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7 Diseases |  |
379 Trials |
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379 Trials |  |
12426 News |  |
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- | methadone / Generic mfg.
New P4 trial, Surgery: Methadone for pain following spinal surgery (EUDRACT) - Dec 23, 2020
P4, N=150, Ongoing, Sponsor: Lone Nikolajsen
- | morphine sulphate / Generic mfg.
Preclinical, Journal: Harmaline potentiates morphine-induced antinociception via affecting the ventral hippocampal GABA-A receptors in mice. (Pubmed Central) - Dec 22, 2020
These findings favor the notion that GABAergic mechanisms in the vHip facilitate harmaline-induced potentiation of morphine response in the tail-flick test in part through GABA-A receptors. These findings shall provide insights and strategies into the development of pain suppressing drugs.
- | morphine sulphate / Generic mfg., haloperidol / Generic mfg.
Journal: Haloperidol potentiates antinociceptive effects of morphine and disrupt opioid tolerance. (Pubmed Central) - Dec 22, 2020
Adverse effects of constipation or motor incoordination were not shown in animals treated with morphine+haloperidol. In conclusion, haloperidol enhances the antinociceptive effects of morphine without significant adverse effects, as it is able to disrupt or delay the morphine-tolerance in neuropathic pain.
- | morphine sulphate / Generic mfg.
Enrollment open: Enhanced Recovery After Cesarean Section With Low Dose Intrathecal Morphine. (clinicaltrials.gov) - Dec 22, 2020
P=N/A, N=60, Recruiting, Sponsor: Minia University
In conclusion, haloperidol enhances the antinociceptive effects of morphine without significant adverse effects, as it is able to disrupt or delay the morphine-tolerance in neuropathic pain. Not yet recruiting --> Recruiting
- | Enrollment open: Adding Nalbuphine for Control of Intrathecal Morphine Pruritus (clinicaltrials.gov) - Dec 22, 2020
P2, N=70, Recruiting, Sponsor: Minia University
Not yet recruiting --> Recruiting Not yet recruiting --> Recruiting
- | morphine sulphate / Generic mfg.
Trial completion: PctIbfFKUI: Effect of Paracetamol and Ibuprofen Reducing Morphine Requirements After Total Knee Arthroplasty (clinicaltrials.gov) - Dec 22, 2020
P2/3, N=36, Completed, Sponsor: Indonesia University
Not yet recruiting --> Recruiting Recruiting --> Completed
- | morphine sulphate / Generic mfg.
New trial: Intrathecal Morphine for Robotic-assisted Laparoscopic Hysterectomy. (clinicaltrials.gov) - Dec 19, 2020
P=N/A, N=80, Recruiting, Sponsor: Karlstad Central Hospital
- | morphine sulphate / Generic mfg.
Enrollment open: Supra-inguinal Fascia Iliaca Compartment Block on Postoperative Management in Total Hip Arthroplasty by Posterior Approach (clinicaltrials.gov) - Dec 17, 2020
P4, N=75, Recruiting, Sponsor: University of Liege
Recruiting --> Completed Not yet recruiting --> Recruiting
- | morphine sulphate / Generic mfg.
New trial: Evaluation of Peripheral Itch Mechanisms Following Injection of Morphine (clinicaltrials.gov) - Dec 17, 2020
P=N/A, N=26, Not yet recruiting, Sponsor: Aalborg University
- | morphine sulphate / Generic mfg., dexmedetomidine / Generic mfg.
Trial completion, Surgery: Efficacy of Dexmedetomidine Versus Morphine as an Adjunct to Bupivacaine in Caudal Anesthesia. (clinicaltrials.gov) - Dec 16, 2020
P=N/A, N=50, Completed, Sponsor: Cairo University
Not yet recruiting --> Recruiting Recruiting --> Completed
- | morphine sulphate / Generic mfg.
Enrollment closed: EMPOWER: Randomized Trial of Online Chronic Pain Management Program to Reduce Reliance on Opioid Analgesic Medications (clinicaltrials.gov) - Dec 11, 2020
P=N/A, N=402, Active, not recruiting, Sponsor: University of Cincinnati
Recruiting --> Completed Enrolling by invitation --> Active, not recruiting
- | morphine sulphate / Generic mfg.
Enrollment change, Trial withdrawal: Nasal Fentanyl for Chronic Cancer Pain (clinicaltrials.gov) - Dec 10, 2020
P3, N=0, Withdrawn, Sponsor: Norwegian University of Science and Technology
Enrolling by invitation --> Active, not recruiting N=108 --> 0 | Recruiting --> Withdrawn
- | morphine sulphate / Generic mfg.
Trial completion, Enrollment change: Effect of Mu-opioid Receptor Genetics on 3 Doses of Spinal Morphine for Postoperative Analgesia After Cesarean Section (clinicaltrials.gov) - Dec 10, 2020
P4, N=169, Completed, Sponsor: Columbia University
N=108 --> 0 | Recruiting --> Withdrawn Recruiting --> Completed | N=300 --> 169
- | ketorolac / Generic mfg., morphine sulphate / Generic mfg., hydromorphone hydrochloride / Generic mfg.
Trial completion date, Trial primary completion date: PATIENCE: Initial Pain Management in Pediatric Pancreatitis: Opioid vs. Non-Opioid (clinicaltrials.gov) - Dec 10, 2020
P2, N=50, Not yet recruiting, Sponsor: Boston Children's Hospital
Recruiting --> Completed | N=300 --> 169 Trial completion date: Mar 2021 --> Feb 2022 | Trial primary completion date: Feb 2021 --> Jan 2022
- | morphine sulphate / Generic mfg., clonidine / Generic mfg.
Trial suspension: Sensorial and Physiological Mechanism-based Assessments of Perioperative Pain (clinicaltrials.gov) - Dec 9, 2020
P3, N=150, Suspended, Sponsor: Dr. Jean A. Ouellet, MD, FRCSC
Trial completion date: Mar 2021 --> Feb 2022 | Trial primary completion date: Feb 2021 --> Jan 2022 Recruiting --> Suspended
- | morphine sulphate / Generic mfg.
Trial completion: ENIGME: Evaluation of the Analgesia Nociception Index and Videopupillometry to Predict a Child's Post-tonsillectomy Morphine Prescription (clinicaltrials.gov) - Dec 3, 2020
P=N/A, N=93, Completed, Sponsor: University Hospital, Limoges
Recruiting --> Suspended Recruiting --> Completed
- | morphine sulphate / Generic mfg.
New trial: Efficacy of Caudal Block on Intra-operative Anal Sphincter Muscle Tone and Post-operative Analgesia During Anal Sphincter Sparing Procedures Under General Anaesthesia (clinicaltrials.gov) - Dec 3, 2020
P=N/A, N=26, Not yet recruiting, Sponsor: Kasr El Aini Hospital
- | New P1 trial, Surgery: Multimodal Opioid-free Anesthesia Versus Opioid-based Anesthesia for Patients Undergoing Cardiac Valve Surgeries: RCT (clinicaltrials.gov) - Nov 30, 2020
P1, N=60, Recruiting, Sponsor: Cairo University
- | morphine sulphate / Generic mfg.
Trial completion date: Vital-signs-integrated Patient-assisted Intravenous Opioid Analgesia (clinicaltrials.gov) - Nov 24, 2020
P2, N=20, Active, not recruiting, Sponsor: KK Women's and Children's Hospital
Recruiting --> Completed Trial completion date: Aug 2020 --> Mar 2021
- | morphine sulphate / Generic mfg.
New trial, Surgery: Ultrasound Guided ESP Block Versus Intrathecal Morphine for Postoperative Analgesia in Major HPB Surgery. (clinicaltrials.gov) - Nov 19, 2020
P=N/A, N=40, Not yet recruiting, Sponsor: Assiut University
- | morphine sulphate / Generic mfg.
New trial, Surgery: Effects of Anaesthesia on Inflammatory Markers (clinicaltrials.gov) - Nov 16, 2020
P=N/A, N=75, Recruiting, Sponsor: Assiut University
- | methadone / Generic mfg.
Trial completion date, Trial primary completion date: Perioperative Methadone Use to Decrease Opioid Requirement in Pediatric Spinal Fusion Patients (clinicaltrials.gov) - Nov 13, 2020
P3, N=44, Recruiting, Sponsor: Medical College of Wisconsin
Trial completion date: Aug 2020 --> Mar 2021 Trial completion date: Sep 2020 --> Sep 2021 | Trial primary completion date: Sep 2020 --> Sep 2021
- || ketorolac / Generic mfg., morphine sulphate / Generic mfg., ketamine / Generic mfg.
Trial completion date, Trial primary completion date: ANA01: Anesthetics and Analgesics in Children (clinicaltrials.gov) - Nov 13, 2020
P=N/A, N=120, Recruiting, Sponsor: Kanecia Zimmerman, MD MPH
Trial completion date: Sep 2020 --> Sep 2021 | Trial primary completion date: Sep 2020 --> Sep 2021 Trial completion date: Sep 2021 --> Jun 2023 | Trial primary completion date: Sep 2020 --> Jun 2022
- | morphine sulphate / Generic mfg.
Trial completion: Continuous Wound Catheter Analgesia Associated With Intravenous Morphine PCA After Thoracotomy (clinicaltrials.gov) - Nov 10, 2020
P4, N=92, Completed, Sponsor: University Hospital, Strasbourg, France
Trial completion date: Sep 2021 --> Jun 2023 | Trial primary completion date: Sep 2020 --> Jun 2022 Recruiting --> Completed
- | morphine sulphate / Generic mfg., nefopam / Generic mfg., paracetamol / Generic mfg.
New P3 trial: The Effect of Intraoperative Nefopam, Ketoprofen and Paracetamol Combination vs Ketoprofen and Paracetamol Combination on Postoperative Morphine Requirements After Laparoscopic Cholecystectomy: A Randomized, Controlled Trial (clinicaltrials.gov) - Nov 10, 2020
P3, N=90, Not yet recruiting, Sponsor: American University of Beirut Medical Center
- | morphine sulphate / Generic mfg.
Trial completion date, Trial primary completion date: Intraoperative Magnesium Sulfate Administration During Orthotopic Liver Transplantation (clinicaltrials.gov) - Nov 9, 2020
P=N/A, N=60, Recruiting, Sponsor: Fayoum University Hospital
Recruiting --> Completed Trial completion date: Jul 2020 --> Jul 2021 | Trial primary completion date: Jun 2020 --> Jun 2021
- |||||| morphine sulphate / Generic mfg.
New trial: Gene Polymorphisms and Morphine Analgesic Consumption (clinicaltrials.gov) - Nov 9, 2020
P, N=300, Recruiting, Sponsor: Hamad Medical Corporation
- | morphine sulphate / Generic mfg.
New trial: Enhanced Recovery After Cesarean Section With Low Dose Intrathecal Morphine. (clinicaltrials.gov) - Nov 5, 2020
P=N/A, N=60, Not yet recruiting, Sponsor: Minia University
- | morphine sulphate / Generic mfg.
Trial completion date, Trial primary completion date, Surgery: LUMBES: Lumbar Erector Spinae Plane Block for Back Surgery (clinicaltrials.gov) - Nov 5, 2020
P3, N=80, Recruiting, Sponsor: Dr M. B. Breebaart
Trial completion date: Jul 2020 --> Jul 2021 | Trial primary completion date: Jun 2020 --> Jun 2021 Trial completion date: Feb 2020 --> Dec 2021 | Trial primary completion date: Feb 2020 --> Dec 2021
- | morphine sulphate / Generic mfg.
Enrollment open: Post-cesarean Analgesia With Epidural Morphine Following Epidural 2-chloroprocaine (clinicaltrials.gov) - Nov 4, 2020
P4, N=80, Recruiting, Sponsor: The University of Texas Health Science Center, Houston
Trial completion date: Feb 2020 --> Dec 2021 | Trial primary completion date: Feb 2020 --> Dec 2021 Not yet recruiting --> Recruiting
- | ketamine / Generic mfg.
Trial completion date, Trial primary completion date: Comparison of Low-dose Ketamine to Opioids in the Management of Acute Pain in Patients Presenting to the Emergency Department With Long Bone Fractures (clinicaltrials.gov) - Nov 3, 2020
P2, N=30, Not yet recruiting, Sponsor: The University of Texas Health Science Center, Houston
Not yet recruiting --> Recruiting Trial completion date: Jun 2020 --> Jun 2022 | Trial primary completion date: May 2020 --> Dec 2021
- | morphine sulphate / Generic mfg., ketamine / Generic mfg.
New trial: Implications of Different Analgesic Models on Inflammatory Markers After Laparoscopic Cholecystectomy (clinicaltrials.gov) - Oct 30, 2020
P=N/A, N=100, Recruiting, Sponsor: Assiut University
- | New P3 trial: Recommendations of Enhanced Recovery Interventions for Patient's Clinical Team and Collection of Associated Data (clinicaltrials.gov) - Oct 27, 2020
P3, N=35485, Not yet recruiting, Sponsor: Jennifer Holder-Murray
- | morphine sulphate / Generic mfg.
Enrollment open: A Randomized Control Trial Comparing Analgesic Benefits of Ultrasound-guided Single vs Continuous Quadratus Lumborum Blocks (QLB)vs Intrathecal Morphine(ITM) for Post Cesarean Section Pain (clinicaltrials.gov) - Oct 23, 2020
P4, N=75, Recruiting, Sponsor: The University of Texas Health Science Center, Houston
Trial completion date: Jun 2020 --> Jun 2022 | Trial primary completion date: May 2020 --> Dec 2021 Not yet recruiting --> Recruiting
- | morphine sulphate / Generic mfg.
Trial completion date, Trial primary completion date: EMPOWER: Randomized Trial of Online Chronic Pain Management Program to Reduce Reliance on Opioid Analgesic Medications (clinicaltrials.gov) - Oct 22, 2020
P=N/A, N=400, Enrolling by invitation, Sponsor: University of Cincinnati
Not yet recruiting --> Recruiting Trial completion date: Jan 2022 --> Oct 2021 | Trial primary completion date: Jan 2022 --> Oct 2021
- | morphine sulphate / Generic mfg.
Trial completion date, Trial primary completion date: Neuraxial Preservative Free Morphine for Normal Spontaneous Vaginal Delivery (clinicaltrials.gov) - Oct 22, 2020
P4, N=140, Recruiting, Sponsor: Icahn School of Medicine at Mount Sinai
Trial completion date: Jan 2022 --> Oct 2021 | Trial primary completion date: Jan 2022 --> Oct 2021 Trial completion date: Dec 2020 --> Dec 2021 | Trial primary completion date: Dec 2020 --> Dec 2021
- | morphine sulphate / Generic mfg.
Enrollment open: Ultrasound Guided Femoral Nerve Block (clinicaltrials.gov) - Oct 22, 2020
P=N/A, N=60, Recruiting, Sponsor: Beth Israel Deaconess Medical Center
Trial completion date: Dec 2020 --> Dec 2021 | Trial primary completion date: Dec 2020 --> Dec 2021 Active, not recruiting --> Recruiting
- | morphine sulphate / Generic mfg., paracetamol / Generic mfg.
Trial completion, Trial primary completion date: ParaMoED: Efficacy of Paracetamol in Addition to Morphine to Improve Analgesia in the Emergency Department (clinicaltrials.gov) - Oct 19, 2020
P4, N=222, Completed, Sponsor: Bruno Minotti
Active, not recruiting --> Recruiting Recruiting --> Completed | Trial primary completion date: Jul 2020 --> Oct 2020
- | New P2 trial: Adding Nalbuphine for Control of Intrathecal Morphine Pruritus (clinicaltrials.gov) - Oct 19, 2020
P2, N=70, Not yet recruiting, Sponsor: Minia University
- | morphine sulphate / Generic mfg., tramadol hydrochloride / Generic mfg.
New P2/3 trial: Effect of Tramadol Versus Morphine on PD1 and PD1-ligand in Patients With Chronic Cancer Pain (clinicaltrials.gov) - Oct 19, 2020
P2/3, N=15, Recruiting, Sponsor: Assiut University
- || ASP8062 / Astellas
Trial completion: A Study to Assess the Safety, Tolerability and Pharmacokinetics of Multiple Doses of ASP8062 With a Single Dose of Morphine in Recreational Opioid Using Participants (clinicaltrials.gov) - Oct 14, 2020
P1, N=24, Completed, Sponsor: Astellas Pharma Global Development, Inc.
Recruiting --> Completed | Trial primary completion date: Jul 2020 --> Oct 2020 Recruiting --> Completed
- | morphine sulphate / Generic mfg., ropivacaine / Generic mfg.
New P4 trial: Effect of Epidural Anesthesia and Analgesia on Quality of Recovery After Radical Prostatectomy. (clinicaltrials.gov) - Oct 14, 2020
P4, N=70, Recruiting, Sponsor: University Hospital of Split
- |||| STR-324 / Stragen
New P2 trial: Dose Finding Study of STR-324 (clinicaltrials.gov) - Oct 12, 2020
P2, N=116, Not yet recruiting, Sponsor: Stragen France
- | morphine sulphate / Generic mfg.
Trial completion date, Trial primary completion date: Topical Morphine for Analgesia in Patients With Skin Grafts (clinicaltrials.gov) - Oct 9, 2020
P3, N=40, Not yet recruiting, Sponsor: Rambam Health Care Campus
Recruiting --> Completed Trial completion date: May 2010 --> Dec 2021 | Trial primary completion date: May 2010 --> Dec 2021
- || morphine sulphate / Generic mfg., paracetamol / Generic mfg.
Clinical, Journal: Pediatric Post-Tonsillectomy Opioid Prescribing Practices. (Pubmed Central) - Oct 7, 2020
Utilization of order sets with standardized analgesic medication regimen of acetaminophen, ibuprofen, and opioid helped effectively reduce opioid amount per dose, total opioid amount dispensed, and variability in the total opioid amount dispensed while maintaining pain control. An increase in post-tonsillectomy hemorrhage was recognized following this implementation which did not persist after the study period despite continuation of intervention.
- | morphine sulphate / Generic mfg.
Trial initiation date: PAciFy Cough: Morphine Sulfate/Placebo for the Treatment of PulmonAry Fibrosis Cough (clinicaltrials.gov) - Oct 7, 2020
P3, N=44, Not yet recruiting, Sponsor: Royal Brompton & Harefield NHS Foundation Trust
An increase in post-tonsillectomy hemorrhage was recognized following this implementation which did not persist after the study period despite continuation of intervention. Initiation date: Aug 2020 --> Nov 2020
- | morphine sulphate / Generic mfg.
New P4 trial: Supra-inguinal Fascia Iliaca Compartment Block on Postoperative Management in Total Hip Arthroplasty by Posterior Approach (clinicaltrials.gov) - Oct 5, 2020
P4, N=75, Not yet recruiting, Sponsor: University of Liege
- | dexmedetomidine / Generic mfg.
Phase classification: Effect of Dexmedetomidine on Postoperative Glucose and Insulin Levels. (clinicaltrials.gov) - Oct 1, 2020
P4, N=40, Completed, Sponsor: Pontificia Universidad Catolica de Chile
Initiation date: Aug 2020 --> Nov 2020 Phase classification: P=N/A --> P4
- | morphine sulphate / Generic mfg.
New P2 trial: Granisetron vs Granisetron and Dexamethasone on the Reduction of Postoperative Nausea and Vomiting (clinicaltrials.gov) - Sep 30, 2020
P2, N=126, Recruiting, Sponsor: Universiti Sains Malaysia
- | morphine sulphate / Generic mfg.
Enrollment change, Trial termination: IV Acetaminophen vs IV Morphine for Pain Control in Pregnant Women (clinicaltrials.gov) - Sep 28, 2020
P=N/A, N=163, Terminated, Sponsor: The University of Texas Health Science Center, Houston
Phase classification: P=N/A --> P4 N=330 --> 163 | Recruiting --> Terminated; Difficulties in recruitment