morphine sulphate / Generic mfg. 
Welcome,         Profile    Billing    Logout  
 7 Diseases   379 Trials   379 Trials   12426 News 


«12...141142143144145146147148149150151...216217»
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Transcriptomic Response Analysis of Escherichia coli to Palladium Stress. (Pubmed Central) -  Oct 27, 2021   
    It has a wide range of applications from automobile catalytic converters to the pharmaceutical production of morphine...Moreover, the expression of several carbohydrate, amino acid, and nucleotide transport and metabolism genes was vastly changed. These results bring us one step closer to the generation of genetically engineered E. coli strains with enhanced capabilities for Pd nanoparticles synthesis.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal:  Prescription Opioids Dispensed to Patients with Cancer with Bone Metastasis: 2011-2017. (Pubmed Central) -  Oct 27, 2021   
    Among patients with at least one day of opioids in a quarter, the average morphine milligram equivalents dispensed declined by 37% and 11% (p<0.001 for both) for privately insured and MA patients, respectively. Our findings raise concerns about potential unintended consequences related to population-level reduction in opioid prescribing.
  • ||||||||||  morphine sulphate / Generic mfg., methadone / Generic mfg.
    Journal:  Serious health-related suffering and palliative care in South Asian countries. (Pubmed Central) -  Oct 27, 2021   
    Current evidence is insufficient to show an equivalent analgesic benefit of IPLA to TAP block. The solutions involve the introduction of national programs for palliative care, demonstration of culturally appropriate best practices as proof of concept, favourable legislation for medical opioid access, community participation, engagement of civil society to improve awareness, inclusion of palliative and adding EOLC to medical education and need-based research.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  miR-128 participates in the pathogenesis of chronic constipation by regulating the p38α/M-CSF inflammatory signaling pathway. (Pubmed Central) -  Oct 27, 2021   
    Here, we successfully constructed a murine model of CC based on morphine and rhubarb...Furthermore, co-culture assays indicated that regulating expression of miR-128 in colonic epithelial cells induced the secretion of IL-6 and TNF-α by macrophages. In conclusion, our study demonstrated that miR-128 regulated the p38α/M-CSF signaling pathway to promote chronic inflammatory responses and changes in the immune microenvironment of the colon, thereby offering potential insights into the pathogenesis of CC and therapeutic targets for its treatment.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Morphine alkaloids: History, biology, and synthesis. (Pubmed Central) -  Oct 27, 2021   
    The biosynthesis of the title alkaloid as well as all total and formal syntheses of morphine and codeine published after 1996 are discussed in detail. The last section of this chapter provides a detailed overview of medicinally relevant derivatives of the title alkaloid.
  • ||||||||||  tramadol hydrochloride / Generic mfg.
    Clinical, Review, Journal:  Full Opioid Agonists and Tramadol: Pharmacological and Clinical Considerations. (Pubmed Central) -  Oct 27, 2021   
    The most recognized full agonist opioids are heroin, morphine, codeine, oxycodone, meperidine, and fentanyl...Methadone acts as a synthetic opioid analgesic similar to morphine in both quality and quantity; however, methadone lasts longer and in oral form, has higher efficacy, and is considered a diphenylheptane...Chronic opioid usage has also established a relationship to opioid-induced hypogonadism and adrenal suppression. Physicians must be stewards of opioid use and use opioids only when necessary.
  • ||||||||||  Dynastat (parecoxib) / Pfizer
    Clinical, Journal:  Comparing the Efficacy of Postoperative Pain Control Between Intravenous Parecoxib and Oral Diclofenac in ACL Reconstruction. (Pubmed Central) -  Oct 27, 2021   
    The parecoxib group had significantly lower mean VAS than the diclofenac group at 4 hours (P = .047) and 8 hours (P = .005), and the mean cumulative morphine consumption in the parecoxib group was significantly lower than in the diclofenac group at all time points (P < .05) except 4 hours postoperatively. This study found that IV parecoxib was more effective than oral diclofenac in controlling postoperative pain and resulted in lower postoperative morphine consumption within the first 24 hours after ACLR.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  The Extract of Corydalis yanhusuo Prevents Morphine Tolerance and Dependence. (Pubmed Central) -  Oct 25, 2021   
    Together, these data indicate that YHS may be useful as a co-medication in morphine therapies to limit adverse morphine effects. Because YHS is readily available and safe, it may have an immediate positive impact to curb the opioid epidemic.
  • ||||||||||  morphine sulphate / Generic mfg.
    Enrollment change, Trial termination:  Quadratus Lumborum Block for Post-Cesarean Analgesia (clinicaltrials.gov) -  Oct 22, 2021   
    P=N/A,  N=8, Terminated, 
    Because YHS is readily available and safe, it may have an immediate positive impact to curb the opioid epidemic. N=75 --> 8 | Recruiting --> Terminated; Not feasible due to difficulty with recruitment.
  • ||||||||||  morphine sulphate / Generic mfg.
    PK/PD data, Preclinical, Journal:  Blood-Placental Barrier Transfers and Pharmacokinetics of Unbound Morphine in Pregnant Rats with Multiple Microdialysis Systems. (Pubmed Central) -  Oct 22, 2021   
    In conclusion, the high metabolite ratio suggests that morphine has the characteristics of rapid biotransformation, and the mother-to-fetus transfer ratio indicates that morphine and M3G partially transfer the blood-placental barrier in pregnant rats. This newly developed multiple microdialysis coupled to UHPLC-MS/MS system can be applied to the studies of maternal pharmacokinetics and blood-placental transfer in pregnant rats.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal:  The effect of intravenous acetaminophen on patient outcomes within a large integrated delivery network. (Pubmed Central) -  Oct 22, 2021   
    Intravenous acetaminophen was not associated with improvement in the following patient outcomes: total length of stay, ICU length of stay, total narcotic use, likelihood of receiving a discharge narcotic prescription, and 30-day readmission rate. Based on these findings, clinicians may reconsider the routine use of intravenous acetaminophen.
  • ||||||||||  gabapentin / Generic mfg.
    Journal:  Paroxysmal Sympathetic Hyperactivity. (Pubmed Central) -  Oct 22, 2021   
    Treatment includes reducing any external stimulation that can trigger the episodes, and starting abortive (e.g., intravenous morphine) and preventive medications (e.g., gabapentin, propranolol, clonidine). Prompt and adequate treatment of PSH may reduce the likelihood of secondary complications, such as dehydration, weight loss and malnutrition, and muscle contractures.
  • ||||||||||  morphine sulphate / Generic mfg.
    Review, Journal:  Opioid-Mediated HIV-1 Immunopathogenesis. (Pubmed Central) -  Oct 22, 2021   
    Further, the combinatorial effects of HIV-1/HIV-1 proteins and morphine have demonstrated activation of inflammatory signaling in the host system...Overall, this review provides recent insights into the role of opioids in HIV-1 immunopathogenesis. Graphical abstract.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Comparison of peri-operative outcomes between minimally invasive sentinel nodes versus full lymphadenectomy for endometrial cancer. (Pubmed Central) -  Oct 22, 2021   
    There was no difference in narcotic use in milligram intravenous equivalents of morphine in surgery (20.9 vs 22.2; p = .37), recovery (4.6 vs 4.9; p = .73), or total dose (25.4 vs 27.0; p = .33)...There was no difference between the sentinel group and the lymphadenectomy group with respect to age, EBL (P=0.23), use of a preoperative ERAS program (P=0.82), or BMI (34.0 vs 33.7; P=0.87).  The use of full lymphadenectomy was very dependent on the surgeon (P<0.001) There was no difference in mg of IV morphine equivalent in surgery (20.9 vs. 22.2; P=0.37), recovery (4.6 vs 4.9; P=0.73), or total dose (25.4 vs 27.0; P=0.33).  The surgical procedure was longer with lymphadenectomy (185.2 vs 214.2; P<0.001).  The relative risk (RR) of discharge from recovery was lower 0.71 (95%tile 0.51-0.97;p = 0.03).  The hospital stay was longer with lymphadenectomy (16.3 hr vs 25.5 hr;P<0.001) and same day discharge less frequent (48.5% vs 13.8%;P<0.001) A multivariate analysis confirmed that sentinel node biopsy was associated with an increased RR of discharge of 1.68 (95%tile 1.11 - 2.53; p = 0.01) : Total narcotic requirements are similar between sentinel node biopsy and lymphadenectomy. However, sentinel node biopsy is associated with a shorter surgical time, recovery time, and hospital stay.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal:  Maintenance of the Neuroprotective Function of the Amino Group Blocked Fluorescence-Agmatine. (Pubmed Central) -  Oct 22, 2021   
    Agmatine, an endogenous derivative of arginine, has been found to be effective in treating idiopathic pain, convulsion, stress-mediated behavior, and attenuate the withdrawal symptoms of drugs like morphine...We also found that the agmatine-FITC treatment reduced the expression of nitric oxide production in NMDA-treated cells. This study suggests that even if the amino end of agmatine is blocked, it can perform its neuroprotective function.
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  An excitatory lateral hypothalamic circuit orchestrating pain behaviors in mice. (Pubmed Central) -  Oct 22, 2021   
    Finally, we find that LH activation evokes additive to synergistic antinociceptive interactions with morphine and restores morphine antinociception following the development of morphine tolerance. Our findings identify LH neurons as a lateral hypothalamic cell type involved in nociception and demonstrate their potential as a target for analgesia.
  • ||||||||||  Olinvyk (oliceridine) / Trevena, Jiangsu NHWA Pharma
    Journal:  CHARMM Force-Field Parameters for Morphine, Heroin, and Oliceridine, and Conformational Dynamics of Opioid Drugs. (Pubmed Central) -  Oct 22, 2021   
    From potential energy profiles for bond twists and from interactions between opioids and water, we derived a set of force-field parameters that allow a good description of structural properties and intermolecular interactions of the opioids. Potential of mean force profiles computed from molecular dynamics simulations indicate that fentanyl and oliceridine have complex energy landscapes with relatively small energy penalties, suggesting that interactions with the receptor could select different binding poses of the drugs.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal:  Accelerometric Evaluation of the Locomotor Pattern After Administration of Morphine in Conscious Healthy Horses. (Pubmed Central) -  Oct 22, 2021   
    For the propulsion component of power, these differences were observed for 20 min when compared to baseline values. The administration of 0.2 mg/kg of morphine to conscious healthy horses produces limited effects on the gait pattern of horses and the effects on locomotor activity are minimal at this dose, not being an important concern for the administration of analgesia in a clinical setting.
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  Sex differences in behavioral and brainstem transcriptomic neuroadaptations following neonatal opioid exposure in outbred mice. (Pubmed Central) -  Oct 22, 2021   
    Neonatal outbred Swiss Webster Cartworth Farms White (CFW) mice were administered morphine (15 mg/kg, s.c.) twice daily from postnatal day 1 (P1) to P14, an approximation of the third trimester of human gestation...The development of murine models for measuring neurobehavioral responses is critical for informing the neurobiological adaptations underlying NOWS. Using outbred mice that more closely model human genetic variation, we discovered several sex differences in behavioral timing and severity of NOWS-model behaviors as well as transcriptomic adaptations in brain tissue that together suggest distinct mechanisms and sex-specific therapeutics for reversing withdrawal symptoms and restoring brain function.
  • ||||||||||  morphine sulphate / Generic mfg., methamphetamine / Generic mfg., methadone / Generic mfg.
    Clinical, Journal:  Investigation of drugs of abuse in educational institutions using wastewater analysis. (Pubmed Central) -  Oct 22, 2021   
    Although a good agreement between data from this study and other studies implementing wastewater analysis was observed, there was a discrepancy with Slovenian epidemiological survey data. Finally, despite certain drawbacks of the method, its application to detect drug residues in educational institutions provides a non-invasive insight into drug use trends.
  • ||||||||||  oxycodone/acetaminophen / Generic mfg., gabapentin / Generic mfg.
    [VIRTUAL] A Case of Isaac Syndrome with Refractory Neuropathic Pain () -  Oct 21, 2021 - Abstract #ANA2021ANA_436;    
    After starting IVIg muscle fasciculations improved with only minor improvement in pain and patient was transitioned to oral Percocet and Gabapentin...Sensory manifestations such as neuropathic pain are rare but as illustrated by our patient can be the most distressing symptom. In our patient not only was neuropathic pain disabling but it also showed the least response to IVIg during follow-up.