morphine sulphate / Generic mfg. 
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  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Morphine-induced respiratory depression is independent of ß-arrestin2 signalling. (Pubmed Central) -  Jun 22, 2021   
    We found no clinically important increase in pain scores or opioid consumption in association with higher BMI in patients 8 to 18 years of age recovering from elective non-cardiac surgery. Our findings do not support the original suggestion that ß-arrestin2 signalling plays a key role in opioid-induced respiratory depression and call into question the concept of developing G protein-biased μ-opioid receptor agonists as a strategy for the development of safer opioid analgesic drugs.
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  Fatty acid amide hydrolase inhibition in the central nervous system prevents and reverses morphine tolerance in male and female mice. (Pubmed Central) -  Jun 22, 2021   
    Our findings do not support the original suggestion that ß-arrestin2 signalling plays a key role in opioid-induced respiratory depression and call into question the concept of developing G protein-biased μ-opioid receptor agonists as a strategy for the development of safer opioid analgesic drugs. The results support a role for central FAAH-regulated lipid signaling in the modulation of opiate tolerance, and point to FAAH as a potential target for opiate-sparing medications.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal:  The Efficacy of Medical Marijuana in the Treatment of Cancer-Related Pain. (Pubmed Central) -  Jun 22, 2021   
    The results support a role for central FAAH-regulated lipid signaling in the modulation of opiate tolerance, and point to FAAH as a potential target for opiate-sparing medications. Medical records were reviewed for ESAS, to measure physical and emotional symptoms, and opiate consumption, converted into morphine milligram equivalents (MME)...MMJ(+) improved oncology patients' ESAS scores despite opioid dose reductions and should be considered a viable adjuvant therapy for palliative management.
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  EGFR signaling causes morphine tolerance and mechanical sensitization in rats. (Pubmed Central) -  Jun 22, 2021   
    Taken together, these results suggest a direct mechanistic link between opioid tolerance and neuropathic pain. EGFR antagonism could eventually play an important role in the treatment of opioid tolerance and severe neuropathic pain that requires ever increasing doses of opioids.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal:  Morphine alters respiratory control but not other key OSA phenotypes: A randomised trial. (Pubmed Central) -  Jun 22, 2021   
    CO was also delivered via nasal mask on therapeutic CPAP to quantify hypercapnic ventilatory responses during non-REM sleep.Compared to placebo, 40 mg of morphine did not change Pcrit (-0.1±2.4 versus -0.4±2.2 cmHO, p=0.58), genioglossus muscle responsiveness (-2.2[-0.87 to -5.4] versus -1.2[-0.3 to -3.5]microV/cmHO, p=0.22), or arousal threshold (-16.7±6.8 versus -15.4±6.0 cmHO, p=0.41), but did reduce loop gain (-10.1±2.6 versus -4.4±2.1 dimensionless, p=0.04) and hypercapnic ventilatory responses (7.3±1.2 versus 6.1±1.5 L·min, p=0.006).Concordant with recent clinical findings, 40 mg of MS-Contin does not systematically impair airway collapsibility, pharyngeal muscle responsiveness or the arousal threshold in moderately severe OSA patients. However, consistent with blunted chemosensitivity, ventilatory control is altered.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  The effects of a morphine shortage on emergency department pain control. (Pubmed Central) -  Jun 22, 2021   
    Removing IV morphine in the ED, without a compensatory rise in alternative opioids, does not appear to significantly impact analgesia or disposition. These data favor a more limited opioid use strategy in the ED.
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
    Journal:  Activation of μ opioid receptors by MT-45 and its fluorinated derivatives. (Pubmed Central) -  Jun 22, 2021   
    Fluorinated derivatives of MT-45 are potent μ receptor agonists and this may pose a danger to illicit opioid users. Inhibition of NMDA receptors by a metabolite of MT-45 may contribute to the reported dissociative effects.
  • ||||||||||  methionine enkephalin (IRT-101) / Immune Therap, Cytocom
    Journal:  Voltage modulates the effect of μ receptor activation in a ligand-dependent manner. (Pubmed Central) -  Jun 22, 2021   
    We did not find significant differences in operative times, but significantly more patients were pain-free on the first postoperative day and had shorter hospital stays. Our results indicate a strong ligand-dependent modulation of MOP activity by the membrane potential, suggesting preferential activity of morphine in neurons with high neuronal activity.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal:  Minimal clinically important differences in average, best, worst and current intensity and unpleasantness of chronic breathlessness. (Pubmed Central) -  Jun 22, 2021   
    Our results indicate a strong ligand-dependent modulation of MOP activity by the membrane potential, suggesting preferential activity of morphine in neurons with high neuronal activity. An improvement of about 10 mm on a 100 mm VAS is likely to be clinically meaningful across commonly used measures of chronic breathlessness (current intensity, unpleasantness, and average, best and worst intensity over the last 24 h) - to evaluate clinical benefit and effects in therapeutic trials.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal:  Impact of fascia iliaca block on pain, opioid consumption, and ambulation for patients with hip fractures - a prospective, randomized study. (Pubmed Central) -  Jun 22, 2021   
    An improvement of about 10 mm on a 100 mm VAS is likely to be clinically meaningful across commonly used measures of chronic breathlessness (current intensity, unpleasantness, and average, best and worst intensity over the last 24 h) - to evaluate clinical benefit and effects in therapeutic trials. A single perioperative FIB for patients with hip fractures undergoing surgery may decrease opioid consumption and increase the likelihood that a patient is discharged home.
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  Melatonin alleviates morphine analgesic tolerance in mice by decreasing NLRP3 inflammasome activation. (Pubmed Central) -  Jun 22, 2021   
    Concordantly, we observed a significantly elevated level of serum IL-1β, which indicates an increase of NLRP3 inflammasome activity associated with the reduced level of serum melatonin, in heroin-addicted patients relative to healthy individuals. Our results provide a solid basis for conducting a clinical trial with the co-administration of melatonin and morphine for the relief of severe pain.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  EVA technology and proteomics: a two-pronged attack on Cultural Heritage. (Pubmed Central) -  Jun 22, 2021   
    Some important applications are reported, such as the findings of the renal pathology and assumption of morphine in the original manuscript of Master I Margarita by Bulgakov, the presence of TBC bacterium in Chekhov's shirt and in a letter by Orwell, the Y. pestis and anthrax bacteria in the death registries of Milan's lazaretto in the 1630 plague bout, as well as ample traces of five metals in Kepler's manuscripts, suggesting his potential practice of alchemy...A family of EVA films is described, enlarging its use to dedicated applications, such as the capture of drugs of abuse in the pages of famous writers and even in the paintings of fauvists. It is hoped that the present methodology could open the doors of museums, state archives and private collections for detecting biological traces left by artists, literates and men of culture in their masterpieces.
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  Novel oral nanoparticle formulation of sustained release naloxone with mild withdrawal symptoms in mice. (Pubmed Central) -  Jun 22, 2021   
    A single dose of 1 or 5 mg/kg NP-naloxone was highly effective at inhibiting the activating effects of repeated administration of 10 mg/kg morphine for at least up to 24 h. Onset of action was approximately 5 min...At the 5 mg/kg dose, NP Naloxone precipitated approximately 40% of jumping withdrawal behaviors of injectable naloxone. Thus, this study demonstrates that orally administered naloxone based on polymer nanoparticles has high potential to be developed to circumvent OIRD and withdrawal symptoms.
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg., paracetamol / Generic mfg.
    Clinical, Journal:  The emerging role of pectoral nerve block (PECS block) in breast surgery: A case-matched analysis. (Pubmed Central) -  Jun 22, 2021   
    PECS block can reduce intraoperative use of opioids and analgesic drugs, and is associated with reduced occurrence of PONV. Selected patients can receive breast-conserving surgery with PECS plus sedation, avoiding general anesthesia.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal:  Evaluation of an Intrathecal Drug Delivery Protocol Leads to Rapid Reduction of Systemic Opioids in the Oncological Population. (Pubmed Central) -  Jun 22, 2021   
    The findings of this study suggest that IV lidocaine can be a good choice in pain management in biliary colic and can reduce pain in less time than morphine sulfate (in 10 min) without adding significant side effects; however, our primary outcome was the comparison of these two drugs after 60 min of drug administration in pain reduction which showed no significant difference between two groups. The article that follows is purposed at demonstrating how IT opioid plus bupivacaine achieves sustained acceptable pain relief while simultaneously rapidly reducing oral morphine equivalents (OME)...IDDSs with opioid plus bupivacaine represent a safe and efficient route toward expeditious pain relief and decreased OMEs in the cancer pain population.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  A Novel Method to Study Reward-Context Associations Paired With Drug-Seeking Behaviors. (Pubmed Central) -  Jun 22, 2021   
    We restructured the apparatus allowing for insertion of bottles so that mice could orally self-administer sucrose or morphine-containing solutions in a specific context...This model combines the distinct contextual cues associated with conditioned place preference and combines them with voluntary self-administration, thus enabling researchers to measure behavior using a model that incorporates spatial memory involved in affective states, while also providing a quantifiable readout of context/environment-specific drug seeking In conclusion, we combined CPP and voluntary intake to establish a novel technique to assess not only preference for a context associated with rewarding stimuli (natural or drug), but also seeking, retention, and locomotor activity. This model can be further utilized to examine other drugs of abuse, extinction training, other learning models, or to allow for the assessment of neurobiological manipulations.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal:  Quality improvement assessment of a bianchi-technique pediatric orchiopexy perioperative pain management pathway. (Pubmed Central) -  Jun 22, 2021   
    We have demonstrated that orchiopexies repaired using the Bianchi technique following the care pathway established at Alberta Children's Hospital are associated with minimal pain scores. Our QI project suggests that combining a Bianchi technique with a simple multimodal analgesic approach including local infiltration, negates the need for regional anesthesia techniques, yet still provides adequate analgesia.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal, Adverse events:  TREK-1 channel activation as a new analgesic strategy devoid of opioid adverse effects. (Pubmed Central) -  Jun 22, 2021   
    Preoperative oral Duloxetine of 60 mg, for patients subjected to MRM is the optimal dose considering its analgesic efficacy and side effects. This proof-of-concept study shows that TREK-1 activators could constitute a novel class of painkillers, inspired by the mechanism of action of opioids but devoid of their adverse effects.
  • ||||||||||  remifentanil / Generic mfg., morphine sulphate / Generic mfg.
    Clinical, Journal:  Mu opioid receptors on distinct neuronal populations mediate different aspects of opioid reward-related behaviors. (Pubmed Central) -  Jun 22, 2021   
    We show that MOR deletion from D1 neurons reduced opioid (morphine and oxycodone)-induced hyperlocomotion, whereas deleting MORs from A2a neurons resulted in enhanced opioid-induced locomotion, and deleting MORs from D2 or ChAT neurons had no effect...We first assessed the acquisition of this behavior using remifentanil as the reinforcing opioid and found no effect of genotype...In this study we deleted selective populations of these receptors that are enriched in the striatum and studied the effect of each deletion on reward-related behaviors. We found that each population plays a specific role in reward demonstrating a more complex role than previously thought of how these receptors mediate reward.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal:  Weight Loss as an Effective Strategy to Decrease Opioid Use and Frequency of Vaso-Occlusive Crises in Patients with Sickle Cell Disease. (Pubmed Central) -  Jun 22, 2021   
    A 35-year-old woman with SCD and morbid obesity (body mass index [BMI] of 42 kg/m) required high doses of opioids for pain control [870 morphine milligram equivalents (MME) per day], and experienced monthly hospitalizations for VOCs that precluded her from working or having meaningful interpersonal relationships...The pervasive use and overreliance on opioid analgesics in the treatment of VOCs increase morbidity and mortality among patients with SCD. This case study offers compelling evidence for weight loss through a multidisciplinary program as an adjunctive therapy to decrease the use of opioids and frequency of hospitalizations for VOCs.
  • ||||||||||  celecoxib oral / Generic mfg.
    Journal:  Celecoxib Significantly Reduces Opioid Use After Shoulder Arthroplasty. (Pubmed Central) -  Jun 22, 2021   
    Multimodal pain control using celecoxib is an effective way to reduce postoperative opioid use in shoulder arthroplasty patients. Preoperative opioid use is associated with higher levels of opioid use after shoulder arthroplasty.