morphine sulphate / Generic mfg. 
Welcome,         Profile    Billing    Logout  
 7 Diseases   379 Trials   379 Trials   12426 News 


«12...146147148149150151152153154155156...216217»
  • ||||||||||  Entresto (sacubitril/valsartan) / Novartis, ROVI Pharmaceuticals Laboratories
    Journal:  Pharmacological Management of Heart Failure: A Century of Expert Opinions in Cecil Textbook of Medicine. (Pubmed Central) -  Oct 1, 2021   
    The pharmacological management of heart failure in the past century has progressed in fits and starts, with latent periods between significant advances lasting 8-40 years. In chronological order, the major advances were efficient diuresis, afterload reduction, and blunting the neurohormonal response to hemodynamic stress and cardiac remodeling.
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Review, Journal:  Modulatory effect of opioid administration on the activity of cholinesterase enzyme: a systematic review of mice/rat models. (Pubmed Central) -  Oct 1, 2021   
    Direct inhibitory action of morphine and the other opioid ligands believed responsible for the decrease in the ChE activity...Simulation studies can also examine the structure-function relationships and provide important details to better understand the mechanism of action of opioid compounds on ChE activity. In addition, understanding how opioids impact ChE activity may help perform proper interventions for drug abstinence.
  • ||||||||||  MoxDuo IR (morphine + oxycodone) / QRxPharma, AbbVie, Arymo (morphine) / Assertio
    Journal:  Association of partial systemic exposure and abuse potential for opioid analgesics with abuse deterrence labeling claims supporting product-specific guidance. (Pubmed Central) -  Sep 30, 2021   
    Extensive pharmacokinetic (PK) and subjective response data from 11 clinical abuse potential trials in recreational opioid users following oral and nasal administration of intact and manipulated oxycodone, hydrocodone and morphine products from the FDA internal database were utilized for the present analysis...Our findings support FDA's recommendation of comparative PK studies with early partial AUCs as a supportive PK metric for the assessment of abuse deterrent properties of generic opioid drug products in the general and product-specific guidance's of ADFs. The study was partially funded by Fiscal Year 2017 Critical Path of the Center for Drug Evaluation and Research at the U.S. Food and Drug Administration.
  • ||||||||||  morphine sulphate / Generic mfg.
    Trial completion:  Post-cesarean Analgesia With Epidural Morphine Following Epidural 2-chloroprocaine (clinicaltrials.gov) -  Sep 30, 2021   
    P4,  N=44, Completed, 
    Not yet recruiting --> Recruiting | Trial completion date: Feb 2024 --> May 2024 | Initiation date: May 2021 --> Aug 2021 | Trial primary completion date: Feb 2024 --> May 2024 Recruiting --> Completed
  • ||||||||||  morphine sulphate / Generic mfg., ropivacaine / Generic mfg.
    Journal:  Ultrasound-Guided Transmuscular Quadratus Lumbar Block Reduces Opioid Consumption after Laparoscopic Partial Nephrectomy. (Pubmed Central) -  Sep 30, 2021   
    Patient-controlled intravenous analgesia with morphine was initiated immediately upon surgery completion...Patients in the TQLB group had fewer episodes of PONV (20% vs. 47%, χ=4.8, P=0.028) in the first 24 h after surgery and higher scores for quality of recovery (mean, 138.6 vs. 131.9, t=-2.164, P=0.035) 120 h after surgery than the controls. Conclusions TQLB resulted in an opioid-sparing effect during the early postoperative period following LPN, as well as a lower incidence of PONV and improved quality of recovery.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal:  Opioid Use Increases the Risk of Delirium in Critically Ill Adults Independently of Pain. (Pubmed Central) -  Sep 30, 2021   
    Conclusions TQLB resulted in an opioid-sparing effect during the early postoperative period following LPN, as well as a lower incidence of PONV and improved quality of recovery. Receipt of an opioid in the ICU increases the odds of transitioning to delirium in a dose-dependent fashion.
  • ||||||||||  morphine sulphate / Generic mfg., hydromorphone hydrochloride / Generic mfg.
    Clinical, Journal:  Relative potency of intravenous oxymorphone compared to other µ opioid agonists in humans - pilot study outcomes. (Pubmed Central) -  Sep 30, 2021   
    Oxymorphone was far more potent than the comparator opioids, particularly on abuse potential outcomes. Overall, these findings may help explain surveillance reports that demonstrate, after adjusting for prescription availability, oxymorphone is injected at the highest frequency, relative to other prescription opioids.
  • ||||||||||  midazolam hydrochloride / Generic mfg.
    Retrospective data, Journal:  Palliative Sedation in COVID-19 End-of-Life Care. Retrospective Cohort Study. (Pubmed Central) -  Sep 29, 2021   
    End-of-life palliative sedation in patients with COVID-19 was initiated quite late. Clinicians should anticipate the need for palliative sedation in these patients and recognize the breathlessness, pain, and agitation/delirium that foreshadow death.
  • ||||||||||  methadone / Generic mfg.
    Trial completion date, Trial primary completion date:  Perioperative Methadone Use to Decrease Opioid Requirement in Pediatric Spinal Fusion Patients (clinicaltrials.gov) -  Sep 29, 2021   
    P3,  N=44, Recruiting, 
    Recruiting --> Active, not recruiting | Trial primary completion date: May 2021 --> Aug 2021 Trial completion date: Sep 2021 --> Dec 2021 | Trial primary completion date: Sep 2021 --> Dec 2021
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal:  Opioid Use Following Inpatient Versus Outpatient Total Joint Arthroplasty. (Pubmed Central) -  Sep 29, 2021   
    Outpatient TJA patients who received opioid prescriptions were prescribed a similar amount of opioids as those undergoing inpatient TJA procedures, but were significantly less likely to become persistent opioid users, even when controlling for patient factors. Outpatient TJA, as compared with inpatient TJA, does not appear to be a risk factor for new opioid dependence, and these findings support the continued transition to the outpatient-TJA model for lower-risk patients.
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  Sintocalmy, a Passiflora incarnata Based Herbal, Attenuates Morphine Withdrawal in Mice. (Pubmed Central) -  Sep 29, 2021   
    No alterations were found in GFAP levels, however SME 50 mg/kg prevented the S100B increase in the frontal cortex and DNA damage. This study shows anti-addiction effects for a commercial standardized extract of P. incarnata and suggests the relevance of proper clinical assessment.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal:  Does epidural analgesia really enhance recovery in pediatric surgery patients? (Pubmed Central) -  Sep 29, 2021   
    AESOPS-1 may demonstrate practical and scalable strategies to lower unnecessary population exposure to opioids. The use of EA in pediatric surgery patients was associated with lower pain scores despite lower systemic opioid requirements in the early post-operative period.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal:  Standardizing Discharge Opioid Prescriptions in Kidney Transplant Patients Decreases Opioid Usage. (Pubmed Central) -  Sep 29, 2021   
    The use of EA in pediatric surgery patients was associated with lower pain scores despite lower systemic opioid requirements in the early post-operative period. A protocol targeting discharge opioids significantly reduced the amount of opioids prescribed in kidney transplant recipients; most patients subsequently received no opioids at discharge.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal:  Opioid-Sparing Multimodal Analgesia Protocol for Lumpectomy Patients Results in Superior Postoperative Pain Control. (Pubmed Central) -  Sep 29, 2021   
    Implementation of an opioid-sparing multimodal analgesia protocol for lumpectomy patients resulted in superior pain control without a routine opioid prescription. Surgeons can improve their own patients' outcomes while addressing the larger societal issue of the opioid crisis by adopting similar protocols that decrease the quantity of opioids available for diversion.
  • ||||||||||  Duodopa (levodopa/carbidopa intraduodenal gel infusion) / AbbVie
    [VIRTUAL] PKG for the management of advance Parkinson's Disease () -  Sep 29, 2021 - Abstract #MDSCongress2021MDS_Congress_308;    
    It helps to adjust medication to improve the condition and can be used for remote monitoring of the patients. It can be used to assess patients for advance treatment or delay advance treatment (cost saving).
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  Identification of Morphine and Heroin-Treatment in Mice Using Metabonomics. (Pubmed Central) -  Sep 28, 2021   
    Moreover, heroin and morphine reduced the levels of aconitic acid, cysteine, glycine, and oxalic acid in urine. The results show 3-Hydroxybutyric acid, tryptophan, citric acid and 2-ketoglutaric acid can be used as potential markers of opiate abuse in serum, while oxalic acid, aconitic acid, cysteine, and glycine can be used as potential markers in urine.
  • ||||||||||  hydroxychloroquine / Generic mfg., ketamine / Generic mfg.
    Clinical, Journal:  Protocol-based cardiotoxicity monitoring in hydroxychloroquine medicated COVID-19 pediatric patients. (Pubmed Central) -  Sep 28, 2021   
    Clinical trials are evolving to define hydroxychloroquine effectivity and safety. Our considerable pediatric population supports the need for cardiotoxicity monitoring during therapy but suggest its use seems to be safe in COVID-19 pediatric patients, even in association with other QT-prolonging therapies.
  • ||||||||||  propranolol / Generic mfg.
    Enrollment change, Trial termination:  PRO_GENE_POP: Genetic Predictors of Analgesic Efficacy of Propranolol for Treating Postoperative Pain (clinicaltrials.gov) -  Sep 28, 2021   
    P2,  N=10, Terminated, 
    This higher index of suspicion of OPIAD could lead to earlier recognition of symptoms and increase the positive predictive value of diagnostic laboratory tests. N=106 --> 10 | Suspended --> Terminated; Difficulty with recruitment
  • ||||||||||  OxiFast (oxycodone immediate release) / Purdue, Shionogi, Mundipharma
    Enrollment change, Trial withdrawal:  Multimodal Analgesia in Shoulder Arthroplasty (clinicaltrials.gov) -  Sep 28, 2021   
    P3,  N=0, Withdrawn, 
    Initiation date: Aug 2021 --> Nov 2021 N=18 --> 0 | Terminated --> Withdrawn
  • ||||||||||  ketorolac / Generic mfg., morphine sulphate / Generic mfg., hydromorphone hydrochloride / Generic mfg.
    Trial completion date, Trial primary completion date:  PATIENCE: Initial Pain Management in Pediatric Pancreatitis: Opioid vs. Non-Opioid (clinicaltrials.gov) -  Sep 27, 2021   
    P2,  N=50, Not yet recruiting, 
    N=18 --> 0 | Terminated --> Withdrawn Trial completion date: Feb 2022 --> Nov 2022 | Trial primary completion date: Jan 2022 --> Nov 2022
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal:  Design considerations for a remote randomized multi-site clinical trial evaluating an e-health self-management program for chronic pain patients receiving opioid therapy. (Pubmed Central) -  Sep 26, 2021   
    Based on the adverse consequences and inadequate evidence of effectiveness for long-term opioid therapy (LOT), the CDC developed recommendations to decrease the use of LOT and morphine equivalent dose (MED) for patients receiving LOT...Opioid prescription information will be collected from the participants' electronic health record (EHR) from baseline through 6 months post-active treatment. This paper describes design considerations for this unique trial which is conducted completely remotely, with no in-person visits, and utilizes the EHR for participant identification and primary outcome collection.