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7 Diseases |  |
379 Trials |
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379 Trials |  |
12426 News |  |
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- | morphine sulphate / Generic mfg.
Journal: Agonist dependency of the second phase access of β-arrestin 2 to the heteromeric µ-V1b receptor. (Pubmed Central) - Nov 10, 2021
In contrast, the second-phase access of β-arrestin 2 was agonist dependent, indicating a possible pharmacological intervention strategy. Therefore, our efficient method should be useful for evaluating chemicals that directly target the vasopressin binding site in the µ-V1b heteromer to reduce the second-phase access of β-arrestin 2 and thereby to alleviate tolerance to morphine analgesia.
- | morphine sulphate / Generic mfg.
Journal: Development and Initial Internal Validation of a Novel Classification System for Perioperative Expectations Following Minimally Invasive Degenerative Lumbar Spine Surgery. (Pubmed Central) - Nov 10, 2021
We present a novel classification system and initial internal validation to describe the perioperative expectations following various MIS surgeries in the degenerative lumbar spine. This initial description serves as the basis for ongoing external validation.
- || morphine sulphate / Generic mfg.
Clinical, Journal: Intrathecal Morphine for Analgesia in Minimally Invasive Cardiac Surgery: A Randomized, Placebo-controlled, Double-blinded Clinical Trial. (Pubmed Central) - Nov 10, 2021
This initial description serves as the basis for ongoing external validation. When given before induction of anesthesia for totally endoscopic coronary artery bypass, intrathecal morphine decreases use of postoperative opioids and produces significant postoperative analgesia for 48 h.
- | morphine sulphate / Generic mfg.
Retrospective data, Journal: Persistent Postoperative Opioid Prescription Fulfillment and Peripheral Nerve Blocks for Ambulatory Shoulder Surgery: A Retrospective Cohort Study. (Pubmed Central) - Nov 10, 2021
When given before induction of anesthesia for totally endoscopic coronary artery bypass, intrathecal morphine decreases use of postoperative opioids and produces significant postoperative analgesia for 48 h. This retrospective analysis found no association between receipt of a peripheral nerve block and a lower incidence of persistent postoperative opioid prescription fulfillment in ambulatory shoulder surgery patients.
- || morphine sulphate / Generic mfg.
Clinical, Retrospective data, Journal: Decreasing Inpatient Opioid Use Following Orthognathic Surgery. (Pubmed Central) - Nov 10, 2021
Intravenous TXA and PONV control may provide additional benefit to decreasing inpatient opioid consumption. More research as to the mechanisms and ideal clinical applications for both IV acetaminophen and TXA are warranted.
- ||| morphine sulphate / Generic mfg.
hydrocodone to morphine equivalent ratio https://t.co/kGKtc5Dw09 #hpm #PalliativeCare (Twitter) - Nov 9, 2021
- | morphine sulphate / Generic mfg., ketamine / Generic mfg.
Trial initiation date: KLOE: Ketamine Low dOse Evaluation on Morphine Consumption in Traumatic Patient (clinicaltrials.gov) - Nov 8, 2021
P4, N=140, Not yet recruiting, Sponsor: Assistance Publique Hopitaux De Marseille
More research as to the mechanisms and ideal clinical applications for both IV acetaminophen and TXA are warranted. Initiation date: Oct 2021 --> Jan 2022
- ||| morphine sulphate / Generic mfg.
another drug which needs to be taken long before one knows if their illness may develop complications. They did this with morphine based pain killers. So instead of saying just take one when the pain is bad, they had folks taking it every day regardless of pain. shameless. (Twitter) - Nov 8, 2021
- | morphine sulphate / Generic mfg.
Journal: Different Roles of Beclin1 in the Interaction Between Glia and Neurons after Exposure to Morphine and the HIV- Trans-Activator of Transcription (Tat) Protein. (Pubmed Central) - Nov 7, 2021
Overall, our findings show that there is a Beclin1-driven interaction between Tat and morphine in glia and neurons. Moreover, reduced glial-Beclin1 may provide a layer of protection to neurons under stressful conditions, such as when exposed to morphine and Tat.
- | morphine sulphate / Generic mfg.
Journal: The day-night differences in ERK1/2, GSK3β activity and c-Fos levels in the brain, and the responsiveness of various brain structures to morphine. (Pubmed Central) - Nov 7, 2021
We thus provide further evidence for diurnal variations in the activity of brain regions outside the suprachiasmatic nucleus indicated by the temporal changes in the molecular substrate. We suggest that these changes are responsible for generating diurnal variation in the reward behavior or analgesic effect of opioid administration.
- | fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg., dexmedetomidine / Generic mfg.
Journal: Preemptive light sedation in intensive care unit may reduce pulmonary complications in geriatrics receiving pancreaticoduodenectomy. (Pubmed Central) - Nov 7, 2021
We suggest that these changes are responsible for generating diurnal variation in the reward behavior or analgesic effect of opioid administration. Postoperative preemptive light sedation in the ICU in geriatric patients following PD may not only reduce the rates of postoperative pulmonary complications and gastroparesis but also improve postoperative quality of life without prolonging the postoperative hospital LOS.
- | morphine sulphate / Generic mfg.
Journal: Correlation study between anatomopathological data and levels of blood morphine concentrations in heroin-related deaths. (Pubmed Central) - Nov 7, 2021
The results demonstrated a statistically significant correlation between the two variables: individuals with low total blood morphine values tended to have a higher pathological score. Our study provides useful assessment tools for forensic practice, confirming the need to combine two important disciplines in drug death investigation: forensic pathology and toxicology.
- | morphine sulphate / Generic mfg.
Journal: Laparoscopic approach to refractory extraspinal sciatica and pudendal pain caused by intrapelvic nerve entrapment. (Pubmed Central) - Nov 7, 2021
Preoperative chronic opioid use (≥ 4 months of ≥ 10 mg morphine equivalents/day) was a predictor of poor surgical outcome-clinically relevant pain reduction was observed in only 30.8% in this group of patients, compared to 91.5% in patients not regularly taking opioids preoperatively (p < 0.01)...Our results indicate that the LANN technique is an effective and reproducible approach to relieve pain secondary to intrapelvic nerve entrapments and that preoperative chronic opioid therapy significantly reduces the likelihood of a successful surgical outcome. This study provides detailed information on perioperative complication and postoperative course, which is essential for patient consenting.
- || Clinical, Review, Journal: Suicide committed by a paramedic using a cocktail of drugs: Morphine, etomidate, diazepam and rocuronium. Case report and review of literature. (Pubmed Central) - Nov 7, 2021
Toxicological studies revealed that the man had also been taking sertraline, a commonly used antidepressant. The reasons for suicide among healthcare professionals are the same as for the general population; however, given the extremely high work-related stress and easy availability of drugs that can be effectively used to commit suicide, a special approach to the issue is necessary.
- ||| morphine sulphate / Generic mfg.
I use it for part of my treatment for diabetes neurological neuropathy and yes I no different to treatment for MS but been a god send for me I take 5 different treatments for my pain including having to inject morphine which am allowed to do because I inject and pump insulin (Twitter) - Nov 6, 2021
- | morphine sulphate / Generic mfg.
Journal: Dynorphin and Enkephalin Opioid Peptides and Transcripts in Spinal Cord and Dorsal Root Ganglion During Peripheral Inflammatory Hyperalgesia and Allodynia. (Pubmed Central) - Nov 6, 2021
These studies form the foundational framework for understanding how endogenous spinal opioid peptides are involved in nociceptive circuit modulation. (48/50).
- || morphine sulphate / Generic mfg.
Clinical, Journal: Evolution of Analgesic Tolerance and Opioid-Induced Hyperalgesia over 6 months: Double-blind randomized trial incorporating experimental pain models. (Pubmed Central) - Nov 6, 2021
P=N/A
Eleven were taking no opioids at study entry and eleven were taking between 35 and 122 morphine equivalents...Overall benefit was small, and 18% of patients had evidence of both tolerance and OIH. Future work requires a different approach than a classic RCT design.
- | fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg., levamisole / Generic mfg.
Retrospective data, Journal: Opioid Overdose Deaths with Buprenorphine Detected in Postmortem Toxicology: a Retrospective Analysis. (Pubmed Central) - Nov 6, 2021
Although data are limited, buprenorphine may provide some risk mitigation against full agonist opioid overdose including fentanyl. Further work should explore the use of postmortem concentrations of buprenorphine, norbuprenorphine, and other opioid metabolites to determine the role of buprenorphine in fatal overdose pharmacology.
- | morphine sulphate / Generic mfg.
Journal: Paternal exposure to morphine during adolescence potentiates morphine withdrawal in male offspring: Involvement of the lateral paragigantocellularis nucleus. (Pubmed Central) - Nov 6, 2021
Moreover, the lack of alteration in maternal behavior toward morphine-sired offspring indicates that this is due to germline-dependent transmission of epigenetic traits across generations. Preconception paternal exposure to morphine during adolescence potentiates opiate withdrawal signs in male offspring which is mediated, at least in part, by epigenetic alteration of LPGi-related brain circuitry.
- | morphine sulphate / Generic mfg.
Journal: Magnetic Resistance Sensory System for the Quantitative Measurement of Morphine. (Pubmed Central) - Nov 6, 2021
Compared with other optical detection instruments, the system has good specificity because there is no background noise in the detection sample. The size of the whole system is 98mm62mm78mm, and it has the characteristics of compactness and fast detection.
- | morphine sulphate / Generic mfg.
Journal: D-Cystine di(m)ethyl ester reverses the deleterious effects of morphine on ventilation and arterial blood gas chemistry while promoting antinociception. (Pubmed Central) - Nov 6, 2021
D-cystine diEE and D-cystine diME may be clinically useful agents that can effectively reverse the negative effects of morphine on breathing and gas-exchange in the lungs while promoting antinociception. Our study suggests that the D-cystine thiolesters are able to differentially modulate the intracellular signaling cascades that mediate morphine-induced ventilatory depression as opposed to those that mediate morphine-induced antinociception and sedation.
- | morphine sulphate / Generic mfg.
Journal: Bone pain from spinal metastases: Iodine-125 brachytherapy. (Pubmed Central) - Nov 6, 2021
Our study suggests that the D-cystine thiolesters are able to differentially modulate the intracellular signaling cascades that mediate morphine-induced ventilatory depression as opposed to those that mediate morphine-induced antinociception and sedation. CT-guided I brachytherapy is an effective and safe intervention for patients with spinal metastasis-induced pain who are not able to receive radiation therapy.
- | morphine sulphate / Generic mfg.
Retrospective data, Journal: Suprascapular nerve block is a clinically attractive alternative to interscalene nerve block during arthroscopic shoulder surgery: a meta-analysis of randomized controlled trials. (Pubmed Central) - Nov 6, 2021
Our high-level evidence established SSNB as an effective and safe analgesic technique and a clinically attractive alternative to interscalene block with the SSNB'S advantage of similar pain control, morphine use, and less nerve block-related complications during arthroscopic shoulder surgery, especially for severe chronic obstructive pulmonary disease, obstructive sleep apnea, and morbid obesity. Given our meta-analysis's relevant possible biases, we required more adequately powered and better-designed RCT studies with long-term follow-up to reach a firmer conclusion.
- | morphine sulphate / Generic mfg.
Journal: Thoraco-Lumbar Interfascial Plane (TLIP) block results in opioid-free post-operative recovery after percutaneous / endoscopic TLIF surgery. (Pubmed Central) - Nov 6, 2021
TLIP block significantly improves patient outcome at hospital discharge after TLIF surgery without post-operative administration of opioids. A prospective study is recommended to confirm our preliminary results.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Role of ultralow dose of naloxone as an adjuvant to fentanyl-bupivacaine in thoracic paravertebral block analgesia after modified radical mastectomy: Randomized controlled trial. (Pubmed Central) - Nov 6, 2021
A prospective study is recommended to confirm our preliminary results. Using naloxone as additives in PVB has been promising and effective in controlling post-mastectomy pain.
- || morphine sulphate / Generic mfg.
Clinical, Retrospective data, Journal: Can the implementation of the Opioid Start Talking form impact the amount of opioid use in patients after ankle fracture repair? (Pubmed Central) - Nov 6, 2021
Overall, the administration of the OST form to patients with ankle fractures did not result in a decrease in MMEs prescribed within 120 days of surgery. Although it is a start in the battle against the opioid epidemic, further evaluation of the effectiveness of the OST form is necessary.
- || morphine sulphate / Generic mfg.
Retrospective data, Review, Journal: Efficacy and safety of intrathecal morphine in total knee arthroplasty: A systematic review and meta-analysis. (Pubmed Central) - Nov 6, 2021
ITM reduces pain at 4 and 24 hours post-operatively with no effect on cumulative morphine consumption. The only feared side effect is pruritus.
- | morphine sulphate / Generic mfg., hydromorphone hydrochloride / Generic mfg.
Observational data, Retrospective data, Journal: Comparison of Opioid Prescription Pattern Trends amongst DENTAC and Selected Departments of the Carl R. Darnall Army Medical Center, Fort Hood, TX, from 2010 to 2017. (Pubmed Central) - Nov 6, 2021
Overall, the Family Medicine department showed the most drastic change in opioid prescription patterns from 1 JAN 2010 to 31 DEC 2017 at the Carl R. Darnall Army Medical Center, Fort Hood, TX. The most common types of opioid medication prescribed in the same period of time within the four departments were characterized by morphine and hydromorphone components.
- || morphine sulphate / Generic mfg.
Clinical, Journal: Liposomal Bupivacaine Infiltration Versus Bupivacaine Hydrochloride for the Management of Unilateral Total Knee Arthroplasty in Geriatric Patients at a 287-Bed Community Hospital. (Pubmed Central) - Nov 6, 2021
There was no statistically significant difference in mean total opioid consumption (oral morphine equivalents) between the bupivacaine HCl (n = 25) and liposomal groups (n = 85) respectively, 93.76 versus 83.72 mg; P = .569...There was not a statistically significant difference in mean total opioid consumption between the 2 groups. Additionally, the use of non-opioid analgesics, mean pain scores, and hospital lengths of stay were similar in both groups.
- | morphine sulphate / Generic mfg.
Preclinical, Journal: Comparison of Antinociceptive Effect of Octreotide With Morphine in a Rat Model of Acute Inflammatory Pain. (Pubmed Central) - Nov 6, 2021
Variations in the sst2r expression suggest its involvement in pain modulation at the spinal level. This information may have clinical relevance.
- || morphine sulphate / Generic mfg.
Clinical, Journal: Use of continuous passive motion device after arthroscopic hip surgery decreases post-operative pain: A randomized controlled trial. (Pubmed Central) - Nov 6, 2021
The total morphine equivalent dose consumed in the first two post-operative weeks was higher in the control group compared to the CPM group, although this difference was not statistically significant...A study with a larger sample of patients might elucidate more differences between the two groups. II, therapeutic.
- |||| morphine sulphate / Generic mfg.
Clinical: Really? Sweden(10M pop): 15,000 deaths. 160,000 in longcovid. Elderly were given palliative care and morphine instead of oxygen and thousands died, some in their rooms at care homes. 200,000 surgeries cancelled, incl children's (Twitter) - Nov 5, 2021
- || vancomycin / Generic mfg., morphine sulphate / Generic mfg.
Drug agonist of MRGPRX2 vancomycin, nondepolarizing NBDA, narcotics like morphine, codeine, fluroquinolones. #acaai21 (Twitter) - Nov 5, 2021
- dexamethasone / Generic mfg.
COVID-19 Infection and Outcomes at a Comprehensive Sickle Cell Center (GWCC - Hall B5, Level 1) - Nov 5, 2021 - Abstract #ASH2021ASH_4768;
By genotype, 64% of patients were SS, 31% were SC and 5% were Sβ + thalassemia. 35% of patient were on hydroxyurea for disease modification with the majority of them being of the SS genotype and 31% had elevated fetal hemoglobin determined by a percentage fetal hemoglobin above 5% by hemoglobin electrophoresis.
- morphine sulphate / Generic mfg.
Chronic Opioid Use Is Highly Prevalent in Patients Undergoing Allogeneic Transplant and Impacts Long Term Outcomes (GWCC - Hall B5, Level 1) - Nov 5, 2021 - Abstract #ASH2021ASH_3411;
Daily opioid doses were converted to morphine milligram milliequivalents (MME) using standard conversion factors...In addition, we show the negative impact of baseline COU on overall survival, even when adjusted for disease- and transplant-related factors. These data highlight the need to improve understanding and management of pain in hematologic malignancies as well as to reinforce the need for continuous reassessment of the use of opioids prior to and after allo-HSCT.
- || morphine sulphate / Generic mfg.
Review, Journal: The "culture" of pain control: A review of opioid-induced dysbiosis (OID) in antinociceptive tolerance. (Pubmed Central) - Nov 5, 2021
Perspective: This article reviews the current literature on opioid-induced dysbiosis (OID) of gut bacteria, including its qualitative nature, influence on antinociceptive tolerance, and future prospects. This work may help identify targets for new opioid-sparing strategies.
- | amitriptyline / Generic mfg., gabapentin / Generic mfg.
Preclinical, Journal: Assessment of the anti-hyperalgesic efficacy of J-2156, relative to clinically available analgesic/adjuvant agents in a rat model of mild to moderate chronic mechanical low back pain (LBP). (Pubmed Central) - Nov 5, 2021
These findings attest to the face validity of our model. J-2156 at 10 and 30 mg/kg alleviated secondary hyperalgesia in the lumbar axial deep tissues at L1 with a non-significant trend for relief of primary hyperalgesia in the corresponding tissues at L4/L5 in these animals.
- || morphine sulphate / Generic mfg.
Clinical, Journal: Pruritus after continuous administration of epidural morphine for post-cesarean delivery analgesia: a case control study. (Pubmed Central) - Nov 5, 2021
Higher concentrations of morphine, multipara, and assisted reproductive treatment were factors associated with a higher probability of pruritus. Pain level or combined local anesthetics could moderate the association between morphine concentration and pruritus.
- | glibenclamide / Generic mfg.
Journal: Bupleurum falcatum L. alleviates nociceptive and neuropathic pain: Potential Mechanisms of Action. (Pubmed Central) - Nov 5, 2021
The present data also suggest activating the L-arginine-NO-cGMP-KATP channel pathway as well as interaction of opioid, PPA, and cannabinoid receptors in the BFEO anti-nociceptive activities. These results also propose that BFEO could effectively attenuate allodynia in CSC mice.
- || Dynastat (parecoxib) / Pfizer
Clinical, Journal: Perioperative Outcomes of Patients Who Were Not Candidates for Additional Nonsteroidal Anti-inflammatory Drugs in a Multimodal Pain Control Regimen for Total Knee Arthroplasty. (Pubmed Central) - Nov 5, 2021
The control group comprised patients who received parenteral parecoxib every 12 hours during the first 48 hours after TKA...The No-NSAIDs group had significantly higher VAS scores in 6-96 hours and consumed more morphine at 24 hours and 48 hours after the surgery than the control group...They also tended to have greater blood loss and the rising of cardiac biomarkers during the first 48 hours after TKA. Hence, these patients may benefit from supplementary analgesia and appropriate perioperative monitoring.
- || morphine sulphate / Generic mfg.
Clinical, Journal: Multidisciplinary Presurgical Education: Clinical Impact on Children With Orofacial Clefts Undergoing Maxillary Distraction via Rigid External Distraction. (Pubmed Central) - Nov 4, 2021
Hence, these patients may benefit from supplementary analgesia and appropriate perioperative monitoring. Multidisciplinary presurgical education is a beneficial adjunct in the care of patients with orofacial clefts and maxillary hypoplasia undergoing maxillary advancement with a RED.
- | morphine sulphate / Generic mfg.
Journal: Inhibition of Hsp90 in the spinal cord enhances the antinociceptive effects of morphine by activating an ERK-RSK pathway. (Pubmed Central) - Nov 4, 2021
The additive effects of Hsp90 inhibition were abolished upon intrathecal inhibition of ERK, RSK, or protein synthesis. This mechanism downstream of MOR, localized to the spinal cord and repressed by Hsp90, may potentially be used to enhance the efficacy and presumably decrease the side effects of opioid therapy.
- | morphine sulphate / Generic mfg.
Preclinical, Journal: Chronic opioid exposure differentially modulates oxycodone self-administration in male and female rats. (Pubmed Central) - Nov 4, 2021
Finally, females with prior morphine exposure demonstrated the lowest motivation to SA oxycodone in the progressive ratio test. Contrary to our initial hypothesis, our findings suggest that prior opioid exposure increases vulnerability to initiate misuse more in males and decreases the reinforcing efficacy of oxycodone in females.
- || Clinical, Journal: Use of Injectable Opioid Agonist Therapy in a In-Patient Setting for a Pregnant Patient With Opioid Use Disorder: A Case Report. (Pubmed Central) - Nov 4, 2021
This case report highlights iOAT as an option during pregnancy and describes the in-patient setting as appropriate to retain high-risk patients in care. This approach may benefit those who are refractory to standard opioid agonist treatment, the numbers of whom may be rising as tolerance to the illicit supply increases.
- || morphine sulphate / Generic mfg.
Clinical, Journal: Algorithm for management of an incarcerated inguinal hernia in the emergency settings with manual reduction. Taxis, the technique and its safety. (Pubmed Central) - Nov 4, 2021
It likely reduces the risk and complications of anaesthesia and surgery in the emergency settings. GPS Taxis should be considered as first line treatment in the majority of patients presenting with an acute inguinal hernia when existing bowel infarction is unlikely.
- | morphine sulphate / Generic mfg.
Preclinical, Journal: HIV-1 Tat and morphine decrease murine inter-male social interactions and associated oxytocin levels in the prefrontal cortex, amygdala, and hypothalamic paraventricular nucleus. (Pubmed Central) - Nov 4, 2021
In Tat(+) or morphine-exposed mice, regional levels of CRF and oxytocin correlated with alterations in behavior in the social interaction and novelty tests. Overall, decreased expression of oxytocin in the prefrontal cortico-hippocampal-amygdalar circuit is associated with morphine- and HIV-Tat-induced deficits in social behavior.
- || morphine sulphate / Generic mfg.
Clinical, Journal: The management of patients admitted to hospital with vertebral fragility fractures: experience from a UK university hospital. (Pubmed Central) - Nov 4, 2021
Quality standards and re-organising care in hip fracture has led to improved outcomes. A similar approach in vertebral fragility fractures might also deliver improved outcomes.
- | ceftriaxone / Generic mfg., morphine sulphate / Generic mfg.
Journal: The role of hippocampal glial glutamate transporter (GLT-1) in morphine-induced behavioral responses. (Pubmed Central) - Nov 4, 2021
It seems that hippocampal GLT-1 can be affected by chronic morphine administration and involved in morphine dependence. Therefore, its activation may reduce morphine side effects by reducing hippocampal glutamate.
- | morphine sulphate / Generic mfg.
Retrospective data, Journal: Impact of a severe complication two years after laparoscopic Roux-en-Y gastric bypass: a cohort study from the Scandinavian Obesity Surgery Registry. (Pubmed Central) - Nov 4, 2021
An SC resulted in higher antidepressant, PPI and opioid use as well as higher need for in-hospital care during the first 2 postoperative years. Affected patients should therefore receive special attention during follow up.
- || morphine sulphate / Generic mfg.
Retrospective data, Review, Journal: Impact of enhanced recovery after caesarean delivery on maternal outcomes: A systematic review and meta-analysis. (Pubmed Central) - Nov 4, 2021
ERAC does not significantly affect maternal hospital readmission rates following discharge. Further studies are required to determine which ERAC interventions to implement and which outcomes best determine ERAC efficacy.