morphine sulphate / Generic mfg. 
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  • ||||||||||  morphine sulphate / Generic mfg.
    Trial completion date, Trial initiation date, Trial suspension, Trial primary completion date:  Intrathecal Morphine vs. Intrathecal Morphine and Regional Anesthesia After Cesarean Section. (clinicaltrials.gov) -  May 22, 2024   
    P4,  N=100, Suspended, 
    Trial completion date: May 2024 --> Sep 2024 | Initiation date: Jan 2024 --> Jul 2024 | Not yet recruiting --> Suspended | Trial primary completion date: May 2024 --> Sep 2024
  • ||||||||||  morphine sulphate / Generic mfg.
    Enrollment open, Trial initiation date, Head-to-Head:  KETOAPP: Intravenous Ketorolac Vs. Morphine In Children With Acute Abdominal Pain (clinicaltrials.gov) -  May 20, 2024   
    P3,  N=495, Recruiting, 
    As we cannot claim either technique to be better or worse, there remains flexibility for use of either technique. Not yet recruiting --> Recruiting | Initiation date: Jan 2024 --> May 2024
  • ||||||||||  morphine sulphate / Generic mfg., oxycodone/acetaminophen / Generic mfg.
    Observational data, Journal:  Postoperative Opioid Usage and Disposal Strategies After Arthroscopic Procedures in a Young Cohort: A Prospective Observational Study. (Pubmed Central) -  May 17, 2024   
    Patients were prescribed either 5 mg hydrocodone-325 mg acetaminophen or 5 mg oxycodone-325 mg acetaminophen based on surgeon preference...Opioid medication consumption was converted to morphine milligram equivalents (MMEs)...Approximately 60% of total opioids prescribed went unused, and one-fourth of patients intended to keep their remaining medication for future usage. We have provided general prescribing guidelines and recommend that surgeons carefully consider customizing their opioid prescriptions on the basis of procedure site to balance optimal postoperative analgesia with avoidance of dissemination of excess opioids.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal, Surgery:  How low can we go? A randomized controlled trial of low-quantity initial opioid prescriptions for shoulder surgery. (Pubmed Central) -  May 16, 2024   
    After shoulder surgery, an initial prescription of fewer opioid pills was associated with less maximum possible opioid consumption without an increase in the percentage of patients requesting opioid refills or contacting the provider's office for pain-related concerns. An initial postoperative prescription of fewer 5-mg oxycodone pills may be equally or more effective compared with larger quantities for most patients.
  • ||||||||||  Miostat (carbachol) / Novartis
    Preclinical, Journal:  Analgesic effect of a cholinergic agonist (carbachol) in a sural nerve ligation-induced hypersensitivity mouse model. (Pubmed Central) -  May 16, 2024   
    Intracerebroventricular administration of carbachol at 7?days after ligation produced a marked analgesic effect against mechanical and thermal stimuli, which was stronger and longer-lasting than morphine at all experimental time points. These findings suggest that cholinergic nerves are involved in allodynia and hyperalgesia of the SN ligation neuropathic pain model.
  • ||||||||||  meloxicam / Generic mfg., morphine sulphate / Generic mfg.
    Journal:  Behavioral and pharmacological characterization of planarian nociception. (Pubmed Central) -  May 16, 2024   
    Secondly, the NSAID meloxicam drastically reduced chemically-induced scrunching by up to 60% and reduced heat avoidance in place preference tests. Thus, we managed to characterize both behavioral and pharmacological aspects of G. dorotocephala's nociception, further developing the use of planarians as a replacement model in pain studies and more globally the study of invertebrate nociception.
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Review, Journal:  Advances in animal models of prenatal opioid exposure. (Pubmed Central) -  May 15, 2024   
    Early animal models of prenatal opioid exposure primarily used the prototypical opioid, morphine, and opioid exposure that was often limited to a narrow period during gestation...Newer models utilize both prescription and nonprescription opioids and vary the onset and duration of opioid exposure. In this review, we summarize novel prenatal opioid exposure models developed in recent years and attempt to reconcile results between studies while critically identifying gaps within the current literature.
  • ||||||||||  morphine sulphate / Generic mfg., ropivacaine / Generic mfg.
    Journal:  Efficacy of opioid-sparing analgesia after median sternotomy with continuous bilateral parasternal subpectoral plane blocks. (Pubmed Central) -  May 15, 2024   
    In this review, we summarize novel prenatal opioid exposure models developed in recent years and attempt to reconcile results between studies while critically identifying gaps within the current literature. Continuous bilateral parasternal subpectoral plane blocks may further reduce poststernotomy pain and opioid consumption within the context ERAS multimodal analgesia.
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
    Journal:  Comparison Between Erector Spinae Plane Block versus Serratus Anterior Plane Block Regarding Analgesia and Stress Response After Modified Radical Mastectomy: Randomized Controlled Trial. (Pubmed Central) -  May 14, 2024   
    Statistically significant reductions in pain scores were observed in group A compared to groups B and C. Moreover, group A exhibited a significant decrease in postoperative morphine consumption, serum cortisol levels 1 hour post-surgery (P = 0.021), MAP, and postoperative vomiting and nausea compared to group B. Furthermore, groups A and B showed statistically significant improvements in all parameters compared to group C. The study demonstrates that ESPB provides superior analgesic effects compared to SAPB in patients undergoing MRM, with reduced morphine use and lower postoperative cortisol levels. Both blocks offer more effective pain control than intravenous morphine alone.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  A Series of 8 Illicit Fentanyl Intoxication Deaths in Infants and Toddlers. (Pubmed Central) -  May 13, 2024   
    As illicit fentanyl use increases, there is a potential for infant exposure and death. The investigation and certification of these deaths and the role of intentional administration versus inadvertent exposure due to caregiver neglect in the context of the certification of the manner of death are described.
  • ||||||||||  morphine sulphate / Generic mfg., gabapentin / Generic mfg.
    Preclinical, Journal:  An experimental model for primary neuropathic corneal pain induced by long ciliary nerve ligation in rats. (Pubmed Central) -  May 13, 2024   
    Meanwhile, consecutive oral gabapentin attenuated LCN ligation-induced corneal hyperalgesia and increased levels of ion channels and inflammation factors in TG. This study provides a reliable primary NCP model induced by LCN ligation in rats using a simple, minimally invasive surgery technique, which may help shed light on the underlying cellular and molecular bases of NCP and aid in developing a new treatment for the disease.
  • ||||||||||  morphine sulphate / Generic mfg.
    Retrospective data, Journal, HEOR:  Impact of overdose on health plan disenrollment among patients prescribed long-term opioids: Retrospective cohort study. (Pubmed Central) -  May 11, 2024   
    Among patients prescribed long-term opioids, overdose events were strongly associated with subsequent health plan disenrollment, especially among primary commercial insurance beneficiaries. These findings raise concerns about the social consequences of overdose, including potential health insurance loss, which may limit patient access to care at a time of heightened vulnerability.
  • ||||||||||  morphine sulphate / Generic mfg.
    Observational data, Journal:  Effectiveness and safety of prehospital analgesia with nalbuphine and paracetamol versus morphine by paramedics - an observational study. (Pubmed Central) -  May 11, 2024   
    These findings raise concerns about the social consequences of overdose, including potential health insurance loss, which may limit patient access to care at a time of heightened vulnerability. Compared to morphine, prehospital analgesia with nalbuphine?+?paracetamol yields favourable effects in terms of analgesic effectiveness and a lower rate of complications and should therefore be considered in future recommendations for prehospital analgesia.
  • ||||||||||  morphine sulphate / Generic mfg., methamphetamine / Generic mfg.
    Review, Journal:  Unraveling the protective effects of curcumin against drugs of abuse. (Pubmed Central) -  May 10, 2024   
    These include the modulation of inflammatory cytokines, maintenance of ion homeostasis, epigenetic regulation, enhancement of antioxidant capacity, as well as the activation of the cAMP response element-binding protein (CREB) and brain-derived neurotrophic factor (BDNF) signaling pathways. These findings suggest that curcumin emerges as a promising therapeutic agent in combatting the detrimental effects induced by drugs of abuse, and further research is warranted to fully comprehend the molecular pathways and optimize its utilization for the prevention and treatment of substance abuse-related neurotoxicity.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Evidence-based prescribing of opioids after laparotomy: A quality-improvement initiative in gynecologic oncology. (Pubmed Central) -  May 10, 2024   
    These findings suggest that curcumin emerges as a promising therapeutic agent in combatting the detrimental effects induced by drugs of abuse, and further research is warranted to fully comprehend the molecular pathways and optimize its utilization for the prevention and treatment of substance abuse-related neurotoxicity. This data was used to develop a calculator for post-discharge opioid prescription size using two factors: 1) age of the patient, 2) oral morphine equivalents (OME) used by patients the day before hospital discharge...The surplus of opioids our patients reported having at home decreased from 1264 doses of 5
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Retrospective data, Review, Journal, Surgery:  Intrathecal Morphine for Cardiac Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. (Pubmed Central) -  May 9, 2024   
    Our meta-analysis concluded that preoperative intrathecal morphine is associated with lower postoperative morphine consumption at 24 h following cardiac surgeries, without prolonging the time to extubation. The use of preoperative intrathecal morphine can be considered part of a multimodal analgesic and opioid-sparing strategy in patients undergoing cardiac surgery.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Patterns of opioid use after surgical discharge: a multicentre, prospective cohort study in 25 countries. (Pubmed Central) -  May 9, 2024   
    The use of preoperative intrathecal morphine can be considered part of a multimodal analgesic and opioid-sparing strategy in patients undergoing cardiac surgery. Our data suggest that the current quantities of opioids provided at discharge exceed patient needs and may contribute to increasing community opioid use and circulation.
  • ||||||||||  morphine sulphate / Generic mfg., ketamine / Generic mfg., dexmedetomidine / Generic mfg.
    New trial, Surgery:  Opioid-free Anaesthesia in Breast Cancer Surgery (clinicaltrials.gov) -  May 8, 2024   
    P=N/A,  N=200, Recruiting, 
  • ||||||||||  morphine sulphate / Generic mfg., naltrexone / Generic mfg.
    Synthesis, pharmacology, and radiosynthesis of [18F](-)FEGR103545, a KOR agonist PET tracer (Exhibit Hall D - Science Pavilion (Convention Center); Screen 19; In-Person Only) -  May 8, 2024 - Abstract #SNMMI2024SNMMI_1848;    
    Unlike the antagonistic behavior of (-)[11C]GR103545 with a Ki of 2. 1 nM at MOR, (-)[18F]FEGR103545 with MOR Ki 44 nM may not provide binding in vivo with PET to MOR enriched brain regions.
  • ||||||||||  ketorolac / Generic mfg.
    Cost Savings and Improved Pain Control with Use of Ketorolac after Donor Nephrectomy (Poster Hall, Exhibit Hall A, Level 2) -  May 6, 2024 - Abstract #ATC2024ATC_1671;    
    Reduced used of neuromuscular blockade is likely associated with decreased hospital costs due to reduced OR time, procedure and medication costs, as well as reduced LOS. Further study is needed to determine the exact costs associated with this change in management.
  • ||||||||||  morphine sulphate / Generic mfg.
    Pregnancy after a Combined Lung and Liver Transplant: An Example of Success (Poster Hall, Exhibit Hall A, Level 2) -  May 6, 2024 - Abstract #ATC2024ATC_1661;    
    Most transplant physicians still advise against a pregnancy after solid organ transplantation but the success rate is growing. Single success stories only show how important continued scientific research and the collection of data is for the future of organ transplantation.
  • ||||||||||  Bridion (sugammadex) / Merck (MSD)
    Patterns in Opioid Use Following Kidney Transplant (Poster Hall, Exhibit Hall A, Level 2) -  May 6, 2024 - Abstract #ATC2024ATC_1590;    
    After discharge, patients used surprisingly few of the narcotics they were prescribed. Many patients lacked understanding of how to appropriately dispose of unused medications, which we highlight as a valuable educational opportunity.