morphine sulphate / Generic mfg. 
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  • ||||||||||  morphine sulphate / Generic mfg.
    [VIRTUAL] Influence of Prior Trauma on Conditioned Responses to Morphine in Mice () -  Jun 28, 2021 - Abstract #CPDD2021CPDD_360;    
    Ongoing analyses are examining whether the behavioral effect of prior FC is associated with the activation of VTA mesolimbic dopamine neurons using immunofluorescence. These results can inform our understanding of therapeutic approaches for PTSD-OUD comorbidity.
  • ||||||||||  fentanyl citrate / Generic mfg.
    [VIRTUAL] A Baker's Dozen: Discriminative Stimulus and Antinociceptive Effects of Thirteen Fentanyl Analogs () -  Jun 28, 2021 - Abstract #CPDD2021CPDD_357;    
    All of the fentanyl analogs produced opioid-like antinociception and at least some morphine-like interoceptive effects and therefore have the potential to be used as substitutes for legal and illegal opioids. Because most of these substances share similar mechanism of action with fentanyl and morphine, and because 10 of the 13 were more potent than morphine, they have the potential for inadvertent overdose.
  • ||||||||||  morphine sulphate / Generic mfg.
    [VIRTUAL] Antinociceptive and Respiratory Depressant Effects of Biased Mu Opioid Agonists in Nonhuman Primates () -  Jun 28, 2021 - Abstract #CPDD2021CPDD_242;    
    Next, 3 to 5-point dose-effect functions for all seven compounds and morphine were determined in squirrel monkeys (n=3-5/group) using cumulative dosing procedures in two assays... These data demonstrate that the absence of β-arrestin recruitment by mu-opioid agonists is not necessarily associated with reduced respiratory depression in nonhuman primates.
  • ||||||||||  [VIRTUAL] Isobolographic Analysis of Alpha2-Adrenergic and Mu-Opioid Receptor Agonists: Schedule-Controlled Responding () -  Jun 28, 2021 - Abstract #CPDD2021CPDD_130;    
    Here, we hypothesized that mu-opioid (morphine and methadone) and adrenergic-alpha2 receptor agonists (lofexidine and clonidine) exert synergistic effects, as assessed with disruptions in lever-pressing behavior for food delivery, increases in hot plate (52°C) response latency (antinociception), and decreases in rectal temperature (hypothermia) in rats...The dose-effect functions of the rate-decreasing and antinociceptive effects of the MOR agonists were shifted to the right by the opioid antagonist naltrexone (0.032-1.0 mg/kg) but not by the alpha 2 adrenergic antagonist yohimbine (3.2 mg/kg)... These results suggest that dual stimulation of mu-opioid and adrenergic-alpha2 recepto agonists, as appears to occur from a single chemical entity (e.g., mitragynine), results in synergistic effects that includes antinociceptive effects, which might also be generalized to other therapeutic effects (e.g., attenuation of opioid withdrawal).
  • ||||||||||  Belviq (lorcaserin) / Eisai
    [VIRTUAL] Effects of Lorcaserin on Opioid-Induced Observable Behavior in Rhesus Monkeys () -  Jun 28, 2021 - Abstract #CPDD2021CPDD_98;    
    The objective of the present study was to determine whether lorcaserin alters behavioral signs indicative of opioid withdrawal in morphine-dependent nonhuman primates. Overall, these data suggest that lorcaserin does not appreciably alter opioid withdrawal signs.
  • ||||||||||  morphine sulphate / Generic mfg., methamphetamine / Generic mfg.
    [VIRTUAL] Vapor Inhalation Models of Drug Self-Administration in Laboratory Rodents () -  Jun 28, 2021 - Abstract #CPDD2021CPDD_15;    
    In the ~60 years since Weeks (1962) and Thompson and Schuster (1964) reported intravenous self-administration (IVSA) of morphine in rats and monkeys, preclinical models for IVSA have been widely applied, whereas models of inhaled drug self-administration have languished, despite the clinical relevance...The long history of IVSA models has identified many criteria for inferring that self-administration has been established, and the workshop will discuss the relative necessity for features such as increasing workloads, dose-substitution, antagonist challenge, escalation, extinction, reinstatement and other methodological features. While self-administration is a primary concern, the workshop will also discuss reinforcing effects and voluntary consumption outside of canonical definitions of self-administration.
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  Inhibitory transmission in the bed nucleus of the stria terminalis in male and female mice following morphine withdrawal. (Pubmed Central) -  Jun 28, 2021   
    Intriguingly, these opposing GABAergic effects were contingent upon activity-dependent dynamics within the ex vivo slice. Our findings suggest that male and female mice exhibit some divergent cellular responses in the BNST following morphine withdrawal, and alterations in BNST inhibitory signaling may contribute to the expression of behaviors following opioid withdrawal.
  • ||||||||||  hydromorphone once daily (CEP-33236) / Teva
    Journal:  Sustained-release Oral Hydromorphone for the Treatment of Opioid Use Disorder. (Pubmed Central) -  Jun 28, 2021   
    The case presented offers promise for the use of once-daily sustained-release oral hydromorphone as a viable treatment option for patients with OUD for whom first-line therapies are not suitable or tolerated. This case report is the first to our knowledge to demonstrate the successful use of oral hydromorphone for treatment of opioid use disorder.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal:  Intrathecal morphine injections in lumbar fusion surgery: Case-control study. (Pubmed Central) -  Jun 26, 2021   
    Use of the TDB patch provides effective pain relief and reduces the requirement for rescue morphine without increasing side effects in comparison with oral celecoxib during the early post-operative stage following TKA. Adding ITM to the analgesia protocol for lumbar fusion provides better management of postoperative pain, without increasing early complications, and it accelerates the recovery process after surgery.
  • ||||||||||  Clinical, Review, Journal:  Opioids and alpha-2-agonists for analgesia and sedation in newborn infants: protocol of a systematic review. (Pubmed Central) -  Jun 26, 2021   
    Adding ITM to the analgesia protocol for lumbar fusion provides better management of postoperative pain, without increasing early complications, and it accelerates the recovery process after surgery. This systematic review will summarize and update our knowledge about neonatal analgesia and sedation including pharmacokinetics/pharmacodynamics, and provide a platform for developing evidence-based guidelines that we can immediately apply to our clinical practice.
  • ||||||||||  morphine sulphate / Generic mfg.
    Retrospective data, Journal:  Conversion of Schedule II Opioids to Buprenorphine Buccal Film: A Retrospective Analysis. (Pubmed Central) -  Jun 26, 2021   
    Most patients were able to convert directly from their long-acting opioid to buprenorphine buccal film and stabilized without the use of concomitant opioids for breakthrough pain. Aggressive titration strategies were associated with greater success.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal:  An enhanced recovery after surgery pathway in pediatric colorectal surgery improves patient outcomes. (Pubmed Central) -  Jun 26, 2021   
    The use of an ERAS pathway reduces opioid utilization, which is associated with a reduction in LOS and expedites the initiation of oral intake, in colorectal pediatric surgery patients. Pediatric ERAS pathways should be incorporated into the care of pediatric patients undergoing colorectal surgery.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Review, Journal:  Clinical and Organizational Impact of the AIRSEAL Insufflation System During Laparoscopic Surgery: A Systematic Review. (Pubmed Central) -  Jun 26, 2021   
    The same was observed in the two sole studies in which pain killers consumption was measured (significant decrease in morphine consumption 24 h after surgery in one study, no difference in the other)...No studies reported economic outcomes. Current literature supports the feasibility of the AIRSEAL system during laparoscopic surgery but more studies are required to establish the added clinical benefit and to explore the preferences of physicians and patients.
  • ||||||||||  oxycodone/acetaminophen / Generic mfg.
    Clinical, Journal:  Opioid prescribing trends in postpartum women: a multicenter study. (Pubmed Central) -  Jun 26, 2021   
    Postpartum opioid prescription rates vary widely among hospitals, but providers within the same hospital tend to follow similar prescribing trends. The variation in prescribing found in our study illustrates the need for clear consensus guidelines for postpartum pain management.
  • ||||||||||  Exparel (bupivacaine liposome injectable suspension) / Pacira
    Clinical, Journal:  A randomized controlled trial of liposomal bupivacaine for pain following obstetrical laceration. (Pubmed Central) -  Jun 26, 2021   
    After obstetric lacerations, there is no proven benefit to lateral and intraperineal injection of liposomal bupivacaine over plain bupivacaine in postpartum vaginal pain scores, quality of life scores, or pain medication utilized. This may be due to low pain scores and opioid usage, both groups benefiting from the intervention, or ineffective perineal injection location.
  • ||||||||||  methadone / Generic mfg.
    Journal:  Delivery dose of methadone, but not buprenorphine, is associated with the risk and severity of neonatal opiate withdrawal syndrome. (Pubmed Central) -  Jun 26, 2021   
    These data may inform future prospective studies on methadone dosing in pregnancy. While medication-assisted treatment agent and dose may have an impact on pertinent neonatal outcomes related to neonatal opioid withdrawal syndrome, the provision of medication-assisted treatment in pregnancy should reflect the goal of prevention of recidivism and maternal mortality and utilize an approach that balances fetal and maternal risk to optimize outcomes.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal:  Lidocaine patches for postcesarean pain control in obese women: a pilot randomized controlled trial. (Pubmed Central) -  Jun 26, 2021   
    This pilot suggests that 5% lidocaine patches applied superior and lateral to the cesarean incision are not effective at reducing the average total dose of morphine milligram equivalents administered in the first 24 hours after cesarean delivery among women with obesity, and they did not seem to improve median pain scores. An appropriately powered randomized trial would not be expected to demonstrate reduction in opioid use or pain.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Trajectories of Opioid Coverage After Long-Term Opioid Therapy Initiation Among a National Cohort of US Veterans. (Pubmed Central) -  Jun 25, 2021   
    Group-based trajectory models were used to identify opioid therapy trajectories based on days of opioid supply (primary outcome) and average daily morphine milligram equivalent dose (AMME; secondary outcome) in each 180-day period following initiation of LTOT...A majority of patients (51.4%) maintained persistent opioid therapy. Further research is needed to assess the risks of opioid-related adverse outcomes among the identified trajectories.
  • ||||||||||  Naldebain (dinalbuphine) / Lumosa Therap
    Retrospective data, Journal:  Comparison of the Efficacy and Safety of Dinalbuphine Sebacate, Patient-Controlled Analgesia, and Conventional Analgesia After Laparotomy for Gynecologic Cancers: A Retrospective Study. (Pubmed Central) -  Jun 25, 2021   
    We aimed to investigate the effects of dinalbuphine sebacate (DNS), fentanyl-based patient-controlled analgesia (PCA), and conventional analgesia (CA) for pain management after laparotomy for gynecologic cancers...The total consumption of morphine equivalents per day was similar between the DNS and PCA groups (142.8 ± 7.3 mg vs 137.7 ± 70.0 mg, p = 0.8032) and lowest in the CA group (11.7 ± 30.7 mg, p < 0.0001)...A single DNS injection was more effective for relieving POP than PCA and CA in the patients who had a longitudinal incision for gynecologic cancer surgery. DNS was well tolerated and had less adverse effects than PCA and CA.
  • ||||||||||  morphine sulphate / Generic mfg., paracetamol / Generic mfg.
    Journal:  Nurse-Administered Analgesic Treatment in Italian Emergency Medical Services: A Nationwide Survey. (Pubmed Central) -  Jun 25, 2021   
    Despite international consensus on the necessity, efficacy, and safety of nurses' prehospital analgesia provision, nurse-administered analgesia protocols are available in less than half of Italian provinces, with substantial differences between northern, central, and southern areas. These results indirectly indicate potential undertreatment of prehospital pain in Italy and yield practice improvements.
  • ||||||||||  clonidine / Generic mfg.
    Retrospective data, Review, Journal:  A Retrospective Review Following the Addition of Clonidine to a Neonatal Abstinence Syndrome Treatment Algorithm. (Pubmed Central) -  Jun 25, 2021   
    In addition, there was a significant decrease in duration of morphine sulfate exposure as well as cumulative dose of morphine required to successfully treat a neonate with NAS in the post-implementation group (26 days vs. 15 days, p = 0.002 and 6.9 mg/kg vs. 3.4 mg/kg, p = 0.031). Addition of clonidine to morphine sulfate as initial therapy for NAS significantly reduced the cumulative exposure as well as duration of exposure to morphine sulfate compared to morphine monotherapy and decrease length of hospital stay.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Review, Journal:  Palliative care services for cancer patients in Nepal, a lower-middle-income country. (Pubmed Central) -  Jun 25, 2021   
    Morphine, a major milestone for pain management, is being manufactured in the country for nearly a decade, yet morphine equivalence mg per capita is far below the global average...Scarcity of treatment centres and expertise, limited finances, lack of awareness among patients and health care workers, and difficult terrain are major barriers for optimal care. Proper implementation of national guidelines, human resource development and integration of palliative care to primary healthcare level would be crucial steps for further improvement.
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  A Novel Mu-Delta Opioid Agonist Demonstrates Enhanced Efficacy with Reduced Tolerance and Dependence in Mouse Neuropathic Pain Models. (Pubmed Central) -  Jun 24, 2021   
    SRI-22141 was more potent than morphine in the tail flick pain test and had equal or enhanced efficacy versus morphine in both neuropathic pain models, with significantly reduced tolerance...Perspective: This study demonstrates that a MOR-DOR dual agonist given chronically in chronic neuropathic pain models has enhanced efficacy with strongly reduced tolerance and dependence, with a further anti-inflammatory effect in the spinal cord. This suggests that MOR-DOR dual agonists could be effective treatments for neuropathic pain with reduced side effects.