morphine sulphate / Generic mfg. 
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  • ||||||||||  fentanyl citrate / Generic mfg., remifentanil / Generic mfg., morphine sulphate / Generic mfg.
    Review, Journal:  The Effect of Opiates on Bone Formation and Bone Healing. (Pubmed Central) -  Aug 20, 2021   
    Conversely, remifentanil has been recently shown to promote in vitro osteoblast differentiation and to inhibit differentiation and maturation of osteoclasts, therefore reducing bone resorption...Opioid antagonists may increase bone density and could represent a possible future treatment for low bone mass density pathologies. However, further trials are warranted to clarify the clinical relevance of these emerging findings from animal studies.
  • ||||||||||  midazolam hydrochloride / Generic mfg.
    Clinical, Journal:  Iatrogenic withdrawal syndrome in specialty pediatric critical care. (Pubmed Central) -  Aug 20, 2021   
    A further study is warranted to elucidate the predictive covariates and precision dosing strategies that use morphine concentration and pain scores as feedbacks. The information learned highlights the need for ongoing conversation and continued study of how best to assess and manage withdrawal syndrome in pediatric critical care environments.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal, Epigenetic controller:  Effect of short-term prescription opioids on DNA methylation of the OPRM1 promoter. (Pubmed Central) -  Aug 20, 2021   
    The information learned highlights the need for ongoing conversation and continued study of how best to assess and manage withdrawal syndrome in pediatric critical care environments. The present study provides evidence that the hypermethylation of the OPRM1 promoter is in response to opioid use and that epigenetic differences in OPRM1 and other sites are associated with a short-term use of therapeutic opioids.
  • ||||||||||  methadone / Generic mfg.
    Review, Journal:  Methadone for Pain Management: A Pharmacotherapeutic Review. (Pubmed Central) -  Aug 20, 2021   
    Particular caution is required when converting patients from other opioids to methadone and for this reason only experienced healthcare providers should undertake such a task. Further randomized trials with larger sample sizes are needed to better define the effective and safe use of methadone for pain management.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal:  Self-Reported Opioid Use and Driving Outcomes among Older Adults: The AAA LongROAD Study. (Pubmed Central) -  Aug 20, 2021   
    However, future work should clarify the effects on driving of opioid use from the effects of the painful medical conditions for which the opioids are being taken. Clinicians should continue to discuss the risks and benefits of opioid medications with patients, including risks related to driving safety.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  A Proposed Opioid Tapering Tool. (Pubmed Central) -  Aug 20, 2021   
    We are exploring the possibility of transitioning our software into other available APIs with the goal of integrating this software into major electronic health record systems. Our group envisions that our software will provide an additional tool within a patient-centered, multi-modal framework in managing patients on COT for CNCP.
  • ||||||||||  pregabalin / Generic mfg., gabapentin / Generic mfg., amphetamine / Generic mfg.
    Journal:  Fatal poisoning among drug users in Denmark in 2017. (Pubmed Central) -  Aug 20, 2021   
    However, deaths due to stimulants, especially cocaine, have increased. The abuse pattern has changed and geographical differences have emerged.
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  Deep Brain Stimulation of the Lateral Hypothalamus Facilitates Extinction and Prevents Reinstatement of Morphine Place Preference in Rats. (Pubmed Central) -  Aug 20, 2021   
    Registry data on HD-SCS in FBSS patients revealed a statistically significant and sustained decrease in pain medication use, not only on opioids, but also on anti-neuropathic agents in neurostimulation-naïve patients, who positively responded to an SCS trial period with at least 50% pain relief and 50% pain medication decrease, but not in rescue patients. HF-DBS facilitated extinction of morphine place preference and disrupted drug priming- and stress-induced renewal of morphine place preference.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Variants of glycosyl hydrolase family 2 β-glucuronidases have increased activity on recalcitrant substrates. (Pubmed Central) -  Aug 20, 2021   
    Furthermore, mutations in the M-loop, which is a loop near the active site, resulted in numerous variants with dramatically increased rates of hydrolysis on drug glucuronides. Specifically, the M-loop variant Q451D/A452E of a β-GUS from Brachyspira pilosicoli has a 50-fold and 25-fold increase in activity on the recalcitrant substrates codeine-6-glucuronide and dihydrocodeine-6-glucuronide, respectively, compared to the parent enzyme.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Retrospective data, Journal:  New Persistent Opioid Use After Orthopaedic Foot and Ankle Surgery: A Study of 348 Patients. (Pubmed Central) -  Aug 20, 2021   
    Other risk factors include recreational drug use, greater alcohol use, and greater age. Orthopaedic foot and ankle surgeons should limit perioperative prescriptions and be cognizant of these other risk factors to limit the negative effects of opioid prescriptions on their patients and communities.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  GABA-cannabinoid interplays in the dorsal hippocampus and basolateral amygdala mediate morphine-induced amnesia. (Pubmed Central) -  Aug 19, 2021   
    It should be noted that the intra-CA1 microinjection of muscimol, intra-BLA microinjection of WIN55,212-2 or AM251 alone could not affect memory consolidation. Accordingly, it can be concluded that there may be a synergistic interaction between the CA1 GABAergic system and the BLA endocannabinoid neurotransmission with respect to the modulation of morphine-induced memory impairment.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Prevention of Pruritis following Spinal Morphine for Scheduled Cesarean Birth. (Pubmed Central) -  Aug 19, 2021   
    Accordingly, it can be concluded that there may be a synergistic interaction between the CA1 GABAergic system and the BLA endocannabinoid neurotransmission with respect to the modulation of morphine-induced memory impairment. Mother-baby nurses can have an impact on the practice of anesthesia providers by advocating for evidence-based dosing of intrathecal morphine to reduce the incidence of pruritis while maintaining effective analgesia for women after cesarean birth.
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
    Journal:  Perceptions of opioid and other illicit drug exposure reported among first responders in the southeast, 2017 to 2018. (Pubmed Central) -  Aug 18, 2021   
    Only a small fraction of first responders believed they had experienced symptoms related to opioid exposure in overdose response calls, but half were concerned about potential exposures and half were unaware of the educational guidance on prevention available. The high level of concern regarding potential exposure warrants the need for the development and or enhancement of targeted educational training interventions and further dissemination of pre-existing training interventions to ensure first responders have the knowledge and understanding of occupational opioid exposures and minimize stress associated with the potential rare exposures.
  • ||||||||||  morphine sulphate / Generic mfg., ketamine / Generic mfg.
    Trial initiation date:  KLOE: Ketamine Low dOse Evaluation on Morphine Consumption in Traumatic Patient (clinicaltrials.gov) -  Aug 18, 2021   
    P4,  N=140, Not yet recruiting, 
    The high level of concern regarding potential exposure warrants the need for the development and or enhancement of targeted educational training interventions and further dissemination of pre-existing training interventions to ensure first responders have the knowledge and understanding of occupational opioid exposures and minimize stress associated with the potential rare exposures. Initiation date: May 2021 --> Oct 2021
  • ||||||||||  morphine sulphate / Generic mfg.
    Trial initiation date:  Individualized Analgesia for Pediatric Adenotonsillectomy (clinicaltrials.gov) -  Aug 18, 2021   
    P4,  N=128, Not yet recruiting, 
    Initiation date: May 2021 --> Oct 2021 Initiation date: Mar 2021 --> Oct 2021
  • ||||||||||  morphine sulphate / Generic mfg.
    Trial completion date, Trial primary completion date:  Gene Polymorphisms and Morphine Analgesic Consumption (clinicaltrials.gov) -  Aug 18, 2021   
    P=N/A,  N=300, Recruiting, 
    Initiation date: Mar 2021 --> Oct 2021 Trial completion date: Mar 2021 --> Dec 2022 | Trial primary completion date: Mar 2021 --> Mar 2022
  • ||||||||||  morphine sulphate / Generic mfg.
    Trial completion date, Trial primary completion date, Adverse events:  Decreased Neuraxial Morphine After Cesarean Delivery (clinicaltrials.gov) -  Aug 18, 2021   
    P1,  N=96, Recruiting, 
    Trial completion date: Mar 2021 --> Dec 2022 | Trial primary completion date: Mar 2021 --> Mar 2022 Trial completion date: Jul 2021 --> Jul 2022 | Trial primary completion date: Jul 2021 --> Jul 2022
  • ||||||||||  ketorolac / Generic mfg.
    Trial completion date, Trial primary completion date:  Effect of Ketorolac on Post Adenotonsillectomy Pain (clinicaltrials.gov) -  Aug 18, 2021   
    P4,  N=120, Recruiting, 
    Trial completion date: Jul 2021 --> Jul 2022 | Trial primary completion date: Jul 2021 --> Jul 2022 Trial completion date: Aug 2021 --> Aug 2022 | Trial primary completion date: Aug 2021 --> Aug 2022
  • ||||||||||  morphine sulphate / Generic mfg., ketamine / Generic mfg., dexmedetomidine / Generic mfg.
    Enrollment change, Trial completion date, Trial suspension, Trial primary completion date, Surgery:  Dexmedetomidine and Ketamine in VATS Surgery (clinicaltrials.gov) -  Aug 18, 2021   
    P=N/A,  N=5, Suspended, 
    Trial completion date: Aug 2021 --> Aug 2022 | Trial primary completion date: Aug 2021 --> Aug 2022 N=120 --> 5 | Trial completion date: Jul 2020 --> Jul 2023 | Recruiting --> Suspended | Trial primary completion date: Feb 2020 --> Dec 2022
  • ||||||||||  Journal:  Provision of Sedation and Treatment of Seizures During Neonatal Therapeutic Hypothermia. (Pubmed Central) -  Aug 18, 2021   
    Dexmedetomidine represents an interesting alternative, with preclinical data suggesting direct efficacy against shivering during induced hypothermia and neuroprotection in the setting of HIE...Traditional therapies, including phenobarbital, fosphenytoin, and benzodiazepines, control seizures in the vast majority of neonates...Unfortunately, levetiracetam is inferior to phenobarbital as first-line therapy for neonatal seizures. Considering both the benefits and risks of traditional anticonvulsant agents, treatment should be limited to the shortest duration indicated, with maintenance therapy reserved for neonates at high risk for recurrent seizures.
  • ||||||||||  morphine sulphate / Generic mfg., alprazolam / Generic mfg.
    New P2 trial:  MAP: Opioid/Benzodiazepine Polydrug Abuse: Aim 3 (clinicaltrials.gov) -  Aug 16, 2021   
    P2,  N=24, Not yet recruiting, 
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  HIV-1 Tat-Induced Astrocytic Extracellular Vesicle miR-7 Impairs Synaptic Architecture. (Pubmed Central) -  Aug 15, 2021   
    Our previous study has demonstrated that both HIV-1 Tat as well as opiates such as morphine, can directly induce synaptic alterations via independent pathways...More importantly, we report that these impairments could be reversed by pretreatment of neurons with a neurotrophic factor platelet-derived growth factor-CC (PDGF-CC). Graphical Abstract.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Morphine selectively disinhibits glutamatergic input from mPFC onto dopamine neurons of VTA, inducing reward. (Pubmed Central) -  Aug 15, 2021   
    Using optogenetic strategy combined with whole-cell patch-clamp, qRT-PCR, immunofluorescence and chemical genetic approach combined with behavioral methods, our results show that: 1) morphine promotes glutamate release from glutamatergic terminals of medial prefrontal cortex (mPFC) neurons projecting to VTA-DA neurons but does not on those from glutamatergic terminals of the lateral hypothalamus (LH) neurons projecting to VTA-DA neurons; 2) different response of glutamatergic neurons projecting to VTA-DA neurons from the mPFC or the LH to morphine is related to the expression of GABA receptors at terminals of these neurons; 3) inhibition of projection neurons from the mPFC to the VTA significantly reduces morphine-induced locomotor activity increase and conditioned place preference but inhibition of projection neurons from the LH to the VTA does not. These results suggest that morphine selectively promotes glutamate release of the glutamatergic input from mPFC onto VTA-DA neurons by removing the inhibition of the GABA receptors in this glutamatergic input from mPFC.