- |||||||||| Dynastat (parecoxib) / Pfizer
Retrospective data, Journal: Earlier Is Better? Timing of Adductor Canal Block for Arthroscopic Knee Surgery under General Anesthesia: A Retrospective Cohort Study. (Pubmed Central) - May 25, 2021
Groups B and C had lower visual analogue scale (VAS) scores upon PACU discharge than Group A. Dynamic, but not at-rest VAS scores, were significantly higher in Group A. Opioid consumption was similar in the ward, but Group A requested more intravenous parecoxib for pain relief...Preoperative or postoperative ACB improved postoperative pain control. Consequently, preoperative ACB is optimal for intraoperative stress suppression and postoperative pain control.
- |||||||||| morphine sulphate / Generic mfg.
Clinical, Journal: Opioid use in medical cannabis authorization adult patients from 2013 to 2018: Alberta, Canada. (Pubmed Central) - May 25, 2021
This short-term study found that medical cannabis authorization showed intermediate effects on opioid use, which was dependent on initial opioid use. Greater observations of changes in OME appear to be in those patients who were on a high dosage of opioids (OME > 100); however, continued surveillance of patients utilizing both opioids and medical cannabis is warranted by clinicians to understand the long-term potential benefits and any harms of ongoing use.
- |||||||||| morphine sulphate / Generic mfg., methamphetamine / Generic mfg.
Journal: AddictGene: An integrated knowledge base for differentially expressed genes associated with addictive substance. (Pubmed Central) - May 25, 2021
The easy-to-use web interface of AddictGene (http://159.226.67.237/sun/addictgedb/) allows users to search and browse multidimensional data on DEGs of their interest: 1) detailed gene-specific information extracted from the original studies; 2) basic information about the specific gene extracted from NCBI; 3) SNP associated with substance dependence and other psychiatry disorders; 4) expression alteration of specific gene in other psychiatric disorders; 5) expression patterns of interested gene across 31 primary and 54 secondary human tissues; 6) functional annotation of interested gene; 7) epigenetic regulators involved in the alteration of specific genes, including histone modifications and DNA methylation; 8) protein-protein interaction for functional linkage with interested gene; 9) drug-gene interaction for potential druggability. AddictGene offers a valuable repository for researchers to study the molecular mechanisms underlying addiction, and might provide valuable insights into potential therapies for drug abuse and relapse.
- |||||||||| morphine sulphate / Generic mfg.
Clinical, Journal: Institutional Reductions in Opioid Prescribing Following Hip Arthroscopy Do Not Change Patient Satisfaction Scores. (Pubmed Central) - May 25, 2021
Prescriptions were converted to milligram morphine equivalents (MME) for direct comparison between different opioids...A reduction in opioids prescribed after a hip arthroscopy is not associated with any statistically significant difference in patient satisfaction with pain management, as measured by the Press-Ganey survey. Level III, retrospective comparative study.
- |||||||||| fentanyl citrate / Generic mfg.
Review, Journal: The anomalous pharmacology of fentanyl. (Pubmed Central) - May 25, 2021
Some of these factors can be considered to represent "anomalous" pharmacological properties of fentanyl when compared to prototypical opioid agonists such as morphine. In this review, we examine the nature of fentanyl's "anomalous" properties, to determine whether there really is a pharmacological basis to support the existence of such properties, and also discuss whether such properties are likely to contribute to overdose deaths involving fentanyls.
- |||||||||| remifentanil / Generic mfg., morphine sulphate / Generic mfg.
[VIRTUAL] Determinants of Opioid Modulation of Pain, Reward and Mood in Humans () - May 22, 2021 - Abstract #IASP2021IASP_113;
One study even reported dose-dependent dysphoric mood after remifentanil treatment...For reward-induced analgesia, we recently found that naloxone blockade reduced expectation-related pain relief, whereas affect voluntary imagery-based reappraisal of pain was opioid-independent. In sum, available data on opioid modulation of pain, reward and mood will be carefully examined and discussed.
- |||||||||| morphine sulphate / Generic mfg.
Clinical, Journal: Experience of morphine therapy for refractory dyspnea as palliative care in advanced heart failure patients. (Pubmed Central) - May 22, 2021
Introducing Efficacy Safety Score (ESS) as a decision tool combined with a wireless monitoring system resulted in less pain, increased satisfaction and more rapid mobilisation for patients in this study. This single-center retrospective study revealed the clinical practice of morphine therapy and suggested that morphine therapy might be feasible for refractory dyspnea as palliative care in advanced HF patients.
- |||||||||| morphine sulphate / Generic mfg., isoflurane / Generic mfg., dexmedetomidine / Generic mfg.
Journal: Effect of insulation with bubble wrap and an absorbent pad on heat loss in anaesthetised cats. (Pubmed Central) - May 22, 2021
This single-center retrospective study revealed the clinical practice of morphine therapy and suggested that morphine therapy might be feasible for refractory dyspnea as palliative care in advanced HF patients. This inexpensive and practical method may reduce perioperative hypothermia, in cats undergoing abdominal surgery.
- |||||||||| morphine sulphate / Generic mfg.
Clinical, Journal: Adoption of Enhanced Surgical Recovery (ESR) Protocol for Lumbar Fusion Decreases In-Hospital Postoperative Opioid Consumption. (Pubmed Central) - May 22, 2021
Regression analysis showed that ESR was strongly associated with in-hospital opioid consumption, accounting for 30% of the variability in Morphine Milligram Equivalents (MME)...Secondary analysis showed that ESR was associated with a shorter length of stay and earlier ambulation. This study showed ESR has the potential to improve recovery after lumbar fusion for degenerative conditions with reduced in-hospital opioid consumption and improved postoperative pain scores.
- |||||||||| morphine sulphate / Generic mfg.
Clinical, Journal: Persistent Opioid Use Among Patients with Urolithiasis: A Population based Study. (Pubmed Central) - May 21, 2021
Furthermore, current literature supported the TLIP block was superior to wound infiltration in terms of opioid consumption. The majority of urolithiasis patients were prescribed opioids and 9% of previously opioid-naïve patients exhibited persistent opioid use 91-180 d after their initial urolithiasis visit.
- |||||||||| morphine sulphate / Generic mfg.
Journal: A Study on the Mechanism of Lavender in the treatment of Insomnia based on Network Pharmacology. (Pubmed Central) - May 21, 2021
The majority of urolithiasis patients were prescribed opioids and 9% of previously opioid-naïve patients exhibited persistent opioid use 91-180 d after their initial urolithiasis visit. The components in the lavender essential oil include the Ethyl 2-(5-methyl-5-vinyltetrahydrofuran-2- yl)propan-2-ylcarbonate(0.774) 5-Oxatricyclo[8.2.04,6]dodecane, 4,12,12-trimethyl-9-methylene-, (1R,4R,6R,10S)-(0.147);P-Cymen-7-ol(0.063);.alpha-Humulenem(0.317);Acetic acid, hexyl ester(1.374); etc. The role lavender plays in the treatment of insomnia might be accomplished through the regulation of the key targets ADRB1 and HLA-DRB1.
- |||||||||| morphine sulphate / Generic mfg.
Clinical, Journal: Single-site retroperitoneoscopy in pediatric metastatic lymphadenopathy. (Pubmed Central) - May 21, 2021
Single-site RS is a safe and feasible technique in carefully selected pediatric surgical oncology patients. RS provides an excellent view of the retroperitoneum, requires less postoperative analgesia, and is associated with faster recovery.
- |||||||||| morphine sulphate / Generic mfg., methadone / Generic mfg.
Clinical, Clinical data, Journal, Real-world evidence: Model-Based Approach To Improve Clinical Outcomes In Neonates With Opioid Withdrawal Syndrome Using Real-World Data. (Pubmed Central) - May 21, 2021
The model evaluation showed that observed and predicted median time on treatment were similar (13.0 vs 13.8 days). A model based framework was developed to describe the MFS-morphine dose relationship using real world data that could potentially be used to develop an adaptive, individualized morphine dosing strategy to improve clinical outcomes in infants with NOWS.
- |||||||||| morphine sulphate / Generic mfg.
Review, Journal: Morphine and myocardial ischaemia-reperfusion. (Pubmed Central) - May 21, 2021
The present review focused on morphine-induced protection in an animal model of myocardial ischaemia-reperfusion and chronic heart failure and the effects of morphine on ST segment elevation myocardial infarction (STEMI) patients who underwent pre-primary percutaneous coronary intervention (pre-PPCI) or PPCI. The signalling pathways involved are also briefly described.
- |||||||||| Exparel (bupivacaine liposome injectable suspension) / Pacira
Clinical, Retrospective data, Journal: Liposomal Bupivacaine Infiltration After Median Sternotomy in Pediatric Cardiac Surgery. (Pubmed Central) - May 21, 2021
Patients receiving anloxone continuous infusion to prevent spinal cord ischemia required greater quantities of opioids and had higher postoperative pain, compared with patients not requiring naloxone. LB is at least as effective as the ON-Q is for providing analgesia after median sternotomy incision in children.
- |||||||||| Olinvyk (oliceridine) / Trevena, Jiangsu NHWA Pharma
Journal: Role of β-arrestin-2 in short- and long-term opioid tolerance in the dorsal root ganglia. (Pubmed Central) - May 21, 2021
Whole-cell current-clamp electrophysiology experiments revealed that 15-18-h overnight exposure to 10 μM morphine in vitro induced acute tolerance in β-arrestin-2 wild-type but not knockout neurons...Consequently, these results indicated that β-arrestin-2 mediates acute but not chronic opioid tolerance in dorsal root ganglia neurons and to antinociception in vivo. This suggests that opioid-induced antinociceptive tolerance may develop even in the absence of β-arrestin-2 activation, and thus significantly affect the clinical utility of biased agonists.
- |||||||||| morphine sulphate / Generic mfg., methamphetamine / Generic mfg.
Clinical, Journal: Estimation of the psychoactive substances consumption within 12 wastewater treatment plants service areas in a certain city of Guangxi, China applying wastewater-based epidemiology. (Pubmed Central) - May 21, 2021
The results demonstrate that KET, MOR, and METH are the most abused psychoactive substances, with the mean consumption of 682.42, 167.81, and 44.56 mg/day/1000 inh, respectively. The psychoactive substance residues of WWTPs influent were analyzed to estimate such substances' consumption in specific areas, so as to provide support for risk prevention and control.
- |||||||||| morphine sulphate / Generic mfg.
Preclinical, Journal: Effects of maternal consumption of morphine on rat skeletal system development. (Pubmed Central) - May 21, 2021
Future analyses will explore the association between POs and adverse outcomes. Histochemistry and immunohistochemistry findings on cartilage and bone matrix formation, as well as protein expression of chondrogenic and osteogenic markers suggest that morphine dependence in pregnant mothers may impair intra-cartilaginous osteogenesis in post-natal rats.
- |||||||||| morphine sulphate / Generic mfg.
Clinical, Journal: Opioid Reduction and Risk Mitigation in VA Primary Care: Outcomes from the Integrated Pain Team Initiative. (Pubmed Central) - May 20, 2021
We did not observe a reduction in postoperative opioid administration at 24 h with a posterior quadratus lumborum block regional anesthesia in patients undergoing elective colorectal surgery. Interdisciplinary biopsychosocial models of pain care can be embedded in primary care and lead to significant improvements in opioid dose and risk mitigation.
- |||||||||| morphine sulphate / Generic mfg., paracetamol / Generic mfg.
Clinical, Journal: Patient-Reported Opioid Pill Consumption After an ED Visit: How Many Pills Are People Using? (Pubmed Central) - May 20, 2021
Interdisciplinary biopsychosocial models of pain care can be embedded in primary care and lead to significant improvements in opioid dose and risk mitigation. In this sample, pill consumption varied by illness category; however, overall, patients were consuming low quantities of pills, and the majority had unused pills 10 days after their ED visit.
- |||||||||| morphine sulphate / Generic mfg.
Retrospective data, Journal: Intrathecal Morphine in Postoperative Analgesia for Colorectal Cancer Surgery: A Retrospective Study. (Pubmed Central) - May 20, 2021
This tolerance development to JHU58 may involve increased coupling of MrgC to β-arrestin-2 and ubiquitin-mediated receptor degradation. This retrospective study demonstrated that ITM + PCA can achieve similar analgesic effects after laparotomy and laparoscopy colorectal cancer surgery compared with PCA alone while resulting in a reduction of oral opioid consumption and lower incidence of sedation.
- |||||||||| morphine sulphate / Generic mfg.
Preclinical, Journal: Effect of the morphine/heroin vaccine on opioid and non-opioid drug-induced antinociception in mice. (Pubmed Central) - May 20, 2021
These results suggest that the antibody titers generated by the M-TT vaccine 1) are capable of reducing morphine-induced antinociception and 2) are selective enough not to alter antinociception induced by non-opioid or synthetic drugs. These characteristics support its potential as a treatment agent for patients with symptoms of pain comorbid to OUD.
- |||||||||| morphine sulphate / Generic mfg.
Clinical, Journal: Conditioned open-label placebo for opioid reduction following spine surgery: a randomized, controlled trial. (Pubmed Central) - May 20, 2021
Daily worst pain scores were also lower in the COLP group (-1.0 point on the 10-point scale; 95% CI: [-2.0, -0.1]), although a significant difference was not detected in average daily pain between the groups (-0.8 point; 95% CI: [-1.7, 0.2]). These findings suggest that COLP may serve as a potential adjuvant analgesic therapy to decrease opioid consumption in the early postoperative period, without increasing pain.
- |||||||||| morphine sulphate / Generic mfg.
Preclinical, Journal: Exogenous SO donor treatment impairs reconsolidation of drug reward memory in mice. (Pubmed Central) - May 20, 2021
In the present study, we used morphine- or cocaine-induced conditioned place preference (CPP) mouse models with retrieval to investigate the effects of exogenous SO donor treatment on reconsolidation of drug reward memory...Our results indicate that exogenous SO impairs reconsolidation of drug reward memory rather than inhibits the expression of drug reward memory. As such, SO2 holds potential for the treatment and prevention of SRADs and should be studied further.
- |||||||||| morphine sulphate / Generic mfg.
Preclinical, Journal: The synergistic effects of Opioid and neuropeptide B/W in rat acute inflammatory and neuropathic pain models. (Pubmed Central) - May 20, 2021
We also found that phosphorylation of extracellular-regulated protein kinase (ERK1/2) following morphine was profoundly potentiated by the application of NPB23 or NPW23. Hence, combination of morphine with either NPB23 or NPW23 reduced dose of morphine required for pain relief in inflammatory and neuropathic pain, while effectively prevented some side-effects of morphine.
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