morphine sulphate / Generic mfg. 
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  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Pharmacological profile and molecular modeling of cyclic opioid analogs incorporating various phenylalanine derivatives. (Pubmed Central) -  Jun 16, 2021   
    Peptide-based agonists of the μ opioid receptor (μOR) are promising therapeutic candidates for pain relief with reduced side effects compared to morphine...The binding of the cyclic analogs to all three OR types (µ, δ, κ) was assessed by radioligand competitive binding assay and their functional activity was determined by calcium mobilization assay. In order to provide structural hypotheses explaining the obtained experimental affinities, the complexes of the cyclic peptides with μOR were subjected to molecular modeling.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Reimbursement, Journal, Medicaid:  Incidence rates of and risk factors for opioid overdose in new users of prescription opioids among US Medicaid enrollees: A cohort study. (Pubmed Central) -  Jun 16, 2021   
    In Medicaid enrollees in four study states during 2002 to 2012, opioid overdose incidence rate per 100 000 person-years among apparent new users of prescription opioids was 247.1, with 251.0 in 2002 and 225.5 in 2012. Younger ages, white race/ethnicity, higher MME opioid daily doses, prior substance use disorders, mental health conditions, and benzodiazepine prescriptions were associated with a higher risk of opioid overdose incidence.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal:  Enhanced Recovery After Surgery Protocol for Primary Cleft Palate Repair: Improving Transition of Care. (Pubmed Central) -  Jun 16, 2021   
    The use of multimodality therapy and increased patient education regarding non-narcotic medications can improve the transition of care from inpatient to outpatient, without sacrificing patient/parent satisfaction. The results of this study merit future study into more restricted use of opioid pain medications with greater emphasis on the use of multimodal therapeutics as primary agents as opposed to adjuncts.
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
    Review, Journal:  GRKs as Key Modulators of Opioid Receptor Function. (Pubmed Central) -  Jun 16, 2021   
    Numerous strategies, such as phosphosite specific antibodies and mass spectrometry have allowed the detection of phosphorylated residues and the use of mutant knock-in mice have shed light on the role of GRK regulation in opioid receptor physiology. Here we review our current understanding on the role of GRKs in the actions of opioid receptors, with a particular focus on the MOR, the target of most commonly used opioid analgesics such as morphine or fentanyl.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Opioid Consumption After Knee Arthroscopy. (Pubmed Central) -  Jun 16, 2021   
    In spite of the low prescription quantity, patients reported high satisfaction rates, low NPRS pain scores, and required no refills. Therefore, we recommend that patients undergoing knee arthroscopy are prescribed no more than 5 oxycodone 5 mg pills.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Neonatalt abstinenssyndrom blant nyfødte barn av mødre i legemiddelassistert rehabilitering. (Pubmed Central) -  Jun 16, 2021   
    Key aspects of the management of neonates born to mothers in opioid maintenance treatment (OMT) were practised in the same manner and in line with national recommendations. However, our study revealed differences between the hospitals, which overall represent a potential for improvement in the treatment of a vulnerable patient group.
  • ||||||||||  morphine sulphate / Generic mfg., methamphetamine / Generic mfg.
    Journal:  Polyoxometalate-Based Frameworks as Adsorbents for Drug of Abuse Extraction from Hair Samples. (Pubmed Central) -  Jun 16, 2021   
    Our results demonstrate that polyoxometalate-based frameworks are suitable sorbents in D-μSPE for molecules containing amine functionalities. The modular design of these networks could in the future be used to expand and tune their substrate binding behavior.
  • ||||||||||  pregabalin / Generic mfg., gabapentin / Generic mfg.
    Clinical, Journal:  Factors Associated with Improvement in Uncontrolled Cancer Pain without Increasing the Opioid Daily Dose among Patients Seen by an Inpatient Palliative Care Team. (Pubmed Central) -  Jun 12, 2021   
    We assessed patient demographics and clinical variables, including cancer type, opioid prescription data (type, route, and oral morphine equivalent daily dose [MEDD]), presence of opioid rotation, psychological consultation, changes in adjuvant medications (e.g., corticosteroids; antiepileptics-gabapentin and pregabalin; benzodiazepines; and neuroleptics), and achievement of CIP. Nearly half of the patients achieved CIP without MEDD increase, suggesting that the multidimensional palliative care intervention is effective in improving pain control in many opioid-tolerant patients without the need to increase the opioid dose.
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  Pellino1 Contributes to Morphine Tolerance by Microglia Activation via MAPK Signaling in the Spinal Cord of Mice. (Pubmed Central) -  Jun 12, 2021   
    Therefore, we conclude that the upregulation of Peli1 in the spinal cord plays a curial role in the development of morphine tolerance via Peli1-dependent mobilization of spinal microglia, activation of MAPK signaling, and production of proinflammatory cytokines. Modulation of Peli1 may be a potential strategy for the prevention of morphine tolerance.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal:  Predictors of Acute Postsurgical Pain following Gastrointestinal Surgery: A Prospective Cohort Study. (Pubmed Central) -  Jun 12, 2021   
    Furthermore, MME consumption (OR 1.15, 95% CI 1.10-1.21, p < 0.001), preoperative anxiety (OR 1.33, 95% CI 1.21-1.46, p < 0.001), and expected postsurgical pain intensity (OR 1.36, 95% CI 1.17-1.57, p < 0.001) were independently associated with APSP severity. These results suggested that the predictors for APSP intensity following gastrointestinal surgery included analgesic consumption, preoperative anxiety, and expected postsurgical pain, which were also the risk factors for APSP severity.
  • ||||||||||  ketamine / Generic mfg., amphetamine / Generic mfg.
    Journal:  The prevalence of alcohol and other drugs in fatal road crashes in Victoria, Australia. (Pubmed Central) -  Jun 12, 2021   
    A decline in the prevalence of alcohol in fatalities suggests that law enforcement and public health strategies in Australia to address road fatalities and drink-driving may have had a positive effect. However, increases were observed in the incidence of other potentially impairing drugs including opioids and amphetamines, specifically methylamphetamine, indicating a concerning trend in road safety in Victoria that warrants further monitoring.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal:  Cervical Endocrine Surgery With a Novel Opioid-Limited Perioperative Protocol. (Pubmed Central) -  Jun 12, 2021   
    These results indicated that catecholamine neurotransmission was involved in the development of PONV in the NTS. Our novel opioid-limited surgery protocol used in conjunction with preoperative counseling is an effective approach for pain control in patients undergoing cervical endocrine surgery and limits opioid exposure throughout the perioperative period.
  • ||||||||||  morphine sulphate / Generic mfg., ketamine / Generic mfg.
    Phase classification, Enrollment change:  Influence of Morphine or Ketamine or Saline Applied During In-hospital Cardiopulmonary Resuscitation on Early Survival (clinicaltrials.gov) -  Jun 11, 2021   
    P1,  N=240, Not yet recruiting, 
    Our novel opioid-limited surgery protocol used in conjunction with preoperative counseling is an effective approach for pain control in patients undergoing cervical endocrine surgery and limits opioid exposure throughout the perioperative period. Phase classification: P=N/A --> P1 | N=2100 --> 240
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Opioids for refractory dyspnoea in palliation (Pubmed Central) -  Jun 11, 2021   
    Conclusively, there seems to be clinical efficacy although further studies are needed. Furthermore, the authors recommend Danish Medical Agency to legislate low-dose morphine to palliative patients with refractory dyspnoea.
  • ||||||||||  morphine sulphate / Generic mfg.
    Review, Journal:  A Comprehensive Review on the Role of Non-Coding RNAs in the Pathophysiology of Bipolar Disorder. (Pubmed Central) -  Jun 11, 2021   
    Furthermore, the authors recommend Danish Medical Agency to legislate low-dose morphine to palliative patients with refractory dyspnoea. Altered expression of these transcripts in bipolar disorder provides clues for identification of the pathogenesis of this disorder and design of targeted therapies for the treatment of patients.
  • ||||||||||  nalbuphine / Endo
    Clinical, Journal:  Influences of Gender on Intravenous Nalbuphine Actions After Major Abdominal Surgery: A Multicenter Study. (Pubmed Central) -  Jun 11, 2021   
    Altered expression of these transcripts in bipolar disorder provides clues for identification of the pathogenesis of this disorder and design of targeted therapies for the treatment of patients. The current study supports the hypothesis that although nalbuphine was found to be an effective and well-tolerated analgesic after major abdominal surgery, females were statistically more responsive than males.
  • ||||||||||  morphine sulphate / Generic mfg.
    Enrollment open, Trial completion date, Trial initiation date, Trial primary completion date:  U/S-guided Continuous Quadratus Lumborum Block III in Percutaneous Nephrolithotomy (clinicaltrials.gov) -  Jun 10, 2021   
    P=N/A,  N=45, Recruiting, 
    The current study supports the hypothesis that although nalbuphine was found to be an effective and well-tolerated analgesic after major abdominal surgery, females were statistically more responsive than males. Not yet recruiting --> Recruiting | Trial completion date: Sep 2021 --> Dec 2021 | Initiation date: Mar 2021 --> Jun 2021 | Trial primary completion date: Sep 2021 --> Dec 2021
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  Effects of morphine on interstitial cells of Cajal in rabbit colon and small intestinal transit: An experimental study. (Pubmed Central) -  Jun 10, 2021   
    Not yet recruiting --> Recruiting | Trial completion date: Sep 2021 --> Dec 2021 | Initiation date: Mar 2021 --> Jun 2021 | Trial primary completion date: Sep 2021 --> Dec 2021 Our findings demonstrate that miR-7 regulates the growth of retinal epithelial cells through various pathways and is a potential therapeutic target for the prevention and treatment of diabetic retinopathy.
  • ||||||||||  morphine sulphate / Generic mfg.
    Review, Journal:  The search for opioid analgesics with limited tolerance liability. (Pubmed Central) -  Jun 10, 2021   
    To this end, agonism at the µ opioid receptor (MOR) with simultaneous antagonism at the δ opioid receptor (DOR) emerged as a promising avenue to obtaining novel analogs devoid of serious adverse effects associated with morphine-based analgesics. In this review we covered up-to-date research on the synthesis of peptide-based ligands with MOR agonist/DOR antagonist profile.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Forskrivning av opioider på blå resept mot langvarige smerter. (Pubmed Central) -  Jun 10, 2021   
    A high proportion of patients with severe, chronic pain who started with opioids on reimbursable prescription became long-term users. A number of patients received higher dosages than are recommended.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Palliation by radiation is also our business ! (Pubmed Central) -  Jun 10, 2021   
    Very often, palliative RT is proposed when other medical treatments (painkillers, morphine…) are no longer efficient, or the patient does not tolerate them anymore...Indeed, patients' wishes and prognosis are taken into account in each and every step of the treatment pathway. Every treatment deserves an individualized approach and benefits from the best available techniques.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal, IO biomarker:  High Mobility Group Box 1/Toll-like Receptor 4 Signaling Increases GABRB3 Expression in Alcohol Exposure. (Pubmed Central) -  Jun 10, 2021   
    A total of 13 overlapping DEGs from the PFC and striatal datasets of the GSE123114 microarray profile were identified, and they were significantly enriched in the morphine addiction pathway...In further experiments, our findings suggest that alcohol exposure modulates Gabrb3 expression through the HMGB1/TLR4 pathway. Moreover, inflammation-associated factors, such as IL-1β and TNFα, may be related to the HMGB1/TLR4-mediated regulation of GABRB3 expression in alcohol exposure.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Sulfonate-isosteric replacement examined within heroin-hapten vaccine design. (Pubmed Central) -  Jun 9, 2021   
    However, neither the H nor H vaccines were able to generate high affinity antibodies to the psychoactive metabolite 6-acetyl morphine (6-AM), in comparison to the H vaccine. Blood brain bio-distribution studies supported these binding results with vaccine efficiency following the trend H > H ≫ H The work described herein provides insight into the use of hapten-isosteric replacement in vaccine drug design.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  The potential role of the orexin reward system in future treatments for opioid drug abuse. (Pubmed Central) -  Jun 8, 2021   
    In this regard, studies on both orexin-1 receptors (OX1Rs) and orexin-2 receptors (OX2Rs) have shown some positive results, suggesting that single orexin receptor antagonists (SORAs) and dual orexin receptor antagonists (DORAs) may hold promising efficacy in the treatment of addiction compared to the currently used methods. We conclude that since current evidence is still preliminary, development of new SORA and DORA compounds and their evaluation in animal and clinical studies will guide us in our future efforts for developing effective medication.