morphine sulphate / Generic mfg. 
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  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Hydromorphone Protects against CO Pneumoperitoneum-Induced Lung Injury via Heme Oxygenase-1-Regulated Mitochondrial Dynamics. (Pubmed Central) -  May 20, 2021   
    Additionally, in clinical patients who received laparoscopic gynecological surgery, pretreatment with hydromorphone resulted in lower serum levels of club cell secretory protein-16 (CC-16) and intercellular adhesion molecule-1 (ICAM-1), a lower prooxidant-antioxidant balance (PAB), and higher heme oxygenase-1 (HO-1) activity than morphine pretreatment. Collectively, our results suggest that hydromorphone protects against CO pneumoperitoneum-induced lung injury via HO-1-regulated mitochondrial dynamics and may be a promising strategy to treat CO pneumoperitoneum-induced lung injury.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Practical Strategies Using Medical Cannabis to Reduce Harms Associated With Long Term Opioid Use in Chronic Pain. (Pubmed Central) -  May 20, 2021   
    Current United States and Canadian Chronic non-cancer pain guidelines recommend careful reassessment of the risk-benefit ratio for doses greater than 90 mg morphine equivalent dose (MED), due to low evidence for improved pain efficacy at higher morphine equivalent dose and a significant increase in morbidity and mortality...We use a structured approach to focus on low dose cannabis (namely, THC) initiation, slow titration, dose optimization and frequent monitoring. When low dose THC is introduced as an adjunctive therapy, we observe better pain control clinically with lower doses of opioids, improved pain related outcomes and reduced opioid related harm.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal:  Enhanced recovery after cystectomy in patients with preoperative narcotic use. (Pubmed Central) -  May 20, 2021   
    Patients with preoperative narcotic exposure report higher pain scores and require more opioid use following radical cystectomy with ERAS and are more likely to be readmitted within 90 days. However, there was no observed difference in hospital stay or complications.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Morphine enhances LPS-induced macrophage apoptosis through a PPARγ-dependent mechanism. (Pubmed Central) -  May 20, 2021   
    In conclusion, the findings of the present study indicated that morphine significantly promoted LPS-induced BMDM apoptosis and caspase-3/9 activation. These results suggested that the intrinsic pathway of apoptosis may be involved in the proapoptotic effects of morphine on LPS-stimulated BMDMs, which may be dependent, at least partially, on PPARγ activation.
  • ||||||||||  morphine sulphate / Generic mfg.
    [VIRTUAL] Single Incision Simultaneous Liver Kidney Transplantation: Outcomes and Feasibility () -  May 18, 2021 - Abstract #ATC2021ATC_1528;    
    Single incision SLK was associated with shorter cold ischemia time for kidney transplant as well as lower overall operative time without any impact on outcome. Further study is required to delineate additional benefit of single incision SLK with particular focus on patient acceptance and recovery from the surgical wound.
  • ||||||||||  dexamethasone / Generic mfg., gabapentin / Generic mfg.
    [VIRTUAL] Multimodal Analgesia Reduces Length of Stay in Living Kidney Donors () -  May 18, 2021 - Abstract #ATC2021ATC_1466;    
    This regimen consists of pharmacist-led pre-procedure pain management education, a transverse abdominis plane (TAP) block with bupivacaine and dexamethasone, scheduled acetaminophen and gabapentin, and as-needed opioids...The total morphine milligram equivalents (MME) donors received while inpatient was significantly less in the MM group vs the historical group on POD 0-2 (Figure 1)... In conclusion, this multimodal analgesic regimen resulted in a significantly shorter LOS, significantly lower PRPS, and significantly lower opioid requirements following living kidney donation.
  • ||||||||||  morphine sulphate / Generic mfg.
    [VIRTUAL] Two-Year Longitudinal Data From the National Restless Legs Syndrome Opioid Registry () -  May 17, 2021 - Abstract #SLEEP2021SLEEP_782;    
    The median dose increase from baseline to two-years was just 10 morphine milligram equivalents (MME)...Individuals at the start of opioid treatment for RLS do not see elevated rates of dose increase past the first year of use. Future longitudinal data will improve our understanding of the efficacy and tolerability of opioids for RLS.
  • ||||||||||  desmopressin / Generic mfg., paracetamol / Generic mfg.
    Clinical, Journal:  Intravenous Paracetamol vs Intranasal Desmopressin for Renal Colic in the Emergency Department: A Randomized Clinical Trial. (Pubmed Central) -  May 15, 2021   
    In patients with PD and "OFF" episodes, APL demonstrated lower C and relative bioavailability but similar exposures (AUCs) versus SC apomorphine within the approved dose range. Our study showed that intranasal desmopressin is as effective as intravenous paracetamol for renal colic pain management; however, significant clinical reduction in pain score occurred faster with intranasal desmopressin.
  • ||||||||||  morphine sulphate / Generic mfg.
    Trial completion, Enrollment change, Trial completion date, Trial primary completion date:  The Efficacy of Serratus Anterior Plane Block (ESAPB) for Thoracotomy: a Prospective Study (clinicaltrials.gov) -  May 13, 2021   
    P=N/A,  N=90, Completed, 
    Our study showed that intranasal desmopressin is as effective as intravenous paracetamol for renal colic pain management; however, significant clinical reduction in pain score occurred faster with intranasal desmopressin. Not yet recruiting --> Completed | N=40 --> 90 | Trial completion date: Jun 2020 --> May 2021 | Trial primary completion date: Dec 2019 --> Dec 2020
  • ||||||||||  morphine sulphate / Generic mfg.
    Trial completion date, Trial primary completion date:  MoreFoRCOPD: Morphine or Fentanyl for Refractory Dyspnea in COPD (clinicaltrials.gov) -  May 11, 2021   
    P4,  N=60, Recruiting, 
    Not yet recruiting --> Completed | N=40 --> 90 | Trial completion date: Jun 2020 --> May 2021 | Trial primary completion date: Dec 2019 --> Dec 2020 Trial completion date: Apr 2021 --> Apr 2022 | Trial primary completion date: Jan 2021 --> Jan 2022
  • ||||||||||  morphine sulphate / Generic mfg.
    Enrollment open, Trial initiation date, Trial primary completion date, Head-to-Head:  KETO-APP: Ketorolac for Moderate to Severe Abdominal Pain in Children (clinicaltrials.gov) -  May 11, 2021   
    P3,  N=100, Recruiting, 
    Trial completion date: Apr 2021 --> Apr 2022 | Trial primary completion date: Jan 2021 --> Jan 2022 Not yet recruiting --> Recruiting | Initiation date: Jan 2021 --> May 2021 | Trial primary completion date: Jul 2022 --> Dec 2022
  • ||||||||||  dexamethasone / Generic mfg., midazolam hydrochloride / Generic mfg.
    [VIRTUAL] A REVIEW OF 48-HOUR CONTINUOUS SUBCUTANEOUS INFUSION UTILISATION IN A COMMUNITY PALLIATIVE CARE SETTING () -  May 10, 2021 - Abstract #MASCCISOO2021MASCC_ISOO_98;    
    Dexamethasone 0.5mg was added to 97% of infusions...All 48-hour CSCI prescriptions included at least 2 medications, with 55% containing 4 drugs. Conclusion These results confirm that 48-hour CSCI’s have been used safely and effectively to administer medications in a community palliative care setting.
  • ||||||||||  morphine sulphate / Generic mfg.
    Enrollment change, Trial completion date, Trial termination, Trial primary completion date, Surgery:  Lidocaine Infusion or Quadratus Lumborum Block and Intrathecal Morphine, Versus Intrathecal Morphine Alone (clinicaltrials.gov) -  May 9, 2021   
    P1,  N=1, Terminated, 
    Levorphanol was associated with improved pain and symptom control and was well tolerated. N=90 --> 1 | Trial completion date: Apr 2022 --> May 2021 | Recruiting --> Terminated | Trial primary completion date: Jan 2022 --> May 2021; Recruitment challenges due to COVID-19
  • ||||||||||  morphine sulphate / Generic mfg.
    Enrollment change, Trial termination:  MORFICUS: MORphine Use in the Fascia Iliaca Compartment Block With UltraSound (clinicaltrials.gov) -  May 6, 2021   
    P4,  N=55, Terminated, 
    N=90 --> 1 | Trial completion date: Apr 2022 --> May 2021 | Recruiting --> Terminated | Trial primary completion date: Jan 2022 --> May 2021; Recruitment challenges due to COVID-19 N=120 --> 55 | Recruiting --> Terminated; COVID-19 crisis.
  • ||||||||||  pregabalin / Generic mfg., gabapentin / Generic mfg., carbamazepine / Generic mfg.
    [VIRTUAL] Analysis of opioid and adjunctive pain medication prescriptions in lung cancer patients. () -  Apr 29, 2021 - Abstract #ASCO2021ASCO_5666;    
    In the period under study, adjunctive medications such as gabapentin were prescribed much less than and rarely without opioids . Some lung cancer patients received ≥3 distinct opioids, with higher rates seen in those with adjunctive medicine prescriptions .
  • ||||||||||  morphine sulphate / Generic mfg.
    [VIRTUAL] Improving cancer pain management in the emergency department: An EMR-based solution. () -  Apr 28, 2021 - Abstract #ASCO2021ASCO_3448;    
    The BPA algorithm identified ED patients with cancer that were taking prescription opioids with a morphine equivalent daily dose (MEDD) of at least 100, as calculated by the EMR... Among cancer patients on chronic opioids presenting to the ED, use of an EMR-based BPA led to more appropriate opioid dosing without the need for opioid reversal agents, and was associated with an overall decrease in hospital admissions.
  • ||||||||||  morphine sulphate / Generic mfg.
    [VIRTUAL] Impact of the VA opioid safety initiative on pain management for cancer patients. () -  Apr 28, 2021 - Abstract #ASCO2021ASCO_1905;    
    The OSI was associated with a decrease in new, persistent, and certain high-risk opioid prescribing as well as an increase in pain-related ED visits . Further research on patient-centered outcomes is required to optimize opioid prescribing policies for patients with cancer.
  • ||||||||||  morphine sulphate / Generic mfg.
    Trial completion, Trial completion date, Trial primary completion date:  Neuroimmune Effects of Opioid Administration (clinicaltrials.gov) -  Apr 27, 2021   
    P1,  N=10, Completed, 
    Further research on patient-centered outcomes is required to optimize opioid prescribing policies for patients with cancer. Recruiting --> Completed | Trial completion date: Dec 2020 --> Mar 2021 | Trial primary completion date: Dec 2020 --> Mar 2021
  • ||||||||||  morphine-6-glucuronide (M6G) / PAION
    Clinical, Journal:  Morphine Use in Renal Failure: A Case Report of Single-Dose Morphine Toxicity in a Patient Requiring Peritoneal Dialysis. (Pubmed Central) -  Apr 24, 2021   
    A 76-year-old African-American female received one dose of morphine sulfate and developed signs and symptoms of morphine toxicity for 2 days, even after multiple peritoneal dialysis sessions. Because of reduced renal clearance of morphine and its metabolites in patients requiring peritoneal dialysis, morphine should be avoided as an analgesic option in this population due to increased risk of morphine toxicity.
  • ||||||||||  morphine sulphate / Generic mfg.
    Trial completion date, Trial primary completion date:  Comparison of 0.1 and 0.05mg Intrathecal Morphine for Post-cesarean Analgesia. (clinicaltrials.gov) -  Apr 22, 2021   
    P1,  N=200, Recruiting, 
    Because of reduced renal clearance of morphine and its metabolites in patients requiring peritoneal dialysis, morphine should be avoided as an analgesic option in this population due to increased risk of morphine toxicity. Trial completion date: Feb 2021 --> Feb 2022 | Trial primary completion date: Feb 2021 --> Feb 2022
  • ||||||||||  morphine sulphate / Generic mfg.
    Enrollment open, Head-to-Head:  TAP Block With Intrathecal Fentanyl vs. Intrathecal Morphine in Cesarean Delivery (clinicaltrials.gov) -  Apr 22, 2021   
    P=N/A,  N=80, Recruiting, 
    Trial completion date: Feb 2021 --> Feb 2022 | Trial primary completion date: Feb 2021 --> Feb 2022 Not yet recruiting --> Recruiting
  • ||||||||||  ropivacaine / Generic mfg.
    Enrollment change, Trial withdrawal:  Adductor Canal Nerve Block Following Total Knee Arthroplasty (clinicaltrials.gov) -  Apr 20, 2021   
    P=N/A,  N=0, Withdrawn, 
    Not yet recruiting --> Recruiting N=15 --> 0 | Terminated --> Withdrawn
  • ||||||||||  Sufenta (sufentanil) / Akorn
    Trial completion, Enrollment change, Trial completion date, Trial primary completion date:  Plasmatic Catecholamines: Randomized Controlled Trial Comparing Epidural Versus Combined Spinal-epidural (clinicaltrials.gov) -  Apr 13, 2021   
    P=N/A,  N=50, Completed, 
    Recruiting --> Completed N=74 --> 50 | Recruiting --> Completed | Trial completion date: Mar 2021 --> Oct 2020 | Trial primary completion date: Feb 2021 --> Oct 2020