morphine sulphate / Generic mfg. 
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  • ||||||||||  morphine sulphate / Generic mfg., methamphetamine / Generic mfg.
    Journal:  Wastewater analysis reveals urban, suburban, and rural spatial patterns of illicit drug use in Dalian, China. (Pubmed Central) -  Jun 1, 2021   
    The results indicate relatively low levels of illicit drug use in rural areas of Dalian, related to low incomes and outflow of the working-age population. Illicit drug use was most prevalent in suburban areas of Dalian, which may be influenced by large floating populations and few anti-drug efforts in suburban areas.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal, Adverse events:  Prenatal opioid analgesics and the risk of adverse birth outcomes. (Pubmed Central) -  Jun 1, 2021   
    Illicit drug use was most prevalent in suburban areas of Dalian, which may be influenced by large floating populations and few anti-drug efforts in suburban areas. Opioid analgesic exposed pregnancies had a small increased risk of preterm birth and possibly stillbirth after accounting for confounding by indication and sociodemographic factors.
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
    Journal:  Platelets and poppies: Do morphine and fentanyl differ? (Pubmed Central) -  Jun 1, 2021   
    Opioid analgesic exposed pregnancies had a small increased risk of preterm birth and possibly stillbirth after accounting for confounding by indication and sociodemographic factors. No abstract available
  • ||||||||||  fentanyl citrate / Generic mfg., hydromorphone hydrochloride / Generic mfg.
    Clinical, Journal:  Hydromorphone Compared to Fentanyl in Patients Receiving Extracorporeal Membrane Oxygenation. (Pubmed Central) -  Jun 1, 2021   
    Patients receiving hydromorphone required less MME compared to fentanyl without any differences in sedative requirements, or agitation-sedation scores at 48 hours. Prospective studies should be completed to validate these findings.
  • ||||||||||  morphine sulphate / Generic mfg., methadone / Generic mfg.
    Review, Journal:  New Approaches in Drug Dependence: Opioids. (Pubmed Central) -  Jun 1, 2021   
    Maintaining a harm reduction approach in the treatment of opioid addiction, a larger range of formulations is available for the prescribers. Embedding the pharmacological, ideally individualized treatment into a holistic, structure-giving concept also requires a reduction of fragmentation of ancillary services available, drug policies, and treatment philosophies on a global scale.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Electrochemical Detection of Morphine in Untreated Human Capillary Whole Blood. (Pubmed Central) -  Jun 1, 2021   
    An interference study with other opioids and possible interferents showed the selectivity of the sensor. This study clearly indicates that these Nafion/SWCNT sensor strips show great promise as a point-of-care rapid test for morphine in blood.
  • ||||||||||  morphine sulphate / Generic mfg.
    [VIRTUAL] Neuromodulation of failed back surgery syndrome (Room Berlin) -  May 30, 2021 - Abstract #EAN2021EAN_1377;    
    All of patients have had successful the trial period, after that was implanted system for chronic neurostimulation: SCS – 94 (87%), PNS – 2 (1,8%), PNFS – 4 (3,7%) and hybrid stimulation: SCS+PNFS – 3 (2,8%), SCS+PNS – 1 (0,9%), SCS+SNRS – 2 (1,8%), SCS+intrathecal morphine pump (IMP) – 1(0,9%) and SCS+IMP+PNFS – 1(0,9%)... Neurostimulation the patients with FBSS has high efficacy and a high level of evidence.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal:  Posttraumatic Stress in Children After Injury: The Role of Acute Pain and Opioid Medication Use. (Pubmed Central) -  May 29, 2021   
    Findings suggest that pain assessment may be a useful addition to pediatric PTSS screening tools and highlight the need for additional research on pharmacological secondary prevention approaches. Given that inadequate pain control and persistent PTSS each hinder recovery and long-term functioning, better understanding of interactions between acute pain and PTSS after injury is essential for improving screening, prevention, and early intervention efforts.
  • ||||||||||  TRV734 / Trevena
    Clinical, P1 data, Journal:  A First-in-Human Clinical Study With TRV734, an Orally Bioavailable G-Protein-Biased Ligand at the μ-Opioid Receptor. (Pubmed Central) -  May 29, 2021   
    Following administration of TRV734 125 mg under fasted or fed conditions, there was no significant difference in bioavailability when given as a solution or drug in capsule to fasted subjects. When drug in capsule was given to subjects following a high-fat meal, absorption was slowed, resulting in decreased peak concentrations, but area under the plasma concentration-time curve was not affected.
  • ||||||||||  ibuprofen / Generic mfg.
    Journal:  μ-Opioid receptors in primary sensory neurons are involved in supraspinal opioid analgesia. (Pubmed Central) -  May 29, 2021   
    We generated Oprm1 conditional knockout (Oprm1-cKO) mice by crossing Advillin mice with Oprm1 mice...Intracerebroventricular injection of morphine or fentanyl produced a potent analgesic effect in wild-type mice, but such an effect was significantly attenuated in Oprm1-cKO mice...Our findings indicate that MORs expressed at primary afferent terminals in the spinal cord contribute to the supraspinal opioid analgesic effect. These presynaptic MORs in the spinal cord may serve as an interface between ascending inhibition and descending modulation that are involved in opioid analgesia.
  • ||||||||||  morphine sulphate / Generic mfg., hydromorphone hydrochloride / Generic mfg., methadone / Generic mfg.
    Clinical, Journal:  Refilling Opioid Prescriptions After Pediatric Orthopaedic Surgery: An Analysis of Incidence and Risk Factors. (Pubmed Central) -  May 29, 2021   
    The volume of opioids during inpatient hospitalization may predict the need for opioid prescription refills after discharge. Clinicians should maximize efforts to achieve pain control with multimodal analgesia and opioid alternatives, and use caution when administering high-dose opioids during postoperative hospitalization.
  • ||||||||||  vancomycin / Generic mfg., morphine sulphate / Generic mfg.
    Review, Journal:  The Multifaceted Mas-Related G Protein-Coupled Receptor Member X2 in Allergic Diseases and Beyond. (Pubmed Central) -  May 29, 2021   
    Different studies have shown its possible role in other allergic diseases as well, such as asthma, atopic dermatitis, contact dermatitis, and chronic spontaneous urticaria. In this review, we sought to cover its function in physiologic processes and responses, as well as in allergic and nonallergic immune disease.
  • ||||||||||  nalbuphine / Endo
    Preclinical, Journal:  Effects of nalbuphine on the cardioprotective effect of morphine in rats. (Pubmed Central) -  May 28, 2021   
    Nalbuphine does not interfere with the cardioprotective effect of morphine in vivo. Therefore, nalbuphine could be safely used or combined with morphine in patients with acute myocardial infarction.
  • ||||||||||  pregabalin / Generic mfg.
    Retrospective data, Review, Journal:  Oral Pregabalin in Cardiac Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. (Pubmed Central) -  May 27, 2021   
    And we found that there were no significant differences between the two groups in extubation time (WMD: 17.24, 95% CI: -24.36-58.84, P = 0.42). Oral pregabalin for cardiac surgery patients can effectively reduce the patient's 24-hour morphine consumption after surgery, shorten the patient's hospital stay, and is more conducive to early postoperative recovery.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal:  Implementation of an enhanced recovery protocol in gynecologic oncology. (Pubmed Central) -  May 27, 2021   
    An overall reduction in narcotic usage, measured as oral morphine milliequivalents (MMEs) was observed in the ERAS relative to the non-ERAS group, during the entire hospital stay (MME 34 versus 68, p < 0.001 and within 72 h postoperatively (MME 34 versus 60, p < 0.005)...This study demonstrated the benefits of ERAS in Gynecologic Oncology. A significant reduction of postoperative narcotic use, earlier return of bowel function and a shorter postoperative hospital stay was seen in the ERAS compared to traditional perioperative care.
  • ||||||||||  morphine sulphate / Generic mfg.
    [VIRTUAL] Chronic morphine administration alters gut-brain homeostasis in SHIV infected rhesus macaques () -  May 27, 2021 - Abstract #IASHIV2021IAS_HIV_1310;    
    A significant reduction of postoperative narcotic use, earlier return of bowel function and a shorter postoperative hospital stay was seen in the ERAS compared to traditional perioperative care. These data indicate that morphine 1) elevates CNS inflammation by altering receptor regulation and selective enhancement of SHIV persistence in sites of neurogenesis; 2) depletes crucial genera that support optimal brain function; 3) Increases macrophage activation in sites enriched with enteric neurons (MUSC), warranting further investigation into mechanisms involved in morphine enhanced alternation of the gut-brain axis during SHIV infection.
  • ||||||||||  morphine sulphate / Generic mfg.
    Review, Journal:  The Implausibility of Neonatal Opioid Toxicity from Breastfeeding. (Pubmed Central) -  May 26, 2021   
    We argue that this explanation is implausible based upon several factors: 1) the exceedingly small amount of opioids passed into breastmilk irrespective of maternal CYP genotype, 2) the observation that significant neonatal opioid accumulation can only occur in the setting of severely impaired renal function, and 3) the previously unreported finding of a markedly elevated codeine concentration in postmortem blood. Finally, a review of the literature identifies a paucity of convincing reports of neonatal opioid toxicity during breast feeding, with no other confirmed cases of neonatal death despite the use of these drugs by millions of nursing mothers over the past two decades.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Neuraxial Anesthesia is Associated with Decreased Pain Scores and PACU Opioid Requirements Compared with General Anesthesia in Hip Arthroscopy. (Pubmed Central) -  May 26, 2021   
    Finally, a review of the literature identifies a paucity of convincing reports of neonatal opioid toxicity during breast feeding, with no other confirmed cases of neonatal death despite the use of these drugs by millions of nursing mothers over the past two decades. Neuraxial anesthesia use in routine hip arthroscopy was associated with lower immediate postoperative pain scores, lower intraoperative and immediate postoperative opioid requirements, and may be associated with shorter anesthesia recovery time without any major adverse events when compared to general anesthesia.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Long-term Success With Diminished Opioid Prescribing After Implementation of Standardized Postoperative Opioid Prescribing Guidelines: An Interrupted Time Series Analysis. (Pubmed Central) -  May 26, 2021   
    Neuraxial anesthesia use in routine hip arthroscopy was associated with lower immediate postoperative pain scores, lower intraoperative and immediate postoperative opioid requirements, and may be associated with shorter anesthesia recovery time without any major adverse events when compared to general anesthesia. In a multi-institutional follow-up prospective study of adult urologic surgery-specific evidence-based guidelines for postoperative prescribing, we demonstrate sustained reduction in OMEs prescribed secondary to guideline implementation and adherence by our providers.
  • ||||||||||  morphine sulphate / Generic mfg., clonidine / Generic mfg.
    Clinical, Journal:  ROUX-IN-Y GASTROJEJUNAL BYPASS: WHICH ANESTHETIC TECHNIQUE HAS BEST RESULTS? (Pubmed Central) -  May 26, 2021   
    In a multi-institutional follow-up prospective study of adult urologic surgery-specific evidence-based guidelines for postoperative prescribing, we demonstrate sustained reduction in OMEs prescribed secondary to guideline implementation and adherence by our providers. Epidural anesthesia with low-dose morphine allowed less pain during the entire hospital stay, with a positive impact on patient recovery.
  • ||||||||||  ketorolac / Generic mfg., morphine sulphate / Generic mfg.
    Clinical, Journal:  No Difference in Pain After Spine Surgery with Local Wound Filtration of Morphine and Ketorolac: A Randomized Controlled Trial. (Pubmed Central) -  May 25, 2021   
    Multimodal wound infiltration with an NSAID and morphine did not yield any clinically important reduction in pain or opioid consumption. Since no substantial benefit of adding these drugs to a patient's aftercare regimen was achieved, and considering the potential risks of administering opioids and NSAIDs (such as, polypharmacy in older patients, serious adverse effects of NSAIDs), we recommend against routine use of this approach in clinical practice.
  • ||||||||||  ketamine / Generic mfg.
    Clinical, Journal:  Ketamine infusion reduces narcotic requirements following gastric bypass surgery: a randomized controlled trial. (Pubmed Central) -  May 25, 2021   
    Topical administration of DEX provided better clinical outcomes on postoperative pain management and knee swelling early after TKA, while intravenous DEX was more effective in decreasing blood inflammatory biomarkers and preventing postoperative nausea. Ketamine successfully reduced the amount of opioids required to control bariatric patients' pain at 24 hours postoperatively, but not over the 48-hour postoperative period.