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7 Diseases |  |
379 Trials |
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379 Trials |  |
12426 News |  |
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- || morphine sulphate / Generic mfg.
Clinical, Journal: Association of trainee involvement in an acute pain service with postoperative opioid use in patients undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy. (Pubmed Central) - Jul 18, 2021
In the matched cohorts, the median postoperative day (POD) 0-3 opioid use [25%, 75% quartile] for the single attending and trainee involvement cohort were 38.5 mg morphine equivalents (MEQ) [14.1 mg, 106.3 mg] and 50.4 mg MEQ [28.4 mg, 91.2 mg], respectively...We found that the addition of a regional anesthesia fellow to the APS team was not associated with statistically significant differences in total opioid consumption or hospital length of stay in this surgical population. The addition of trainees to the infrastructure, with vigilant supervision, is not associated with change in outcomes.
- || morphine sulphate / Generic mfg., paracetamol / Generic mfg.
Clinical, Journal: Effects of Transcutaneous Electrical Nerve Stimulation on Pain, Pulmonary Function, and Respiratory Muscle Strength After Posterolateral Thoracotomy: A Randomized Controlled Trial. (Pubmed Central) - Jul 18, 2021
P1/2
The addition of trainees to the infrastructure, with vigilant supervision, is not associated with change in outcomes. The use of TENS provides a little benefit of pain (in the first 12 h) but failed to demonstrate any improvement in the recovery of ICU patients after 48 h of posterolateral thoracotomy.
- || morphine sulphate / Generic mfg.
Clinical, Journal: Peripheral nerve block use in inpatient and outpatient shoulder arthroplasty: a population-based study evaluating utilization and outcomes. (Pubmed Central) - Jul 18, 2021
In this first national study on PNB use in shoulder arthroplasty, we found increasing PNB use among specifically, inpatient procedures, resulting in particularly reduced opioid use on the day of surgery. While our findings may support PNB use in shoulder arthroplasty, its current low utilization and trends towards more outpatient procedures necessitate continuous monitoring of more extensive benefits.
- || morphine sulphate / Generic mfg.
Clinical, Journal: Bilateral ultrasound-guided thoracic erector spinae plane blocks using a programmed intermittent bolus improve opioid-sparing postoperative analgesia in pediatric patients after open cardiac surgery: a randomized, double-blind, placebo-controlled trial. (Pubmed Central) - Jul 18, 2021
P=N/A
While our findings may support PNB use in shoulder arthroplasty, its current low utilization and trends towards more outpatient procedures necessitate continuous monitoring of more extensive benefits. In pediatric cardiac surgery, the results of this study confirm our hypothesis that bilateral ESPB analgesia with ropivacaine decreases the postoperative morphine consumption at 48 hours and demonstrates better postoperative analgesia compared with a control group.Trial registration number NCT03593642.
- || morphine sulphate / Generic mfg.
Clinical, Journal: Analgesic efficacy of infiltration between the popliteal artery and capsule of the knee (iPACK) block added to local infiltration analgesia and continuous adductor canal block after total knee arthroplasty: a randomized clinical trial. (Pubmed Central) - Jul 18, 2021
The addition of an iPACK block to the LIA and CACB does not reduce the postoperative opioid consumption nor improve analgesia. However, it may improve immediate functional performance and reduce the length of hospitalization after TKA.
- | morphine sulphate / Generic mfg.
Journal: Role of peripheral sensory neuron mu-opioid receptors in nociceptive, inflammatory, and neuropathic pain. (Pubmed Central) - Jul 18, 2021
MOPs in primary sensory neurons contribute to the modulation of neuropathic pain behavior and opioid analgesia. Our observations highlight the clinical potential of peripherally acting opioid agonists in the management of inflammatory and neuropathic pain.
- | morphine sulphate / Generic mfg.
Journal: The cool things to know about TRPM8! (Pubmed Central) - Jul 18, 2021
Cold hypersensitivity is a common symptom of neuropathic pain conditions caused by cancer therapy, spinal cord injury, viral infection, multiple sclerosis, diabetes, or withdrawal symptoms associated with chronic morphine treatment...However, as the activity of TRPM8 is unique in sensing cool temperature as well as warming, it is critical to understand the signaling transduction pathways that control modality-specific activity of TRPM8 in healthy versus pathological settings. This review summarizes recent advances in our understanding of the mechanisms involved in the regulation of the TRPM8 activity.
- | morphine sulphate / Generic mfg., pregabalin / Generic mfg.
Retrospective data, Journal: The combined analgesic effect of pregabalin and morphine in the treatment of pancreatic cancer pain, a retrospective study. (Pubmed Central) - Jul 18, 2021
This review summarizes recent advances in our understanding of the mechanisms involved in the regulation of the TRPM8 activity. The findings of this study supported the use of pregabalin with morphine to relieve pain in patients of pancreatic cancer.
- | morphine sulphate / Generic mfg., hydromorphone hydrochloride / Generic mfg., hydromorphone extended release / Generic mfg.
Retrospective data, Journal: Neuraxial anesthesia provides excellent pain control for pediatric burn patients receiving excision and split-thickness skin grafts - a retrospective case series. (Pubmed Central) - Jul 17, 2021
Spinal anesthesia was most commonly used for split-thickness skin grafting in the pediatric burn population and provides excellent analgesia for patients' immediate post-operative course, including their initial dressing changes, with minimal risk for complications. Pain was well controlled in all subgroups indicating that this strategy can be used flexibly in a variety of pediatric burn patients.
- || In palliative care I rx mainly morphine, hydromorphone, methadone, fentanyl patch, intranasal sufentanil for incidental pain . Some suboxone (rare in pall) (Twitter) - Jul 17, 2021
- | methamphetamine / Generic mfg.
Journal: Differential genetic risk for methamphetamine intake confers differential sensitivity to the temperature-altering effects of other addictive drugs. (Pubmed Central) - Jul 17, 2021
Data from a family of recombinant inbred mouse strains support the influence of Oprm1 genotype, but not Taar1 genotype, on thermal response to morphine. These results nominate Oprm1 as a genetic risk factor for morphine-induced hypothermia, and provide additional evidence for a connection between drug preference and drug thermal response.
- || gabapentin / Generic mfg.
Clinical, Journal: Efficacy Of Preoperative Gabapentin on Pain Severity after Posterior Urethral Surgery:A Randomized, Double-Blind, Placebo-Controlled Study. (Pubmed Central) - Jul 17, 2021
These results nominate Oprm1 as a genetic risk factor for morphine-induced hypothermia, and provide additional evidence for a connection between drug preference and drug thermal response. The consequences of this study revealed that gabapentin effective in controlling posterior urethroplasty postoperative pain, consumption of opioid, nausea, vomiting, drowsiness, and pruritus compared with the placebo group.
- || morphine sulphate / Generic mfg.
PK/PD data, Journal: Physiologically-Based Pharmacokinetic (PBPK) Model of Morphine and Morphine-3-Glucuronide in Nonalcoholic Steatohepatitis (NASH). (Pubmed Central) - Jul 17, 2021
Additionally, NASH-related transporter changes resulted in decreased morphine EHR, which could be important for drugs with extensive EHR. This study is an important first step to predict drug disposition in complex diseases such as NASH using PBPK modeling.
- || morphine sulphate / Generic mfg.
Clinical, Clinical data, Journal: Assessment of Preoperative Opioid Use Prevalence and Clinical Outcomes in Pulmonary Resection. (Pubmed Central) - Jul 17, 2021
One-third of pulmonary resection patients used opioids preoperatively and were at risk of experiencing adverse outcomes and having significantly higher health care utilization. They represent a unique high-risk population that will require novel, targeted interventions.
- || morphine sulphate / Generic mfg.
Clinical, Journal: Clinical Effectiveness of an Outpatient Multidisciplinary Chronic Pain Management Telementoring Service. (Pubmed Central) - Jul 16, 2021
A pain e-consult program was associated with greater reductions in MME/day compared to usual care despite similar rates of non-opioid alternative medication initiation. A prospective, randomized study of this program should be undertaken to confirm these findings.
- || morphine sulphate / Generic mfg.
Morphine’s great stuff most the time (Twitter) - Jul 16, 2021
- | morphine sulphate / Generic mfg., ketamine / Generic mfg.
Trial completion: Implications of Different Analgesic Models on Inflammatory Markers After Laparoscopic Cholecystectomy (clinicaltrials.gov) - Jul 16, 2021
P=N/A, N=110, Completed, Sponsor: Assiut University
A prospective, randomized study of this program should be undertaken to confirm these findings. Recruiting --> Completed
- | morphine sulphate / Generic mfg.
Preclinical, Journal: HIV and opiates dysregulate K-Cl cotransporter 2 (KCC2) to cause GABAergic dysfunction in primary human neurons and Tat-transgenic mice. (Pubmed Central) - Jul 16, 2021
Here, we demonstrate diminished K-Cl cotransporter 2 (KCC2) levels in primary human neurons after exposure to HIV-1 or HIV-1 proteins ± morphine...Using an inducible, Tat-transgenic mouse neuroHIV model, we found that chronic exposure to Tat also reduces KCC2. Our results identify KCC2 as a novel therapeutic target for ameliorating the pathobiology of neuroHIV, especially PWH exposed to opiates.
- | morphine sulphate / Generic mfg.
Journal: Interactions between prelimbic cortex and basolateral amygdala contribute to morphine-induced conditioned taste aversion in conditioning and extinction. (Pubmed Central) - Jul 16, 2021
During extinction, the activity of the PrL correlated negatively with plasma CORT secretions; however, the activity of the BLA may be negatively associated with the plasma CORT levels. The data presented here provide some implications for morphine addiction and dependence.
- | morphine sulphate / Generic mfg.
Retrospective data, Journal: Comparison of intravenous lidocaine versus epidural anesthesia for traumatic rib fracture pain: a retrospective cohort study. (Pubmed Central) - Jul 16, 2021
IVL may be an effective alternative to epidurals for the treatment of rib fracture pain. It should be considered for patients who have contraindications to epidurals or are unable to receive an epidural in a timely manner.
- || fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg., methadone / Generic mfg.
Clinical, Journal: Use of a novel prescribing approach for the treatment of opioid use disorder: Buprenorphine/naloxone micro-dosing - a case series. (Pubmed Central) - Jul 16, 2021
It should be considered for patients who have contraindications to epidurals or are unable to receive an epidural in a timely manner. Buprenorphine/naloxone micro-dosing may offer a promising alternative approach for successful induction for individuals with opioid use disorder who desire treatment with buprenorphine/naloxone, and further research to determine effectiveness is warranted.
- | morphine sulphate / Generic mfg.
Journal: Is transversus abdominis plane block adding anything to intrathecal morphine for postoperative analgesia after cesarean section? (Pubmed Central) - Jul 16, 2021
Buprenorphine/naloxone micro-dosing may offer a promising alternative approach for successful induction for individuals with opioid use disorder who desire treatment with buprenorphine/naloxone, and further research to determine effectiveness is warranted. No abstract available
- | hydroxyurea / Generic mfg.
Reimbursement, Journal, Medicaid: The association between hydroxyurea adherence and opioid utilization among Texas Medicaid enrollees with sickle cell disease. (Pubmed Central) - Jul 16, 2021
Barner and Kang report grants from Novartis Pharmaceuticals, unrelated to this work. A part of this study was presented as a poster at the American Pharmacists Association (APhA) 2019 Annual Meeting and Exposition (March 22-25, 2019, Seattle, WA) and received the 2019 APhA-APRS Presentation Award in the APhA-APRS Contributed Research Paper, Graduate Student/Fellow/Postdoctoral Scholar category.
- | fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
Journal: Development, Validation, and Feasibility Testing of a Yoga Module for Opioid Use Disorder. (Pubmed Central) - Jul 16, 2021
Practices were added or excluded based on the phase. The yoga module that was developed for reducing withdrawal symptoms and cravings in OUD patients was found to be safe, feasible, and potentially useful as an adjunct therapy to conventional treatment.
- | morphine sulphate / Generic mfg.
Journal: Prescription opioid use during pregnancy and risk for preterm birth or term low birthweight. (Pubmed Central) - Jul 15, 2021
However, we could not determine if these risks relate to the drug or to indications for use. Patients who use opioids during pregnancy should be counseled by their practitioners about this and other potential risks associated with opioid use in pregnancy.
- || morphine sulphate / Generic mfg.
Clinical, Retrospective data, Review, Journal: Perioperative gabapentinoid use lowers short-term opioid consumption following lower limb arthroplasty: Systematic review and meta-analysis. (Pubmed Central) - Jul 15, 2021
The addition of gabapentinoids to perioperative multimodal analgesia decreases opioid consumption fol-lowing lower limb arthroplasty, while also lowering rates of nausea, vomiting, and pruritus. Further study is required to evaluate the effect of gabapentinoid use on long-term opioid use and dependence.
- || morphine sulphate / Generic mfg.
Clinical, Journal: Intradermal needling combined with heat-sensitive moxibustion for moderate to severe cancer pain (Pubmed Central) - Jul 15, 2021
Further study is required to evaluate the effect of gabapentinoid use on long-term opioid use and dependence. Intradermal needling combined with heat-sensitive moxibustion can reduce the dose of opioids, improve the quality of life, relief the anxiety in patients with moderate to severe cancer pain, and reduce the incidence of common adverse reaction of opioids.
- | paclitaxel / Generic mfg.
Preclinical, Journal: Efficacy of the World Health Organization analgesic ladder in the paclitaxel-induced pain syndrome in rats. (Pubmed Central) - Jul 15, 2021
Together, analgesics of WHO analgesic ladder reduce both acute and chronic phases of P-IPS, with codeine plus paracetamol presenting more potent, efficacious and long-lasting effect. Thus, in addition to tumor pain, drugs of WHO analgesics ladder could also be useful to treat P-IPS.
- | morphine sulphate / Generic mfg.
Preclinical, Journal: Effect of Essential Oil of Zhumeria majdae on Morphine Tolerance and Dependence in Mice. (Pubmed Central) - Jul 15, 2021
ZMEO had significant effects on morphine tolerance and dependence. The linalool rich essential oil of Z. majdae plays a major role in the reduction of tolerance and dependence induced by morphine.
- | morphine sulphate / Generic mfg.
Journal: Mitigating the Opioid Crisis for Wound Care Providers Using Opioid Stewardship. (Pubmed Central) - Jul 15, 2021
It will introduce, define, and defend with clinical-based evidence a proposed acronym, "MORPHINE," to assist and help shape prescription opioid strategies used for wound care treatment. Implications for practicing wound care specialists need to acknowledge the potential harm that prescribing opioids may cause to their patients.
- | morphine sulphate / Generic mfg., minocycline / Generic mfg.
Journal: Antinociception induced by artemisinin nanocapsule in a model of postoperative pain via spinal TLR4 inhibition. (Pubmed Central) - Jul 15, 2021
To evaluate the involvement of the microglia, astrocytes, and TLR4, minocycline (a microglia inhibitor), fluorocitrate (an astrocyte inhibitor), and Lipopolysaccharide Rhodobacter sphaeroides (LPS-RS), a TLR4 antagonist, were intrathecally injected on the third day of SMIR...The ART nanocapsule had a more potent and longer antinociceptive effect than free ART or morphine...The ART nanocapsule also reduced the increased levels of TLR4, TNF-α, and IL-1β induced by SMIR. These data suggest that the ART nanocapsule has a potent analgesic effect on postoperative pain at the spinal level, and this response involves the inhibition of TLR4 and the proinflammatory cytokines TNF-α and IL-1β.
- || morphine sulphate / Generic mfg.
Review, Journal: Challenges of Combining Opioids and P2Y Inhibitors in Acute Coronary Syndrome: Should the Future Be Opioid Free? (Pubmed Central) - Jul 15, 2021
Morphine has been long recognized as standard of care in the treatment of acute coronary syndrome (ACS) patients; however, its safety has recently been called into question due to a drug interaction with P2Y inhibitors...Alternative strategies may be needed to overcome these interactions; however, no robust data are currently available to support these treatment options. Future research should be aimed at non-opioid treatment options in ACS, as opioid use remains controversial in this population.
- | morphine sulphate / Generic mfg.
Journal: Morphine induces physiological, structural, and molecular benefits in the diabetic myocardium. (Pubmed Central) - Jul 15, 2021
These data show that morphine treatment restores contractile function, ischemic tolerance, mitochondrial structure and function, and membrane dynamics in type II diabetic hearts. These findings suggest potential translational value for short-term, but high-dose morphine administration in diabetic patients undergoing or recovering from acute ischemic cardiovascular events.
- || morphine sulphate / Generic mfg.
Clinical, Journal: Reduced opioid prescribing following arthroscopic meniscectomy does not negatively impact patient satisfaction. (Pubmed Central) - Jul 15, 2021
A reduction in opioids prescribed after arthroscopic meniscectomy was not associated with any difference in patient satisfaction with pain management, as measured by the Press-Ganey survey. LOE: 3.
- | oxycodone IR (PFR06158) / Ensysce Biosciences
Journal: Integrated Systems Analysis of Mixed Neuroglial Cultures Proteome Post Oxycodone Exposure. (Pubmed Central) - Jul 15, 2021
Further analysis by ClueGO identified that the dominant category of differentially expressed protein functions was associated with GDP binding. Since opioid receptors are G-protein coupled receptors (GPCRs), these data indicate that oxy exposure perturbs key pathways associated with synaptic function.
- | morphine sulphate / Generic mfg.
Trial completion date, Trial primary completion date: MORPHEUS I/IIa: Efficacy of Morphine in Reducing the Rate of Early Non-Invasive Ventilation Failure in Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Phase I/IIa (clinicaltrials.gov) - Jul 14, 2021
P1/2, N=24, Recruiting, Sponsor: University Hospital, Grenoble
Since opioid receptors are G-protein coupled receptors (GPCRs), these data indicate that oxy exposure perturbs key pathways associated with synaptic function. Trial completion date: Sep 2022 --> Jul 2024 | Trial primary completion date: Jan 2022 --> Jun 2024
- | morphine sulphate / Generic mfg.
Clinical, Journal: Bilateral Ultrasound-guided Erector Spinae Plane Block for Postoperative Analgesia in Lumbar Spine Surgery: A Randomized Control Trial. (Pubmed Central) - Jul 14, 2021
Trial completion date: Sep 2022 --> Jul 2024 | Trial primary completion date: Jan 2022 --> Jun 2024 US-guided ESP block reduces postoperative opioid requirement and improves patient satisfaction compared with standard analgesia in lumbar spine surgery patients.
- | morphine sulphate / Generic mfg.
Journal: The role of adenosine A1 receptors in the nucleus accumbens during morphine withdrawal. (Pubmed Central) - Jul 14, 2021
Our findings suggest that administration of the A receptor agonist significantly decreased withdrawal behaviors and increased dopamine and noradrenaline concentrations in opioid withdrawal in a dose-dependent manner. These results demonstrate that adenosine receptors should be examined as a potential mechanism that could be exploited for the treatment of morphine withdrawal.
- | morphine sulphate / Generic mfg.
Journal: Surface Enhanced Raman Spectroscopy as a Novel Tool for Rapid Quantification of Heroin and Metabolites in Saliva. (Pubmed Central) - Jul 14, 2021
Additionally, the present study revealed that synergetic effect of a specific gold nano-surface with ability controlling liquid motion and silver nanoparticles increase band numbers and intensities. Therefore, we suggest a fast, accurate and cost-effective method to detect and quantify heroin in biological fluids.
- || morphine sulphate / Generic mfg.
Clinical, Journal: Implementation of a patient-specific tapering protocol at discharge decreases total opioid dose prescribed for 6 weeks after elective primary spine surgery. (Pubmed Central) - Jul 14, 2021
This patient-specific prescribing and tapering protocol effectively decreases the total opioid dose prescribed for 6 weeks postdischarge after elective primary spine surgery. Our experience also demonstrates the potential generalizability of this protocol, which was originally designed for joint replacement patients, to other surgical populations.
- || morphine sulphate / Generic mfg.
Retrospective data, Review, Journal: Analgesic efficacy of cannabinoids for acute pain management after surgery: a systematic review and meta-analysis. (Pubmed Central) - Jul 14, 2021
Notably, there appears to be a signal towards increased postoperative pain and hypotension associated with the addition of perioperative cannabinoids to traditional systemic analgesics. These results do not support the routine use of cannabinoids to manage acute postoperative pain at the present time.
- | morphine sulphate / Generic mfg.
Journal: Reducing harm through the development of good preparation practices for the injection of slow release morphine sulphate capsules. (Pubmed Central) - Jul 14, 2021
The provision of a method that is easy to use, reduces harms associated to the injection of insoluble particles and recovers virtually all the active drug has a large chance to be adopted by people who use drugs. This type of "best practices" can be provided by drug workers and by people who use drugs to actively promote harm reduction.
- || morphine sulphate / Generic mfg.
Clinical, Journal: Postoperative opioid use after lobectomy for primary lung cancer: A propensity-matched analysis of premier hospital data. (Pubmed Central) - Jul 14, 2021
Patients undergoing RL for primary lung cancer received opioids less frequently, and with lower total and average daily doses, compared with those undergoing VATS and open lobectomy. Studies are needed to determine whether early opioid dosage reductions translate into less chronic opioid use.
- || morphine sulphate / Generic mfg.
Clinical, Review, Journal: Deprescribing Opioids in Chronic Non-cancer Pain: Systematic Review of Randomised Trials. (Pubmed Central) - Jul 14, 2021
Studies are needed to determine whether early opioid dosage reductions translate into less chronic opioid use. The small number of studies and heterogeneity prevented firm conclusions to recommend any one opioid-analgesic-deprescribing strategy in patients with chronic pain.
- | morphine sulphate / Generic mfg.
Journal: Evaluation of nalbuphine, butorphanol and morphine in dogs during ovariohysterectomy and on early postoperative pain. (Pubmed Central) - Jul 14, 2021
At the doses used, all premedication protocols provided insufficient intraoperative analgesia, with minimal clinical differences between groups. No premedication provided satisfactory analgesia in the first 6 hours postoperatively.
- | morphine sulphate / Generic mfg., methadone / Generic mfg.
Journal: Aspiration in lethal drug abuse-a consequence of opioid intoxication. (Pubmed Central) - Jul 14, 2021
There are lower opioid concentrations in deceased with signs of aspiration, a fact which strongly points to aspiration as alternative cause of death in opioid-related fatalities. Furthermore, this study highlights the common abuse of slow-release oral morphine in Vienna and discusses alternative medications in substitution programs (buprenorphine/naloxone or tamper-resistant slow-release oral morphine preparations), as they might reduce intravenous abuse and opioid-related deaths.
- | morphine sulphate / Generic mfg.
Journal: Equine uridine diphospho-glucuronosyltransferase 1A1, 2A1, 2B4, 2B31: cDNA cloning, expression and initial characterization of morphine metabolism. (Pubmed Central) - Jul 14, 2021
UGT2B31 contributes to the glucuronidation of morphine; however, it is probably not the main metabolizing enzyme. These results warrant further investigation of equine UGTs, including expression of additional enzymes and further characterization of UGT2B31 as a contributor to morphine metabolism.
- || ketorolac / Generic mfg.
Clinical, Journal: Does IV Acetaminophen Reduce Opioid Requirement in Pediatric Emergency Department Patients with Acute Sickle Cell Crises? (Pubmed Central) - Jul 14, 2021
We conclude that IV acetaminophen, when used in addition to morphine for pediatric sickle cell VOC pain, does not provide an opioid sparing effect. Further searches for adjunctive non-addictive pain medicines are indicated.
- | morphine sulphate / Generic mfg.
Journal: Risk of chronic opioid use after simultaneous versus staged bilateral knee arthroplasty. (Pubmed Central) - Jul 14, 2021
Although patients undergoing staged BTKA <6 months apart were prescribed greater quantities of opioids on discharge, there was no significant difference in the odds of postoperative chronic opioid use compared with simultaneous BTKA. The timing of BTKA procedures does not appear to influence the likelihood of postoperative chronic opioid dependence.
- || dexamethasone / Generic mfg., ketamine / Generic mfg.
Review, Journal: Pain management after open liver resection: Procedure-Specific Postoperative Pain Management (PROSPECT) recommendations. (Pubmed Central) - Jul 14, 2021
Systemic opioids should be considered as rescue analgesics. Further high-quality RCTs are needed to confirm and clarify the efficacy of the recommended analgesic regimen in the context of an enhanced recovery program.