morphine sulphate / Generic mfg. 
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  • ||||||||||  morphine sulphate / Generic mfg.
    Trial completion, Enrollment change, Surgery:  Dosage of Epidural Morphine in Elderly Patients (clinicaltrials.gov) -  Sep 13, 2021   
    P4,  N=88, Completed, 
    Recruiting --> Completed Recruiting --> Completed | N=60 --> 88
  • ||||||||||  morphine sulphate / Generic mfg.
    Review, Journal:  Intrathecal Opioid Dosing During Spinal Anesthesia for Cesarean Section: An Integrative Review. (Pubmed Central) -  Sep 12, 2021   
    Evidence supports the use of lower doses of intrathecal (IT) opioids, specifically 0.1 morphine, to achieve optimal pain management with minimal nausea, vomiting, and pruritus. Lower IT doses have potential to achieve pain management and to alleviate preventable side effects in women delivering via CS.
  • ||||||||||  morphine sulphate / Generic mfg.
    Review, Journal:  Mechanisms of Central Hypogonadism. (Pubmed Central) -  Sep 12, 2021   
    Finally, the HPG axis is susceptible to congenital malformations, with reports of mutations within >50 genes that manifest with congenital CH, including Kallmann Syndrome associated with hyposmia or anosmia (reduction or loss of the sense of smell due to the closely associated migration of GnRH with olfactory neurons during embryogenesis). Analogous to the HPG axis itself, patients with CH are often vulnerable, and their clinical management requires both sensitivity and empathy.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal:  The effect of patient factors on opioid use after anatomic and reverse shoulder arthroplasty. (Pubmed Central) -  Sep 11, 2021   
    After TSA, morphine equivalent dose usage is higher for patients younger than 65 years of age, and several risk factors exist for requiring a refill and having inadequate pain control 6 weeks postoperatively. Prospective studies using these data to guide interventions may be beneficial.
  • ||||||||||  gabapentin / Generic mfg.
    Journal:  Optimizing Perioperative Pain Control After Ambulatory Urogynecologic Surgery. (Pubmed Central) -  Sep 11, 2021   
    Patients infrequently use opiates after ambulatory urogynecologic surgery. The use of a multimodal pain protocol was associated with lower pain scores, and patients in a multimodal pain protocol were more likely to report no pain.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  A history of opioid exposure in females increases the risk of metabolic disorders in their future male offspring. (Pubmed Central) -  Sep 11, 2021   
    In the hypothalamus, proteins involved in energy homeostasis are modified and RNA sequencing revealed down-regulation of genes associated with neuronal plasticity, coupled with up-regulation of genes associated with immune, inflammatory, and metabolic processes that are specific to FSD-maintained MORF1 males. Thus, limited preconception morphine exposure in female rats increases the risk of metabolic syndrome/type 2 diabetes in the next generation.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal:  Risk factors for post-caesarean nausea and vomiting: a prospective prognostic study (Pubmed Central) -  Sep 11, 2021   
    Intraoperative nausea and maternal age < 25 years were the main risk factors for PONV after cesareans under spinal anesthesia. Absence of self-reported nausea during the first trimester was a protective factor for post-cesarean nausea and vomiting.
  • ||||||||||  morphine sulphate / Generic mfg., aspirin / Generic mfg.
    Journal:  Bioresearch of New 1H-pyrrolo[3,4-c]pyridine-1,3(2H)-diones. (Pubmed Central) -  Sep 10, 2021   
    All tested imides 8-15 were more active in the "writhing" test than aspirin, and two of them, 9 and 11, were similar to morphine. In addition, all of the new imides inhibited the locomotor activity in mice to a statistically significant extent, and two of them also prolonged the duration of thiopental sleep.On the basis of the results obtained for the previously synthesized imides and the results presented in this paper, an attempt was madeto determine the relationship between thechemical structure of imides and their analgesic and sedativeproperties.
  • ||||||||||  Sancuso (granisetron) / Solasia
    Trial completion, Enrollment change, Trial completion date, Trial primary completion date:  Effect of Granisetron on Morphine Induced Pruritus in Cesarean Section (clinicaltrials.gov) -  Sep 9, 2021   
    P2,  N=80, Completed, 
    The study showed that bupivacaine-based TPVB provided an effective post-operative analgesic and opioid-sparing effect for simple mastectomy when compared with a saline-based control group that received only intravenous morphine patient controlled analgesia and paracetamol. Not yet recruiting --> Completed | N=40 --> 80 | Trial completion date: Jul 2019 --> Oct 2020 | Trial primary completion date: May 2019 --> Oct 2020
  • ||||||||||  morphine sulphate / Generic mfg.
    LONG-TERM FUNCTIONAL AND PATIENT REPORTED OUTCOMES AFTER ISOLATED RIB FRACTURES () -  Sep 9, 2021 - Abstract #AAST2021AAST_367;    
    Patients were prescribed a mean oral morphine equivalent of 238.4 (SD = 232.5) at discharge... Isolated rib fractures are a non-trivial trauma burden that often result in functional impairments and reduced quality of life even 6-12 months after injury.
  • ||||||||||  morphine sulphate / Generic mfg.
    THE DECLINING USE OF OPIOIDS AT A LEVEL 1 TRAUMA CENTER () -  Sep 9, 2021 - Abstract #AAST2021AAST_265;    
    Our trauma center realized a stepwise reduction in opioid administration in the absence of restrictions surrounding in-hospital opioid prescribing. Although patient satisfaction with pain management over this time is unknown, it appears that regardless of injury severity trauma patients can be managed with less opioids than have been used in the recent past.
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
    PREHOSPTIAL PAIN MANAGEMENT IS EFFECTIVE AND SAFE BUT UNDERUTILIZED IN TRAUMA PATIENTS () -  Sep 9, 2021 - Abstract #AAST2021AAST_207;    
    The use of opioids in the prehospital setting significantly reduced pain among injured patients with few adverse events. Despite its efficacy and safety, the majority of patients with major injuries and severe pain do not receive opioid analgesia in the prehospital setting.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Pain impairs consolidation, but not acquisition or retrieval of a declarative memory. (Pubmed Central) -  Sep 9, 2021   
    Morphine, at a dose that did not affect object recognition memory in control rats, drastically reduced formalin-induced nociceptive behavior without reversing memory impairment...However, when formalin-induced nociceptive response was blocked by a local anesthetic, memory impairment was prevented. These findings suggest that pain-induced impairment in the consolidation of object recognition memory does not directly depend on the intensity of nociceptive activity.
  • ||||||||||  SCH-23390 / Boehringer Ingelheim
    Journal:  Restraint Stress Potentiated Morphine Sensitization: Involvement of Dopamine Receptors within the Nucleus Accumbens. (Pubmed Central) -  Sep 9, 2021   
    The results revealed that intra-NAc administration of D1/D2-like dopamine receptor antagonists, SCH-23390 or sulpiride, respectively, blocked morphine sensitization-induced by RS and morphine co-administration in rats for three consecutive days. This work provides new insight into the determinant role of accumbal dopamine receptors in morphine sensitization produced by RS-morphine co-administration.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Comparative Toxicity Assessment of Kratom Decoction, Mitragynine and Speciociliatine Versus Morphine on Zebrafish (Danio rerio) Embryos. (Pubmed Central) -  Sep 8, 2021   
    While exposure to morphine induced significant morphological malformations such as pericardial oedema, spinal curvature (lordosis), and yolk edema in zebrafish embryos. Our findings provide evidence for embryonic developmental toxicity of kratom decoction and its alkaloids both mitragynine and speciociliatine at the highest concentration, hence suggesting that kratom consumption may have potential teratogenicity risk during pregnancy and thereby warrants further investigations.
  • ||||||||||  naproxen ER / Generic mfg., ibuprofen / Generic mfg.
    Journal:  Use of analgesics in oral care (Pubmed Central) -  Sep 8, 2021   
    A dentist in general practice or a dental specialist needs to know, the mechanism of action and the most important interactions, contraindications and adverse effects of each of these groups of medications. Attention is needed when prescribing analgesics to risk groups such as frail elderly, pregnant and lactating women, and children.
  • ||||||||||  morphine sulphate / Generic mfg.
    Enrollment change:  PCA Cues: Patient Controlled Analgesia Pump Cues on Patient Satisfaction (clinicaltrials.gov) -  Sep 8, 2021   
    P=N/A,  N=176, Completed, 
    Attention is needed when prescribing analgesics to risk groups such as frail elderly, pregnant and lactating women, and children. N=120 --> 176
  • ||||||||||  morphine sulphate / Generic mfg.
    Trial completion, Trial completion date:  Factors Associated With Failed Spinal Anesthesia for Cesarean Delivery (clinicaltrials.gov) -  Sep 8, 2021   
    P=N/A,  N=440, Completed, 
    Recruiting --> Completed Recruiting --> Completed | Trial completion date: Apr 2021 --> Aug 2021
  • ||||||||||  ondansetron / Generic mfg., morphine sulphate / Generic mfg.
    Unusual Etiology of Papillary Stenosis Resulting in Pancreatitis (Shoreline Exhibit Hall) -  Sep 8, 2021 - Abstract #ACG2021ACG_3133;    
    Several cases have been reported of specifically papillary stenosis secondary to CD inflammation, but few have been due to anatomical obstruction resulting from the disease. It is well known that patients with CD are at increased risk of developing acute and chronic pancreatitis, but most commonly idiopathic.
  • ||||||||||  Olinvyk (oliceridine) / Trevena, Jiangsu NHWA Pharma
    Journal:  Oliceridine for the Management of Acute Postoperative Pain. (Pubmed Central) -  Sep 8, 2021   
    DEA rescheduling of HCPs was associated with a significant reduction in prescription opioid exposures, suggesting that rescheduling high-risk drugs may be an effective strategy to improve public health. Oliceridine has obvious analgesic effects in patients with moderate or severe pain after surgery; additionally, it has a favorable safety and tolerability profile.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal:  Race, pain, and opioids among patients with chronic pain in a safety-net health system. (Pubmed Central) -  Sep 8, 2021   
    Lower past-year maximum MME dose, despite higher average pain and less injection drug use, may represent bias away from prescribing opioids for chronic pain among Black patients. This could be due to unmeasured implicit provider bias or patient-level factors (e.g., utilizing non-opioid pain coping strategies or being less likely to request additional opioids).
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  Sex dependent alteration of epigenetic marks after chronic morphine treatment in mice organs. (Pubmed Central) -  Sep 8, 2021   
    Our results reveal, for the first time, that chronic morphine treatment induced changes in DNA methylation/hydroxymethylation and histone modification in- vivo at the systemic level, revealing a potential physiological effect on the regulation of gene expression. Notably, morphine-induced epigenetic modification occurs in a sex-dependent manner, revealing the existence of different underlying mechanisms of epigenetic modification in male and female mice.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal:  Improving quality and efficiency of care for advanced appendicitis in children. (Pubmed Central) -  Sep 8, 2021   
    Reduced post-operative length of stay and reduction in practice variation were achieved after implementation of a 'fast-track' protocol for children with advanced appendicitis. Additional benefits of this protocol include reduced provision of intravenous morphine analgesia, decreased resource use and cost savings.
  • ||||||||||  morphine sulphate / Generic mfg., methadone / Generic mfg.
    Clinical, Review, Journal:  The suitability of oral diacetylmorphine in treatment-refractory patients with heroin dependence: A scoping review. (Pubmed Central) -  Sep 7, 2021   
    Based on all published data, it is unlikely that oral diacetylmorphine produces a substantial 'rush'. Prescription of oral diacetylmorphine might therefore be effective only for treatment-refractory patients with heroin dependence (i) as maintenance treatment for those who never injected or inhaled opioids; (ii) as maintenance treatment for those who want to switch from injection to oral administration of diacetylmorphine; and/or (iii) to reduce opioid withdrawal symptoms.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Review, Journal:  A review of evidence-based clinical practice on fascia iliaca compartment block for lower limb injury. (Pubmed Central) -  Sep 7, 2021   
    For the knee, femoral bone, and hip region surgery, the fascia iliaca compartment block (FICB) provided better anesthesia quality, reduced systemic morphine consumption, and had fewer complications than epidural anesthesia. Anesthetists and surgical department staff should promote the FICB's benefits by emphasizing its superiority in pain management.