- |||||||||| morphine sulphate / Generic mfg.
Journal: Opioid receptors signaling network. (Pubmed Central) - Nov 4, 2021
Opioid receptors belong to the class A G-protein-coupled receptors and are activated by alkaloid opiates such as morphine, and endogenous ligands such as endorphins and enkephalins...We believe that the public availability of an opioid receptor signaling pathway map can accelerate biomedical research in this area because of its high therapeutic significance. The opioid receptors signaling pathway map is uploaded to a freely available web resource, WikiPathways enabling ease of access ( https://www.wikipathways.org/index.php/Pathway:WP5093 ).
- |||||||||| cetirizine oral / Generic mfg., morphine sulphate / Generic mfg.
DIRECT PROVOCATION TESTING TO MORPHINE IN A PATIENT WITH SEVERE ALLERGIC SYMPTOMS TO OPIOIDS (Hall B (1st Floor); Monitor 01) - Nov 2, 2021 - Abstract #ACAAI2021ACAAI_702;
She tolerated fentanyl and tapentadol...Cetirizine/famotidine pre-treatment prevented distressing allergic symptoms from direct mast cell release. We review the clinical differences and diagnostic approaches to distinguish between IgE-mediated vs. non-IgE-mediated opioid reactions.
- |||||||||| Trial termination, Surgery: Post Operative Pain Control After Pediatric Hip Surgery (clinicaltrials.gov) - Nov 2, 2021
P=N/A, N=42, Terminated,
We review the clinical differences and diagnostic approaches to distinguish between IgE-mediated vs. non-IgE-mediated opioid reactions. Completed --> Terminated; Funding was exhausted prior to enrolling intended number of patients.
- |||||||||| fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg., hydromorphone hydrochloride / Generic mfg.
Journal: A Continuous Observation Workflow Time Study to Assess Intravenous Push Waste. (Pubmed Central) - Nov 2, 2021
There are financially significant costs associated with wasting both the product and the valuable time of a skilled workforce. Optimizing product size, taking special note to match product availability with common practice use, would reduce the associated financial burden on our health-systems nationwide.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Melatonin Blocks Morphine-Induced Place Preference: Involvement of GLT-1, NF-κB, BDNF, and CREB in the Nucleus Accumbens. (Pubmed Central) - Nov 2, 2021
However, melatonin treatment administered 30 min before morphine treatment attenuated morphine place preference and reversed GLT-1, BDNF, NF-κB, and CREB expression levels. In conclusion, the study results indicate, for the first time, the new potential targets of melatonin in modulating morphine-induced CPP.
- |||||||||| morphine sulphate / Generic mfg.
Preclinical, Review, Journal: The Role of Mu-Opioids for Reward and Threat Processing in Humans: Bridging the Gap from Preclinical to Clinical Opioid Drug Studies. (Pubmed Central) - Nov 1, 2021
Studies of acute opioid agonist effects indicate that with non-sedative doses, drugs such as morphine and buprenorphine can mimic endogenous opioid effects on liking and wanting...Relevant candidate systems for future research include dopamine, serotonin and endocannabinoid signalling. Nevertheless, it is possible that endogenous opioid fine-tuning of reward and threat processing, when unbalanced by e.g. opioid misuse, could over time develop into symptoms associated with opioid use disorder, such as anhedonia and depression/anxiety.
- |||||||||| morphine sulphate / Generic mfg.
Journal: New targets of morphine postconditioning protection of the myocardium in ischemia/reperfusion injury: Involvement of HSP90/Akt and C5a/NF-κB. (Pubmed Central) - Nov 1, 2021
In addition, C5a inhibitor PMX enhanced the MP-induced downregulation of NF-κB, while NF-κB inhibitor QNZ had no effect on C5a, indicating that the C5a/NF-κB signaling pathway is involved in MP-induced cardioprotection. HSP90 is critical for MP-mediated cardioprotection possibly by promoting the phosphorylation of Akt and inhibiting the activation of C5a and NF-κB signaling and the subsequent myocardial inflammation, ultimately attenuating the infarct size and cardiomyocyte apoptosis.
- |||||||||| ketamine / Generic mfg., pregabalin / Generic mfg., gabapentin / Generic mfg.
Clinical, Journal: Impact of the 2018 Society of Critical Care Medicine Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Guidelines on Nonopioid Analgesic Use and Related Outcomes in Critically Ill Adults After Major Surgery. (Pubmed Central) - Nov 1, 2021
The 2019 (vs 2017) group spent more ICU days with severe pain (p = 0.04). At our center, Pain, Agitation/Sedation, Delirium, Immobility, and Sleep guideline publication had little effect on nonopioid analgesic or opioid prescribing practices in critically ill surgical adults.
- |||||||||| morphine sulphate / Generic mfg., aspirin / Generic mfg.
Treatment Strategies for AMI - Pearls & Pitfalls () - Nov 1, 2021 - Abstract #ACEP2021ACEP_451;
Should anyone still get morphine, oxygen, nitrates, and/or aspirin? Emergency department therapies, new and old, such as reperfusion, heparin, nitrates, antiplatelet agents, beta blockers, antithrombins, opiates, supplemental oxygen, pain control, statins, & percutaneous coronary intervention will be covered, reviewing the latest literature & guidelines.
- |||||||||| morphine sulphate / Generic mfg.
[VIRTUAL] Opioid Taper Initiative from Inpatient Rehabilitation () - Nov 1, 2021 - Abstract #AAPMR2021AAPMR_724;
There was also a 16% reduction in the maximum daily morphine milligram equivalent initially prescribed at IPR admission. This project demonstrates that an interdisciplinary team-based approach to opioid tapering during IPR can help prevent excess opioid prescribing during IPR and reduce opioid prescriptions into the community at discharge.
- |||||||||| baclofen / Generic mfg.
[VIRTUAL] Intrathecal Baclofen Pump for Refractory Dystonia and Opisthotonic Posturing: A Case Report () - Nov 1, 2021 - Abstract #AAPMR2021AAPMR_685;
With persistent opisthotonic posturing and dystonia present at 1 month post injury, patient underwent Abobotulinumtoxin A and Phenol injections at time of G-tube placement, and exam under sedation was notable for continued lumbar lordosis and bilateral hip extension with inability to flex hips to neutral... ITB can be useful in refractory opisthotonic posturing management.
- |||||||||| morphine sulphate / Generic mfg.
[VIRTUAL] Veteran Opioid Tapers: A Retrospective Chart Review () - Nov 1, 2021 - Abstract #AAPMR2021AAPMR_628;
When clinicians discuss the risks and benefits of opioid tapers, these results suggest that opioid tapers have long-term benefits in anxiety, depression, pain intensity, and interference. Future research should focus on opioid taper rates, long-term outcomes, and guidelines to expand individualized evidence-based opioid tapers.
- |||||||||| morphine sulphate / Generic mfg.
[VIRTUAL] Outcomes of a Comprehensive Pain Rehabilitation Program on Fibromyalgia Patients () - Nov 1, 2021 - Abstract #AAPMR2021AAPMR_590;
Opioid doses were recalculated into oral morphine equivalents (OME)... FMS patients experience marked clinical improvements in pain severity, physical and emotional health, and functional capacity when treated with a comprehensive pain rehabilitation with concomitant medication tapering including opioids.
- |||||||||| morphine sulphate / Generic mfg.
[VIRTUAL] Do Muscle Relaxants Decrease Total Opioid Use After Lumbar Spine Surgery? A Retrospective Analysis () - Nov 1, 2021 - Abstract #AAPMR2021AAPMR_559;
Setting : Tertiary care academic medical center Participants : 1,218 consecutive patients with a history of lumbar spinal surgery at an academic medical center Interventions : Retrospective chart review study Main Outcome Measures : Total oral morphine equivalent dose (OME) for the 3 months following spinal surgery A total of 1,218 patients were included in the analysis... This study does not support the routine use of muscle relaxants for the purpose of decreasing opiate use in lumbar spine surgery patients.
- |||||||||| morphine sulphate / Generic mfg.
[VIRTUAL] Do Muscle Relaxants Decrease Total Opioid Use After Lumbar Spine Surgery? A Retrospective Analysis () - Nov 1, 2021 - Abstract #AAPMR2021AAPMR_85;
Setting : Tertiary care academic medical center Participants : 1,218 consecutive patients with a history of lumbar spinal surgery at an academic medical center Interventions : Retrospective chart review study Main Outcome Measures : Total oral morphine equivalent dose (OME) for the 3 months following spinal surgery Results : A total of 1,218 patients were included in the analysis...While the average OME dose prescribed for those who were co-prescribed a muscle relaxant was higher, the difference was not statistically significant different (p=0.58). Conclusions : This study does not support the routine use of muscle relaxants for the purpose of decreasing opiate use in lumbar spine surgery patients.
- |||||||||| morphine sulphate / Generic mfg.
Clinical, Journal: Multimodal Analgesia and Discharge Opioid Requirements in Burn Patients. (Pubmed Central) - Oct 31, 2021
The primary outcome was the change in opioid requirements (measured in oral morphine equivalents) between discharge and first follow-up interval...A total of 152 patients were included for analysis, 76 in the multimodal cohort and 76 in the nonmultimodal cohort. The multimodal cohort was noted to have increased total body surface area burned and prolonged number of days spent in the intensive care unit at baseline; however, the multimodal cohort exhibited a more significant decrease in opioid requirements from discharge to first follow-up interval when compared with the nonmultimodal cohort (106.6 vs 75.4 mg, P = .039).
- |||||||||| fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
Clinical, Journal, Real-world evidence: Patterns of real-world opioid prescribing in Australian general practice (2013-18). (Pubmed Central) - Oct 31, 2021
The private-medicines market is a small but growing component of opioid use in Australia and one way in which prescribers and patients can avoid access restrictions in the public market for these medicines. Although fentanyl patch prescribing declined, there is room for improvement in prescribing fentanyl patches among opioid-naïve patients, and co-prescribing of fentanyl patches with other sedatives.
- |||||||||| ketorolac / Generic mfg.
A service evaluation investigating patient experience of pain following elective orthopaedic surgery at Orpington Hospital, UK (Channel 1 - ePosters [VIRTUAL]) - Oct 31, 2021 - Abstract #Euroanaesthesia2021Euroanaesthesia_866;
All patients reporting pain received morphine in recovery, 3/17 also received other analgesics (including tramadol, ketorolac and paracetamol)...7/8 received intraoperative paracetamol (the exception being a patient having spinal), 3/8 received a non-steroidal anti-inflammatory (ketorolac or diclofenac), 4/8 received morphine and one received clonidine...Those patients receiving GA with LAI experienced significantly more pain than those receiving spinal anaesthesia. Investigating the basis of this finding, and excluding confounders, will be the focus of further work.
- |||||||||| ketamine / Generic mfg.
Postoperative Analgesia After Open Liver Surgery: A systematic review (Channel 1 - ePosters [VIRTUAL]) - Oct 31, 2021 - Abstract #Euroanaesthesia2021Euroanaesthesia_767;
This approach is associated with highest effectiveness and least side effects. NSAIDs should be administered on a pre-scheduled basis and opioids show the highest efficacy and safety profile when administered as patient-controlled analgesia.
- |||||||||| fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
Short-term effects of opioids on size and vulnerability of murine atherosclerotic lesions ([VIRTUAL]) - Oct 31, 2021 - Abstract #Euroanaesthesia2021Euroanaesthesia_760;
Morphine leads to an increased size of atherosclerotic lesions and drives apoptosis of monocytes within the plaque, resulting in a higher plaque vulnerability. These effects are likely mediated via the Mu-opioid-receptor.
- |||||||||| morphine sulphate / Generic mfg.
Opioid Free-Anaesthesia in lumbar spine surgery: a prospective randomized single blinded trial ([VIRTUAL]) - Oct 31, 2021 - Abstract #Euroanaesthesia2021Euroanaesthesia_752;
Opioid-free lumbar spine surgery, including lumbar fusion, is feasible and is very similar to traditional opioid-sparing regiment. OFA for lumbar surgery represents an opportunity to minimize perioperative exposure exposure without adversely affecting pain control or recovery
- |||||||||| morphine sulphate / Generic mfg.
Arnold-Chiari malformation in pregnant woman: choosing the best anaesthetic option for caesarean delivery (Channel 1 - ePosters [VIRTUAL]) - Oct 31, 2021 - Abstract #Euroanaesthesia2021Euroanaesthesia_650;
Slowly and at constant rate, 10 mg of hyperbaric 0,5% bupivacaine and 0,1 mg of morphine were administered in the intrathecal space...Concerns are related to the transient increase in intracranial pressure that accompanies general anaesthesia, but also the differential between the pressure of the cerebrospinal fluid above the foramen magnum and in the spinal canal, which can worsen after puncture in the subarachnoid space, leading to amygdala herniation with consequent strangulation of the brainstem. In individuals who have already undergone surgical correction and have no residual disease, a neuraxial approach is considered harmless.
- |||||||||| gabapentin / Generic mfg.
Liposomal bupivacaine evaluation in patients undergoing hemorrhoidectomy: A retrospective cohort study ([VIRTUAL]) - Oct 31, 2021 - Abstract #Euroanaesthesia2021Euroanaesthesia_591;
Oral acetaminophen (1000 mg) and gabapentin (600 mg) were administered before surgery and liposome bupivacaine (EXPAREL, 266mg/30 mL, n=47) or bupivacaine (0.25%, 125mg, 50ml, n=47) was infiltrated during surgery...Hydromorphone was administered for pain scores > 7 and oxycodone for pain scores > 4 and <7...However, the oral morphine equivalents were similar between groups. In this cohort of patients (stapled/excision hemorrhoidectomy) there was a marginal benefit with EXPAREL local infiltration.
- |||||||||| dexamethasone / Generic mfg.
Perioperative anesthetic considerations for Fabry disease during emergency surgery (Channel 1 - ePosters [VIRTUAL]) - Oct 31, 2021 - Abstract #Euroanaesthesia2021Euroanaesthesia_579;
Monitored neuromuscular blockade was reversed with sugammadex...Pain was managed with paracetamol, metamizole and morphine...Learning points:The main problem with Fabry disease comes with renal and cardiac organic impairment. During perioperative care close monitoring should be done so a correct systemic perfusion is guaranteed and no organ dysfunction appears, particularly with special reference to lung, heart, brain and kidneys.
- |||||||||| Chirocaine (levobupivacaine) / Purdue, AbbVie
Osteogenesis Imperfecta – Neuraxial anaesthesia and Challenges ([VIRTUAL]) - Oct 31, 2021 - Abstract #Euroanaesthesia2021Euroanaesthesia_553;
Besides the unconfirmed hypothetical hemorrhagic risk, a spinal anesthesia is safer than a continuous block and provides better pain control. In our opinion, the benefits outweigh the risk of GA in this setting.
- |||||||||| morphine sulphate / Generic mfg., sevoflurane / Generic mfg., dexmedetomidine / Generic mfg.
Impact of opioid-free anaesthesia on postoperative nausea, vomiting and pain after gynaecological laparoscopy - a randomised controlled trial ([VIRTUAL]) - Oct 31, 2021 - Abstract #Euroanaesthesia2021Euroanaesthesia_551;
152 patients undergoing gynaecological laparoscopy were randomly assigned for opioid-free anaesthesia (Group OF) with dexmedetomidine, esketamine and sevoflurane or to have opioid-inclusive anaesthesia (Group C) with sufentanil and sevoflurane. Opioid-free multimodal general anaesthesia has no beneficial effect on PONV, pain scores or morphine consumption in patients undergoing gynaecological laparoscopy but is associated with delayed recovery.
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