelor-induced platelet inhibition. Overall, 68.8% of patients were discharged on an opioid analgesic with predictive factors being severe headache (OR 2.52; 1.04 - 6.14) and oral morphine milligram equivalents ?60
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Current Status of Cognition and Clinical Practice of Refractory Cancer Pain in Shanghai: A Questionnaire Survey. (Pubmed Central) -  Apr 15, 2024   
    Oral immediate-release morphine and intravenous or subcutaneous morphine injection have been the common treatment approach for transient cancer pain exacerbations...Despite multiple available analgesic measures, the treatment of RCP remains challenging. Improving the understanding of medical staff towards RCP, improving treatment techniques, and increasing the accessibility of multiple drug types are important ways to improve the satisfaction of cancer pain management in the future.